General Lee may refer to:
- Charles Lee (general) (1732-1782), American Revolutionary War general
- Henry Lee III (1756-1818), major general during the Whiskey Rebellion campaign, father of Robert E. Lee
- Robert E. Lee (1807-1870), general in the Confederate States Army during the American Civil War
- John C. H. Lee (1887-1958), SHAEF's deputy theater commander for supply and administration
- Hayato Tani (1946), Japanese actor, best known for his role of General Lee in Takeshi's Castle
- The General Lee, the car driven by Bo and Luke Duke in the 1979-1985 American television series, The Dukes of Hazzard
- M3 Lee, medium tank used in World War II
- General Beauregard Lee, the name for one of the groundhogs that predicts the weather on the American holiday known as Groundhog Day