Glucuronate-1-phosphate uridylyltransferase: Difference between revisions
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{{enzyme |
{{infobox enzyme |
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| Name = glucuronate-1-phosphate uridylyltransferase |
| Name = glucuronate-1-phosphate uridylyltransferase |
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| EC_number = 2.7.7.44 |
| EC_number = 2.7.7.44 |
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| CAS_number = 52228-05-4 |
| CAS_number = 52228-05-4 |
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| GO_code = 0047350 |
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| IUBMB_EC_number = 2/7/7/44 |
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In [[enzymology]], a '''glucuronate-1-phosphate uridylyltransferase''' ({{EC number|2.7.7.44}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
In [[enzymology]], a '''glucuronate-1-phosphate uridylyltransferase''' ({{EC number|2.7.7.44}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
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Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[uridine triphosphate|UTP]] and [[1-phospho-alpha-D-glucuronate]], whereas its two [[product (chemistry)|products]] are [[diphosphate]] and [[UDP-glucuronate]]. |
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[uridine triphosphate|UTP]] and [[1-phospho-alpha-D-glucuronate]], whereas its two [[product (chemistry)|products]] are [[diphosphate]] and [[UDP-glucuronate]]. |
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This enzyme belongs to the family of [[transferase]]s, specifically those transferring phosphorus-containing [[nucleotide]] groups ([[nucleotidyltransferase]]s). The systematic name of this enzyme class is '''UTP:1-phospho-alpha-D-glucuronate uridylyltransferase'''. Other names in common use include '''UDP-glucuronate pyrophosphorylase''', '''UDP-D-glucuronic acid pyrophosphorylase''', '''UDP-glucuronic acid pyrophosphorylase''', and '''uridine diphosphoglucuronic pyrophosphorylase'''. This enzyme participates in [[pentose and glucuronate interconversions]] and [[ascorbate and aldarate metabolism]]. |
This enzyme belongs to the family of [[transferase]]s, specifically those transferring phosphorus-containing [[nucleotide]] groups ([[nucleotidyltransferase]]s). The [[List of enzymes|systematic name]] of this enzyme class is '''UTP:1-phospho-alpha-D-glucuronate uridylyltransferase'''. Other names in common use include '''UDP-glucuronate pyrophosphorylase''', '''UDP-D-glucuronic acid pyrophosphorylase''', '''UDP-glucuronic acid pyrophosphorylase''', and '''uridine diphosphoglucuronic pyrophosphorylase'''. This enzyme participates in [[pentose and glucuronate interconversions]] and [[ascorbate and aldarate metabolism]]. |
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==References== |
== References == |
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{{reflist|1}} |
{{reflist|1}} |
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* {{cite journal | |
* {{cite journal | vauthors = Roberts RM | title = The formation of uridine diphosphate-glucuronic acid in plants. Uridine diphosphate-glucuronic acid pyrophosphorylase from barley seedlings | journal = The Journal of Biological Chemistry | volume = 246 | issue = 16 | pages = 4995–5002 | date = August 1971 | pmid = 5570433 }} |
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{{Kinases}} |
{{Kinases}} |
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{{Enzymes}} |
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{{Portal bar|Biology|border=no}} |
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[[Category:EC 2.7.7]] |
[[Category:EC 2.7.7]] |
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[[Category:Enzymes of unknown structure]] |
[[Category:Enzymes of unknown structure]] |
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Latest revision as of 14:15, 26 August 2023
| glucuronate-1-phosphate uridylyltransferase | |||||||||
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| Identifiers | |||||||||
| EC no. | 2.7.7.44 | ||||||||
| CAS no. | 52228-05-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a glucuronate-1-phosphate uridylyltransferase (EC 2.7.7.44) is an enzyme that catalyzes the chemical reaction
- UTP + 1-phospho-alpha-D-glucuronate diphosphate + UDP-glucuronate
Thus, the two substrates of this enzyme are UTP and 1-phospho-alpha-D-glucuronate, whereas its two products are diphosphate and UDP-glucuronate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:1-phospho-alpha-D-glucuronate uridylyltransferase. Other names in common use include UDP-glucuronate pyrophosphorylase, UDP-D-glucuronic acid pyrophosphorylase, UDP-glucuronic acid pyrophosphorylase, and uridine diphosphoglucuronic pyrophosphorylase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.
References
[edit]- Roberts RM (August 1971). "The formation of uridine diphosphate-glucuronic acid in plants. Uridine diphosphate-glucuronic acid pyrophosphorylase from barley seedlings". The Journal of Biological Chemistry. 246 (16): 4995–5002. PMID 5570433.
