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{{short description|American neuroscientist}}
{{Infobox scientist
| name = Sally Temple
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| citizenship =
| nationality = American
| fields = [[
| workplaces = [[Albany Medical College]]
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| influences =
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| awards = [[MacArthur Fellows Program]]
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'''Sally Temple''' is
==Life==
In 2010 she and John J. Nigro were recipients of the 2010 Citizen Laureate Awards. This award is meant to recognize leaders in the fields of business, industry, government, and academia.<ref name=":1">{{Cite web|title = Stem Cell Researcher Made University at Albany Citizen Laureate - University at Albany-SUNY|url = http://www.albany.edu/news/10149.php|website = www.albany.edu|accessdate = 2015-11-19}}</ref>
Previously, she was a fellow of the [[Alden March Bioethics Institute]].<ref name=":3" />
Temple currently is the scientific director of the [http://neuralsci.org Neural Stem Cell Institute]. She also is a faculty member for [[Albany Medical College]], [[Rensselaer Polytechnic Institute]], and [[University at Albany, SUNY|SUNY Albany]].<ref name=":3" /> Dr. Temple is married to Dr. Jeffrey Stern, a retinal surgeon, who is the other co-founder of the Regenerative Research Foundation and Neural Stem Cell Institute.<ref>{{Cite web|title = Jeffrey Stern - StemCulture|url = http://stemcultures.com/jeffrey-stern/|website = StemCulture|accessdate = 2015-11-20|language = en-US}}</ref>
== Research ==▼
Dr. Temple's current laboratory focuses primarily on neural stem cells and the development for therapies related to eye, brain, and spinal cord disorders<ref name=":0" />.▼
She is a member of the Editorial Board for ''[[Developmental Cell]]''.
▲== Research ==
One of these accomplishments is the isolation and culturing of a progenitor cell line of glia, that indicated the number of cell divisions the cell underwent was determined by internal counting mechanisms<ref name=":3" />. This research also led to her indicating specific markers on progenitor cell lines and external signaling molecules that are involved in the maintenance of neural stem cells<ref name=":2" />. ▼
▲
▲One of
Some of her other research has indicated that the limited success of embryonic stem cell transplants in neurological cases may be due to the introduction of cells at the wrong developmental stage. This may have a huge impact on neurological therapies using stem cells as a future of medicine<ref name=":2" />. ▼
▲Some of her other research has indicated that the limited success of embryonic stem cell transplants in neurological cases may be due to the introduction of cells at the wrong developmental stage. This may have a huge impact on neurological therapies using stem cells as a future of medicine.<ref name=":2" />
She has also provided evidence in her field that has shown that progenitor cells gradually lose the ability to divide. The ''[[FOXG1|Foxg1]]'' [[FOXG1|gene]] is important in this, because a reduction in it's expression results in a delay in this process<ref name=":3" />.▼
▲She has also provided evidence in her field that has shown that progenitor cells gradually lose the ability to divide.
As president of StemCulture, LLC. she is currently working on a new study involving a new product, StemBeads FGF2.<ref name=":0" /> StemCulture, LLC. describe this product as a [[growth factor]] supplement that is able to grow [[FGF2]] dependent stem cell cultures in a more efficient way.<ref>{{Cite web|title = You searched for stem beads fgf2 - StemCulture|url = http://stemcultures.com/?s=stem+beads+fgf2|website = StemCulture|accessdate = 2015-11-20|language = en-US}}</ref> She also recently identified an important human central nervous stem cell that may lead to important developments in retinal disease treatments.<ref>{{Cite web|title = Speaker - Cell Symposia: Stem cells in modeling and treating disease, November 21 - 23, 2013 Cedars-Sinai Medical Center, Los Angeles, USA|url = http://www.cell-symposia-stemcells-modelingtreatingdisease.com/bio-temple.html|website = www.cell-symposia-stemcells-modelingtreatingdisease.com|access-date = 2015-11-20|url-status = dead|archive-url = https://web.archive.org/web/20151120103626/http://www.cell-symposia-stemcells-modelingtreatingdisease.com/bio-temple.html|archive-date = 2015-11-20}}</ref> In 2015, she attended a RPI stem cell and bioengineering meeting and spoke about her [[Retinal pigment epithelium|retinal pigmented epithelial]] (RPE) research. She discussed how her team has been furthering their research into culturing human retinal stem cells and the use of RPE cells in therapy for age-related [[macular degeneration]].<ref>{{Cite web|title = Sally Temple on adult RPEs for vision impairment, IND, & more - The Niche|url = https://www.ipscell.com/2015/06/sally-temple/|website = The Niche|date = 17 June 2015|accessdate = 2015-11-20|language = en-US}}</ref>
=== Patents ===
Temple has a large number of patents related to neural stem cells and for various methods for culture undifferentiated cells.<ref>{{Cite web|title = Patents by Inventor Sally Temple Stern - Justia Patents Database|url = http://patents.justia.com/inventor/sally-temple-stern|website = patents.justia.com|accessdate = 2015-11-20}}</ref>
== Awards ==
== Publications ==
▲2008 - [[MacArthur Fellows Program|MacArthur Fellowship]] - Dr. Temple was awarded this no-strings attached grant intended to supplement the winner's potential for creativity<ref name=":3">{{Cite web|title = Sally Temple — MacArthur Foundation|url = https://www.macfound.org/fellows/813/|website = www.macfound.org|accessdate = 2015-11-19}}</ref>
* ''Spred1, a negative regulator of Ras-MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation, and maintains ventricular zone structure.'' Phoenix TN, Temple S. Genes Dev. 2010 Jan 1;24(1):45-56.
* ''The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells.'' Shen Q, Wang Y, Dimos JT, Fasano CA, Phoenix TN, Lemischka IR, Ivanova NB, Stifani S, Morrisey EE, Temple S. Nat Neurosci. 2006 Jun;9(6):743-51. Epub 2006 May 7.
* ''LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1.'' Capela A, Temple S. Dev Biol. 2006 Mar 15;291(2):300-13. Epub 2006 Feb 3.
* ''Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells.'' Sun Y, Goderie SK, Temple S. Neuron. 2005 Mar 24;45(6):873-86.
* ''LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal.'' Capela A, Temple S. Neuron. 2002 Aug 29;35(5):865-75.
== References ==
{{
== External links ==
* [http://www.neuralsci.org The Neural Stem Cell Institute]
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{{DEFAULTSORT:Temple, Sally}}
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[[Category:Alumni of University College London]]
[[Category:American neuroscientists]]
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[[Category:American women scientists]]▼
[[Category:Columbia University alumni]]
[[Category:MacArthur Fellows]]
[[Category:Year of birth missing (living people)]]
[[Category:Members of the National Academy of Medicine]]
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