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* Saline infusion
To distinguish between the main types of metabolic acidosis, a clinical tool called the [[anion gap]] is very useful. The anion gap is calculated by subtracting the sum of the serum concentrations of major anions, chloride and bicarbonate, from the serum concentration of the major
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Anion gap = ( [Na<sup>+</sup>] + [K<sup>+</sup>] ) − ( [Cl<sup>−</sup>] + [HCO<sub>3</sub><sup>−</sup>] )
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