Hyperhomocysteinemia: Difference between revisions

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=== Bone health ===
Elevated levels of homocysteine have also been linked to increased [[Fracture (bone)|fractures]] in elderly persons. Homocysteine auto-oxidizes and reacts with reactive oxygen intermediates, damaging endothelial cells and increasing the risk of [[thrombus]] formation.<ref>{{cite journal |doi=10.1056/NEJMoa032739 |pmid=15141042 |title=Homocysteine as a Predictive Factor for Hip Fracture in Older Persons |journal=New England Journal of Medicine |volume=350 |issue=20 |pages=2042–9 |year=2004 |last1=McLean |first1=Robert R. |last2=Jacques |first2=Paul F. |last3=Selhub |first3=Jacob |last4=Tucker |first4=Katherine L. |last5=Samelson |first5=Elizabeth J. |last6=Broe |first6=Kerry E. |last7=Hannan |first7=Marian T. |last8=Cupples |first8=L. Adrienne |last9=Kiel |first9=Douglas P. |s2cid=22853996 |url=https://semanticscholar.org/paper/a986ab209653c58cf890e940dd7777992f2f84c7 }}</ref><ref>{{cite journal |doi=10.1056/NEJMoa032546 |pmid=15141041 |title=Homocysteine Levels and the Risk of Osteoporotic Fracture |journal=New England Journal of Medicine |volume=350 |issue=20 |pages=2033–41 |year=2004 |last1=Van Meurs |first1=Joyce B.J. |last2=Dhonukshe-Rutten |first2=Rosalie A.M. |last3=Pluijm |first3=Saskia M.F. |last4=Van Der Klift |first4=Marjolein |last5=De Jonge |first5=Robert |last6=Lindemans |first6=Jan |last7=De Groot |first7=Lisette C.P.G.M. |last8=Hofman |first8=Albert |last9=Witteman |first9=Jacqueline C.M. |last10=Van Leeuwen |first10=Johannes P.T.M. |last11=Breteler |first11=Monique M.B. |last12=Lips |first12=Paul |last13=Pols |first13=Huibert A.P. |last14=Uitterlinden |first14=André G. |hdl=1765/8452 |url=http://repub.eur.nl/pub/8452 |hdl-access=free }}</ref>
 
=== Ectopia lentis ===