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In adult articular chondrocytes, [[siRNA]]-mediated knockdown of SOX-9 or [[RTL3]] results in the downregulation of the other and reduced [[type II collagen]] ([[COL2A1]]) mRNA and protein expression.<ref>{{Cite journal |last1=Ball |first1=Hope C. |last2=Ansari |first2=Mohammad Y. |last3=Ahmad |first3=Nashrah |last4=Novak |first4=Kimberly |last5=Haqqi |first5=Tariq M. |date=November 2021 |title=A retrotransposon gag-like-3 gene RTL3 and SOX-9 co-regulate the expression of COL2A1 in chondrocytes |journal=Connective Tissue Research |volume=62 |issue=6 |pages=615–628 |doi=10.1080/03008207.2020.1828380 |issn=1607-8438 |pmc=8404968 |pmid=33043724}}</ref>
 
== Clinical significance ==