Warthin–Finkeldey cell: Difference between revisions
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A '''Warthin–Finkeldey cell''' is a type of giant multinucleate cell found in hyperplastic [[lymph node]]s early in the course of [[measles]] and also in [[HIV]]-infected individuals,<ref name="Burke1994">{{cite journal |vauthors=Burke AP, Anderson D, Mannan P, Ribas JL, Liang YH, Smialek J, Virmani R | title=Systemic lymphadenopathic histology in human immunodeficiency virus-1-seropositive drug addicts without apparent acquired immunodeficiency syndrome | journal=Hum. Pathol. | year=1994 | volume=25 | issue=3 | pages = 248–56 | pmid=8150456 | doi=10.1016/0046-8177(94)90196-1}}</ref> as well as in [[Kimura disease]],<ref>{{cite journal |vauthors=Abuel-Haija M, Hurford MT | year = 2007 | title = Kimura Disease | journal = Archives of Pathology & Laboratory Medicine | volume = 131 | issue=4 | pages=650–651 | pmid=17425383 | doi=10. |
A '''Warthin–Finkeldey cell''' is a type of giant multinucleate cell found in hyperplastic [[lymph node]]s early in the course of [[measles]] and also in [[HIV]]-infected individuals,<ref name="Burke1994">{{cite journal |vauthors=Burke AP, Anderson D, Mannan P, Ribas JL, Liang YH, Smialek J, Virmani R | title=Systemic lymphadenopathic histology in human immunodeficiency virus-1-seropositive drug addicts without apparent acquired immunodeficiency syndrome | journal=Hum. Pathol. | year=1994 | volume=25 | issue=3 | pages = 248–56 | pmid=8150456 | doi=10.1016/0046-8177(94)90196-1| url=https://zenodo.org/record/1258291 }}</ref> as well as in [[Kimura disease]],<ref>{{cite journal |vauthors=Abuel-Haija M, Hurford MT | year = 2007 | title = Kimura Disease | journal = Archives of Pathology & Laboratory Medicine | volume = 131 | issue=4 | pages=650–651 | pmid=17425383 | doi=10.5858/2007-131-650-KD}} |
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</ref> and more rarely in a number of neoplastic (e.g. [[lymphoma]]) and non-neoplastic lymph node disorders.<ref name="Kjedsberg">{{cite journal |vauthors=Kjeldsberg CR, Kim H | title = Polykaryocytes resembling Warthin-Finkeldey giant cells in reactive and neoplastic lymphoid disorders. | journal = Hum. Pathol. | year = 1981 | volume = 12 | issue=3 | pages = 267–72 | pmid = 7228021 |
</ref> and more rarely in a number of neoplastic (e.g. [[lymphoma]]) and non-neoplastic lymph node disorders.<ref name="Kjedsberg">{{cite journal |vauthors=Kjeldsberg CR, Kim H | title = Polykaryocytes resembling Warthin-Finkeldey giant cells in reactive and neoplastic lymphoid disorders. | journal = Hum. Pathol. | year = 1981 | volume = 12 | issue=3 | pages = 267–72 | pmid = 7228021 | doi=10.1016/S0046-8177(81)80128-1}}</ref> Their origin is uncertain, but they have previously been shown to stain with markers similar to those of [[follicular dendritic cell]]s, including CD21.<ref name="Orenstein">{{cite journal | author = Orenstein JM | journal = Ultrastructural Pathology | year = 1988 | volume = 22 | issue = 4 | pages = 293–303 | title = The Warthin-Finkeldey-Type Giant Cell in HIV Infection, What Is It? | doi=10.3109/01913129809103350| pmid = 9805354 }}</ref> Under the light microscope, these cells consist of a large, grape-like cluster of nuclei.{{cn|date=March 2021}} |
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Latest revision as of 21:42, 2 June 2021
A Warthin–Finkeldey cell is a type of giant multinucleate cell found in hyperplastic lymph nodes early in the course of measles and also in HIV-infected individuals,[1] as well as in Kimura disease,[2] and more rarely in a number of neoplastic (e.g. lymphoma) and non-neoplastic lymph node disorders.[3] Their origin is uncertain, but they have previously been shown to stain with markers similar to those of follicular dendritic cells, including CD21.[4] Under the light microscope, these cells consist of a large, grape-like cluster of nuclei.[citation needed]
References
[edit]- ^ Burke AP, Anderson D, Mannan P, Ribas JL, Liang YH, Smialek J, Virmani R (1994). "Systemic lymphadenopathic histology in human immunodeficiency virus-1-seropositive drug addicts without apparent acquired immunodeficiency syndrome". Hum. Pathol. 25 (3): 248–56. doi:10.1016/0046-8177(94)90196-1. PMID 8150456.
- ^ Abuel-Haija M, Hurford MT (2007). "Kimura Disease". Archives of Pathology & Laboratory Medicine. 131 (4): 650–651. doi:10.5858/2007-131-650-KD. PMID 17425383.
- ^ Kjeldsberg CR, Kim H (1981). "Polykaryocytes resembling Warthin-Finkeldey giant cells in reactive and neoplastic lymphoid disorders". Hum. Pathol. 12 (3): 267–72. doi:10.1016/S0046-8177(81)80128-1. PMID 7228021.
- ^ Orenstein JM (1988). "The Warthin-Finkeldey-Type Giant Cell in HIV Infection, What Is It?". Ultrastructural Pathology. 22 (4): 293–303. doi:10.3109/01913129809103350. PMID 9805354.
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