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== Function ==
Ectonucleotidases produce key molecules for purine salvage and consequent replenishment of ATP stores within multiple cell types. Dephosphorylated nucleoside derivatives interact with membrane transporters to enable intracellular uptake. Ectonucleotidases modulate [[P2 receptor|P2]] purinergic signaling, and [[P1 receptors]].<ref>{{Citation|last1=Kukulski|first1=Filip|title=Chapter 9 - Impact of Ectoenzymes on P2 and P1 Receptor Signaling|date=2011-01-01|url=http://www.sciencedirect.com/science/article/pii/B9780123855268000096|work=Advances in Pharmacology|volume=61|pages=263–299|editor-last=Jacobson|editor-first=Kenneth A.|series=Pharmacology of Purine and Pyrimidine Receptors|publisher=Academic Press|language=en|doi=10.1016/b978-0-12-385526-8.00009-6|access-date=2020-11-28|last2=Lévesque|first2=Sébastien A.|last3=Sévigny|first3=Jean|pmid=21586362|isbn=9780123855268 |editor2-last=Linden|editor2-first=Joel}}</ref> In addition, ectonucleotidases generate extracellular adenosine, which abrogates nucleotide-mediated effects and activates adenosine receptors, often with opposing (patho-) physiological effects.<ref>{{cite journal|last=Roberts|first=V|author2=Stagg, J |author3=Dwyer, KM |title=The Role of Ectonucleotidases CD39 and CD73 and Adenosine Signaling in Solid Organ Transplantation.|journal=Frontiers in Immunology|year=2014|volume=5|pages=64|pmid=24600452|doi=10.3389/fimmu.2014.00064|pmc=3927137|doi-access=free}}</ref>
== Adenosine generation ==
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