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{{short description|British geneticist}}
{{EngvarB|date=January 2018}}
{{EngvarB|date=January 2018}}
{{Use dmy dates|date=January 2018}}
{{Use dmy dates|date=January 2018}}
{{Infobox scientist
{{Infobox scientist
| name = Ele Zeggini
| name = Ele Zeggini
| birth_name = Ελευθερία Ζεγγίνη<ref>{{cite web|archiveurl=https://web.archive.org/web/20140728090342/http://www.tanea.gr/news/greece/article/5075493/h-genetistria-poy-ekane-diashma-ta-anwgeia/|archivedate=28 July 2014|url=http://www.tanea.gr/news/greece/article/5075493/h-genetistria-poy-ekane-diashma-ta-anwgeia/|title=Ελευθερία Ζεγγίνη: Η γενετίστρια που έκανε διάσημα τα Ανώγεια|publisher=tanea.gr}}</ref>
| birth_name = {{lang-el|Ελευθερία Ζεγγίνη}}<ref name=tanea>{{cite web |archiveurl=https://web.archive.org/web/20140728090342/http://www.tanea.gr/news/greece/article/5075493/h-genetistria-poy-ekane-diashma-ta-anwgeia/ |archivedate=28 July 2014 |lang=el |url=http://www.tanea.gr/news/greece/article/5075493/h-genetistria-poy-ekane-diashma-ta-anwgeia/ |title=Ελευθερία Ζεγγίνη: Η γενετίστρια που έκανε διάσημα τα Ανώγεια |trans-title=Eleftheria Zengini: The geneticist who made Anogeia famous |date=17 January 2014 |website=tanea.gr |publisher=[[Ta Nea]] |location=Athens |first=Δεβετζόγλου |last=Γιάννης}}</ref><br>{{lang-en|Eleftheria Zeggini}}
| image =
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| birth_date = <!--{{Birth date and age|df=y|YYYY|DD|MM}}-->
| birth_date = <!--{{Birth date and age|df=y|YYYY|DD|MM}}-->
| birth_place =
| birth_place = [[Volos]], [[Greece]]<ref name=tanea/>
| other_names =
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| citizenship =
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| fields = genetic epidemiology
| fields = [[Digital health]]<br>[[Human genetics]]<ref name=gs>{{Google scholar id}}</ref>
| workplaces = {{Plainlist|
| workplaces = {{Plainlist|
* [[Helmholtz Zentrum München]]
* [[Helmholtz Zentrum München]]
* [[Technical University of Munich]]
* [[Wellcome Trust Sanger Institute]]
* [[Wellcome Trust Sanger Institute]]
* [[University of Oxford]]
* [[University of Oxford]]
* [[University of Leicester]]
* [[University of Leicester]]
* [[Wellcome Trust Centre for Human Genetics]]<ref>{{cite web|archiveurl=https://web.archive.org/web/20091118145448/http://www.well.ox.ac.uk/zeggini/|archivedate=18 November 2009|url=http://www.well.ox.ac.uk/zeggini/|publisher=University of Oxford|location=Oxford|title=Wellcome Trust Centre for Human Genetics – Eleftheria Zeggini}}</ref>}}
* [[Wellcome Trust Centre for Human Genetics]]<ref>{{cite web|archiveurl=https://web.archive.org/web/20091118145448/http://www.well.ox.ac.uk/zeggini/|archivedate=18 November 2009|url=http://www.well.ox.ac.uk/zeggini/|publisher=University of Oxford|location=Oxford|title=Wellcome Trust Centre for Human Genetics – Eleftheria Zeggini|website=ox.ac.uk}}</ref>}}
| patrons =
| patrons =
| alma_mater = {{Plainlist|
| alma_mater = {{Plainlist|
* [[University of Manchester Institute of Science and Technology]] (BSc)
* [[UMIST]] (BSc)
* [[University of Manchester]] (PhD)}}
* [[University of Manchester]] (PhD)}}
| thesis_title = Genetic dissection of the major histocompatibility complex in juvenile oligoarthritis
| thesis_title = Genetic dissection of the major histocompatibility complex in juvenile oligoarthritis
| thesis_url = https://www.worldcat.org/oclc/642917758
| thesis_url = http://man-fe.hosted.exlibrisgroup.com/primo_library/libweb/action/display.do?vid=MU_VU1&doc=44MAN_ALMA_DS21145929160001631
| thesis_year = 2002
| thesis_year = 2002
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| influences =
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| awards =
| awards =[[Suffrage Science award]] (2014)
| website = {{URL|https://www.helmholtz-muenchen.de/itg/index.html}}
| website = {{Official URL}}
| spouse =
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}}
}}
'''Eleftheria Zeggini''' is the Director of the Institute of Translational Genomics in Helmhotz Zentrum Munchen in Neuherberg, Germany.<ref>{{cite web |title=Star geneticist Eleftheria Zeggini leaves Cambridge to join Helmholtz Munich |url=https://www.helmholtz-muenchen.de/en/aktuelles/latest-news/press-information-news/article/45066/index.html |accessdate=28 April 2019}}</ref>
'''Eleftheria Zeggini''' ({{lang-el|Ελευθερία Ζεγγίνη}}) is a director of the institute of [[genomics|translational genomics]] in [[Helmholtz Zentrum München]] and a professor at the [[Technical University of Munich]] (TUM).<ref name=epmc>{{EuropePMC}}</ref><Ref name=gs/><ref>{{cite web |title=Star geneticist Eleftheria Zeggini leaves Cambridge to join Helmholtz Munich |url=https://www.helmholtz-muenchen.de/en/aktuelles/latest-news/press-information-news/article/45066/index.html |website=helmholtz-muenchen.de|accessdate=28 April 2019}}</ref>
⚫
Previously she served as a research group leader at the [[Wellcome Trust Sanger Institute]] from 2008 to 2018<ref name=orcid>Eleftheria Zeggini's {{ORCID|0000-0003-4238-659X}}</ref><ref>{{cite web|url=https://www.ebi.ac.uk/about/news/press-releases/best-practice-awards-2017 |title=Driving gender equality in science &#124; |publisher=[[European Bioinformatics Institute]] |date= 7 March 2017|accessdate=2020-01-14}}</ref> and an [[Honorary title (academic)|honorary professor]] in the department of [[health sciences]] at the [[University of Leicester]] in the UK.<ref>{{cite web|archiveurl=https://web.archive.org/web/20151101151833/http://www2.le.ac.uk/departments/health-sciences/research/gen-epi/people|publisher=University of Leicester|archivedate=1 November 2015|url=http://www2.le.ac.uk/departments/health-sciences/research/gen-epi/people|title=People in the Department of Health Sciences}}</ref><ref name=twitter>{{twitter}}</ref><ref name=scopus/><ref name=sangerbio>{{cite web|archiveurl=https://web.archive.org/web/20151111122324/http://www.sanger.ac.uk/people/directory/zeggini-eleftheria|archivedate=11 November 2015|url=http://www.sanger.ac.uk/people/directory/zeggini-eleftheria|title=Professor Eleftheria Zeggini, Group Leader|publisher=[[Wellcome Trust Sanger Institute]]|location=Hinxton}}</ref>
Until her departure in 2018 she was a
⚫
research group leader at the [[Wellcome Trust Sanger Institute]] and an [[Honorary title (academic)|Honorary Professor]] in the Department of Health Sciences at the [[University of Leicester]] in the UK.<ref name=orcid>Eleftheria Zeggini's {{ORCID|0000-0003-4238-659X}}</ref><ref>{{cite web|archiveurl=https://web.archive.org/web/20151101151833/http://www2.le.ac.uk/departments/health-sciences/research/gen-epi/people|publisher=University of Leicester|archivedate=1 November 2015|url=http://www2.le.ac.uk/departments/health-sciences/research/gen-epi/people|title=People in the Department of Health Sciences}}</ref><ref name=twitter>{{twitter}}</ref><ref name=scopus/><ref name=sangerbio>{{cite web|archiveurl=https://web.archive.org/web/20151111122324/http://www.sanger.ac.uk/people/directory/zeggini-eleftheria|archivedate=11 November 2015|url=http://www.sanger.ac.uk/people/directory/zeggini-eleftheria|title=Professor Eleftheria Zeggini, Group Leader|publisher=[[Wellcome Trust Sanger Institute]]|location=Hinxton}}</ref>


==Education==
==Education==
Zeggini was educated at the [[University of Manchester Institute of Science and Technology]] (UMIST) where she was awarded a Bachelor of Science degree in [[Biochemistry]] in 1999. She continued her studies on the [[immunogenetics]] of the [[major histocompatibility complex]] in [[childhood arthritis]] at the [[Arthritis Research UK|Arthritis Research Campaign (ARC)]] Epidemiology Unit at the [[University of Manchester]], and was awarded a PhD in 2002.<ref name=zphd>{{cite thesis |degree=PhD |first=Eleftheria |last=Zeggini |title=Genetic dissection of the major histocompatibility complex in juvenile oligoarthritis |publisher=University of Manchester |year=2002 |url=http://man-fe.hosted.exlibrisgroup.com/primo_library/libweb/action/display.do?vid=MU_VU1&doc=44MAN_ALMA_DS21145929160001631 |archiveurl=https://www.webcitation.org/6dHCHu1tM?url=http://man-fe.hosted.exlibrisgroup.com/primo_library/libweb/action/display.do?vid%3DMU_VU1%26doc%3D44MAN_ALMA_DS21145929160001631 |archivedate=24 November 2015 |deadurl=yes |df= }}</ref><ref name="Zeggini2002">{{cite journal|last1=Zeggini|first1=E.|title=Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis|journal=Rheumatology|volume=41|issue=4|year=2002|pages=462–465|issn=1460-2172|doi=10.1093/rheumatology/41.4.462|pmid=11961180}}</ref>
Zeggini was educated at the [[University of Manchester Institute of Science and Technology]] (UMIST) where she was awarded a [[Bachelor of Science]] degree in [[Biochemistry]] in 1999. She continued her studies on the [[immunogenetics]] of the [[major histocompatibility complex]] in [[childhood arthritis]] at the [[Arthritis Research UK]] epidemiology unit at the [[University of Manchester]], and was awarded a [[PhD]] in 2002.<ref name=zphd>{{cite thesis |degree=PhD|oclc=642917758 |first=Eleftheria |last=Zeggini |title=Genetic dissection of the major histocompatibility complex in juvenile oligoarthritis |publisher=University of Manchester |year=2002 |url=https://www.librarysearch.manchester.ac.uk/permalink/44MAN_INST/bofker/alma992976702118301631|website=manchester.ac.uk |archiveurl=https://www.webcitation.org/6dHCHu1tM?url=http://man-fe.hosted.exlibrisgroup.com/primo_library/libweb/action/display.do?vid=MU_VU1&doc=44MAN_ALMA_DS21145929160001631 |archivedate=24 November 2015 |url-status=dead |accessdate=25 November 2015 }}</ref><ref name="Zeggini2002">{{cite journal|last1=Zeggini|first1=E.|title=Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis|journal=Rheumatology|volume=41|issue=4|year=2002|pages=462–465|issn=1460-2172|doi=10.1093/rheumatology/41.4.462|pmid=11961180|doi-access=free}}</ref>


==Career and research==
==Career and research==
Following her PhD, Zeggini was a [[postdoctoral researcher]] at the [[Wellcome Trust Centre for Human Genetics]] at the [[University of Oxford]] where she later became a [[Wellcome Trust]] Research Career Development Fellow. She has been a group leader at the Sanger since 2008.<ref name=orcid/> According to [[Scopus]]<ref name=scopus>{{Scopus|id=6602598642}}</ref> her most cited work has been published in ''[[Science (journal)|Science]]''<ref>{{Cite journal | doi = 10.1126/science.1141634| title = A Common Variant in the FTO Gene is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity| journal = Science| volume = 316| issue = 5826| pages = 889–94| year = 2007| last1 = Frayling | first1 = T. M.| last2 = Timpson | first2 = N. J.| last3 = Weedon | first3 = M. N.| last4 = Zeggini | first4 = E.| last5 = Freathy | first5 = R. M.| last6 = Lindgren | first6 = C. M.| last7 = Perry | first7 = J. R. B.| last8 = Elliott | first8 = K. S.| last9 = Lango | first9 = H.| last10 = Rayner | first10 = N. W.| last11 = Shields | first11 = B.| last12 = Harries | first12 = L. W.| last13 = Barrett | first13 = J. C.| last14 = Ellard | first14 = S.| last15 = Groves | first15 = C. J.| last16 = Knight | first16 = B.| last17 = Patch | first17 = A. -M. | last18 = Ness | first18 = A. R.| last19 = Ebrahim | first19 = S.| last20 = Lawlor | first20 = D. A.| last21 = Ring | first21 = S. M.| last22 = Ben-Shlomo | first22 = Y.| last23 = Jarvelin | first23 = M. -R. | last24 = Sovio | first24 = U.| last25 = Bennett | first25 = A. J.| last26 = Melzer | first26 = D.| last27 = Ferrucci | first27 = L.| last28 = Loos | first28 = R. J. F.| last29 = Barroso | first29 = I.| last30 = Wareham | first30 = N. J.| display-authors = 29 | pmid=17434869 | pmc=2646098| bibcode = 2007Sci...316..889F}}</ref><ref>{{Cite journal | last1 = Zeggini | first1 = E. | last2 = Weedon | first2 = M. N. | last3 = Lindgren | first3 = C. M. | last4 = Frayling | first4 = T. M. | last5 = Elliott | first5 = K. S. | last6 = Lango | first6 = H. | last7 = Timpson | first7 = N. J. | last8 = Perry | first8 = J. R. B. | last9 = Rayner | first9 = N. W. | last10 = Freathy | first10 = R. M. | last11 = Barrett | first11 = J. C. | last12 = Shields | first12 = B. | last13 = Morris | first13 = A. P. | last14 = Ellard | first14 = S. | last15 = Groves | first15 = C. J. | last16 = Harries | first16 = L. W. | last17 = Marchini | first17 = J. L. | last18 = Owen | first18 = K. R. | last19 = Knight | first19 = B. | last20 = Cardon | first20 = L. R. | last21 = Walker | first21 = M. | last22 = Hitman | first22 = G. A. | last23 = Morris | first23 = A. D. | last24 = Doney | first24 = A. S. F.| author25 = Wellcome Trust Case Control Consortium (WTCCC) | last26 = Burton | first26 = P. R. | last27 = McCarthy | first27 = D. G. | last28 = Hattersley | first28 = N. | last29 = Deloukas | first29 = P. | last30 = Duncanson | first30 = A. | last31 = Kwiatkowski | first31 = D. P. | title = Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes | journal = Science | volume = 316 | issue = 5829 | pages = 1336–1341 | year = 2007 | pmid = 17463249 | doi = 10.1126/science.1142364 | bibcode = 2007Sci...316.1336Z | pmc = 3772310 }}</ref> and ''[[Nature Genetics]]''.<ref name="ZegginiScott2008">{{cite journal|last1=Zeggini|first1=Eleftheria|last2=Scott|first2=Laura J|last3=Saxena|first3=Richa|last4=Voight|first4=Benjamin F|last5=Marchini|first5=Jonathan L|last6=Hu|first6=Tianle|last7=de Bakker|first7=Paul IW|last8=Abecasis|first8=Gonçalo R|last9=Almgren|first9=Peter|last10=Andersen|first10=Gitte|last11=Ardlie|first11=Kristin|last12=Boström|first12=Kristina Bengtsson|last13=Bergman|first13=Richard N|last14=Bonnycastle|first14=Lori L|last15=Borch-Johnsen|first15=Knut|last16=Burtt|first16=Noël P|last17=Chen|first17=Hong|last18=Chines|first18=Peter S|last19=Daly|first19=Mark J|last20=Deodhar|first20=Parimal|last21=Ding|first21=Chia-Jen|last22=Doney|first22=Alex S F|last23=Duren|first23=William L|last24=Elliott|first24=Katherine S|last25=Erdos|first25=Michael R|last26=Frayling|first26=Timothy M|last27=Freathy|first27=Rachel M|last28=Gianniny|first28=Lauren|last29=Grallert|first29=Harald|last30=Grarup|first30=Niels|last31=Groves|first31=Christopher J|last32=Guiducci|first32=Candace|last33=Hansen|first33=Torben|last34=Herder|first34=Christian|last35=Hitman|first35=Graham A|last36=Hughes|first36=Thomas E|last37=Isomaa|first37=Bo|last38=Jackson|first38=Anne U|last39=Jørgensen|first39=Torben|last40=Kong|first40=Augustine|last41=Kubalanza|first41=Kari|last42=Kuruvilla|first42=Finny G|last43=Kuusisto|first43=Johanna|last44=Langenberg|first44=Claudia|last45=Lango|first45=Hana|last46=Lauritzen|first46=Torsten|last47=Li|first47=Yun|last48=Lindgren|first48=Cecilia M|last49=Lyssenko|first49=Valeriya|last50=Marvelle|first50=Amanda 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M|last83=Weedon|first83=Michael N|last84=Willer|first84=Cristen J|last85=Illig|first85=Thomas|last86=Hveem|first86=Kristian|last87=Hu|first87=Frank B|last88=Laakso|first88=Markku|last89=Stefansson|first89=Kari|last90=Pedersen|first90=Oluf|last91=Wareham|first91=Nicholas J|last92=Barroso|first92=Inês|last93=Hattersley|first93=Andrew T|last94=Collins|first94=Francis S|last95=Groop|first95=Leif|last96=McCarthy|first96=Mark I|last97=Boehnke|first97=Michael|last98=Altshuler|first98=David|title=Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes|journal=Nature Genetics|volume=40|issue=5|year=2008|pages=638–645|issn=1061-4036|doi=10.1038/ng.120|pmid=18372903|pmc=2672416}}</ref><ref name="WillerSpeliotes2008">{{cite journal|last1=Willer|first1=Cristen J|last2=Speliotes|first2=Elizabeth K|last3=Loos|first3=Ruth J F|last4=Li|first4=Shengxu|last5=Lindgren|first5=Cecilia M|last6=Heid|first6=Iris 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S|last100=Vollenweider|first100=Peter|last101=Waeber|first101=Gerard|last102=Wallace|first102=Chris|last103=Watanabe|first103=Richard M|last104=Waterworth|first104=Dawn M|last105=Watkins|first105=Nicholas|last106=Witteman|first106=Jacqueline C M|last107=Zeggini|first107=Eleftheria|last108=Zhai|first108=Guangju|last109=Zillikens|first109=M Carola|last110=Altshuler|first110=David|last111=Caulfield|first111=Mark J|last112=Chanock|first112=Stephen J|last113=Farooqi|first113=I Sadaf|last114=Ferrucci|first114=Luigi|last115=Guralnik|first115=Jack M|last116=Hattersley|first116=Andrew T|last117=Hu|first117=Frank B|last118=Jarvelin|first118=Marjo-Riitta|last119=Laakso|first119=Markku|last120=Mooser|first120=Vincent|last121=Ong|first121=Ken K|last122=Ouwehand|first122=Willem H|last123=Salomaa|first123=Veikko|last124=Samani|first124=Nilesh J|last125=Spector|first125=Timothy D|last126=Tuomi|first126=Tiinamaija|last127=Tuomilehto|first127=Jaakko|last128=Uda|first128=Manuela|last129=Uitterlinden|first129=André G|last130=Wareham|first130=Nicholas J|last131=Deloukas|first131=Panagiotis|last132=Frayling|first132=Timothy M|last133=Groop|first133=Leif C|last134=Hayes|first134=Richard B|last135=Hunter|first135=David J|last136=Mohlke|first136=Karen L|last137=Peltonen|first137=Leena|last138=Schlessinger|first138=David|last139=Strachan|first139=David P|last140=Wichmann|first140=H-Erich|last141=McCarthy|first141=Mark I|last142=Boehnke|first142=Michael|last143=Barroso|first143=Inês|last144=Abecasis|first144=Gonçalo R|last145=Hirschhorn|first145=Joel N|title=Six new loci associated with body mass index highlight a neuronal influence on body weight regulation|journal=Nature Genetics|volume=41|issue=1|year=2008|pmid=19079261|pages=25–34|issn=1061-4036|doi=10.1038/ng.287|pmc=2695662|displayauthors=29}}</ref>
Following her PhD, Zeggini was a [[postdoctoral researcher]] at the [[Wellcome Trust Centre for Human Genetics]] at the [[University of Oxford]] where she later became a [[Wellcome Trust]] research career development [[fellow]].{{fact|date=November 2020}} She has been a group leader at the Sanger since 2008.<ref name=orcid/> {{As of|2020}}, according to [[Google scholar]]<ref name=gs/> and [[Scopus]]<ref name=scopus>{{Scopus id}}</ref> her most cited work has been published in ''[[Science (journal)|Science]]''<ref>{{Cite journal | doi = 10.1126/science.1141634| title = A Common Variant in the FTO Gene is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity| journal = Science| volume = 316| issue = 5826| pages = 889–94| year = 2007| last1 = Frayling | first1 = T. M.| last2 = Timpson | first2 = N. J.| last3 = Weedon | first3 = M. N.| last4 = Zeggini | first4 = E.| last5 = Freathy | first5 = R. M.| last6 = Lindgren | first6 = C. M.| last7 = Perry | first7 = J. R. B.| last8 = Elliott | first8 = K. S.| last9 = Lango | first9 = H.| last10 = Rayner | first10 = N. W.| last11 = Shields | first11 = B.| last12 = Harries | first12 = L. W.| last13 = Barrett | first13 = J. C.| last14 = Ellard | first14 = S.| last15 = Groves | first15 = C. J.| last16 = Knight | first16 = B.| last17 = Patch | first17 = A. -M. | last18 = Ness | first18 = A. R.| last19 = Ebrahim | first19 = S.| last20 = Lawlor | first20 = D. A.| last21 = Ring | first21 = S. M.| last22 = Ben-Shlomo | first22 = Y.| last23 = Jarvelin | first23 = M. -R. | last24 = Sovio | first24 = U.| last25 = Bennett | first25 = A. J.| last26 = Melzer | first26 = D.| last27 = Ferrucci | first27 = L.| last28 = Loos | first28 = R. J. F.| last29 = Barroso | first29 = I.| last30 = Wareham | first30 = N. J.| display-authors = 7 | pmid=17434869 | pmc=2646098| bibcode = 2007Sci...316..889F}}</ref><ref>{{Cite journal | last1 = Zeggini | first1 = E. | last2 = Weedon | first2 = M. N. | last3 = Lindgren | first3 = C. M. | last4 = Frayling | first4 = T. M. | last5 = Elliott | first5 = K. S. | last6 = Lango | first6 = H. | last7 = Timpson | first7 = N. J. | last8 = Perry | first8 = J. R. B. | last9 = Rayner | first9 = N. W. | last10 = Freathy | first10 = R. M. | last11 = Barrett | first11 = J. C. | last12 = Shields | first12 = B. | last13 = Morris | first13 = A. P. | last14 = Ellard | first14 = S. | last15 = Groves | first15 = C. J. | last16 = Harries | first16 = L. W. | last17 = Marchini | first17 = J. L. | last18 = Owen | first18 = K. R. | last19 = Knight | first19 = B. | last20 = Cardon | first20 = L. R. | last21 = Walker | first21 = M. | last22 = Hitman | first22 = G. A. | last23 = Morris | first23 = A. D. | last24 = Doney | first24 = A. S. F.| author25 = Wellcome Trust Case Control Consortium (WTCCC) | last26 = Burton | first26 = P. R. | last27 = McCarthy | first27 = D. G. | last28 = Hattersley | first28 = N. | last29 = Deloukas | first29 = P. | last30 = Duncanson | first30 = A. | last31 = Kwiatkowski | first31 = D. P. |display-authors=7| title = Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes | journal = Science | volume = 316 | issue = 5829 | pages = 1336–1341 | year = 2007 | pmid = 17463249 | doi = 10.1126/science.1142364 | bibcode = 2007Sci...316.1336Z | pmc = 3772310 }}</ref> and ''[[Nature Genetics]]''.<ref name="ZegginiScott2008">{{cite journal|last1=Zeggini|first1=Eleftheria|last2=Scott|first2=Laura J|last3=Saxena|first3=Richa|last4=Voight|first4=Benjamin F|last5=Marchini|first5=Jonathan L|last6=Hu|first6=Tianle|last7=de Bakker|first7=Paul IW|last8=Abecasis|first8=Gonçalo R|last9=Almgren|first9=Peter|last10=Andersen|first10=Gitte|last11=Ardlie|first11=Kristin|last12=Boström|first12=Kristina Bengtsson|last13=Bergman|first13=Richard N|last14=Bonnycastle|first14=Lori L|last15=Borch-Johnsen|first15=Knut|last16=Burtt|first16=Noël P|last17=Chen|first17=Hong|last18=Chines|first18=Peter S|last19=Daly|first19=Mark J|last20=Deodhar|first20=Parimal|last21=Ding|first21=Chia-Jen|last22=Doney|first22=Alex S F|last23=Duren|first23=William L|last24=Elliott|first24=Katherine S|last25=Erdos|first25=Michael R|last26=Frayling|first26=Timothy M|last27=Freathy|first27=Rachel M|last28=Gianniny|first28=Lauren|last29=Grallert|first29=Harald|last30=Grarup|first30=Niels|last31=Groves|first31=Christopher J|last32=Guiducci|first32=Candace|last33=Hansen|first33=Torben|last34=Herder|first34=Christian|last35=Hitman|first35=Graham A|last36=Hughes|first36=Thomas E|last37=Isomaa|first37=Bo|last38=Jackson|first38=Anne U|last39=Jørgensen|first39=Torben|last40=Kong|first40=Augustine|last41=Kubalanza|first41=Kari|last42=Kuruvilla|first42=Finny G|last43=Kuusisto|first43=Johanna|last44=Langenberg|first44=Claudia|last45=Lango|first45=Hana|last46=Lauritzen|first46=Torsten|last47=Li|first47=Yun|last48=Lindgren|first48=Cecilia M|last49=Lyssenko|first49=Valeriya|last50=Marvelle|first50=Amanda 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M|last83=Weedon|first83=Michael N|last84=Willer|first84=Cristen J|last85=Illig|first85=Thomas|last86=Hveem|first86=Kristian|last87=Hu|first87=Frank B|last88=Laakso|first88=Markku|last89=Stefansson|first89=Kari|last90=Pedersen|first90=Oluf|last91=Wareham|first91=Nicholas J|last92=Barroso|first92=Inês|last93=Hattersley|first93=Andrew T|last94=Collins|first94=Francis S|last95=Groop|first95=Leif|last96=McCarthy|first96=Mark I|last97=Boehnke|first97=Michael|last98=Altshuler|first98=David|display-authors=11|title=Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes|journal=Nature Genetics|volume=40|issue=5|year=2008|pages=638–645|issn=1061-4036|doi=10.1038/ng.120|pmid=18372903|pmc=2672416}}</ref><ref name="WillerSpeliotes2008">{{cite journal|last1=Willer|first1=Cristen J|last2=Speliotes|first2=Elizabeth K|last3=Loos|first3=Ruth J F|last4=Li|first4=Shengxu|last5=Lindgren|first5=Cecilia M|last6=Heid|first6=Iris 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S|last100=Vollenweider|first100=Peter|last101=Waeber|first101=Gerard|last102=Wallace|first102=Chris|last103=Watanabe|first103=Richard M|last104=Waterworth|first104=Dawn M|last105=Watkins|first105=Nicholas|last106=Witteman|first106=Jacqueline C M|last107=Zeggini|first107=Eleftheria|last108=Zhai|first108=Guangju|last109=Zillikens|first109=M Carola|last110=Altshuler|first110=David|last111=Caulfield|first111=Mark J|last112=Chanock|first112=Stephen J|last113=Farooqi|first113=I Sadaf|last114=Ferrucci|first114=Luigi|last115=Guralnik|first115=Jack M|last116=Hattersley|first116=Andrew T|last117=Hu|first117=Frank B|last118=Jarvelin|first118=Marjo-Riitta|last119=Laakso|first119=Markku|last120=Mooser|first120=Vincent|last121=Ong|first121=Ken K|last122=Ouwehand|first122=Willem H|last123=Salomaa|first123=Veikko|last124=Samani|first124=Nilesh J|last125=Spector|first125=Timothy D|last126=Tuomi|first126=Tiinamaija|last127=Tuomilehto|first127=Jaakko|last128=Uda|first128=Manuela|last129=Uitterlinden|first129=André G|last130=Wareham|first130=Nicholas J|last131=Deloukas|first131=Panagiotis|last132=Frayling|first132=Timothy M|last133=Groop|first133=Leif C|last134=Hayes|first134=Richard B|last135=Hunter|first135=David J|last136=Mohlke|first136=Karen L|last137=Peltonen|first137=Leena|last138=Schlessinger|first138=David|last139=Strachan|first139=David P|last140=Wichmann|first140=H-Erich|last141=McCarthy|first141=Mark I|last142=Boehnke|first142=Michael|last143=Barroso|first143=Inês|last144=Abecasis|first144=Gonçalo R|last145=Hirschhorn|first145=Joel N|title=Six new loci associated with body mass index highlight a neuronal influence on body weight regulation|journal=Nature Genetics|volume=41|issue=1|year=2008|pmid=19079261|pages=25–34|issn=1061-4036|doi=10.1038/ng.287|pmc=2695662|display-authors=11}}</ref>


{{As of|2015}} her work investigates the [[genetics]] of complex [[phenotypic trait]]s in humans using [[genetic association]] studies to identify [[Locus (genetics)|novel disease loci]].<ref name="Zeggini2011">{{cite journal|last1=Zeggini|first1=Eleftheria|title=Next-generation association studies for complex traits|journal=Nature Genetics|volume=43|issue=4|year=2011|pages=287–288|issn=1061-4036|doi=10.1038/ng0411-287|pmc=3435533|pmid=21445070}}</ref><ref name="CrawfordBabron2012">{{cite journal|last1=Crawford|first1=Dana C.|last2=Babron|first2=Marie-Claude|last3=de Tayrac|first3=Marie|last4=Rutledge|first4=Douglas N.|last5=Zeggini|first5=Eleftheria|last6=Génin|first6=Emmanuelle|title=Rare and Low Frequency Variant Stratification in the UK Population: Description and Impact on Association Tests|journal=PLoS ONE|volume=7|issue=10|year=2012|pages=e46519|issn=1932-6203|doi=10.1371/journal.pone.0046519|pmc=3465327|pmid=23071581|bibcode=2012PLoSO...746519B}} {{open access}}</ref> In a study published in 2017, her team reported the discovery of a genetic variant in Mediterranean Cretan villagers that protected them against the harmful effects of 'bad' fats and [[cholesterol]] as well as decrease the risk of [[Cardiovascular disease|cardiovascular disease.]]<ref>{{Cite news|url=https://uk.news.yahoo.com/cretans-don-t-heart-disease-143600061.html|title=Cretans don’t get heart disease despite high-fat diet due to good genes|access-date=2018-02-03|language=en-GB}}</ref>
{{As of|2015}} her work investigates the [[genetics]] of complex [[phenotypic trait]]s in humans using [[genetic association]] studies to identify [[Locus (genetics)|novel disease loci]].<ref name="Zeggini2011">{{cite journal|last1=Zeggini|first1=Eleftheria|title=Next-generation association studies for complex traits|journal=Nature Genetics|volume=43|issue=4|year=2011|pages=287–288|issn=1061-4036|doi=10.1038/ng0411-287|pmc=3435533|pmid=21445070}}</ref><ref name="CrawfordBabron2012">{{cite journal|last1=Crawford|first1=Dana C.|last2=Babron|first2=Marie-Claude|last3=de Tayrac|first3=Marie|last4=Rutledge|first4=Douglas N.|last5=Zeggini|first5=Eleftheria|last6=Génin|first6=Emmanuelle|title=Rare and Low Frequency Variant Stratification in the UK Population: Description and Impact on Association Tests|journal=PLOS ONE|volume=7|issue=10|year=2012|pages=e46519|issn=1932-6203|doi=10.1371/journal.pone.0046519|pmc=3465327|pmid=23071581|bibcode=2012PLoSO...746519B|doi-access=free}} {{open access}}</ref> In a study published in 2017, her team reported the discovery of a genetic variant in [[Mediterranean]] [[Crete|Cretan]] villagers that protected them against the harmful effects of 'bad' fats and [[cholesterol]] as well as decrease the risk of [[cardiovascular disease]].<ref>{{Cite news|url=https://uk.news.yahoo.com/cretans-don-t-heart-disease-143600061.html|title=Cretans don't get heart disease despite high-fat diet due to good genes|access-date=2018-02-03|language=en-GB|website=uk.news.yahoo.com|publisher=[[Yahoo!]]}}</ref>

===Awards and honours===
Zeggini won the [[Suffrage Science award]] in 2014.<ref name=suff>{{cite web | title=Sanger Institute researcher becomes Suffrage Science awardee | website=Wellcome Sanger Institute | date=2014-10-13 | url=https://www.sanger.ac.uk/news_item/2014-10-13-sanger-institute-researcher-becomes-suffrage-science-awardee/ | access-date=2020-11-22}}</ref>

==Personal life==
Zeggini was born and raised in [[Volos]], [[Greece]].<ref name=tanea/>


==References==
==References==
{{reflist|35em}}
{{reflist}}


{{Authority control}}
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[[Category:Living people]]
[[Category:Living people]]
[[Category:Year of birth missing (living people)]]
[[Category:Year of birth missing (living people)]]
[[Category:21st-century British biologists]]
[[Category:21st-century British biologists]]
[[Category:21st-century women scientists]]
[[Category:21st-century British women scientists]]
[[Category:British geneticists]]
[[Category:British geneticists]]
[[Category:British women biologists]]
[[Category:British women biologists]]

Latest revision as of 13:25, 13 January 2024

Ele Zeggini
Born
Greek: Ελευθερία Ζεγγίνη[3]
English: Eleftheria Zeggini

Volos, Greece[3]
Alma mater
AwardsSuffrage Science award (2014)
Scientific career
FieldsDigital health
Human genetics[1]
Institutions
ThesisGenetic dissection of the major histocompatibility complex in juvenile oligoarthritis (2002)
Websitewww.helmholtz-muenchen.de/itg/staff/staff-details/ma/8984/Professor-Zeggini/ Edit this at Wikidata

Eleftheria Zeggini (Greek: Ελευθερία Ζεγγίνη) is a director of the institute of translational genomics in Helmholtz Zentrum München and a professor at the Technical University of Munich (TUM).[4][1][5] Previously she served as a research group leader at the Wellcome Trust Sanger Institute from 2008 to 2018[6][7] and an honorary professor in the department of health sciences at the University of Leicester in the UK.[8][9][10][11]

Bildung

[edit]

Zeggini was educated at the University of Manchester Institute of Science and Technology (UMIST) where she was awarded a Bachelor of Science degree in Biochemistry in 1999. She continued her studies on the immunogenetics of the major histocompatibility complex in childhood arthritis at the Arthritis Research UK epidemiology unit at the University of Manchester, and was awarded a PhD in 2002.[12][13]

Career and research

[edit]

Following her PhD, Zeggini was a postdoctoral researcher at the Wellcome Trust Centre for Human Genetics at the University of Oxford where she later became a Wellcome Trust research career development fellow.[citation needed] She has been a group leader at the Sanger since 2008.[6] As of 2020, according to Google scholar[1] and Scopus[10] her most cited work has been published in Science[14][15] and Nature Genetics.[16][17]

As of 2015 her work investigates the genetics of complex phenotypic traits in humans using genetic association studies to identify novel disease loci.[18][19] In a study published in 2017, her team reported the discovery of a genetic variant in Mediterranean Cretan villagers that protected them against the harmful effects of 'bad' fats and cholesterol as well as decrease the risk of cardiovascular disease.[20]

Awards and honours

[edit]

Zeggini won the Suffrage Science award in 2014.[21]

Personal life

[edit]

Zeggini was born and raised in Volos, Greece.[3]

References

[edit]
  1. ^ a b c Eleftheria Zeggini publications indexed by Google Scholar Edit this at Wikidata
  2. ^ "Wellcome Trust Centre for Human Genetics – Eleftheria Zeggini". ox.ac.uk. Oxford: University of Oxford. Archived from the original on 18 November 2009.
  3. ^ a b c Γιάννης, Δεβετζόγλου (17 January 2014). "Ελευθερία Ζεγγίνη: Η γενετίστρια που έκανε διάσημα τα Ανώγεια" [Eleftheria Zengini: The geneticist who made Anogeia famous]. tanea.gr (in Greek). Athens: Ta Nea. Archived from the original on 28 July 2014.
  4. ^ Eleftheria Zeggini publications from Europe PubMed Central
  5. ^ "Star geneticist Eleftheria Zeggini leaves Cambridge to join Helmholtz Munich". helmholtz-muenchen.de. Retrieved 28 April 2019.
  6. ^ a b Eleftheria Zeggini's ORCID 0000-0003-4238-659X
  7. ^ "Driving gender equality in science |". European Bioinformatics Institute. 7 March 2017. Retrieved 14 January 2020.
  8. ^ "People in the Department of Health Sciences". University of Leicester. Archived from the original on 1 November 2015.
  9. ^ Eleftheria Zeggini on X Edit this at Wikidata
  10. ^ a b Eleftheria Zeggini publications indexed by the Scopus bibliographic database. (subscription required)
  11. ^ "Professor Eleftheria Zeggini, Group Leader". Hinxton: Wellcome Trust Sanger Institute. Archived from the original on 11 November 2015.
  12. ^ Zeggini, Eleftheria (2002). Genetic dissection of the major histocompatibility complex in juvenile oligoarthritis. manchester.ac.uk (PhD thesis). University of Manchester. OCLC 642917758. Archived from the original on 24 November 2015. Retrieved 25 November 2015.
  13. ^ Zeggini, E. (2002). "Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis". Rheumatology. 41 (4): 462–465. doi:10.1093/rheumatology/41.4.462. ISSN 1460-2172. PMID 11961180.
  14. ^ Frayling, T. M.; Timpson, N. J.; Weedon, M. N.; Zeggini, E.; Freathy, R. M.; Lindgren, C. M.; Perry, J. R. B.; et al. (2007). "A Common Variant in the FTO Gene is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity". Science. 316 (5826): 889–94. Bibcode:2007Sci...316..889F. doi:10.1126/science.1141634. PMC 2646098. PMID 17434869.
  15. ^ Zeggini, E.; Weedon, M. N.; Lindgren, C. M.; Frayling, T. M.; Elliott, K. S.; Lango, H.; Timpson, N. J.; et al. (2007). "Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes". Science. 316 (5829): 1336–1341. Bibcode:2007Sci...316.1336Z. doi:10.1126/science.1142364. PMC 3772310. PMID 17463249.
  16. ^ Zeggini, Eleftheria; Scott, Laura J; Saxena, Richa; Voight, Benjamin F; Marchini, Jonathan L; Hu, Tianle; de Bakker, Paul IW; Abecasis, Gonçalo R; Almgren, Peter; Andersen, Gitte; Ardlie, Kristin; et al. (2008). "Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes". Nature Genetics. 40 (5): 638–645. doi:10.1038/ng.120. ISSN 1061-4036. PMC 2672416. PMID 18372903.
  17. ^ Willer, Cristen J; Speliotes, Elizabeth K; Loos, Ruth J F; Li, Shengxu; Lindgren, Cecilia M; Heid, Iris M; Berndt, Sonja I; Elliott, Amanda L; Jackson, Anne U; Lamina, Claudia; Lettre, Guillaume; et al. (2008). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nature Genetics. 41 (1): 25–34. doi:10.1038/ng.287. ISSN 1061-4036. PMC 2695662. PMID 19079261.
  18. ^ Zeggini, Eleftheria (2011). "Next-generation association studies for complex traits". Nature Genetics. 43 (4): 287–288. doi:10.1038/ng0411-287. ISSN 1061-4036. PMC 3435533. PMID 21445070.
  19. ^ Crawford, Dana C.; Babron, Marie-Claude; de Tayrac, Marie; Rutledge, Douglas N.; Zeggini, Eleftheria; Génin, Emmanuelle (2012). "Rare and Low Frequency Variant Stratification in the UK Population: Description and Impact on Association Tests". PLOS ONE. 7 (10): e46519. Bibcode:2012PLoSO...746519B. doi:10.1371/journal.pone.0046519. ISSN 1932-6203. PMC 3465327. PMID 23071581. Open access icon
  20. ^ "Cretans don't get heart disease despite high-fat diet due to good genes". uk.news.yahoo.com. Yahoo!. Retrieved 3 February 2018.
  21. ^ "Sanger Institute researcher becomes Suffrage Science awardee". Wellcome Sanger Institute. 13 October 2014. Retrieved 22 November 2020.
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