Chromosome 22: Difference between revisions

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| genbank_id = CM000684
|caption=Human chromosome 22 pair after [[G banding|G-banding]].<br/>One is from mother, one is from father.|image2=Human_male_karyotpe_high_resolution_-_Chromosome_22.png}}
'''Chromosome 22''' is one of the 23 pairs of [[chromosome]]s in human [[cell (biology)|cells]]. Humans normally have two copies of chromosome 22 in each cell. Chromosome 22 is the second smallest human chromosome ([[Chromosome 21 (human)|chromosome 21]] being smaller), spanning about 49 million [[DNA]] [[base pair]]s and representing between 1.5 and 2% of the total DNA in [[cell (biology)|cells]].
 
In 1999, researchers working on the [[Human Genome Project]] announced they had determined the sequence of base pairs that make up this chromosome. Chromosome 22 was the first human chromosome to be fully sequenced.<ref>{{cite journal |last= Mayor |first= Susan |year= 1999 |title= First human chromosome is sequenced |journal= BMJ |volume= 319 |issue= 7223 |pages= 1453 |publisher= BMJ Group |pmc= 1117192 |doi=10.1136/bmj.319.7223.1453a |pmid=10582915}}</ref>
 
Human chromosomes are numbered by their apparent size in the [[karyotype]], with [[Chromosome 1]] being the largest and Chromosome 22 having originally been identified as the smallest. However, genome sequencing has revealed that [[Chromosome 21]] is actually smaller than Chromosome 22.
Chromosome 22 was originally identified as the smallest chromosome. After extensive research, however, researchers concluded that chromosome 21 was smaller. The numbering of these chromosomes wasn't rearranged because of chromosome 21 being known by that designation as the chromosome that can lead to [[Down syndrome]], or trisomy 21.{{cn|date=December 2017}}
 
==Genes==