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== Diagnosis ==
A blood test can be performed to quantify total homocysteine concentration in the plasma, of which approximately 80% is generally protein-bound. Classification of hyperhomocysteinemia is defined with respect to serum concentration as follows:{{cn}}
* Moderate: 15–30 nmol/mL (or μmol/L)
* Intermediate: 30–100 nmol/mL
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