Famprofazone: Difference between revisions
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{{Short description|NSAID analgesic medication}} |
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{{Drugbox |
{{Drugbox |
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| IUPAC_name = 1-methyl-5-{[methyl(1-phenylpropan-2-yl)amino]methyl}-2-phenyl-4-(propan-2-yl)-1,2-dihydro-3''H''-pyrazol-3-one |
| IUPAC_name = 1-methyl-5-{[methyl(1-phenylpropan-2-yl)amino]methyl}-2-phenyl-4-(propan-2-yl)-1,2-dihydro-3''H''-pyrazol-3-one |
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| metabolism = |
| metabolism = |
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| elimination_half-life = |
| elimination_half-life = |
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| excretion = |
| excretion = |
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<!--Identifiers--> |
<!--Identifiers--> |
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| UNII_Ref = {{fdacite|correct|FDA}} |
| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = HN0NCX453C |
| UNII = HN0NCX453C |
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| ChEMBL = 1475693 |
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<!--Chemical data--> |
<!--Chemical data--> |
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| C=24 | H=31 | N= |
| C=24 | H=31 | N=3 | O=1 |
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| molecular_weight = 377.52 g/mol |
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| smiles = O=C2\C(=C(/N(N2c1ccccc1)C)CN(C(C)Cc3ccccc3)C)C(C)C |
| smiles = O=C2\C(=C(/N(N2c1ccccc1)C)CN(C(C)Cc3ccccc3)C)C(C)C |
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'''Famprofazone''' ('''Gewodin''', '''Gewolen''') is a [[ |
'''Famprofazone''' ('''Gewodin''', '''Gewolen''') is a [[nonsteroidal anti-inflammatory agent]] (NSAID) of the [[pyrazolone]] series which is available [[over-the-counter]] in some countries such as [[Taiwan]].<ref name="isbn3-88763-075-0">{{cite book | author = Swiss Pharmaceutical Society | title = Index Nominum 2000: International Drug Directory (Book with CD-ROM) | publisher = Medpharm Scientific Publishers | location = Boca Raton | year = 2000 | pages = 1932 | isbn = 3-88763-075-0 | url = https://books.google.com/books?id=5GpcTQD_L2oC&q=famprofazone&pg=PA426}}</ref><ref name="isbn0-7514-0499-3">{{cite book | vauthors = Hall JA, Morton I | title = Concise dictionary of pharmacological agents: properties and synonyms | publisher = Kluwer Academic | year = 1999 | pages = 342 | isbn = 0-7514-0499-3 | url = https://books.google.com/books?id=mqaOMOtk61IC&q=famprofazone&pg=PA118}}</ref><ref name="pmid20663288">{{cite journal | vauthors = Chan KH, Hsu MC, Tseng CY, Chu WL | title = Famprofazone use can be misinterpreted as methamphetamine abuse | journal = Journal of Analytical Toxicology | volume = 34 | issue = 6 | pages = 347–353 | year = 2010 | pmid = 20663288 | doi = 10.1093/jat/34.6.347 | doi-access = }}</ref> It has [[analgesic]], [[anti-inflammatory]], and [[antipyretic]] effects.<ref name="isbn3-88763-075-0"/><ref name="isbn0-7514-0499-3"/> Famprofazone has been known to produce [[methamphetamine]] as an [[activity (chemistry)|active]] [[metabolite]], with 15–20% of an oral dose being converted to it.<ref name="pmid1496827">{{cite journal | vauthors = Oh ES, Hong SK, Kang GI | title = Plasma and urinary concentrations of methamphetamine after oral administration of famprofazone to man | journal = Xenobiotica; the Fate of Foreign Compounds in Biological Systems | volume = 22 | issue = 3 | pages = 377–384 | date = March 1992 | pmid = 1496827 | doi = 10.3109/00498259209046649 }}</ref><ref name="pmid9491970">{{cite journal | vauthors = Shin HS, Park BB, Choi SN, Oh JJ, Hong CP, Ryu H | title = Identification of new urinary metabolites of famprofazone in humans | journal = Journal of Analytical Toxicology | volume = 22 | issue = 1 | pages = 55–60 | year = 1998 | pmid = 9491970 | doi = 10.1093/jat/22.1.55 | doi-access = free }}</ref> As a result, famprofazone has occasionally been implicated in causing positives on [[drug test]]s for [[substituted amphetamine|amphetamine]]s.<ref name="pmid20663288"/> |
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== See also == |
== See also == |
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* [[Difenamizole]] |
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* [[Morazone]] |
* [[Morazone]] |
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== References == |
== References == |
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{{ |
{{reflist|30em}} |
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{{NSAIDs}} |
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{{Anti-inflammatory products}} |
{{Anti-inflammatory products}} |
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{{Analgesics}} |
{{Analgesics}} |
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{{Monoamine releasing agents}} |
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{{Adrenergics}} |
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{{Xenobiotic-sensing receptor modulators}} |
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{{Dopaminergics}} |
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{{Phenethylamines}} |
{{Phenethylamines}} |
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[[Category:Amines]] |
[[Category:Amines]] |
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[[Category: |
[[Category:Nonsteroidal anti-inflammatory drugs]] |
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[[Category:Pyrazolones]] |
[[Category:Pyrazolones]] |
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[[Category:Stimulants]] |
[[Category:Stimulants]] |
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[[Category:Norepinephrine-dopamine releasing agents]] |
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[[Category:Isopropyl compounds]] |
Latest revision as of 08:34, 23 December 2023
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Clinical data | |
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Routes of administration | Oral |
ATC code |
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Legal status | |
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Identifiers | |
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CAS Number | |
PubChem CID | |
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UNII | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.041.153 |
Chemical and physical data | |
Formula | C24H31N3O |
Molar mass | 377.532 g·mol−1 |
3D model (JSmol) | |
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Famprofazone (Gewodin, Gewolen) is a nonsteroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan.[1][2][3] It has analgesic, anti-inflammatory, and antipyretic effects.[1][2] Famprofazone has been known to produce methamphetamine as an active metabolite, with 15–20% of an oral dose being converted to it.[4][5] As a result, famprofazone has occasionally been implicated in causing positives on drug tests for amphetamines.[3]
See also
[edit]References
[edit]- ^ a b Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932. ISBN 3-88763-075-0.
- ^ a b Hall JA, Morton I (1999). Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. p. 342. ISBN 0-7514-0499-3.
- ^ a b Chan KH, Hsu MC, Tseng CY, Chu WL (2010). "Famprofazone use can be misinterpreted as methamphetamine abuse". Journal of Analytical Toxicology. 34 (6): 347–353. doi:10.1093/jat/34.6.347. PMID 20663288.
- ^ Oh ES, Hong SK, Kang GI (March 1992). "Plasma and urinary concentrations of methamphetamine after oral administration of famprofazone to man". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 22 (3): 377–384. doi:10.3109/00498259209046649. PMID 1496827.
- ^ Shin HS, Park BB, Choi SN, Oh JJ, Hong CP, Ryu H (1998). "Identification of new urinary metabolites of famprofazone in humans". Journal of Analytical Toxicology. 22 (1): 55–60. doi:10.1093/jat/22.1.55. PMID 9491970.