Ectonucleotidase: Difference between revisions

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There are four major families of ectonucleotidases in the liver microenvironment namely [[CD39]]/NTPDases (ecto-nucleotide triphosphate diphosphohydrolases), Nucleotide pyrophosphatase/phosphodiesterase (NPP)-type ecto-phosphodiesterases, alkaline phosphatases and ecto-5’-nucleotidases/[[CD73]]
 
== FunctionsFunction ==
 
Ectonucleotidases also produce the key molecules for purine salvage and consequent replenishment of ATP stores within multiple cell types. Indeed, although nucleotides do not appear to be taken up by cells, dephosphorylated nucleoside derivatives interact with several specific transporters to enable intracellular uptake via membrane passage.
 
== Adenosine generation ==