Bcl-2: Difference between revisions

'''Bcl-2''', encoded in humans by the '''''BCL2''''' [[gene]], is the founding member of the [[apoptosis regulator proteins, Bcl-2 family|Bcl-2 family]] of [[regulator protein]]s. BCL2 blocks programmed cell death ([[apoptosis]]) <ref>{{Cite journal |last=Hockenbery |first=D. |last2=Nuñez |first2=G. |last3=Milliman |first3=C. |last4=Schreiber |first4=R. D. |last5=Korsmeyer |first5=S. J. |date=1990-11-22 |title=Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death |url=https://pubmed.ncbi.nlm.nih.gov/2250705/ |journal=Nature |volume=348 |issue=6299 |pages=334–336 |doi=10.1038/348334a0 |issn=0028-0836 |pmid=2250705}}</ref> while other BCL2 family membermembers can either inhibit or induce it.<ref name="pmid6093263">{{cite journal | vauthors = Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM | title = Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation | journal = Science | volume = 226 | issue = 4678 | pages = 1097–9 | date = Nov 1984 | pmid = 6093263 | doi = 10.1126/science.6093263 | bibcode = 1984Sci...226.1097T }}</ref><ref name="pmid2875799">{{cite journal | vauthors = Cleary ML, Smith SD, Sklar J | s2cid = 31493780 | title = Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation | journal = Cell | volume = 47 | issue = 1 | pages = 19–28 | date = Oct 1986 | pmid = 2875799 | doi = 10.1016/0092-8674(86)90362-4 }}</ref> It was the first apoptosis regulator identified in any organism.<ref>{{cite journal |vauthors=Kelly GL, Strasser A |title=Toward Targeting Antiapoptotic MCL-1 for Cancer Therapy |year=2020 |journal=Annual Review of Cancer Biology |volume=4 |pages=299–313 |doi=10.1146/annurev-cancerbio-030419-033510 |doi-access=free|hdl=11343/252362 |hdl-access=free }}</ref>