CDK5R2: Difference between revisions

CDK5R2
Identifiers
Aliases	CDK5R2, NCK5AI, P39, p39nck5ai, cyclin-dependent kinase 5, regulatory subunit 2 (p39), cyclin dependent kinase 5 regulatory subunit 2
External IDs	OMIM: 603764; MGI: 1330828; HomoloGene: 2924; GeneCards: CDK5R2; OMA:CDK5R2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,962,155 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,896,891 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; right frontal lobe; ; putamen; ; nucleus accumbens; ; cingulate gyrus; ; anterior cingulate cortex; ; lateral nuclear group of thalamus; ; caudate nucleus; ; pituitary gland;
	Top expressed in
	superior frontal gyrus; ; neural layer of retina; ; supraoptic nucleus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; prefrontal cortex; ; cerebellar cortex; ; lateral septal nucleus; ; olfactory tubercle; ; hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cyclin-dependent protein serine/threonine kinase activator activity; lipid binding; actin binding;
Cellular component	cytoplasm; protein kinase 5 complex; plasma membrane; membrane; growth cone; neuron projection;
Biological process	positive regulation of protein kinase activity; regulation of cyclin-dependent protein serine/threonine kinase activity; neuron migration; hippocampus development; layer formation in cerebral cortex; cerebellum development; positive regulation of protein serine/threonine kinase activity; superior olivary nucleus maturation; positive regulation of calcium ion-dependent exocytosis; positive regulation of cyclin-dependent protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	8941
	12570
	ENSG00000171450
	ENSMUSG00000090071
	Q13319
	O35926
	NM_003936
	NM_009872
	NP_003927
	NP_034002
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 20:58, 3 March 2023

Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene.^[5]^[6]

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase-activating proteins.^[6]

Interactions

CDK5R2 has been shown to interact with Actinin, alpha 1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171450 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090071 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH (November 1995). "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator". The Journal of Biological Chemistry. 270 (45): 26897–903. doi:10.1074/jbc.270.45.26897. PMID 7592934.
^ ^a ^b "Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)".
^ Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". The Journal of Neuroscience. 22 (18): 7879–91. doi:10.1523/JNEUROSCI.22-18-07879.2002. PMC 6758084. PMID 12223541.

طراحی سایت فروشگاهی

External links

Human CDK5R2 genome location and CDK5R2 gene details page in the UCSC Genome Browser.

Humbert S, Dhavan R, Tsai L (March 2000). "p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton". Journal of Cell Science. 113 (6): 975–83. doi:10.1242/jcs.113.6.975. PMID 10683146.
Humbert S, Lanier LM, Tsai LH (July 2000). "Synaptic localization of p39, a neuronal activator of cdk5". NeuroReport. 11 (10): 2213–6. doi:10.1097/00001756-200007140-00030. PMID 10923673. S2CID 24971519.
Muravenko OV, Gizatullin RZ, Protopopov AI, Kashuba VI, Zabarovsky ER, Zelenin AV (2000). "Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization". Cytogenetics and Cell Genetics. 89 (3–4): 160–1. doi:10.1159/000015602. PMID 10965112. S2CID 83701584.
Agarwal-Mawal A, Paudel HK (June 2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2". The Journal of Biological Chemistry. 276 (26): 23712–8. doi:10.1074/jbc.M010002200. PMID 11320080.
Patzke H, Tsai LH (March 2002). "Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29". The Journal of Biological Chemistry. 277 (10): 8054–60. doi:10.1074/jbc.M109645200. PMID 11784720.
Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". The Journal of Neuroscience. 22 (18): 7879–91. doi:10.1523/JNEUROSCI.22-18-07879.2002. PMC 6758084. PMID 12223541.
Sakashita G, Shima H, Komatsu M, Urano T, Kikuchi A, Kikuchi K (February 2003). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells". Journal of Biochemistry. 133 (2): 165–71. doi:10.1093/jb/mvg020. PMID 12761178.
Rademakers R, Sleegers K, Theuns J, Van den Broeck M, Bel Kacem S, Nilsson LG, Adolfsson R, van Duijn CM, Van Broeckhoven C, Cruts M (2005). "Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease". Neurobiology of Aging. 26 (8): 1145–51. doi:10.1016/j.neurobiolaging.2004.10.003. PMID 15917097. S2CID 25396010.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171450 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090071 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7592934-5] Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH (November 1995). "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator". The Journal of Biological Chemistry. 270 (45): 26897–903. doi:10.1074/jbc.270.45.26897. PMID 7592934.

[entrez-6] "Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)".

[pmid12223541-7] Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH (September 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". The Journal of Neuroscience. 22 (18): 7879–91. doi:10.1523/JNEUROSCI.22-18-07879.2002. PMC 6758084. PMID 12223541.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=8941}}
+{{Infobox_gene}}
-'''Cyclin-dependent kinase 5 activator 2''' is an [[enzyme]] that in humans is encoded by the ''CDK5R2'' [[gene]].<ref name="pmid7592934">{{cite journal | author = Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH | title = An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator | journal = J Biol Chem | volume = 270 | issue = 45 | pages = 26897–903 | year = 1995 | month = Dec | pmid = 7592934 | pmc =  | doi =10.1074/jbc.270.45.26897  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8941| accessdate = }}</ref>
+'''Cyclin-dependent kinase 5 activator 2''' is an [[enzyme]] that in humans is encoded by the ''CDK5R2'' [[gene]].<ref name="pmid7592934">{{cite journal | vauthors = Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH | title = An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator | journal = The Journal of Biological Chemistry | volume = 270 | issue = 45 | pages = 26897–903 | date = November 1995 | pmid = 7592934 | doi = 10.1074/jbc.270.45.26897 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8941}}</ref>
+The protein encoded by this gene is a neuron-specific activator of [[CDK5]] [[Protein kinase|kinase]]. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to [[cyclins]], and thus may define a distinct family of [[cyclin-dependent kinase]]-activating proteins.<ref name="entrez"/>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene is a neuron-specific activator of [[cyclin-dependent kinase|CDK5]] kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins.<ref name="entrez">{{cite web | title = Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8941| accessdate = }}</ref>
-}}
-==Interactions==
+== Interactions ==
-CDK5R2 has been shown to [[Protein-protein_interaction|interact]] with [[Actinin, alpha 1]].<ref name=pmid12223541>{{cite journal |last=Dhavan |first=Rani |authorlink= |coauthors=Greer Paul L, Morabito Maria A, Orlando Lianna R, Tsai Li-Huei |year=[[2002]]|month=Sep. |title=The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner |journal=J. Neurosci. |volume=22 |issue=18 |pages=7879–91 |publisher= |location = United States| issn = | pmid = 12223541 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
+CDK5R2 has been shown to [[Protein-protein interaction|interact]] with [[Actinin, alpha 1]].<ref name=pmid12223541>{{cite journal | vauthors = Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH | title = The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner | journal = The Journal of Neuroscience | volume = 22 | issue = 18 | pages = 7879–91 | date = September 2002 | pmid = 12223541 | doi = 10.1523/JNEUROSCI.22-18-07879.2002 | doi-access = free | pmc = 6758084 }}</ref>
-==References==
+== References ==
 {{reflist}}
+[https://deltasoftco.com/ecommerce-website-design/ طراحی سایت فروشگاهی]
-==Further reading==
+== External links ==
+* {{UCSC gene info|CDK5R2}}
+== Further reading ==
 {{refbegin | 2}}
+* {{cite journal | vauthors = Humbert S, Dhavan R, Tsai L | title = p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton | journal = Journal of Cell Science | volume = 113 | issue = 6 | pages = 975–83 | date = March 2000 | doi = 10.1242/jcs.113.6.975 | pmid = 10683146 }}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Humbert S, Lanier LM, Tsai LH | title = Synaptic localization of p39, a neuronal activator of cdk5 | journal = NeuroReport | volume = 11 | issue = 10 | pages = 2213–6 | date = July 2000 | pmid = 10923673 | doi = 10.1097/00001756-200007140-00030 | s2cid = 24971519 }}
-| citations =
-*{{cite journal  | author=Humbert S, Dhavan R, Tsai L |title=p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton. |journal=J. Cell. Sci. |volume=113 |issue=  6|pages= 975–83 |year= 2000 |pmid= 10683146 |doi=  }}
+* {{cite journal | vauthors = Muravenko OV, Gizatullin RZ, Protopopov AI, Kashuba VI, Zabarovsky ER, Zelenin AV | title = Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 89 | issue = 3–4 | pages = 160–1 | year = 2000 | pmid = 10965112 | doi = 10.1159/000015602 | s2cid = 83701584 }}
-*{{cite journal  | author=Humbert S, Lanier LM, Tsai LH |title=Synaptic localization of p39, a neuronal activator of cdk5. |journal=Neuroreport |volume=11 |issue= 10 |pages= 2213–6 |year= 2001 |pmid= 10923673 |doi=10.1097/00001756-200007140-00030  }}
+* {{cite journal | vauthors = Agarwal-Mawal A, Paudel HK | title = Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 23712–8 | date = June 2001 | pmid = 11320080 | doi = 10.1074/jbc.M010002200 | doi-access = free }}
-*{{cite journal  | author=Muravenko OV, Gizatullin RZ, Protopopov AI, ''et al.'' |title=Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 3-4 |pages= 160–1 |year= 2000 |pmid= 10965112 |doi=10.1159/000015602  }}
+* {{cite journal | vauthors = Patzke H, Tsai LH | title = Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8054–60 | date = March 2002 | pmid = 11784720 | doi = 10.1074/jbc.M109645200 | doi-access = free }}
-*{{cite journal  | author=Agarwal-Mawal A, Paudel HK |title=Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23712–8 |year= 2001 |pmid= 11320080 |doi= 10.1074/jbc.M010002200 }}
+* {{cite journal | vauthors = Dhavan R, Greer PL, Morabito MA, Orlando LR, Tsai LH | title = The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner | journal = The Journal of Neuroscience | volume = 22 | issue = 18 | pages = 7879–91 | date = September 2002 | pmid = 12223541 | doi =  10.1523/JNEUROSCI.22-18-07879.2002| doi-access = free | pmc = 6758084 }}
-*{{cite journal  | author=Patzke H, Tsai LH |title=Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8054–60 |year= 2002 |pmid= 11784720 |doi= 10.1074/jbc.M109645200 }}
+* {{cite journal | vauthors = Sakashita G, Shima H, Komatsu M, Urano T, Kikuchi A, Kikuchi K | title = Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells | journal = Journal of Biochemistry | volume = 133 | issue = 2 | pages = 165–71 | date = February 2003 | pmid = 12761178 | doi = 10.1093/jb/mvg020 }}
-*{{cite journal  | author=Dhavan R, Greer PL, Morabito MA, ''et al.'' |title=The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner. |journal=J. Neurosci. |volume=22 |issue= 18 |pages= 7879–91 |year= 2002 |pmid= 12223541 |doi=  }}
+* {{cite journal | vauthors = Rademakers R, Sleegers K, Theuns J, Van den Broeck M, Bel Kacem S, Nilsson LG, Adolfsson R, van Duijn CM, Van Broeckhoven C, Cruts M | title = Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease | journal = Neurobiology of Aging | volume = 26 | issue = 8 | pages = 1145–51 | year = 2005 | pmid = 15917097 | doi = 10.1016/j.neurobiolaging.2004.10.003 | s2cid = 25396010 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Sakashita G, Shima H, Komatsu M, ''et al.'' |title=Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells. |journal=J. Biochem. |volume=133 |issue= 2 |pages= 165–71 |year= 2004 |pmid= 12761178 |doi=10.1093/jb/mvg020  }}
-*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
-*{{cite journal  | author=Rademakers R, Sleegers K, Theuns J, ''et al.'' |title=Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. |journal=Neurobiol. Aging |volume=26 |issue= 8 |pages= 1145–51 |year= 2005 |pmid= 15917097 |doi= 10.1016/j.neurobiolaging.2004.10.003 }}
-}}
 {{refend}}
-{{gene-2-stub}}
+{{gene-2-stub}}
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-[[ru:CDK5R2]]
-[[uk:CDK5R2]]