Nicotinate phosphoribosyltransferase: Difference between revisions
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{{enzyme |
{{infobox enzyme |
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| Name = |
| Name = Nicotinate phosphoribosyltransferase |
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| EC_number = 6.3.4.21 |
| EC_number = 6.3.4.21 |
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| CAS_number = 9030-26-6 |
| CAS_number = 9030-26-6 |
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| GO_code = 0004516 |
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| IUBMB_EC_number = 6/3/4/21 |
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| image = 4yub.jpg |
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| width = 270 |
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| caption = Nicotinate phosphoribosyltransferase dimer, Human |
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In [[enzymology]], a '''nicotinate phosphoribosyltransferase''' ({{ |
In [[enzymology]], a '''nicotinate phosphoribosyltransferase''' ({{EnzExplorer|6.3.4.21}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
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:nicotinate + 5-phospho- |
:nicotinate + 5-phospho-α-<small>D</small>-ribose 1-diphosphate + ATP + H<sub>2</sub>O <math>\rightleftharpoons</math> nicotinate <small>D</small>-ribonucleotide + diphosphate + ADP + phosphate |
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Thus, the four [[substrate (biochemistry)|substrates]] of this enzyme are [[nicotinate]], [[Phosphoribosyl pyrophosphate|5-phospho-alpha-D-ribose 1-diphosphate]], [[Adenosine triphosphate|ATP]], and [[Water|H<sub>2</sub>O]], whereas its four [[product (chemistry)|products]] are [[nicotinate D-ribonucleotide]], [[diphosphate]], [[Adenosine diphosphate|ADP]], and [[phosphate]]. |
Thus, the four [[substrate (biochemistry)|substrates]] of this enzyme are [[nicotinate]], [[Phosphoribosyl pyrophosphate|5-phospho-alpha-D-ribose 1-diphosphate]], [[Adenosine triphosphate|ATP]], and [[Water|H<sub>2</sub>O]], whereas its four [[product (chemistry)|products]] are [[nicotinate D-ribonucleotide]], [[diphosphate]], [[Adenosine diphosphate|ADP]], and [[phosphate]]. |
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This enzyme belongs to the family of [[ligase]]s, specifically those forming generic carbon-nitrogen bonds. The [[List of enzymes|systematic name]] of this enzyme class is '''5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming) '''. Other names in common use include '''niacin ribonucleotidase''', '''nicotinic acid mononucleotide glycohydrolase''', '''nicotinic acid mononucleotide pyrophosphorylase''', and '''nicotinic acid phosphoribosyltransferase'''. This enzyme participates in [[nicotinate and nicotinamide metabolism]]. |
This enzyme belongs to the family of [[ligase]]s, specifically those forming generic carbon-nitrogen bonds. The [[List of enzymes|systematic name]] of this enzyme class is '''5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming) '''. <!--Other names in common use include '''niacin ribonucleotidase''', '''nicotinic acid mononucleotide glycohydrolase''', '''nicotinic acid mononucleotide pyrophosphorylase''', and '''nicotinic acid phosphoribosyltransferase'''. This enzyme participates in [[nicotinate and nicotinamide metabolism]]. What is the evidence that all these names are common use? Citations needed --> |
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==Structural studies== |
==Structural studies== |
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{{Ligases CO CS and CN}} |
{{Ligases CO CS and CN}} |
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{{Enzymes}} |
{{Enzymes}} |
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{{Portal bar| |
{{Portal bar|Biology|border=no}} |
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[[Category:EC 6.3.4]] |
[[Category:EC 6.3.4]] |
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[[Category:Enzymes of known structure]] |
[[Category:Enzymes of known structure]] |
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Latest revision as of 15:09, 26 August 2023
| Nicotinate phosphoribosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Nicotinate phosphoribosyltransferase dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 6.3.4.21 | ||||||||
| CAS no. | 9030-26-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a nicotinate phosphoribosyltransferase (EC 6.3.4.21) is an enzyme that catalyzes the chemical reaction
- nicotinate + 5-phospho-α-D-ribose 1-diphosphate + ATP + H2O nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
Thus, the four substrates of this enzyme are nicotinate, 5-phospho-alpha-D-ribose 1-diphosphate, ATP, and H2O, whereas its four products are nicotinate D-ribonucleotide, diphosphate, ADP, and phosphate.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is 5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming) .
Structural studies
[edit]As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1VLP, 1YBE, 1YIR, 1YTD, 1YTE, 1YTK, and 2F7F.
References
[edit]- IMSANDE J (1961). "Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli". J. Biol. Chem. 236: 1494–7. PMID 13717628.
- IMSANDE J, HANDLER P (1961). "Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophos-phorylase". J. Biol. Chem. 236: 525–30. PMID 13717627.
- Kosaka A, Spivey HO, Gholson RK (1971). "Nicotinate phosphoribosyltransferase of yeast. Purification and properties". J. Biol. Chem. 246 (10): 3277–83. PMID 4324895.
