Jump to content

Cyclin A1: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous edit
Content deleted Content added
VisualWikitext
m fixing page range dashes using Project:AWB
Add: s2cid. | Use this bot. Report bugs. | #UCB_CommandLine 1964/13232
 
(36 intermediate revisions by 27 users not shown)
Line 1: Line 1:
{{cs1 config|name-list-style=vanc}}
{{PBB|geneid=8900}}
{{Short description|Protein-coding gene in the species Homo sapiens}}
⚫
'''Cyclin-A1''' is a [[protein]] that in humans is encoded by the ''CCNA1'' [[gene]].<ref name="pmid9041194">{{cite journal | author = Yang R, Morosetti R, Koeffler HP | title = Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines | journal = Cancer Res | volume = 57 | issue = 5 | pages = 913–20 | year = 1997 | month = Mar | pmid = 9041194 | pmc = | doi = }}</ref>
{{Infobox_gene}}
⚫
'''Cyclin-A1''' is a [[protein]] that in humans is encoded by the ''CCNA1'' [[gene]].<ref name="pmid9041194">{{cite journal | vauthors = Yang R, Morosetti R, Koeffler HP | title = Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines | journal = Cancer Res. | volume = 57 | issue = 5 | pages = 913–920 | date = March 1997 | pmid = 9041194 }}</ref>


== Function ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
⚫
| summary_text = The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins.<ref name="entrez">{{cite web | title = Entrez Gene: CCNA1 cyclin A1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8900| accessdate = }}</ref>
}}


⚫
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the [[cell cycle|cell division cycle]]. Cyclins function as activating subunits of enzymatic [[multiprotein complex|complex]] together with [[cyclin-dependent kinases|cyclin-dependent kinases (CDKs)]]. Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of [[meiosis]]. This cyclin binds both [[Cdk1]] and [[Cdk2]] kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor [[E2F1]], and the Kip/Cip family of CDK-inhibitor proteins.<ref name="entrez">{{Cite web| title = Entrez Gene: CCNA1 cyclin A1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8900}}</ref>
==Interactions==
Cyclin A1 has been shown to [[Protein-protein_interaction|interact]] with [[E2F1]],<ref name=pmid10022926>{{cite journal | quotes = yes |last=Yang |first=R |authorlink= |coauthors=Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P |year=[[1999]]|month=Mar. |title=Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins |journal=Mol. Cell. Biol. |volume=19 |issue=3 |pages=2400–7 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10022926 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[CDC20]],<ref name=pmid10679238>{{cite journal | quotes = yes |last=Ohtoshi |first=A |authorlink= |coauthors=Maeda T, Higashi H, Ashizawa S, Hatakeyama M |year=[[2000]]|month=Feb. |title=Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue=2 |pages=530–4 |publisher= |location = UNITED STATES| issn = 0006-291X| pmid = 10679238 |doi = 10.1006/bbrc.2000.2167 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Retinoblastoma protein]],<ref name=pmid10022926/> [[Cyclin-dependent kinase 2]],<ref name=pmid8565853>{{cite journal | quotes = yes |last=Sweeney |first=C |authorlink= |coauthors=Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M |year=[[1996]]|month=Jan. |title=A distinct cyclin A is expressed in germ cells in the mouse |journal=Development |volume=122 |issue=1 |pages=53–64 |publisher= |location = ENGLAND| issn = 0950-1991| pmid = 8565853 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9041194>{{cite journal | quotes = yes |last=Yang |first=R |authorlink= |coauthors=Morosetti R, Koeffler H P |year=[[1997]]|month=Mar. |title=Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines |journal=Cancer Res. |volume=57 |issue=5 |pages=913–20 |publisher= |location = UNITED STATES| issn = 0008-5472| pmid = 9041194 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11264176>{{cite journal | quotes = yes |last=Müller-Tidow |first=C |authorlink= |coauthors=Wang W, Idos G E, Diederichs S, Yang R, Readhead C, Berdel W E, Serve H, Saville M, Watson R, Koeffler H P |year=[[2001]]|month=Apr. |title=Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function |journal=Blood |volume=97 |issue=7 |pages=2091–7 |publisher= |location = United States| issn = 0006-4971| pmid = 11264176| pmid = 11264149 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10559988>{{cite journal | quotes = yes |last=Brown |first=N R |authorlink= |coauthors=Noble M E, Endicott J A, Johnson L N |year=[[1999]]|month=Nov. |title=The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases |journal=Nat. Cell Biol. |volume=1 |issue=7 |pages=438–43 |publisher= |location = England| issn = 1465-7392| pmid = 10559988 |doi = 10.1038/15674 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[GPS2 (gene)|GPS2]],<ref name=pmid15159402>{{cite journal | quotes = yes |last=Diederichs |first=Sven |authorlink= |coauthors=Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten |year=[[2004]]|month=Aug. |title=Identification of interaction partners and substrates of the cyclin A1-CDK2 complex |journal=J. Biol. Chem. |volume=279 |issue=32 |pages=33727–41 |publisher= |location = United States| issn = 0021-9258| pmid = 15159402 |doi = 10.1074/jbc.M401708200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MYBL2]]<ref name=pmid11264176/> and [[GNB2L1]].<ref name=pmid15159402/>


==References==
== Interactions ==
{{reflist}}


Cyclin-A1 [[Protein-protein interaction|interacts]] with:
⚫
==Further reading==
{{div col|colwidth=20em}}
⚫
{{refbegin | 2}}
* [[CDC20]],<ref name = pmid10679238>{{cite journal | vauthors = Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Hatakeyama M | title = Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex | journal = Biochem. Biophys. Res. Commun. | volume = 268 | issue = 2 | pages = 530–534 | date = February 2000 | pmid = 10679238 | doi = 10.1006/bbrc.2000.2167 }}</ref>
{{PBB_Further_reading
* [[Cyclin-dependent kinase 2]],<ref name = pmid9041194 /><ref name = pmid8565853>{{cite journal | vauthors = Sweeney C, Murphy M, Kubelka M, Ravnik SE, Hawkins CF, Wolgemuth DJ, Carrington M | title = A distinct cyclin A is expressed in germ cells in the mouse | journal = Development | volume = 122 | issue = 1 | pages = 53–64 | date = January 1996 | doi = 10.1242/dev.122.1.53 | pmid = 8565853 }}</ref><ref name = pmid11264176>{{cite journal | vauthors = Müller-Tidow C, Wang W, Idos GE, Diederichs S, Yang R, Readhead C, Berdel WE, Serve H, Saville M, Watson R, Koeffler HP | title = Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function | journal = Blood | volume = 97 | issue = 7 | pages = 2091–2097 | date = April 2001 | pmid = 11264176 | doi = 10.1182/blood.v97.7.2091| doi-access = free }}</ref><ref name = pmid10559988>{{cite journal | vauthors = Brown NR, Noble ME, Endicott JA, Johnson LN | title = The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases | journal = Nat. Cell Biol. | volume = 1 | issue = 7 | pages = 438–443 | date = November 1999 | pmid = 10559988 | doi = 10.1038/15674 | s2cid = 17988582 }}</ref>
| citations =
*{{cite journal | author=Hall M, Bates S, Peters G |title=Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. |journal=Oncogene |volume=11 |issue= 8 |pages= 1581–8 |year= 1995 |pmid= 7478582 |doi= }}
* [[E2F1]],<ref name = pmid10022926>{{cite journal | vauthors = Yang R, Müller C, Huynh V, Fung YK, Yee AS, Koeffler HP | title = Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 2400–2407 | date = March 1999 | pmid = 10022926 | pmc = 84032 | doi = 10.1128/mcb.19.3.2400}}</ref>
* [[GNB2L1]],<ref name = pmid15159402/>
⚫
*{{cite journal | author=Xu M, Sheppard KA, Peng CY, ''et al.'' |title=Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. |journal=Mol. Cell. Biol. |volume=14 |issue= 12 |pages= 8420–31 |year= 1994 |pmid= 7969176 |doi= }}
* [[GPS2 (gene)|GPS2]],<ref name = pmid15159402>{{cite journal | vauthors = Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C | title = Identification of interaction partners and substrates of the cyclin A1-CDK2 complex | journal = J. Biol. Chem. | volume = 279 | issue = 32 | pages = 33727–33741 | date = August 2004 | pmid = 15159402 | doi = 10.1074/jbc.M401708200 | doi-access = free }}</ref>
⚫
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi= }}
* [[MYBL2]],<ref name = pmid11264176/> and
⚫
*{{cite journal | author=O'Connor PM, Ferris DK, Pagano M, ''et al.'' |title=G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. |journal=J. Biol. Chem. |volume=268 |issue= 11 |pages= 8298–308 |year= 1993 |pmid= 8463339 |doi= }}
* [[Retinoblastoma protein]].<ref name = pmid10022926/>
⚫
*{{cite journal | author=Sweeney C, Murphy M, Kubelka M, ''et al.'' |title=A distinct cyclin A is expressed in germ cells in the mouse. |journal=Development |volume=122 |issue= 1 |pages= 53–64 |year= 1996 |pmid= 8565853 |doi= }}
{{Div col end}}
⚫
*{{cite journal | author=Wang H, Shao N, Ding QM, ''et al.'' |title=BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. |journal=Oncogene |volume=15 |issue= 2 |pages= 143–57 |year= 1997 |pmid= 9244350 |doi= 10.1038/sj.onc.1201252 }}
⚫
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi= }}
⚫
*{{cite journal | author=Liu D, Matzuk MM, Sung WK, ''et al.'' |title=Cyclin A1 is required for meiosis in the male mouse. |journal=Nat. Genet. |volume=20 |issue= 4 |pages= 377–80 |year= 1998 |pmid= 9843212 |doi= 10.1038/3855 }}
⚫
*{{cite journal | author=Yang R, Müller C, Huynh V, ''et al.'' |title=Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2400–7 |year= 1999 |pmid= 10022926 |doi= }}
⚫
*{{cite journal | author=Ravnik SE, Wolgemuth DJ |title=Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage. |journal=Dev. Biol. |volume=207 |issue= 2 |pages= 408–18 |year= 1999 |pmid= 10068472 |doi= 10.1006/dbio.1998.9156 }}
⚫
*{{cite journal | author=Yang R, Nakamaki T, Lübbert M, ''et al.'' |title=Cyclin A1 expression in leukemia and normal hematopoietic cells. |journal=Blood |volume=93 |issue= 6 |pages= 2067–74 |year= 1999 |pmid= 10068680 |doi= }}
⚫
*{{cite journal | author=Müller C, Yang R, Beck-von-Peccoz L, ''et al.'' |title=Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11220–8 |year= 1999 |pmid= 10196209 |doi= }}
⚫
*{{cite journal | author=Ruffner H, Jiang W, Craig AG, ''et al.'' |title=BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 4843–54 |year= 1999 |pmid= 10373534 |doi= }}
⚫
*{{cite journal | author=Brown NR, Noble ME, Endicott JA, Johnson LN |title=The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. |journal=Nat. Cell Biol. |volume=1 |issue= 7 |pages= 438–43 |year= 2001 |pmid= 10559988 |doi= 10.1038/15674 }}
⚫
*{{cite journal | author=Liu D, Liao C, Wolgemuth DJ |title=A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice. |journal=Dev. Biol. |volume=224 |issue= 2 |pages= 388–400 |year= 2000 |pmid= 10926775 |doi= 10.1006/dbio.2000.9776 }}
⚫
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi= }}
⚫
*{{cite journal | author=Müller-Tidow C, Bornemann C, Diederichs S, ''et al.'' |title=Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodology. |journal=FEBS Lett. |volume=490 |issue= 1-2 |pages= 75–8 |year= 2001 |pmid= 11172814 |doi= }}
⚫
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
⚫
*{{cite journal | author=Müller-Tidow C, Wang W, Idos GE, ''et al.'' |title=Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. |journal=Blood |volume=97 |issue= 7 |pages= 2091–7 |year= 2001 |pmid= 11264176 |doi= }}
}}
{{refend}}


== References ==
{{gene-13-stub}}
{{Reflist}}


⚫
== Further reading ==
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
⚫
{{Refbegin| 2}}
{{PBB_Controls
* {{cite journal | vauthors = Hall M, Bates S, Peters G | title = Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins | journal = Oncogene | volume = 11 | issue = 8 | pages = 1581–1588 | year = 1995 | pmid = 7478582 }}
| update_page = yes
⚫
* {{cite journal | vauthors = Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H | title = Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation | journal = Mol. Cell. Biol. | volume = 14 | issue = 12 | pages = 8420–8431 | year = 1994 | pmid = 7969176 | pmc = 359381 | doi = 10.1128/MCB.14.12.8420}}
| require_manual_inspection = no
⚫
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| update_protein_box = yes
⚫
* {{cite journal | vauthors = O'Connor PM, Ferris DK, Pagano M, Draetta G, Pines J, Hunter T, Longo DL, Kohn KW | title = G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently | journal = J. Biol. Chem. | volume = 268 | issue = 11 | pages = 8298–8308 | year = 1993 | doi = 10.1016/S0021-9258(18)53096-9 | pmid = 8463339 | doi-access = free }}
| update_summary = yes
⚫
* {{cite journal | vauthors = Sweeney C, Murphy M, Kubelka M, Ravnik SE, Hawkins CF, Wolgemuth DJ, Carrington M | title = A distinct cyclin A is expressed in germ cells in the mouse | journal = Development | volume = 122 | issue = 1 | pages = 53–64 | year = 1996 | doi = 10.1242/dev.122.1.53 | pmid = 8565853 }}
| update_citations = yes
⚫
* {{cite journal | vauthors = Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN | title = BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases | journal = Oncogene | volume = 15 | issue = 2 | pages = 143–157 | year = 1997 | pmid = 9244350 | doi = 10.1038/sj.onc.1201252 | s2cid = 11930784 | doi-access = }}
}}
⚫
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
⚫
* {{cite journal | vauthors = Liu D, Matzuk MM, Sung WK, Guo Q, Wang P, Wolgemuth DJ | title = Cyclin A1 is required for meiosis in the male mouse | journal = Nat. Genet. | volume = 20 | issue = 4 | pages = 377–380 | year = 1998 | pmid = 9843212 | doi = 10.1038/3855 | s2cid = 23356816 }}
⚫
* {{cite journal | vauthors = Yang R, Müller C, Huynh V, Fung YK, Yee AS, Koeffler HP | title = Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 2400–2407 | year = 1999 | pmid = 10022926 | pmc = 84032 | doi = 10.1128/mcb.19.3.2400}}
⚫
* {{cite journal | vauthors = Ravnik SE, Wolgemuth DJ | title = Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage | journal = Dev. Biol. | volume = 207 | issue = 2 | pages = 408–418 | year = 1999 | pmid = 10068472 | doi = 10.1006/dbio.1998.9156 | doi-access = free }}
⚫
* {{cite journal | vauthors = Yang R, Nakamaki T, Lübbert M, Said J, Sakashita A, Freyaldenhoven BS, Spira S, Huynh V, Müller C, Koeffler HP | title = Cyclin A1 expression in leukemia and normal hematopoietic cells | journal = Blood | volume = 93 | issue = 6 | pages = 2067–2074 | year = 1999 | pmid = 10068680 }}
⚫
* {{cite journal | vauthors = Müller C, Yang R, Beck-von-Peccoz L, Idos G, Verbeek W, Koeffler HP | title = Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 11220–11228 | year = 1999 | pmid = 10196209 | doi = 10.1074/jbc.274.16.11220 | doi-access = free }}
⚫
* {{cite journal | vauthors = Ruffner H, Jiang W, Craig AG, Hunter T, Verma IM | title = BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site | journal = Mol. Cell. Biol. | volume = 19 | issue = 7 | pages = 4843–4854 | year = 1999 | pmid = 10373534 | pmc = 84283 | doi = 10.1128/MCB.19.7.4843}}
⚫
* {{cite journal | vauthors = Brown NR, Noble ME, Endicott JA, Johnson LN | title = The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases | journal = Nat. Cell Biol. | volume = 1 | issue = 7 | pages = 438–443 | year = 1999 | pmid = 10559988 | doi = 10.1038/15674 | s2cid = 17988582 }}
⚫
* {{cite journal | vauthors = Liu D, Liao C, Wolgemuth DJ | title = A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice | journal = Dev. Biol. | volume = 224 | issue = 2 | pages = 388–400 | year = 2000 | pmid = 10926775 | doi = 10.1006/dbio.2000.9776 | doi-access = free }}
⚫
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–1795 | year = 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
⚫
* {{cite journal | vauthors = Müller-Tidow C, Bornemann C, Diederichs S, Westermann A, Klümpen S, Zuo P, Wang W, Berdel WE, Serve H | title = Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodology | journal = FEBS Lett. | volume = 490 | issue = 1–2 | pages = 75–78 | year = 2001 | pmid = 11172814 | doi = 10.1016/S0014-5793(01)02128-7 | doi-access = free }}
⚫
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Rep. | volume = 1 | issue = 3 | pages = 287–292 | year = 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
⚫
* {{cite journal | vauthors = Müller-Tidow C, Wang W, Idos GE, Diederichs S, Yang R, Readhead C, Berdel WE, Serve H, Saville M, Watson R, Koeffler HP | title = Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function | journal = Blood | volume = 97 | issue = 7 | pages = 2091–2097 | year = 2001 | pmid = 11264176 | doi = 10.1182/blood.V97.7.2091 | doi-access = free }}
{{Refend}}

{{Cell cycle proteins}}

[[Category:Cell cycle regulators]]

Latest revision as of 20:58, 22 December 2023

CCNA1
Identifiers
AliasesCCNA1, CT146, Cyclin A1
External IDsOMIM: 604036; MGI: 108042; HomoloGene: 31203; GeneCards: CCNA1; OMA:CCNA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

8900

12427

Ensembl

ENSG00000133101

ENSMUSG00000027793

UniProt

P78396

Q61456

RefSeq (mRNA)

NM_001111045
NM_001111046
NM_001111047
NM_003914

NM_007628
NM_001305221

RefSeq (protein)

NP_001104515
NP_001104516
NP_001104517
NP_003905

NP_001292150
NP_031654

Location (UCSC)Chr 13: 36.43 – 36.44 MbChr 3: 54.95 – 54.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene.[5]

Function

[edit]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis. This cyclin binds both Cdk1 and Cdk2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F1, and the Kip/Cip family of CDK-inhibitor proteins.[6]

Interactions

[edit]

Cyclin-A1 interacts with:

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133101 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027793 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Yang R, Morosetti R, Koeffler HP (March 1997). "Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines". Cancer Res. 57 (5): 913–920. PMID 9041194.
  6. ^ "Entrez Gene: CCNA1 cyclin A1".
  7. ^ Ohtoshi A, Maeda T, Higashi H, Ashizawa S, Hatakeyama M (February 2000). "Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex". Biochem. Biophys. Res. Commun. 268 (2): 530–534. doi:10.1006/bbrc.2000.2167. PMID 10679238.
  8. ^ Sweeney C, Murphy M, Kubelka M, Ravnik SE, Hawkins CF, Wolgemuth DJ, Carrington M (January 1996). "A distinct cyclin A is expressed in germ cells in the mouse". Development. 122 (1): 53–64. doi:10.1242/dev.122.1.53. PMID 8565853.
  9. ^ a b Müller-Tidow C, Wang W, Idos GE, Diederichs S, Yang R, Readhead C, Berdel WE, Serve H, Saville M, Watson R, Koeffler HP (April 2001). "Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function". Blood. 97 (7): 2091–2097. doi:10.1182/blood.v97.7.2091. PMID 11264176.
  10. ^ Brown NR, Noble ME, Endicott JA, Johnson LN (November 1999). "The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases". Nat. Cell Biol. 1 (7): 438–443. doi:10.1038/15674. PMID 10559988. S2CID 17988582.
  11. ^ a b Yang R, Müller C, Huynh V, Fung YK, Yee AS, Koeffler HP (March 1999). "Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins". Mol. Cell. Biol. 19 (3): 2400–2407. doi:10.1128/mcb.19.3.2400. PMC 84032. PMID 10022926.
  12. ^ a b Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C (August 2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". J. Biol. Chem. 279 (32): 33727–33741. doi:10.1074/jbc.M401708200. PMID 15159402.

Further reading

[edit]
Retrieved from "https://en.wikipedia.org/w/index.php?title=Cyclin_A1&oldid=1191323645"