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== Research ==
SOD has been used in experimental treatment of chronic inflammation in [[Inflammatory bowel disease|inflammatory bowlbowel]] conditions.<ref>{{cite journal | vauthors = Seguí J, Gironella M, Sans M, Granell S, Gil F, Gimeno M, Coronel P, Piqué JM, Panés J | display-authors = 6 | title = Superoxide dismutase ameliorates TNBS-induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine | journal = Journal of Leukocyte Biology | volume = 76 | issue = 3 | pages = 537–544 | date = September 2004 | pmid = 15197232 | doi = 10.1189/jlb.0304196 | s2cid = 15028921 }}</ref><ref name="pmid15197232">{{cite journal | vauthors = Seguí J, Gironella M, Sans M, Granell S, Gil F, Gimeno M, Coronel P, Piqué JM, Panés J | display-authors = 6 | title = Superoxide dismutase ameliorates TNBS-induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine | journal = Journal of Leukocyte Biology | volume = 76 | issue = 3 | pages = 537–544 | date = September 2004 | pmid = 15197232 | doi = 10.1189/jlb.0304196 | s2cid = 15028921 | doi-access = free }}</ref> SOD may ameliorate [[Cisplatin|cis-platinum]]-induced [[nephrotoxicity]] (rodent studies).<ref>{{cite journal | vauthors = McGinness JE, Proctor PH, Demopoulos HB, Hokanson JA, Kirkpatrick DS | title = Amelioration of cis-platinum nephrotoxicity by orgotein (superoxide dismutase) | journal = Physiological Chemistry and Physics | volume = 10 | issue = 3 | pages = 267–277 | year = 1978 | pmid = 733940 }}</ref> As "Orgotein" or "ontosein", a pharmacologically-active purified bovine liver SOD, it is also effective in the treatment of urinary tract inflammatory disease in man.<ref>{{cite journal | vauthors = Marberger H, Huber W, Bartsch G, Schulte T, Swoboda P | title = Orgotein: a new antiinflammatory metalloprotein drug evaluation of clinical efficacy and safety in inflammatory conditions of the urinary tract | journal = International Urology and Nephrology | volume = 6 | issue = 2 | pages = 61–74 | year = 1974 | pmid = 4615073 | doi = 10.1007/bf02081999 | s2cid = 23880216 }}</ref> For a time, bovine liver SOD even had regulatory approval in several European countries for such use. This was cut short by concerns about [[prion disease]].{{Citation needed|date=August 2017}}
An [[Superoxide dismutase mimetics|SOD-mimetic]] agent, [[TEMPOL]], is currently in clinical trials for radioprotection and to prevent radiation-induced [[dermatitis]].<ref>{{ClinicalTrialsGov|NCT01324141|Topical MTS-01 for Dermatitis During Radiation and Chemotherapy for Anal Cancer}}</ref> TEMPOL and similar SOD-mimetic nitroxides exhibit a multiplicity of actions in diseases involving oxidative stress.<ref>{{cite journal | vauthors = Wilcox CS | title = Effects of tempol and redox-cycling nitroxides in models of oxidative stress | journal = Pharmacology & Therapeutics | volume = 126 | issue = 2 | pages = 119–145 | date = May 2010 | pmid = 20153367 | pmc = 2854323 | doi = 10.1016/j.pharmthera.2010.01.003 }}</ref>
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