GNRHR: Difference between revisions

GNRHR
Identifiers
Aliases	GNRHR, GNRHR1, GRHR, HH7, LHRHR, LRHR, gonadotropin releasing hormone receptor
External IDs	OMIM: 138850; MGI: 95790; HomoloGene: 350; GeneCards: GNRHR; OMA:GNRHR - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	67,754,388 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	86,345,760 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; testicle; ; ganglionic eminence; ; ventricular zone; ; sural nerve; ; tibialis anterior muscle; ; prefrontal cortex; ; corpus callosum; ; gonad; ; deltoid muscle;
	Top expressed in
	lumbar subsegment of spinal cord; ; pituitary gland; ; embryo; ; anterior pituitary; ; right ventricle; ; vastus lateralis muscle; ; central gray substance of midbrain; ; lumbar spinal ganglion; ; digastric muscle; ; nucleus of stria terminalis;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein-hormone receptor activity; signal transducer activity; G protein-coupled receptor activity; peptide binding; gonadotropin-releasing hormone receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane; integral component of plasma membrane;
Biological process	multicellular organism development; signal transduction; G protein-coupled receptor signaling pathway; cellular response to gonadotropin-releasing hormone; cellular response to hormone stimulus;
	Sources:Amigo / QuickGO
Orthologs
	2798
	14715
	ENSG00000109163
	ENSMUSG00000029255
	P30968
	Q01776
	NM_001012763; NM_000406
	NM_010323; NM_001310651; NM_001310653
	NP_000397; NP_001012781
	NP_001297580; NP_001297582; NP_034453
	Wikidata
View/Edit Human	View/Edit Mouse

Browse history interactively

← Previous edit

Content deleted Content added

VisualWikitext

Inline

Latest revision as of 04:12, 14 January 2024

Gonadotropin-releasing hormone receptor is a protein that in humans is encoded by the GNRHR gene.^[5]^[6]

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109163 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029255 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chi L, Zhou W, Prikhozhan A, Flanagan C, Davidson JS, Golembo M, Illing N, Millar RP, Sealfon SC (May 1993). "Cloning and characterization of the human GnRH receptor". Mol Cell Endocrinol. 91 (1–2): R1–6. doi:10.1016/0303-7207(93)90278-R. PMID 8386108. S2CID 22807298.
^ ^a ^b "Entrez Gene: GNRHR gonadotropin-releasing hormone receptor".

Michel U, Farnworth P, Findlay JK (1993). "Follistatins: more than follicle-stimulating hormone suppressing proteins". Mol. Cell. Endocrinol. 91 (1–2): 1–11. doi:10.1016/0303-7207(93)90248-I. PMID 8472841. S2CID 45296753.
Flanagan CA, Millar RP, Illing N (1998). "Advances in understanding gonadotrophin-releasing hormone receptor structure and ligand interactions". Rev. Reprod. 2 (2): 113–20. doi:10.1530/ror.0.0020113. PMID 9414473.
Limonta P, Moretti RM, Marelli MM, Motta M (2004). "The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans". Frontiers in Neuroendocrinology. 24 (4): 279–95. doi:10.1016/j.yfrne.2003.10.003. PMID 14726258. S2CID 33327806.
Bédécarrats GY, Kaiser UB (2007). "Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function". Semin. Reprod. Med. 25 (5): 368–78. doi:10.1055/s-2007-984743. PMID 17710733. S2CID 260316708.
Kakar SS, Musgrove LC, Devor DC, et al. (1992). "Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor". Biochem. Biophys. Res. Commun. 189 (1): 289–95. doi:10.1016/0006-291X(92)91556-6. PMID 1333190.
Kakar SS, Grizzle WE, Neill JD (1995). "The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary". Mol. Cell. Endocrinol. 106 (1–2): 145–9. doi:10.1016/0303-7207(94)90196-1. PMID 7534732. S2CID 30402769.
Leung PC, Squire J, Peng C, et al. (1995). "Mapping of the gonadotropin-releasing hormone (GnRH) receptor gene to human chromosome 4q21.2 by fluorescence in situ hybridization". Mamm. Genome. 6 (4): 309–10. doi:10.1007/BF00352431. PMID 7613048. S2CID 22885474.
Fan NC, Peng C, Krisinger J, Leung PC (1995). "The human gonadotropin-releasing hormone receptor gene: complete structure including multiple promoters, transcription initiation sites, and polyadenylation signals". Mol. Cell. Endocrinol. 107 (2): R1–8. doi:10.1016/0303-7207(94)03460-B. PMID 7768323. S2CID 25743883.
Fan NC, Jeung EB, Peng C, et al. (1994). "The human gonadotropin-releasing hormone (GnRH) receptor gene: cloning, genomic organization and chromosomal assignment". Mol. Cell. Endocrinol. 103 (1–2): R1–6. doi:10.1016/0303-7207(94)90087-6. PMID 7958384. S2CID 54265042.
Grosse R, Schöneberg T, Schultz G, Gudermann T (1997). "Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor". Mol. Endocrinol. 11 (9): 1305–18. doi:10.1210/mend.11.9.9966. PMID 9259321.
Kakar SS (1997). "Molecular structure of the human gonadotropin-releasing hormone receptor gene". Eur. J. Endocrinol. 137 (2): 183–92. doi:10.1530/eje.0.1370183. PMID 9272108.
de Roux N, Young J, Misrahi M, et al. (1997). "A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor". N. Engl. J. Med. 337 (22): 1597–602. doi:10.1056/NEJM199711273372205. PMID 9371856.
Layman LC, Cohen DP, Jin M, et al. (1998). "Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism". Nat. Genet. 18 (1): 14–5. doi:10.1038/ng0198-14. PMID 9425890. S2CID 39436682.
de Roux N, Young J, Brailly-Tabard S, et al. (1999). "The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred". J. Clin. Endocrinol. Metab. 84 (2): 567–72. doi:10.1210/jcem.84.2.5449. PMID 10022417. S2CID 23561496.
Caron P, Chauvin S, Christin-Maitre S, et al. (1999). "Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration". J. Clin. Endocrinol. Metab. 84 (3): 990–6. doi:10.1210/jcem.84.3.5518. PMID 10084584.
Kottler ML, Bergametti F, Carrë MC, et al. (1999). "Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene". Eur. J. Endocrinol. 140 (6): 561–9. doi:10.1530/eje.0.1400561. PMID 10366411.
Pralong FP, Gomez F, Castillo E, et al. (1999). "Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor". J. Clin. Endocrinol. Metab. 84 (10): 3811–6. doi:10.1210/jcem.84.10.6042. PMID 10523035.

External links

"Gonadotrophin-Releasing Hormone Receptors: GnRH receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109163 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029255 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8386108-5] Chi L, Zhou W, Prikhozhan A, Flanagan C, Davidson JS, Golembo M, Illing N, Millar RP, Sealfon SC (May 1993). "Cloning and characterization of the human GnRH receptor". Mol Cell Endocrinol. 91 (1–2): R1–6. doi:10.1016/0303-7207(93)90278-R. PMID 8386108. S2CID 22807298.

[entrez-6] "Entrez Gene: GNRHR gonadotropin-releasing hormone receptor".

[1]

[2]

[3]

[4]

[5]

[6]

@@ Line 1: / Line 1: @@
+{{cs1 config|name-list-style=vanc}}
 {{Short description|Protein-coding gene in the species Homo sapiens}}
 {{Infobox_gene}}
 '''Gonadotropin-releasing hormone receptor''' is a [[protein]] that in humans is encoded by the ''GNRHR'' [[gene]].<ref name="pmid8386108">{{cite journal | vauthors = Chi L, Zhou W, Prikhozhan A, Flanagan C, Davidson JS, Golembo M, Illing N, Millar RP, Sealfon SC | author9-link = Stuart C. Sealfon | title = Cloning and characterization of the human GnRH receptor | journal = Mol Cell Endocrinol | volume = 91 | issue = 1–2 | pages = R1–6 |date=May 1993 | pmid = 8386108 | doi =10.1016/0303-7207(93)90278-R  | s2cid = 22807298 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNRHR gonadotropin-releasing hormone receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2798}}</ref>
-This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: GNRHR gonadotropin-releasing hormone receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2798}}</ref>
+This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.<ref name="entrez"/>
 ==See also==
@@ Line 16: / Line 17: @@
 *{{cite journal  |vauthors=Flanagan CA, Millar RP, Illing N |title=Advances in understanding gonadotrophin-releasing hormone receptor structure and ligand interactions. |journal=Rev. Reprod. |volume=2 |issue= 2 |pages= 113–20 |year= 1998 |pmid= 9414473 |doi=10.1530/ror.0.0020113  }}
 *{{cite journal  |vauthors=Limonta P, Moretti RM, Marelli MM, Motta M |title=The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans. |journal=Frontiers in Neuroendocrinology |volume=24 |issue= 4 |pages= 279–95 |year= 2004 |pmid= 14726258 |doi=10.1016/j.yfrne.2003.10.003  |s2cid=33327806 }}
-*{{cite journal  |vauthors=Bédécarrats GY, Kaiser UB |title=Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function. |journal=Semin. Reprod. Med. |volume=25 |issue= 5 |pages= 368–78 |year= 2007 |pmid= 17710733 |doi= 10.1055/s-2007-984743 }}
+*{{cite journal  |vauthors=Bédécarrats GY, Kaiser UB |title=Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function. |journal=Semin. Reprod. Med. |volume=25 |issue= 5 |pages= 368–78 |year= 2007 |pmid= 17710733 |doi= 10.1055/s-2007-984743 |s2cid=260316708 }}
 *{{cite journal  |vauthors=Kakar SS, Musgrove LC, Devor DC |title=Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor. |journal=Biochem. Biophys. Res. Commun. |volume=189 |issue= 1 |pages= 289–95 |year= 1992 |pmid= 1333190 |doi=10.1016/0006-291X(92)91556-6  |display-authors=etal}}
 *{{cite journal  |vauthors=Kakar SS, Grizzle WE, Neill JD |title=The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary. |journal=Mol. Cell. Endocrinol. |volume=106 |issue= 1–2 |pages= 145–9 |year= 1995 |pmid= 7534732 |doi=10.1016/0303-7207(94)90196-1  |s2cid=30402769 }}
@@ Line 22: / Line 23: @@
 *{{cite journal  |vauthors=Fan NC, Peng C, Krisinger J, Leung PC |title=The human gonadotropin-releasing hormone receptor gene: complete structure including multiple promoters, transcription initiation sites, and polyadenylation signals. |journal=Mol. Cell. Endocrinol. |volume=107 |issue= 2 |pages= R1–8 |year= 1995 |pmid= 7768323 |doi=10.1016/0303-7207(94)03460-B  |s2cid=25743883 }}
 *{{cite journal  |vauthors=Fan NC, Jeung EB, Peng C |title=The human gonadotropin-releasing hormone (GnRH) receptor gene: cloning, genomic organization and chromosomal assignment. |journal=Mol. Cell. Endocrinol. |volume=103 |issue= 1–2 |pages= R1–6 |year= 1994 |pmid= 7958384 |doi=10.1016/0303-7207(94)90087-6  |s2cid=54265042 |display-authors=etal}}
-*{{cite journal  |vauthors=Grosse R, Schöneberg T, Schultz G, Gudermann T |title=Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor. |journal=Mol. Endocrinol. |volume=11 |issue= 9 |pages= 1305–18 |year= 1997 |pmid= 9259321 |doi=10.1210/me.11.9.1305  |doi-access=free }}
+*{{cite journal  |vauthors=Grosse R, Schöneberg T, Schultz G, Gudermann T |title=Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor. |journal=Mol. Endocrinol. |volume=11 |issue= 9 |pages= 1305–18 |year= 1997 |pmid= 9259321 |doi=10.1210/mend.11.9.9966  |doi-access=free }}
 *{{cite journal  | author=Kakar SS |title=Molecular structure of the human gonadotropin-releasing hormone receptor gene. |journal=Eur. J. Endocrinol. |volume=137 |issue= 2 |pages= 183–92 |year= 1997 |pmid= 9272108 |doi=10.1530/eje.0.1370183  }}
-*{{cite journal  |vauthors=de Roux N, Young J, Misrahi M |title=A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor. |journal=N. Engl. J. Med. |volume=337 |issue= 22 |pages= 1597–602 |year= 1997 |pmid= 9371856 |doi=10.1056/NEJM199711273372205  |display-authors=etal}}
+*{{cite journal  |vauthors=de Roux N, Young J, Misrahi M |title=A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor. |journal=N. Engl. J. Med. |volume=337 |issue= 22 |pages= 1597–602 |year= 1997 |pmid= 9371856 |doi=10.1056/NEJM199711273372205  |display-authors=etal|doi-access=free }}
 *{{cite journal  |vauthors=Layman LC, Cohen DP, Jin M |title=Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism. |journal=Nat. Genet. |volume=18 |issue= 1 |pages= 14–5 |year= 1998 |pmid= 9425890 |doi= 10.1038/ng0198-14 |s2cid=39436682 |display-authors=etal}}
-*{{cite journal  |vauthors=de Roux N, Young J, Brailly-Tabard S |title=The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 2 |pages= 567–72 |year= 1999 |pmid= 10022417 |doi=10.1210/jc.84.2.567  |display-authors=etal}}
+*{{cite journal  |vauthors=de Roux N, Young J, Brailly-Tabard S |title=The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 2 |pages= 567–72 |year= 1999 |doi=10.1210/jcem.84.2.5449 |pmid= 10022417 |s2cid=23561496 |display-authors=etal|doi-access=free }}
-*{{cite journal  |vauthors=Caron P, Chauvin S, Christin-Maitre S |title=Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 3 |pages= 990–6 |year= 1999 |pmid= 10084584 |doi=10.1210/jc.84.3.990  |display-authors=etal|doi-access=free }}
+*{{cite journal  |vauthors=Caron P, Chauvin S, Christin-Maitre S |title=Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 3 |pages= 990–6 |year= 1999 |pmid= 10084584 |doi=10.1210/jcem.84.3.5518  |display-authors=etal|doi-access=free }}
 *{{cite journal  |vauthors=Kottler ML, Bergametti F, Carrë MC |title=Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene. |journal=Eur. J. Endocrinol. |volume=140 |issue= 6 |pages= 561–9 |year= 1999 |pmid= 10366411 |doi=10.1530/eje.0.1400561  |display-authors=etal|doi-access=free }}
-*{{cite journal  |vauthors=Pralong FP, Gomez F, Castillo E |title=Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 10 |pages= 3811–6 |year= 1999 |pmid= 10523035 |doi=10.1210/jc.84.10.3811  |display-authors=etal}}
+*{{cite journal  |vauthors=Pralong FP, Gomez F, Castillo E |title=Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 10 |pages= 3811–6 |year= 1999 |doi=10.1210/jcem.84.10.6042 |pmid= 10523035 |display-authors=etal|doi-access=free }}
 {{refend}}
 ==External links==
-*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3035 | title = Gonadotrophin-Releasing Hormone Receptors: GnRH receptor | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology }}
+*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3035 | title = Gonadotrophin-Releasing Hormone Receptors: GnRH receptor | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-04 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303181711/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3035 | url-status = dead }}
 {{NLM content}}

Latest revision as of 04:12, 14 January 2024

See also

References

Further reading

External links