Bactericide: Difference between revisions

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{{wiktionary|bactericide}}
ants: Activity, Action, and Resistance
 
A '''bactericide''' or '''bacteriocide''', sometimes abbreviated '''Bcidal''', is a substance that kills [[bacteria]]. Bactericides are [[disinfectant]]s, [[antiseptic]]s, or [[antibiotic]]s.<ref>{{cite journal
|journal=Clin Microbiol Rev
|year=1999
|volume=12
|issue=1
|pages=147–179
|pmc=88911
ants|title=Antiseptics and Disinfectants: Activity, Action, and Resistance
|pmid=9880479 | last1 = McDonnell | first1 = G | last2 = Russell | first2 = AD | doi=10.1128/cmr.12.1.147}}</ref>
 
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*concentrated [[alcohols]] (mainly [[ethanol]], [[1-propanol]], called also [[n-propanol]] and [[2-propanol]], called [[isopropanol]] and mixtures thereof; further, [[2-phenoxyethanol]] and 1- and [[2-phenoxypropanol]]s are used),
*[[phenols|phenolic substances]] (such as [[phenol]] (also called "carbolic acid"), [[cresol]]s such as [[thymol]], halogenated (chlorinated, brominated) phenols, such as [[hexachlorophene]], [[triclosan]], [[trichlorophenol]], [[tribromophenol]], [[pentachlorophenol]], salts and isomers thereof),
*[[cationic surfactants]], such as some [[quaternary ammonium cation]]s (such as [[benzalkonium chloride]], [[cetyl trimethylammonium bromide]] or chloride, [[didecyldimethylammonium chloride]], [[cetylpyridinium chloride]], [[benzethonium chloride]]) and others, non-quaternary compounds, such as [[chlorhexidine]], [[glucoprotamine]], [[octenidine]] dihydrochloride etc.),
*strong [[oxidizer]]s, such as [[ozone]] and [[permanganate]] solutions;
*[[heavy metals]] and their salts, such as colloidal [[silver]], [[silver nitrate]], [[Mercury(II) chloride|mercury chloride]], [[organomercury|phenylmercury]] salts, [[copper sulfate]], [[copper oxide-chloride]] etc. Heavy metals and their salts are the most toxic and environment-hazardous bactericides and therefore their use is strongly discouraged or prohibited
* strong [[acid]]s (phosphoric, nitric, sulfuric, amidosulfuric, toluenesulfonic acids), pH < 1, and
*[[alkali]]s (sodium, potassium, calcium hydroxides), such as of pH > 13, particularly under elevated temperature (above 60 °C), kills bacteria.
 
==Antiseptics==
As [[antiseptic]]s (i.e., germicide agents that can be used on human or animal body, skin, mucoses, wounds and the like), few of zygotesthe above-mentioned disinfectants can be used, under proper conditions (mainly concentration, pH, temperature and toxicity toward humans and animals). Among them, some important are
*properly diluted [[chlorine]] preparations (f.e. [[Dakin's Solution|Dakin's solution]], 0.5% sodium or potassium hypochlorite solution, pH-adjusted to pH 7 – 8, or 0.5 – 1% solution of sodium benzenesulfochloramide ([[chloramine]] B)), some
 
*[[iodine]] preparations, such as [[iodophor|iodopovidone]] in various [[Galenic formulation|galenic]]s (ointment, solutions, wound plasters), in the past also [[Lugol's solution]],
*[[peroxide]]s such as urea perhydrate solutions and pH-[[Buffer solution|buffered]] 0.1 – 0.25% peracetic acid solutions,
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*weak [[organic acids]] such as [[sorbic acid]], [[benzoic acid]], [[lactic acid]] and [[salicylic acid]]
*some [[phenol]]ic compounds, such as [[hexachlorophene]], [[triclosan]] and Dibromol, and
*cationic surfactants, such as nature0.05 – 0.5% benzalkonium, 0.5 – 4% [[chlorhexidine]], 0.1 – 2% octenidine solutions.
Others are generally not applicable as safe antiseptics, either because of their [[corrosive]] or [[toxic]] nature.
 
==Antibiotics==