SUGT1: Difference between revisions

SUGT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RL1
Identifiers
Aliases	SUGT1, SGT1, SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
External IDs	OMIM: 604098; MGI: 1915205; HomoloGene: 4877; GeneCards: SUGT1; OMA:SUGT1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	52,700,909 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	79,872,636 bp
RNA expression pattern
	Top expressed in
	cardiac muscle tissue of right atrium; ; pancreatic epithelial cell; ; myocardium of left ventricle; ; oocyte; ; cartilage tissue; ; parietal pleura; ; tibia; ; pancreatic ductal cell; ; gingival epithelium; ; tendon of biceps brachii;
	Top expressed in
	morula; ; morula; ; blastocyst; ; otic vesicle; ; medial ganglionic eminence; ; abdominal wall; ; epiblast; ; superior surface of tongue; ; otic placode; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; nucleus; kinetochore; ubiquitin ligase complex; protein-containing complex;
Biological process	regulation of protein stability; mitotic cell cycle; protein stabilization;
	Sources:Amigo / QuickGO
Orthologs
	10910
	67955
	ENSG00000165416
	ENSMUSG00000022024
	Q9Y2Z0
	Q9CX34
	NM_001130912; NM_006704; NM_001320831
	NM_026474
	NP_001124384; NP_001307760; NP_006695
	NP_080750
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 01:41, 29 May 2023

Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene.^[5]^[6]

Function

This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.^[6]

Interactions

SUGT1 has been shown to interact with S100A6.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165416 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022024 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P (July 1999). "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex". Molecular Cell. 4 (1): 21–33. doi:10.1016/S1097-2765(00)80184-7. PMID 10445024.
^ ^a ^b "Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)".
^ Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.

Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.
Niikura Y, Kitagawa K (December 2003). "Identification of a novel splice variant: human SGT1B (SUGT1B)". DNA Sequence. 14 (6): 436–41. doi:10.1080/10425170310001623644. PMID 15018354. S2CID 20578581.
Zou X, Ji C, Wang L, Wu M, Zheng H, Xu J, Jin F, Gu S, Ying K, Xie Y, Mao Y (April 2004). "Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1". DNA Sequence. 15 (2): 140–3. doi:10.1080/1042517032000160215. PMID 15346769. S2CID 37324928.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
da Silva Correia J, Miranda Y, Leonard N, Ulevitch R (April 2007). "SGT1 is essential for Nod1 activation". Proceedings of the National Academy of Sciences of the United States of America. 104 (16): 6764–9. Bibcode:2007PNAS..104.6764D. doi:10.1073/pnas.0610926104. PMC 1871859. PMID 17420470.
Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J, Filipek A (June 2007). "Hsp70 is a new target of Sgt1--an interaction modulated by S100A6". Biochemical and Biophysical Research Communications. 357 (4): 1148–53. doi:10.1016/j.bbrc.2007.04.073. PMID 17466273.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165416 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022024 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10445024-5] Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P (July 1999). "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex". Molecular Cell. 4 (1): 21–33. doi:10.1016/S1097-2765(00)80184-7. PMID 10445024.

[entrez-6] "Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)".

[pmid12746458-7] Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.

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@@ Line 1: / Line 1: @@
+{{Short description|Human protein and coding gene}}
 {{Infobox_gene}}
-'''Suppressor of G2 allele of SKP1 homolog''' is a [[protein]] that in humans is encoded by the ''SUGT1'' [[gene]].<ref name="pmid10445024">{{cite journal | author = Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P | title = SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex | journal = Mol Cell | volume = 4 | issue = 1 | pages = 21–33 |date=Aug 1999 | pmid = 10445024 | pmc =  | doi =10.1016/S1097-2765(00)80184-7  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10910| accessdate = }}</ref>
+'''Suppressor of G2 allele of SKP1 homolog''' is a [[protein]] that in humans is encoded by the ''SUGT1'' [[gene]].<ref name="pmid10445024">{{cite journal | vauthors = Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P | title = SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex | journal = Molecular Cell | volume = 4 | issue = 1 | pages = 21–33 | date = July 1999 | pmid = 10445024 | doi = 10.1016/S1097-2765(00)80184-7 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10910}}</ref>
+== Function ==
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.<ref name="entrez">{{cite web | title = Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10910| accessdate = }}</ref>
-}}
+This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.<ref name="entrez">{{cite web | title = Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10910}}</ref>
-==Interactions==
-SUGT1 has been shown to [[Protein-protein_interaction|interact]] with [[S100A6]].<ref name=pmid12746458>{{cite journal |last=Nowotny |first=Marcin |authorlink= |author2=Spiechowicz Magdalena |author3=Jastrzebska Beata |author4=Filipek Anna |author5=Kitagawa Katsumi |author6=Kuznicki Jacek  |date=Jul 2003 |title=Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins |journal=J. Biol. Chem. |volume=278 |issue=29 |pages=26923–8 |publisher= |location = United States| issn = 0021-9258| pmid = 12746458 |doi = 10.1074/jbc.M211518200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
-==References==
+== Interactions ==
+SUGT1 has been shown to [[Protein-protein interaction|interact]] with [[S100A6]].<ref name=pmid12746458>{{cite journal | vauthors = Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J | title = Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 26923–8 | date = July 2003 | pmid = 12746458 | doi = 10.1074/jbc.M211518200 | doi-access = free }}</ref>
+== References ==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
+* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nature Biotechnology | volume = 21 | issue = 5 | pages = 566–9 | date = May 2003 | pmid = 12665801 | doi = 10.1038/nbt810 | s2cid = 23783563 }}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J | title = Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 26923–8 | date = July 2003 | pmid = 12746458 | doi = 10.1074/jbc.M211518200 | doi-access = free }}
-| citations =
-*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+* {{cite journal | vauthors = Niikura Y, Kitagawa K | title = Identification of a novel splice variant: human SGT1B (SUGT1B) | journal = DNA Sequence | volume = 14 | issue = 6 | pages = 436–41 | date = December 2003 | pmid = 15018354 | doi = 10.1080/10425170310001623644 | s2cid = 20578581 }}
-*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
+* {{cite journal | vauthors = Zou X, Ji C, Wang L, Wu M, Zheng H, Xu J, Jin F, Gu S, Ying K, Xie Y, Mao Y | title = Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1 | journal = DNA Sequence | volume = 15 | issue = 2 | pages = 140–3 | date = April 2004 | pmid = 15346769 | doi = 10.1080/1042517032000160215 | s2cid = 37324928 }}
-*{{cite journal   |vauthors=Nowotny M, Spiechowicz M, Jastrzebska B, etal |title=Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26923–8 |year= 2003 |pmid= 12746458 |doi= 10.1074/jbc.M211518200 }}
+* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = January 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }}
-*{{cite journal  | author=Niikura Y, Kitagawa K |title=Identification of a novel splice variant: human SGT1B (SUGT1B). |journal=DNA Seq. |volume=14 |issue= 6 |pages= 436–41 |year= 2004 |pmid= 15018354 |doi=  10.1080/10425170310001623644}}
+* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = October 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 | s2cid = 14294292 }}
-*{{cite journal   |vauthors=Zou X, Ji C, Wang L, etal |title=Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1. |journal=DNA Seq. |volume=15 |issue= 2 |pages= 140–3 |year= 2004 |pmid= 15346769 |doi=  10.1080/1042517032000160215}}
+* {{cite journal | vauthors = da Silva Correia J, Miranda Y, Leonard N, Ulevitch R | title = SGT1 is essential for Nod1 activation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 16 | pages = 6764–9 | date = April 2007 | pmid = 17420470 | pmc = 1871859 | doi = 10.1073/pnas.0610926104 | bibcode = 2007PNAS..104.6764D | doi-access = free }}
-*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
+* {{cite journal | vauthors = Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J, Filipek A | title = Hsp70 is a new target of Sgt1--an interaction modulated by S100A6 | journal = Biochemical and Biophysical Research Communications | volume = 357 | issue = 4 | pages = 1148–53 | date = June 2007 | pmid = 17466273 | doi = 10.1016/j.bbrc.2007.04.073 }}
-*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
-*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
-*{{cite journal  | author=da Silva Correia J, Miranda Y, Leonard N, Ulevitch R |title=SGT1 is essential for Nod1 activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 16 |pages= 6764–9 |year= 2007 |pmid= 17420470 |doi= 10.1073/pnas.0610926104  | pmc=1871859 }}
-*{{cite journal   |vauthors=Spiechowicz M, Zylicz A, Bieganowski P, etal |title=Hsp70 is a new target of Sgt1--an interaction modulated by S100A6. |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 4 |pages= 1148–53 |year= 2007 |pmid= 17466273 |doi= 10.1016/j.bbrc.2007.04.073 }}
-}}
 {{refend}}
 {{PDB Gallery|geneid=10910}}
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+{{gene-13-stub}}
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