CYP3A4: Difference between revisions

* [[ginkgo biloba]],<ref name="pmid19883715">{{cite journal | vauthors = Kimura Y, Ito H, Ohnishi R, Hatano T | title = Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activity | journal = Food and Chemical Toxicology | volume = 48 | issue = 1 | pages = 429–35 | date = January 2010 | pmid = 19883715 | doi = 10.1016/j.fct.2009.10.041 | quote = Ginko Biloba has been shown to contain the potent inhibitor amentoflavone }}</ref>

* [[sesamin]]<ref name="pmid22645625">{{cite journal | vauthors = Lim YP, Ma CY, Liu CL, Lin YH, Hu ML, Chen JJ, Hung DZ, Hsieh WT, Huang JD | title = Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation | journal = Evidence-Based Complementary and Alternative Medicine | volume = 2012 | pages = 242810 | year = 2012 | pmid = 22645625 | pmc = 3356939 | doi = 10.1155/2012/242810 | doi-access = free }}</ref> (a [[lignan]] constituent in [[sesame]] seeds and oil),

* [[piperine]],<ref>{{cite journal | vauthors = Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, Fromm MF | s2cid = 7398172 | title = Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4 | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 302 | issue = 2 | pages = 645–50 | date = August 2002 | pmid = 12130727 | doi = 10.1124/jpet.102.034728 }}</ref>

* [[isoniazid|isoniazid,]]<ref>{{cite journal | vauthors = Wen X, Wang JS, Neuvonen PJ, Backman JT | s2cid = 19299097 | title = Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes | journal = European Journal of Clinical Pharmacology | volume = 57 | issue = 11 | pages = 799–804 | date = January 2002 | pmid = 11868802 | doi = 10.1007/s00228-001-0396-3 }}</ref>

* [[serenoa]].<ref>{{cite journal | pmc=4033990 | date=2010 | last1=Ekstein | first1=D. | last2=Schachter | first2=S. C. | title=Natural Products in Epilepsy—the Present Situation and Perspectives for the Future | journal=Pharmaceuticals (Basel, Switzerland) | volume=3 | issue=5 | pages=1426–1445 | doi=10.3390/ph3051426 | pmid=27713311 | doi-access=free }}</ref>

====Strong inducers:====

* [[carbamazepine|carbamazepine,]]<ref name="FDA_drug_development"/><ref name=lange6th>{{cite book | vauthors = Flower R, Rang HP, Dale MM, Ritter JM |title=Rang & Dale's pharmacology |publisher=Churchill Livingstone |location=Edinburgh |year=2007 |isbn=978-0-443-06911-6 }}{{page needed|date=November 2015}}</ref>

* [[antiandrogen]]s:

** [[enzalutamide]],<ref>{{cite web | title = Highlights of Prescribing Information: XTANDI (enzalutamide) capsules for oral use | url = https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203415lbl.pdf | work = Astellas Pharma US, Inc. | publisher = U.S. Food and Drug Administration | date = August 2012 }}</ref>

** [[apalutamide]];

* [[phenytoin]]<ref name="FDA_drug_development"/><ref>{{cite journal | vauthors = Johannessen SI, Landmark CJ | title = Antiepileptic drug interactions - principles and clinical implications | journal = Current Neuropharmacology | volume = 8 | issue = 3 | pages = 254–67 | date = September 2010 | pmid = 21358975 | pmc = 3001218 | doi = 10.2174/157015910792246254 }}</ref> ([[anticonvulsant]]),

* [[rifampin]].<ref name="FDA_drug_development"/>

====Weak inducers:====

* [[upadacitinib]].<ref name="Rinvoq-2020" /><ref name="Austria-Codex-DE" />

====Inducers of unspecified potency:====

* [[anticonvulsant]]s, [[mood stabilizers]]:

** [[oxcarbazepine]],<ref name=Flockhart/>

** [[topiramate]];<ref>{{cite journal | vauthors = Nallani SC, Glauser TA, Hariparsad N, Setchell K, Buckley DJ, Buckley AR, Desai PB | title = Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate | journal = Epilepsia | volume = 44 | issue = 12 | pages = 1521–8 | date = December 2003 | pmid = 14636322 | doi = 10.1111/j.0013-9580.2003.06203.x | s2cid = 6915760 }}</ref>

* [[barbiturates]]:<ref name=lange6th/>

** [[phenobarbital|phenobarbital,]]<ref name=Flockhart/><ref name=FASS/>

** [[butalbital]]:

* [[St. John's wort|St. John's wort,]]<ref name=Flockhart/><ref name=FASS/>

* some [[bactericidal]]s:

** [[rifampicin|rifampicin,]]<ref name=Flockhart/><ref name=lange6th/>

** [[rifabutin]];<ref name=Flockhart/><ref name=FASS/>

* some non-nucleoside [[reverse-transcriptase inhibitor]]s:<ref name=nnrti/>

** [[efavirenz]],<ref name=Flockhart/>

** [[nevirapine]];<ref name=Flockhart/>

* [[troglitazone]] ([[hypoglycemic]]),

* [[glucocorticoids]]<ref name=Flockhart/> ([[blood glucose]] increase, [[immunosuppressive]]),

* [[modafinil]]<ref name="pmid34633961" /><ref name=Flockhart/> ([[stimulant]]),

* [[capsaicin]],<ref>{{cite journal | vauthors = Han EH, Kim HG, Choi JH, Jang YJ, Lee SS, Kwon KI, Kim E, Noh K, Jeong TC, Hwang YP, Chung YC, Kang W, Jeong HG | s2cid = 26584141 | title = Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein β activation | journal = Molecular Nutrition & Food Research | volume = 56 | issue = 5 | pages = 797–809 | date = May 2012 | pmid = 22648626 | doi = 10.1002/mnfr.201100697 }}</ref>

* [[brigatinib]],<ref name=Flockhart/>

* [[clobazam]],<ref name=Flockhart/>

* [[dabrafenib|dabrafenib,]]<ref name=Flockhart/>

* [[elagolix]],<ref name=Flockhart/>

* [[eslicarbazepine|eslicarbazepine,]]<ref name=Flockhart/>

* [[letermovir]],<ref name=Flockhart/>

* [[lorlatinib]],<ref name=Flockhart/>

* [[oritavancin|oritavancin,]]<ref name=Flockhart/>

* [[perampanel|perampanel,]]<ref name=Flockhart/>

* [[telotristat]].<ref name=Flockhart/>