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Importing Wikidata short description: Protein-coding gene in the species Homo sapiens (shortdescs-in-category) |
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{PBB|geneid=8941}} |
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{{Infobox_gene}} |
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'''Cyclin-dependent kinase 5 activator 2''' is an [[enzyme]] that in humans is encoded by the ''CDK5R2'' [[gene]].<ref name="pmid7592934">{{cite journal | |
'''Cyclin-dependent kinase 5 activator 2''' is an [[enzyme]] that in humans is encoded by the ''CDK5R2'' [[gene]].<ref name="pmid7592934">{{cite journal | vauthors = Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH | title = An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator | journal = The Journal of Biological Chemistry | volume = 270 | issue = 45 | pages = 26897–903 | date = November 1995 | pmid = 7592934 | doi = 10.1074/jbc.270.45.26897 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8941}}</ref> |
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⚫ | The protein encoded by this gene is a neuron-specific activator of [[CDK5]] [[Protein kinase|kinase]]. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to [[cyclins]], and thus may define a distinct family of [[cyclin-dependent kinase]]-activating proteins.<ref name="entrez"/> |
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==Interactions== |
== Interactions == |
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⚫ | CDK5R2 has been shown to [[Protein- |
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⚫ | CDK5R2 has been shown to [[Protein-protein interaction|interact]] with [[Actinin, alpha 1]].<ref name=pmid12223541>{{cite journal | vauthors = Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH | title = The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner | journal = The Journal of Neuroscience | volume = 22 | issue = 18 | pages = 7879–91 | date = September 2002 | pmid = 12223541 | doi = 10.1523/JNEUROSCI.22-18-07879.2002 | doi-access = free | pmc = 6758084 }}</ref> |
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[https://deltasoftco.com/ecommerce-website-design/ طراحی سایت فروشگاهی] |
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== External links == |
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* {{UCSC gene info|CDK5R2}} |
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* {{cite journal | vauthors = Humbert S, Dhavan R, Tsai L | title = p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton | journal = Journal of Cell Science | volume = 113 | issue = 6 | pages = 975–83 | date = March 2000 | doi = 10.1242/jcs.113.6.975 | pmid = 10683146 }} |
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{{PBB_Further_reading |
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* {{cite journal | vauthors = Humbert S, Lanier LM, Tsai LH | title = Synaptic localization of p39, a neuronal activator of cdk5 | journal = NeuroReport | volume = 11 | issue = 10 | pages = 2213–6 | date = July 2000 | pmid = 10923673 | doi = 10.1097/00001756-200007140-00030 | s2cid = 24971519 }} |
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| citations = |
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*{{cite journal |
* {{cite journal | vauthors = Muravenko OV, Gizatullin RZ, Protopopov AI, Kashuba VI, Zabarovsky ER, Zelenin AV | title = Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 89 | issue = 3–4 | pages = 160–1 | year = 2000 | pmid = 10965112 | doi = 10.1159/000015602 | s2cid = 83701584 }} |
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*{{cite journal |
* {{cite journal | vauthors = Agarwal-Mawal A, Paudel HK | title = Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 23712–8 | date = June 2001 | pmid = 11320080 | doi = 10.1074/jbc.M010002200 | doi-access = free }} |
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*{{cite journal |
* {{cite journal | vauthors = Patzke H, Tsai LH | title = Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8054–60 | date = March 2002 | pmid = 11784720 | doi = 10.1074/jbc.M109645200 | doi-access = free }} |
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*{{cite journal |
* {{cite journal | vauthors = Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH | title = The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner | journal = The Journal of Neuroscience | volume = 22 | issue = 18 | pages = 7879–91 | date = September 2002 | pmid = 12223541 | doi = 10.1523/JNEUROSCI.22-18-07879.2002| doi-access = free | pmc = 6758084 }} |
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*{{cite journal |
* {{cite journal | vauthors = Sakashita G, Shima H, Komatsu M, Urano T, Kikuchi A, Kikuchi K | title = Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells | journal = Journal of Biochemistry | volume = 133 | issue = 2 | pages = 165–71 | date = February 2003 | pmid = 12761178 | doi = 10.1093/jb/mvg020 }} |
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*{{cite journal |
* {{cite journal | vauthors = Rademakers R, Sleegers K, Theuns J, Van den Broeck M, Bel Kacem S, Nilsson LG, Adolfsson R, van Duijn CM, Van Broeckhoven C, Cruts M | title = Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease | journal = Neurobiology of Aging | volume = 26 | issue = 8 | pages = 1145–51 | year = 2005 | pmid = 15917097 | doi = 10.1016/j.neurobiolaging.2004.10.003 | s2cid = 25396010 }} |
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*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} |
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*{{cite journal | author=Sakashita G, Shima H, Komatsu M, ''et al.'' |title=Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells. |journal=J. Biochem. |volume=133 |issue= 2 |pages= 165–71 |year= 2004 |pmid= 12761178 |doi=10.1093/jb/mvg020 }} |
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*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }} |
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*{{cite journal | author=Rademakers R, Sleegers K, Theuns J, ''et al.'' |title=Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. |journal=Neurobiol. Aging |volume=26 |issue= 8 |pages= 1145–51 |year= 2005 |pmid= 15917097 |doi= 10.1016/j.neurobiolaging.2004.10.003 }} |
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[[ru:CDK5R2]] |
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[[uk:CDK5R2]] |
Latest revision as of 20:58, 3 March 2023
Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene.[5][6]
The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase-activating proteins.[6]
Interactions
[edit]CDK5R2 has been shown to interact with Actinin, alpha 1.[7]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000171450 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090071 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH (November 1995). "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator". The Journal of Biological Chemistry. 270 (45): 26897–903. doi:10.1074/jbc.270.45.26897. PMID 7592934.
- ^ a b "Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)".
- ^ Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". The Journal of Neuroscience. 22 (18): 7879–91. doi:10.1523/JNEUROSCI.22-18-07879.2002. PMC 6758084. PMID 12223541.
External links
[edit]- Human CDK5R2 genome location and CDK5R2 gene details page in the UCSC Genome Browser.
Further reading
[edit]- Humbert S, Dhavan R, Tsai L (March 2000). "p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton". Journal of Cell Science. 113 (6): 975–83. doi:10.1242/jcs.113.6.975. PMID 10683146.
- Humbert S, Lanier LM, Tsai LH (July 2000). "Synaptic localization of p39, a neuronal activator of cdk5". NeuroReport. 11 (10): 2213–6. doi:10.1097/00001756-200007140-00030. PMID 10923673. S2CID 24971519.
- Muravenko OV, Gizatullin RZ, Protopopov AI, Kashuba VI, Zabarovsky ER, Zelenin AV (2000). "Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization". Cytogenetics and Cell Genetics. 89 (3–4): 160–1. doi:10.1159/000015602. PMID 10965112. S2CID 83701584.
- Agarwal-Mawal A, Paudel HK (June 2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2". The Journal of Biological Chemistry. 276 (26): 23712–8. doi:10.1074/jbc.M010002200. PMID 11320080.
- Patzke H, Tsai LH (March 2002). "Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29". The Journal of Biological Chemistry. 277 (10): 8054–60. doi:10.1074/jbc.M109645200. PMID 11784720.
- Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". The Journal of Neuroscience. 22 (18): 7879–91. doi:10.1523/JNEUROSCI.22-18-07879.2002. PMC 6758084. PMID 12223541.
- Sakashita G, Shima H, Komatsu M, Urano T, Kikuchi A, Kikuchi K (February 2003). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells". Journal of Biochemistry. 133 (2): 165–71. doi:10.1093/jb/mvg020. PMID 12761178.
- Rademakers R, Sleegers K, Theuns J, Van den Broeck M, Bel Kacem S, Nilsson LG, Adolfsson R, van Duijn CM, Van Broeckhoven C, Cruts M (2005). "Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease". Neurobiology of Aging. 26 (8): 1145–51. doi:10.1016/j.neurobiolaging.2004.10.003. PMID 15917097. S2CID 25396010.