Metabolic acidosis: Difference between revisions

Chronic metabolic acidosis is most often caused by a decreased capacity of the kidneys to excrete excess acids through renal ammoniagenesis. The typical Western diet generates 2075-30100 mEq of acid daily<ref>{{citationCite journal |last=Weaver |first=Connie M. needed|date=May2013-05-06 2021|title=Potassium and Health123 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650509/ |journal=Advances in Nutrition |volume=4 |issue=3 |pages=368S–377S |doi=10.3945/an.112.003533 |issn=2161-8313 |pmc=3650509 |pmid=23674806}}</ref>, and individuals with normal kidney function increase the production of ammonia to get rid of this dietary acid. As kidney function declines, the tubules lose the ability to excrete excess acid, and this results in buffering of acid using serum bicarbonate, as well as bone and muscle stores.<ref>{{Cite web|url=https://www.uptodate.com/contents/pathogenesis-consequences-and-treatment-of-metabolic-acidosis-in-chronic-kidney-disease|title=Pathogenesis, consequences, and treatment of metabolic acidosis in chronic kidney disease|last=Kovesdy|first=Csaba|website=UpToDate}}</ref>