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{{Short description|Protein-coding gene in humans}}
{{PBB|geneid=51806}}
{{Infobox_gene}}
'''Calmodulin-like protein 5''' is a [[protein]] that in humans is encoded by the ''CALML5'' [[gene]].<ref name="pmid10777582">{{cite journal | authorvauthors = Mehul B, Bernard D, Simonetti L, Bernard MA, Schmidt R | title = Identification and cloning of a new calmodulin-like protein from human epidermis | journal = J Biol Chem | volume = 275 | issue = 17 | pages = 12841–7 |date=Jun 2000 | pmid = 10777582 | pmc = | doi =10.1074/jbc.275.17.12841 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CALML5 calmodulin-like 5| url = httphttps://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51806| accessdate = }}</ref>
 
| summary_text = This gene encodes a novel [[calcium]] binding protein expressed in the [[epidermis]] and related to the [[calmodulin]] family of [[Calcium-binding protein|calcium binding proteins]]. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes[[keratinocyte]]s. In addition, it can associate with [[transglutaminase]] 3, shown to be a key enzyme in the terminal differentiation of [[keratinocytes]].<ref name="entrez" />▼
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▲| summary_text = This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.<ref name="entrez" />
}}
 
==References==
{{reflist}}
 
==External links==
* {{UCSC gene info|CALML5}}
* {{PDBe-KB2|Q9NZT1|Human Calmodulin-like protein 5}}
 
==Further reading==
{{refbegin | 2}}
*{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
{{PBB_Further_reading
*{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
| citations =
*{{cite journal | authorvauthors=MaruyamaMéhul KB, SuganoBernard SD, Schmidt R |title=OligoCalmodulin-cappinglike skin protein: a simplenew method to replace the cap structuremarker of eukaryotickeratinocyte mRNAs with oligoribonucleotidesdifferentiation |journal=GeneJ. Invest. Dermatol. |volume=138116 |issue= 1–26 |pages= 171–4905–9 |year= 19942001 |pmid= 812529811407979 |doi= 10.10161046/0378j.0022-1119(94)90802202x.2001.01376.x |doi-8access= free }}
*{{cite journal | authorvauthors=SuzukiDurussel YI, Yoshitomo-NakagawaMéhul KB, MaruyamaBernard K, ''et al.''D |title=ConstructionCation- and characterizationpeptide-binding ofproperties aof fullhuman lengthcalmodulin-enrichedlike and a 5'-end-enriched cDNAskin libraryprotein |journal=GeneBiochemistry |volume=20041 |issue= 1–217 |pages= 149–565439–48 |year= 19972002 |pmid= 937314911969404 |doi=10.10161021/S0378-1119(97)00411-3 bi016062z |display-authors=etal}}
*{{cite journal | authorvauthors=MéhulStrausberg BRL, BernardFeingold DEA, SchmidtGrouse RLH |title=Calmodulin-likeGeneration skinand protein:initial aanalysis newof markermore ofthan 15,000 full-length human and mouse keratinocytecDNA differentiationsequences |journal=JProc. InvestNatl. DermatolAcad. Sci. U.S.A. |volume=11699 |issue= 626 |pages= 905–916899–903 |year= 20012003 |pmid= 1140797912477932 |doi= 10.10461073/jpnas.0022-202x242603899 | pmc=139241 |bibcode=2002PNAS.2001.01376.x9916899M |display-authors=etal|doi-access=free }}
*{{cite journal | authorvauthors=DurusselGerhard IDS, MéhulWagner BL, BernardFeingold D, ''et al.''EA |title=Cation-The andstatus, peptide-bindingquality, propertiesand expansion of humanthe calmodulinNIH full-likelength cDNA project: the Mammalian Gene skinCollection protein(MGC) |journal=BiochemistryGenome Res. |volume=4114 |issue= 1710B |pages= 5439–482121–7 |year= 20022004 |pmid= 1196940415489334 |doi= 10.10211101/bi016062zgr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal | authorvauthors=StrausbergRual RLJF, FeingoldVenkatesan EAK, GrouseHao LH, ''et al.''T |title=GenerationTowards anda initialproteome-scale analysismap of morethe thanhuman 15,000 fullprotein-length human and mouseprotein cDNAinteraction sequencesnetwork |journal=Proc. Natl. Acad. Sci. U.S.A.Nature |volume=99437 |issue= 267062 |pages= 16899–9031173–8 |year= 20032005 |pmid= 1247793216189514 |doi= 10.10731038/pnasnature04209 |bibcode=2005Natur.242603899 437.1173R | pmcs2cid=1392414427026 |display-authors=etal}}
*{{cite journal | authorvauthors=GerhardMéhul DSB, WagnerBernard LD, FeingoldBrouard EA, ''et al.''M |title=TheInfluence status,of quality,calcium andon expansionthe proteolytic degradation of the NIH fullcalmodulin-lengthlike cDNAskin project:protein the(calmodulin-like Mammalianprotein Gene5) Collectionin (MGC)psoriatic epidermis |journal=GenomeExp. ResDermatol. |volume=1415 |issue= 10B6 |pages= 2121–7469–77 |year= 20042006 |pmid= 1548933416689864 |doi= 10.11011111/grj.2596504 1600-0625.2006.00433.x | pmcs2cid=52892832717375 |display-authors=etal}}
*{{cite journal | authorvauthors=RualBabini JFE, VenkatesanBertini KI, HaoCapozzi T, ''et al.''F |title=TowardsA astructural proteome-scaleand dynamic mapcharacterization of the humanEF-hand protein-protein interaction networkCLSP |journal=NatureStructure |volume=43714 |issue= 70626 |pages= 1173–81029–38 |year= 20052006 |pmid= 1618951416765896 |doi= 10.10381016/nature04209j.str.2006.04.004 |display-authors=etal|doi-access=free }}
*{{cite journal | authorvauthors=MéhulEwing BRM, BernardChu DP, BrouardElisma M, ''et al.''F |title=Influence of calcium on the proteolyticLarge-scale degradationmapping of the calmodulin-like skinhuman protein (calmodulin-like protein 5)interactions inby psoriaticmass epidermisspectrometry |journal=ExpMol. DermatolSyst. Biol. |volume=153 |issue= 6 1|pages= 469–7789 |year= 20062007 |pmid= 1668986417353931 |doi= 10.11111038/j.1600-0625.2006.00433.xmsb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal | author=Babini E, Bertini I, Capozzi F, ''et al.'' |title=A structural and dynamic characterization of the EF-hand protein CLSP |journal=Structure |volume=14 |issue= 6 |pages= 1029–38 |year= 2006 |pmid= 16765896 |doi= 10.1016/j.str.2006.04.004 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
}}
{{refend}}
{{PDB Gallery|geneid=51806}}
 
[[Category:EF-hand-containing proteins]]
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