PHTPP

PHTPP
Identifiers
	IUPAC name 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol;
CAS Number	805239-56-9;
PubChem CID	11201035;
ChemSpider	9376104;
CompTox Dashboard (EPA)	DTXSID10458573 ;
Chemical and physical data
Formula	C20H11F6N3O
Molar mass	423.311259 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F;

PHTPP is a synthetic, non-steroidal, and highly selective antagonist of ERβ that is used in scientific research to study the function of this receptor.^[1]^[2] It possesses 36-fold selectivity for ERβ over ERα, and is a silent antagonist of ERβ.^[3]

References

^ Neurosteroids. Frontiers E-books. pp. 95–. ISBN 978-2-88919-078-2.
^ Cytoplasmic and Nuclear Receptors—Advances in Research and Application: 2012 Edition. ScholarlyEditions. 26 December 2012. pp. 220–. ISBN 978-1-4649-9741-9.
^ Compton DR, Sheng S, Carlson KE, Rebacz NA, Lee IY, Katzenellenbogen BS, Katzenellenbogen JA (2004). "Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity". J. Med. Chem. 47 (24): 5872–93. doi:10.1021/jm049631k. PMID 15537344.

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Identifiers
IUPAC name 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol
CAS Number	805239-56-9
PubChem CID	11201035
ChemSpider	9376104
CompTox Dashboard (EPA)	DTXSID10458573
Chemical and physical data
Formula	C₂₀H₁₁F₆N₃O
Molar mass	423.311259 g/mol g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F