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Laudanosine also occurs naturally in minute amounts (0.1%) in [[opium]], from which it was first isolated in 1871.<ref>{{cite book |chapterurl=http://books.google.com/books?id=KxTKLlac60wC&pg=PA55&dq=laudanosine&sig=ACfU3U2OZxmvO0Pl8Jnp8KuGXHzMllcnQA#PPA48,M1 |chapter=The Benzylisoquinoline Alkaloids |author=Burger A |title=The Alkaloids: Chemistry and Physiology |origyear=1954 |year=2005 |volume=4 |editor=Manske RHF, Holmes HL (eds.) |pages=p. 48 |location=New York |publisher=Academic Press |isbn=0124695043}} Retrieved September 18, 2008 through [[Google Book Search]].</ref> Partial [[Dehydration reaction|dehydrogenation]] of laudanosine will lead to [[papaverine]], the alkaloid found in the opium poppy plant (''Papaver somniferum'').
Laudanosine is a [[benzyltetrahydroisoquinoline]] [[alkaloid]]. It has been shown to interact with [[GABA receptor]]s, [[opioid receptor]]s, and [[nicotinic acetylcholine receptor]]s,<ref name=Fodale/><ref>{{cite journal |author=Katz Y, Weizman A, Pick CG, Pasternak GW, Liu L, Fonia O, Gavish M |title=Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity |journal= Brain Res |volume=646 |issue=2 |pages=235-241 |year=1994 |month=May |pmid=8069669 }}</ref> but not benzodiazepinergic or muscarinic receptors which are also involved in epilepsy and other types of seizures.<ref>{{cite journal |author= Katz Y, Gavish M |title= Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors |journal= Anesthesiol |volume=70|issue=1 |pages= 109-111 |year=1989 |month= Jan |pmid= 2536252 }}</ref>
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