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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Cyclic nucleotide-gated channel alpha 1''', also known as '''CNGA1''', is a human [[gene]] encoding an [[ion channel]] protein.<ref name="entrez">{{cite web | title = Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1259|website=Ncbi.nlm.nih.gov| access-date =2016-08-02 }}</ref> Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium.<ref>{{Cite journal|last1=Kaupp|first1=U. Benjamin|last2=Niidome|first2=Tetsuhiro|last3=Tanabe|first3=Tsutomu|last4=Terada|first4=Shoichi|last5=Bönigk|first5=Wolfgang|last6=Stühmer|first6=Walter|last7=Cook|first7=Neil J.|last8=Kangawa|first8=Kenji|last9=Matsuo|first9=Hisayuki|date=December 1989|title=Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel|journal=Nature|volume=342|issue=6251|pages=762–766|doi=10.1038/342762a0|pmid=2481236|issn=0028-0836|bibcode=1989Natur.342..762K|hdl=11858/00-001M-0000-002B-B7A4-3|s2cid=4254661|hdl-access=free}}</ref> In [[Photoreceptor cell|rod photoreceptors]], however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio.<ref>{{Cite journal|last1=Zheng|first1=Jie|last2=Trudeau|first2=Matthew C.|last3=Zagotta|first3=William N.|date=December 2002|title=Rod Cyclic Nucleotide-Gated Channels Have a Stoichiometry of Three CNGA1 Subunits and One CNGB1 Subunit|journal=Neuron|volume=36|issue=5|pages=891–896|doi=10.1016/s0896-6273(02)01099-1|pmid=12467592|s2cid=15365006|issn=0896-6273|doi-access=free}}</ref><ref>{{Cite journal|last1=Zhong|first1=Haining|last2=Molday|first2=Laurie L.|last3=Molday|first3=Robert S.|last4=Yau|first4=King-Wai|date=November 2002|title=The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry|journal=Nature|volume=420|issue=6912|pages=193–198|doi=10.1038/nature01201|pmid=12432397|issn=0028-0836|pmc=2877395|bibcode=2002Natur.420..193Z}}</ref><ref>{{Cite journal|last1=Weitz|first1=Dietmar|last2=Ficek|first2=Nicole|last3=Kremmer|first3=Elisabeth|last4=Bauer|first4=Paul J.|last5=Kaupp|first5=U.Benjamin|date=December 2002|title=Subunit Stoichiometry of the CNG Channel of Rod Photoreceptors|journal=Neuron|volume=36|issue=5|pages=881–889|doi=10.1016/s0896-6273(02)01098-x|pmid=12467591|s2cid=17176092|issn=0896-6273|doi-access=free}}</ref> The addition of the [[CNGB1]] channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current.<ref>{{Cite journal|last1=Chen|first1=T.-Y.|last2=Peng|first2=Y.-W.|last3=Dhallan|first3=R. S.|last4=Ahamed|first4=B.|last5=Reed|first5=R. R.|last6=Yau|first6=K.-W.|date=April 1993|title=A new subunit of the cyclic nucleotide-gated cation channel in retinal rods|journal=Nature|volume=362|issue=6422|pages=764–767|doi=10.1038/362764a0|pmid=7682292|issn=0028-0836|bibcode=1993Natur.362..764C|s2cid=4350775}}</ref> When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, [[Hyperpolarization (biology)|hyperpolarization]] of the membrane potential.
'''Cyclic nucleotide-gated channel alpha 1''', also known as '''CNGA1''', is a human [[gene]] encoding an [[ion channel]] protein.<ref name="entrez">{{cite web | title = Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1259| accessdate = }}</ref>

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==See also==
==See also==
* [[Cyclic nucleotide-gated ion channel]]
* [[Cyclic nucleotide-gated ion channel]]


==References==
==References==
{{reflist}}
{{Reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin|}}
* {{cite journal | vauthors = Hofmann F, Biel M, Kaupp UB | title = International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 455–62 | date = December 2005 | pmid = 16382102 | doi = 10.1124/pr.57.4.8 | s2cid = 45853869 }}
{{PBB_Further_reading
* {{cite journal | vauthors = Pittler SJ, Lee AK, Altherr MR, Howard TA, Seldin MF, Hurwitz RL, Wasmuth JJ, Baehr W | title = Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel | journal = The Journal of Biological Chemistry | volume = 267 | issue = 9 | pages = 6257–62 | date = March 1992 | doi = 10.1016/S0021-9258(18)42689-0 | pmid = 1372902 | doi-access = free }}
| citations =
*{{cite journal | author=Hofmann F, Biel M, Kaupp UB |title=International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 455–62 |year= 2006 |pmid= 16382102 |doi= 10.1124/pr.57.4.8 }}
* {{cite journal | vauthors = Arsenault TV, Sauder DN, Harley CB, McKenzie RC | title = Identification and characterization of a partial cDNA expressing interleukin-1-like activity in keratinocytes | journal = Molecular Immunology | volume = 29 | issue = 3 | pages = 431–8 | date = March 1992 | pmid = 1372959 | doi = 10.1016/0161-5890(92)90031-R }}
*{{cite journal | author=Pittler SJ, Lee AK, Altherr MR |title=Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel. |journal=J. Biol. Chem. |volume=267 |issue= 9 |pages= 6257–62 |year= 1992 |pmid= 1372902 |doi= |display-authors=etal}}
* {{cite journal | vauthors = Dhallan RS, Macke JP, Eddy RL, Shows TB, Reed RR, Yau KW, Nathans J | title = Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression | journal = The Journal of Neuroscience | volume = 12 | issue = 8 | pages = 3248–56 | date = August 1992 | pmid = 1379636 | pmc = 6575660 | doi = 10.1523/JNEUROSCI.12-08-03248.1992}}
*{{cite journal | author=Arsenault TV, Sauder DN, Harley CB, McKenzie RC |title=Identification and characterization of a partial cDNA expressing interleukin-1-like activity in keratinocytes. |journal=Mol. Immunol. |volume=29 |issue= 3 |pages= 431–8 |year= 1992 |pmid= 1372959 |doi=10.1016/0161-5890(92)90031-R }}
* {{cite journal | vauthors = Dryja TP, Finn JT, Peng YW, McGee TL, Berson EL, Yau KW | title = Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 22 | pages = 10177–81 | date = October 1995 | pmid = 7479749 | pmc = 40759 | doi = 10.1073/pnas.92.22.10177 | bibcode = 1995PNAS...9210177D | doi-access = free }}
*{{cite journal | author=Dhallan RS, Macke JP, Eddy RL |title=Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression. |journal=J. Neurosci. |volume=12 |issue= 8 |pages= 3248–56 |year= 1992 |pmid= 1379636 |doi= |display-authors=etal}}
* {{cite journal | vauthors = Distler M, Biel M, Flockerzi V, Hofmann F | title = Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells | journal = Neuropharmacology | volume = 33 | issue = 11 | pages = 1275–82 | date = November 1994 | pmid = 7532814 | doi = 10.1016/0028-3908(94)90027-2 | s2cid = 35784152 | url = https://epub.ub.uni-muenchen.de/3654/1/3654.pdf }}
*{{cite journal | author=Dryja TP, Finn JT, Peng YW |title=Mutations in the gene encoding the alpha subunit of the rod cGMP-gated channel in autosomal recessive retinitis pigmentosa. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 22 |pages= 10177–81 |year= 1995 |pmid= 7479749 |doi=10.1073/pnas.92.22.10177 | pmc=40759 |display-authors=etal}}
* {{cite journal | vauthors = Griffin CA, Ding CL, Jabs EW, Hawkins AL, Li X, Levine MA | title = Human rod cGMP-gated cation channel gene maps to 4p12-->centromere by chromosomal in situ hybridization | journal = Genomics | volume = 16 | issue = 1 | pages = 302–3 | date = April 1993 | pmid = 7683629 | doi = 10.1006/geno.1993.1187 | doi-access = free }}
* {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Research | volume = 6 | issue = 9 | pages = 807–28 | date = September 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 | doi-access = free }}
*{{cite journal | author=Distler M, Biel M, Flockerzi V, Hofmann F |title=Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells. |journal=Neuropharmacology |volume=33 |issue= 11 |pages= 1275–82 |year= 1995 |pmid= 7532814 |doi=10.1016/0028-3908(94)90027-2 }}
*{{cite journal | author=Griffin CA, Ding CL, Jabs EW |title=Human rod cGMP-gated cation channel gene maps to 4p12-->centromere by chromosomal in situ hybridization. |journal=Genomics |volume=16 |issue= 1 |pages= 302–3 |year= 1993 |pmid= 7683629 |doi= 10.1006/geno.1993.1187 |display-authors=etal}}
* {{cite journal | vauthors = Paloma E, Martínez-Mir A, García-Sandoval B, Ayuso C, Vilageliu L, Gonzàlez-Duarte R, Balcells S | title = Novel homozygous mutation in the alpha subunit of the rod cGMP gated channel (CNGA1) in two Spanish sibs affected with autosomal recessive retinitis pigmentosa | journal = Journal of Medical Genetics | volume = 39 | issue = 10 | pages = 66e–66 | date = October 2002 | pmid = 12362048 | pmc = 1734976 | doi = 10.1136/jmg.39.10.e66 }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 |display-authors=etal}}
* {{cite journal | vauthors = Cheng CH, Yew DT, Kwan HY, Zhou Q, Huang Y, Liu Y, Chan WY, Yao X | title = An endogenous RNA transcript antisense to CNG(alpha)1 cation channel mRNA | journal = Molecular Biology of the Cell | volume = 13 | issue = 10 | pages = 3696–705 | date = October 2002 | pmid = 12388767 | pmc = 129976 | doi = 10.1091/mbc.E02-03-0127 }}
*{{cite journal | author=Paloma E, Martínez-Mir A, García-Sandoval B |title=Novel homozygous mutation in the alpha subunit of the rod cGMP gated channel (CNGA1) in two Spanish sibs affected with autosomal recessive retinitis pigmentosa. |journal=J. Med. Genet. |volume=39 |issue= 10 |pages= E66 |year= 2002 |pmid= 12362048 |doi=10.1136/jmg.39.10.e66 | pmc=1734976 |display-authors=etal}}
* {{cite journal | vauthors = Zhong H, Molday LL, Molday RS, Yau KW | title = The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry | journal = Nature | volume = 420 | issue = 6912 | pages = 193–8 | date = November 2002 | pmid = 12432397 | pmc = 2877395 | doi = 10.1038/nature01201 | bibcode = 2002Natur.420..193Z }}
*{{cite journal | author=Cheng CH, Yew DT, Kwan HY |title=An endogenous RNA transcript antisense to CNG(alpha)1 cation channel mRNA. |journal=Mol. Biol. Cell |volume=13 |issue= 10 |pages= 3696–705 |year= 2003 |pmid= 12388767 |doi= 10.1091/mbc.E02-03-0127 | pmc=129976 |display-authors=etal}}
* {{cite journal | vauthors = Zheng J, Trudeau MC, Zagotta WN | title = Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit | journal = Neuron | volume = 36 | issue = 5 | pages = 891–6 | date = December 2002 | pmid = 12467592 | doi = 10.1016/S0896-6273(02)01099-1 | s2cid = 15365006 | doi-access = free }}
*{{cite journal | author=Zhong H, Molday LL, Molday RS, Yau KW |title=The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry. |journal=Nature |volume=420 |issue= 6912 |pages= 193–8 |year= 2002 |pmid= 12432397 | pmc=2877395 |doi= 10.1038/nature01201 }}
* {{cite journal | vauthors = Kang K, Bauer PJ, Kinjo TG, Szerencsei RT, Bönigk W, Winkfein RJ, Schnetkamp PP | title = Assembly of retinal rod or cone Na(+)/Ca(2+)-K(+) exchanger oligomers with cGMP-gated channel subunits as probed with heterologously expressed cDNAs | journal = Biochemistry | volume = 42 | issue = 15 | pages = 4593–600 | date = April 2003 | pmid = 12693957 | doi = 10.1021/bi027276z | url = http://juser.fz-juelich.de/record/30216/files/27726.pdf }}
*{{cite journal | author=Zheng J, Trudeau MC, Zagotta WN |title=Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit. |journal=Neuron |volume=36 |issue= 5 |pages= 891–6 |year= 2003 |pmid= 12467592 |doi=10.1016/S0896-6273(02)01099-1 }}
* {{cite journal | vauthors = Zhang Q, Zulfiqar F, Riazuddin SA, Xiao X, Ahmad Z, Riazuddin S, Hejtmancik JF | title = Autosomal recessive retinitis pigmentosa in a Pakistani family mapped to CNGA1 with identification of a novel mutation | journal = Molecular Vision | volume = 10 | pages = 884–9 | date = November 2004 | pmid = 15570217 }}
*{{cite journal | author=Kang K, Bauer PJ, Kinjo TG |title=Assembly of retinal rod or cone Na(+)/Ca(2+)-K(+) exchanger oligomers with cGMP-gated channel subunits as probed with heterologously expressed cDNAs. |journal=Biochemistry |volume=42 |issue= 15 |pages= 4593–600 |year= 2003 |pmid= 12693957 |doi= 10.1021/bi027276z |display-authors=etal}}
* {{cite journal | vauthors = Shi F, Perez E, Wang T, Peitz B, Lapolt PS | title = Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis | journal = Journal of Andrology | volume = 26 | issue = 2 | pages = 258–63 | year = 2005 | pmid = 15713832 | doi = 10.1002/j.1939-4640.2005.tb01093.x| doi-access = free }}
*{{cite journal | author=Zhang Q, Zulfiqar F, Riazuddin SA |title=Autosomal recessive retinitis pigmentosa in a Pakistani family mapped to CNGA1 with identification of a novel mutation. |journal=Mol. Vis. |volume=10 |issue= |pages= 884–9 |year= 2005 |pmid= 15570217 |doi= |display-authors=etal}}
*{{cite journal | author=Shi F, Perez E, Wang T |title=Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis. |journal=J. Androl. |volume=26 |issue= 2 |pages= 258–63 |year= 2005 |pmid= 15713832 |doi= |display-authors=etal}}
}}
{{refend}}
{{refend}}


==External links==
==External links==
* [http://www.ncbi.nlm.nih.gov/books/NBK1417/ GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview]
* [https://www.ncbi.nlm.nih.gov/books/NBK1417/ GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview]
* {{MeshName|CNGA1+protein,+human}}
* {{MeshName|CNGA1+protein,+human}}


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{{NLM content}}
{{Ion channels|g4}}
{{Ion channels|g4}}

[[Category:Ion channels]]
[[Category:Ion channels]]



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Latest revision as of 01:49, 29 January 2023

CNGA1
Identifiers
AliasesCNGA1, CNCG, CNCG1, CNG-1, CNG1, RCNC1, RCNCa, RCNCalpha, RP49, Cyclic nucleotide-gated channel alpha 1, cyclic nucleotide gated channel alpha 1, cyclic nucleotide gated channel subunit alpha 1
External IDsOMIM: 123825; MGI: 88436; HomoloGene: 55432; GeneCards: CNGA1; OMA:CNGA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

1259

12788

Ensembl

ENSG00000198515

ENSMUSG00000067220

UniProt

P29973

P29974

RefSeq (mRNA)

NM_000087
NM_001142564
NM_001379270

NM_007723

RefSeq (protein)

NP_000078
NP_001136036
NP_001366199
NP_000078.2

NP_031749

Location (UCSC)Chr 4: 47.94 – 48.02 MbChr 5: 72.76 – 72.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein.[5] Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium.[6] In rod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio.[7][8][9] The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current.[10] When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, hyperpolarization of the membrane potential.

See also

[edit]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198515 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067220 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CNGA1 cyclic nucleotide gated channel alpha 1". Ncbi.nlm.nih.gov. Retrieved 2016-08-02.
  6. ^ Kaupp, U. Benjamin; Niidome, Tetsuhiro; Tanabe, Tsutomu; Terada, Shoichi; Bönigk, Wolfgang; Stühmer, Walter; Cook, Neil J.; Kangawa, Kenji; Matsuo, Hisayuki (December 1989). "Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel". Nature. 342 (6251): 762–766. Bibcode:1989Natur.342..762K. doi:10.1038/342762a0. hdl:11858/00-001M-0000-002B-B7A4-3. ISSN 0028-0836. PMID 2481236. S2CID 4254661.
  7. ^ Zheng, Jie; Trudeau, Matthew C.; Zagotta, William N. (December 2002). "Rod Cyclic Nucleotide-Gated Channels Have a Stoichiometry of Three CNGA1 Subunits and One CNGB1 Subunit". Neuron. 36 (5): 891–896. doi:10.1016/s0896-6273(02)01099-1. ISSN 0896-6273. PMID 12467592. S2CID 15365006.
  8. ^ Zhong, Haining; Molday, Laurie L.; Molday, Robert S.; Yau, King-Wai (November 2002). "The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry". Nature. 420 (6912): 193–198. Bibcode:2002Natur.420..193Z. doi:10.1038/nature01201. ISSN 0028-0836. PMC 2877395. PMID 12432397.
  9. ^ Weitz, Dietmar; Ficek, Nicole; Kremmer, Elisabeth; Bauer, Paul J.; Kaupp, U.Benjamin (December 2002). "Subunit Stoichiometry of the CNG Channel of Rod Photoreceptors". Neuron. 36 (5): 881–889. doi:10.1016/s0896-6273(02)01098-x. ISSN 0896-6273. PMID 12467591. S2CID 17176092.
  10. ^ Chen, T.-Y.; Peng, Y.-W.; Dhallan, R. S.; Ahamed, B.; Reed, R. R.; Yau, K.-W. (April 1993). "A new subunit of the cyclic nucleotide-gated cation channel in retinal rods". Nature. 362 (6422): 764–767. Bibcode:1993Natur.362..764C. doi:10.1038/362764a0. ISSN 0028-0836. PMID 7682292. S2CID 4350775.

Further reading

[edit]
[edit]

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