'''Telomerase-binding protein EST1A''' is an [[enzyme]] that in humans is encoded by the ''SMG6'' [[gene]].<ref name="pmid12676087">{{cite journal | author = Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J | title = A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed | journal = Curr Biol | volume = 13 | issue = 7 | pages = 568–74 | year date=Apr 2003 | month = Apr | pmid = 12676087 | pmc = | doi =10.1016/S0960-9822(03)00173-8 }}</ref><ref name="pmid12699629">{{cite journal | author = Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L | title = Functional conservation of the telomerase protein Est1p in humans | journal = Curr Biol | volume = 13 | issue = 8 | pages = 698–704 | year date=Apr 2003 | month = Apr | pmid = 12699629 | pmc = | doi =10.1016/S0960-9822(03)00210-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMG6 Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23293| accessdate = }}</ref> The C-terminus of the EST1A protein contains a [[PIN domain]]. This structure for this domain has been determined by [[X-ray crystallography]].<ref>{{cite journal | author=Takeshita D, Zenno S, Lee WC, ''et al.'' |title=Crystallization and preliminary X-ray analysis of the PIN domain of human EST1A. |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=62 |issue= Pt 7 |pages= 656–8 |year= 2006 |pmid= 16820686 |doi= 10.1107/S1744309106020057 | pmc=2242961 }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
