Skin cancer: Difference between revisions

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Skin cancer is the most common form of cancer, globally accounting for at least 40% of cancer cases.<ref name=Cak2012>{{cite journal | vauthors = Cakir BÖ, Adamson P, Cingi C | title = Epidemiology and economic burden of nonmelanoma skin cancer | journal = Facial Plastic Surgery Clinics of North America | volume = 20 | issue = 4 | pages = 419–422 | date = November 2012 | pmid = 23084294 | doi = 10.1016/j.fsc.2012.07.004 }}</ref><ref>{{cite journal | vauthors = Dubas LE, Ingraffea A | title = Nonmelanoma skin cancer | journal = Facial Plastic Surgery Clinics of North America | volume = 21 | issue = 1 | pages = 43–53 | date = February 2013 | pmid = 23369588 | doi = 10.1016/j.fsc.2012.10.003 }}</ref> The most common type is nonmelanoma skin cancer, which occurs in at least 2–3 million people per year.<ref name="WCR2014" /><ref>{{cite web|title=How common is skin cancer?|url=https://www.who.int/uv/faq/skincancer/en/index1.html|website=World Health Organization|access-date=30 June 2014|url-status=live|archive-url=https://web.archive.org/web/20100927065836/http://www.who.int/uv/faq/skincancer/en/index1.html|archive-date=27 September 2010}}</ref> This is a rough estimate, however, as; good statistics are not kept.<ref name="NCI2013TxPro" /> Of nonmelanoma skin cancers, about 80% are basal-cell cancers and 20% squamous-cell skin cancers.<ref name="ABC2008" /> Basal-cell and squamous-cell skin cancers rarely result in death.<ref name="WCR2014" /> In the United States, they were the cause of less than 0.1% of all cancer deaths.<ref name="NCI2013TxPro" /> Globally in 2012, melanoma occurred in 232,000 people and resulted in 55,000 deaths.<ref name="WCR2014" /> White people in [[Australia]], [[New Zealand]] and [[South Africa]] have the highest rates of melanoma in the world.<ref name="WCR2014" /><ref>{{cite book | vauthors = Harris RE | title=Epidemiology of Chronic Disease |date=2013 |publisher=Jones & Bartlett Publishers |isbn=978-0-7637-8047-0 |page=271 |url=https://books.google.com/books?id=KJLEIvX4wzoC&pg=PA271 }}</ref> The three main types of skin cancer have become more common in the last 20 to 40 years, especially regions where the population is predominantly White.<ref name="Cak2012" /><ref name=WCR2014>{{cite book|title=World Cancer Report 2014.|date=2014|publisher=World Health Organization|isbn=978-9283204299|pages=Chapter 5.14}}</ref>
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Treatments for metastatic melanoma include biologic immunotherapy agents [[ipilimumab]], [[pembrolizumab]], [[nivolumab]], [[cemiplimab]]; [[BRAF inhibitor]]s, such as [[vemurafenib]] and [[dabrafenib]]; and a [[MEK inhibitor]] [[trametinib]].<ref>{{cite journal | vauthors = Maverakis E, Cornelius LA, Bowen GM, Phan T, Patel FB, Fitzmaurice S, He Y, Burrall B, Duong C, Kloxin AM, Sultani H, Wilken R, Martinez SR, Patel F | display-authors = 6 | title = Metastatic melanoma - a review of current and future treatment options | journal = Acta Dermato-Venereologica | volume = 95 | issue = 5 | pages = 516–524 | date = May 2015 | pmid = 25520039 | doi = 10.2340/00015555-2035 | doi-access = free }}</ref>
 
In February 2024, the Food and Drug Administration approved the first cancer treatment that uses tumor-infiltrating lymphocytes, also called TIL therapy, specifically for melanomas that have not improved with other treatments. Additionally, scientists are testing a vaccine designed to match the unique genetic details of a patient's cancer in an advanced clinical trial.<ref>{{Cite news |last=Alcorn |first=Ted |date=April 15, 2024 |title=How to Avoid One of the Deadliest Forms of Skin Cancer |url=https://www.nytimes.com/article/melanoma-skin-cancer-symptoms-risk.html |work=The New York Times}}</ref>
 
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{{Commons category|Skin cancers}}
* {{Curlie|Health/Conditions_and_Diseases/Cancer/Skin}}
* [http://www.oncolex.org/en/Skin-cancer Skin cancer procedures: text, images and videos] {{Webarchive|url=https://web.archive.org/web/20131207034706/http://www.oncolex.org/en/Skin-cancer |date=7 December 2013 }}
 
{{Tumors}}