SUGT1: Difference between revisions
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Changing short description from "Protein-coding gene in the species Homo sapiens" to "Human protein and coding gene" |
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{{Short description|Human protein and coding gene}} |
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{{Infobox_gene}} |
{{Infobox_gene}} |
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'''Suppressor of G2 allele of SKP1 homolog''' is a [[protein]] that in humans is encoded by the ''SUGT1'' [[gene]].<ref name="pmid10445024">{{cite journal | |
'''Suppressor of G2 allele of SKP1 homolog''' is a [[protein]] that in humans is encoded by the ''SUGT1'' [[gene]].<ref name="pmid10445024">{{cite journal | vauthors = Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P | title = SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex | journal = Molecular Cell | volume = 4 | issue = 1 | pages = 21–33 | date = July 1999 | pmid = 10445024 | doi = 10.1016/S1097-2765(00)80184-7 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10910}}</ref> |
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== Function == |
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⚫ | This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.<ref name="entrez">{{cite web | title = Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10910}}</ref> |
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==Interactions== |
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⚫ | SUGT1 has been shown to [[Protein- |
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== Interactions == |
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⚫ | SUGT1 has been shown to [[Protein-protein interaction|interact]] with [[S100A6]].<ref name=pmid12746458>{{cite journal | vauthors = Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J | title = Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 26923–8 | date = July 2003 | pmid = 12746458 | doi = 10.1074/jbc.M211518200 | doi-access = free }}</ref> |
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== References == |
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{{reflist}} |
{{reflist}} |
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==Further reading== |
== Further reading == |
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{{refbegin | 2}} |
{{refbegin | 2}} |
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* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nature Biotechnology | volume = 21 | issue = 5 | pages = 566–9 | date = May 2003 | pmid = 12665801 | doi = 10.1038/nbt810 | s2cid = 23783563 }} |
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{{PBB_Further_reading |
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* {{cite journal | vauthors = Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J | title = Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 26923–8 | date = July 2003 | pmid = 12746458 | doi = 10.1074/jbc.M211518200 | doi-access = free }} |
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*{{cite journal |
* {{cite journal | vauthors = Niikura Y, Kitagawa K | title = Identification of a novel splice variant: human SGT1B (SUGT1B) | journal = DNA Sequence | volume = 14 | issue = 6 | pages = 436–41 | date = December 2003 | pmid = 15018354 | doi = 10.1080/10425170310001623644 | s2cid = 20578581 }} |
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*{{cite journal |
* {{cite journal | vauthors = Zou X, Ji C, Wang L, Wu M, Zheng H, Xu J, Jin F, Gu S, Ying K, Xie Y, Mao Y | title = Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1 | journal = DNA Sequence | volume = 15 | issue = 2 | pages = 140–3 | date = April 2004 | pmid = 15346769 | doi = 10.1080/1042517032000160215 | s2cid = 37324928 }} |
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*{{cite journal |
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = January 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }} |
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*{{cite journal |
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = October 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 | s2cid = 14294292 }} |
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*{{cite journal |
* {{cite journal | vauthors = da Silva Correia J, Miranda Y, Leonard N, Ulevitch R | title = SGT1 is essential for Nod1 activation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 16 | pages = 6764–9 | date = April 2007 | pmid = 17420470 | pmc = 1871859 | doi = 10.1073/pnas.0610926104 | bibcode = 2007PNAS..104.6764D | doi-access = free }} |
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*{{cite journal |
* {{cite journal | vauthors = Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J, Filipek A | title = Hsp70 is a new target of Sgt1--an interaction modulated by S100A6 | journal = Biochemical and Biophysical Research Communications | volume = 357 | issue = 4 | pages = 1148–53 | date = June 2007 | pmid = 17466273 | doi = 10.1016/j.bbrc.2007.04.073 }} |
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*{{cite journal |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }} |
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*{{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }} |
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*{{cite journal | author=da Silva Correia J, Miranda Y, Leonard N, Ulevitch R |title=SGT1 is essential for Nod1 activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 16 |pages= 6764–9 |year= 2007 |pmid= 17420470 |doi= 10.1073/pnas.0610926104 | pmc=1871859 }} |
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*{{cite journal |vauthors=Spiechowicz M, Zylicz A, Bieganowski P, etal |title=Hsp70 is a new target of Sgt1--an interaction modulated by S100A6. |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 4 |pages= 1148–53 |year= 2007 |pmid= 17466273 |doi= 10.1016/j.bbrc.2007.04.073 }} |
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}} |
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{{refend}} |
{{refend}} |
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{{PDB Gallery|geneid=10910}} |
{{PDB Gallery|geneid=10910}} |
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Latest revision as of 01:41, 29 May 2023
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | SUGT1, SGT1, SGT1 homolog, MIS12 kinetochore complex assembly cochaperone | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 604098; MGI: 1915205; HomoloGene: 4877; GeneCards: SUGT1; OMA:SUGT1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene.[5][6]
Function
[edit]This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.[6]
Interactions
[edit]SUGT1 has been shown to interact with S100A6.[7]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000165416 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022024 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P (July 1999). "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex". Molecular Cell. 4 (1): 21–33. doi:10.1016/S1097-2765(00)80184-7. PMID 10445024.
- ^ a b "Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)".
- ^ Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.
Further reading
[edit]- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
- Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.
- Niikura Y, Kitagawa K (December 2003). "Identification of a novel splice variant: human SGT1B (SUGT1B)". DNA Sequence. 14 (6): 436–41. doi:10.1080/10425170310001623644. PMID 15018354. S2CID 20578581.
- Zou X, Ji C, Wang L, Wu M, Zheng H, Xu J, Jin F, Gu S, Ying K, Xie Y, Mao Y (April 2004). "Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1". DNA Sequence. 15 (2): 140–3. doi:10.1080/1042517032000160215. PMID 15346769. S2CID 37324928.
- Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- da Silva Correia J, Miranda Y, Leonard N, Ulevitch R (April 2007). "SGT1 is essential for Nod1 activation". Proceedings of the National Academy of Sciences of the United States of America. 104 (16): 6764–9. Bibcode:2007PNAS..104.6764D. doi:10.1073/pnas.0610926104. PMC 1871859. PMID 17420470.
- Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J, Filipek A (June 2007). "Hsp70 is a new target of Sgt1--an interaction modulated by S100A6". Biochemical and Biophysical Research Communications. 357 (4): 1148–53. doi:10.1016/j.bbrc.2007.04.073. PMID 17466273.