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{{Infobox scientist||
{{Infobox scientist
| name = Carlos Caldas
| name = Carlos Caldas
| honorific_suffix = {{post-nominals|country=GBR|FMedSci|size=100%}}
| honorific_suffix = {{post-nominals|country=GBR|FMedSci|size=100%}}
| image =
| image =
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| caption =
| caption =
| birth_name = Carlos Manuel Simão da Silva Caldas
| birth_name = Carlos Manuel Simão da Silva Caldas
| birth_date = 26 June 1960
| birth_date = 27 June 1960
| birth_place =
| birth_place =
| fields =
| fields =
| workplaces = Cancer Research UK Cambridge Institute, [[University of Cambridge]]
| workplaces = [[University of Cambridge]]
[[Addenbrooke's Hospital]]
[[Addenbrooke's Hospital]] <br> [[Robinson College, Cambridge]]
| education =
| education =
| alma_mater = University of Lisbon Medical School
| alma_mater = University of Lisbon Medical School
| thesis_title =
| thesis_title =
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| known_for =
| influences =
| influences =
| influenced =
| influenced =
| awards = [[Fellow of the Academy of Medical Sciences]]
| awards = [[Fellow of the Academy of Medical Sciences]]
| spouse = <!--(or | spouses = )-->
| spouse = <!--(or | spouses = )-->
| partner = <!--(or | partners = )-->
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| children =
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| website = {{URL|www.cruk.cam.ac.uk/research-groups/caldas-group}}
| website = https://www.oncology.cam.ac.uk/directory/c-caldas
}}
}}
'''Professor Carlos Caldas''' {{post-nominals|country=GBR|4=FMedSci}} is a clinician scientist and Senior Group Leader at the Cancer Research UK Cambridge Institute, [[University of Cambridge]]. He is the Chair of Cancer Medicine at the University of Cambridge, an Honorary Consultant Medical Oncologist at [[Addenbrooke's Hospital]] and Director of the Cambridge Breast Cancer Research Unit.<ref name=":0">{{Cite web|url=https://www.cuh.nhs.uk/cambridge-breast-unit/meet-team/oncologists/prof-c-caldas|title=Prof C Caldas {{!}} Cambridge University Hospitals|website=www.cuh.nhs.uk|access-date=2019-08-29}}</ref><ref>{{Cite web|url=https://www.oncology.cam.ac.uk/directory/c-caldas|title=Professor Carlos Caldas — Department of Oncology|[email protected]|website=www.oncology.cam.ac.uk|language=en|access-date=2019-08-29}}</ref>
'''Professor Carlos Caldas''' {{post-nominals|country=GBR|4=FMedSci}} is a clinician scientist and Professor of Cancer Medicine at the [[University of Cambridge]]. He is the Chair of Cancer Medicine at the University of Cambridge, an Honorary Consultant Medical Oncologist at [[Addenbrooke's Hospital]] and Director of the Cambridge Breast Cancer Research Unit.<ref name=":0">{{Cite web|url=https://www.cuh.nhs.uk/cambridge-breast-unit/meet-team/oncologists/prof-c-caldas|title=Prof C Caldas {{!}} Cambridge University Hospitals|website=www.cuh.nhs.uk|access-date=2019-08-29}}</ref><ref>{{Cite web|url=https://www.oncology.cam.ac.uk/directory/c-caldas|title=Professor Carlos Caldas — Department of Oncology|[email protected]|website=www.oncology.cam.ac.uk|access-date=2019-08-29}}</ref> He is a fellow of [[Robinson College, Cambridge]]<ref>[https://www.robinson.cam.ac.uk/people/professor-carlos-caldas-fmedsci Caldas's Robinson College webpage]</ref> and an Emeritus Senior Investigator at the [[National Institute for Health Research]] (NIHR).<ref>{{Cite web|title=NIHR Senior Investigators 2020|url=https://www.nihr.ac.uk/documents/nihr-senior-investigators-2020-list-of-13th-round-appointments/24106|access-date=2022-02-09|website=NIHR}}</ref>


== Education ==
== Education ==


Professor Carlos Caldas graduated from the [[University of Lisbon]] Medical School before training in Internal Medicine in [[University of Texas Southwestern Medical Center|University of Texas Southwestern]], Dallas and Medical Oncology at [[Johns Hopkins Hospital]], Baltimore. He then moved to the [[Institute of Cancer Research]], London to complete a research fellowship.<ref name=":0" />
Professor Carlos Caldas graduated from the [[University of Lisbon]] Medical School before training in Internal Medicine in [[University of Texas Southwestern Medical Center|University of Texas Southwestern]], Dallas and Medical Oncology at [[Johns Hopkins Hospital]], Baltimore. He then moved to the [[Institute of Cancer Research]], London to complete a research fellowship.<ref name=":0" />


== Research and Career ==
== Research and career ==


Caldas' research focuses on the [[functional genomics]] of [[breast cancer]].<ref>{{Cite web|url=https://scholar.google.co.uk/citations?user=cWlqL14AAAAJ&hl=en|title=Carlos Caldas - Google Scholar Citations|website=scholar.google.co.uk|access-date=2019-08-29}}</ref><ref>{{Cite web|url=https://www.cruk.cam.ac.uk/research-groups/caldas-group|title=Caldas Group|website=Cancer Research UK Cambridge Institute|language=en-GB|access-date=2019-08-29}}</ref> Caldas led the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) study, analysing the [[genome]] and [[transcriptome]] of tumours from nearly 2,000 women and comparing this with long-term clinical information including survival, age and diagnosis. The METABRIC study concluded that breast cancer was at least ten different subtypes, characterised by distinct genomic drivers.<ref>{{Cite journal|last=Aparicio|first=Samuel|last2=Caldas|first2=Carlos|last3=Tavaré|first3=Simon|last4=Brenton|first4=James D.|last5=Børresen-Dale|first5=Anne-Lise|last6=Purushotham|first6=Arnie|last7=Ellis|first7=Ian|last8=Murphy|first8=Leigh|last9=Markowetz|first9=Florian|date=2012-06|title=The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups|url=https://www.nature.com/articles/nature10983|journal=Nature|language=en|volume=486|issue=7403|pages=346–352|doi=10.1038/nature10983|issn=1476-4687}}</ref><ref>{{Cite journal|last=Curtis|first=C.|last2=Shah|first2=S.|last3=Chin|first3=S.|last4=Turashvili|first4=G.|last5=Rueda|first5=O.|last6=Dunning|first6=M.|last7=Speed|first7=D.|last8=Lynch|first8=A.|last9=Samarajiwa|first9=S.|date=2012|title=The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups|url=https://scienceblog.cancerresearchuk.org/2012/04/18/increasing-the-resolution-on-breast-cancer-the-metabric-study/|journal=Nature|doi=10.1038/nature10983|issn=0028-0836}}</ref><ref>{{Cite news|url=https://www.bbc.com/news/health-17740690|title=Breast cancer map 'a key moment'|last=Gallagher|first=James|date=2012-04-18|access-date=2019-08-29|language=en-GB}}</ref> In 2019, the team published research showing the subtype a women's breast cancer is initially placed in could predict the likelyhood of the tumour returning or [[Metastasis|metastasising]] over the next 20 years.<ref>{{Cite journal|last=Curtis|first=Christina|last2=Caldas|first2=Carlos|last3=Aparicio|first3=Samuel|last4=Rueda|first4=Cristina|last5=Pharoah|first5=Paul D.|last6=Ellis|first6=Ian O.|last7=Purushotham|first7=Arnie|last8=Murphy|first8=Leigh|last9=Green|first9=Andrew R.|date=2019-03|title=Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups|url=https://www.nature.com/articles/s41586-019-1007-8|journal=Nature|language=en|volume=567|issue=7748|pages=399–404|doi=10.1038/s41586-019-1007-8|issn=1476-4687}}</ref><ref>{{Cite news|url=https://www.bbc.com/news/health-47553534|title=Cancer's 'internal wiring' predicts relapse risk|last=Gallagher|first=James|date=2019-03-14|access-date=2019-08-29|language=en-GB}}</ref><ref>{{Cite web|url=https://www.independent.co.uk/news/health/breast-cancer-test-return-risk-calculator-genetic-cambridge-study-a8821476.html|title=Breast cancer test could predict chances of disease’s return 20 years later, study shows|date=2019-03-13|website=The Independent|language=en|access-date=2019-08-29}}</ref>
Caldas' research focuses on the [[functional genomics]] of [[breast cancer]].<ref>{{Cite web|url=https://scholar.google.co.uk/citations?user=cWlqL14AAAAJ&hl=en|title=Carlos Caldas - Google Scholar Citations|website=scholar.google.co.uk|access-date=2019-08-29}}</ref><ref>{{Cite web|url=https://www.cruk.cam.ac.uk/research-groups/caldas-group|title=Caldas Group|website=Cancer Research UK Cambridge Institute|access-date=2019-08-29}}</ref> Caldas led the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) study, analysing the [[genome]] and [[transcriptome]] of tumours from nearly 2,000 women and comparing this with long-term clinical information including survival, age and diagnosis. The METABRIC study concluded that breast cancer was at least ten different subtypes, characterised by distinct genomic drivers.<ref>{{Cite journal|last1=Aparicio|first1=Samuel|last2=Caldas|first2=Carlos|last3=Tavaré|first3=Simon|last4=Brenton|first4=James D.|last5=Børresen-Dale|first5=Anne-Lise|last6=Purushotham|first6=Arnie|last7=Ellis|first7=Ian|last8=Murphy|first8=Leigh|last9=Markowetz|first9=Florian|date=June 2012|title=The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups|journal=Nature|volume=486|issue=7403|pages=346–352|doi=10.1038/nature10983|pmid=22522925|issn=1476-4687|pmc=3440846|bibcode=2012Natur.486..346.}}</ref><ref>{{Cite news|url=https://www.bbc.com/news/health-17740690|title=Breast cancer map 'a key moment'|last=Gallagher|first=James|date=2012-04-18|access-date=2019-08-29}}</ref> In 2019, the team published research showing the subtype a women's breast cancer is initially placed in could predict the likelihood of the tumour returning or [[metastasis]]ing over the next 20 years.<ref>{{Cite journal|last1=Curtis|first1=Christina|last2=Caldas|first2=Carlos|last3=Aparicio|first3=Samuel|last4=Rueda|first4=Cristina|last5=Pharoah|first5=Paul D.|last6=Ellis|first6=Ian O.|last7=Purushotham|first7=Arnie|last8=Murphy|first8=Leigh|last9=Green|first9=Andrew R.|date=March 2019|title=Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups|journal=Nature|volume=567|issue=7748|pages=399–404|doi=10.1038/s41586-019-1007-8|pmid=30867590|issn=1476-4687|pmc=6647838|bibcode=2019Natur.567..399R}}</ref><ref>{{Cite news|url=https://www.bbc.com/news/health-47553534|title=Cancer's 'internal wiring' predicts relapse risk|last=Gallagher|first=James|date=2019-03-14|access-date=2019-08-29}}</ref><ref>{{Cite web|url=https://www.independent.co.uk/news/health/breast-cancer-test-return-risk-calculator-genetic-cambridge-study-a8821476.html|title=Breast cancer test could predict chances of disease's return 20 years later, study shows|date=2019-03-13|website=The Independent|access-date=2019-08-29}}</ref>


Professor Caldas leads the Personalised Breast Cancer Programme in Cambridge, where woman diagnosed with breast cancer have a sample of their tumour and blood sent for [[DNA sequencing|DNA]] and [[RNA sequencing]]. The sequencing results help determine the best course of treatment for patients and can reveal if their tumour is developing resistance to treatment.<ref>{{Cite news|url=https://www.bbc.com/news/health-44455354|title=DNA 'barcode' can transform cancer care|last=Walsh|first=Fergus|date=2018-06-27|access-date=2019-08-29|language=en-GB}}</ref><ref>{{Cite web|url=https://www.cambridge-news.co.uk/news/health/breast-cancer-dna-barcode-addenbookes-14942750|title=Breast cancer DNA ‘barcoding’ programme set to expand|last=Pilgrim|first=Tom|date=2018-07-23|website=cambridgenews|access-date=2019-08-29}}</ref><ref>{{Cite web|url=https://www.cuh.nhs.uk/news/breast-unit/pbcp-study-takes-breast-cancer-research-next-level-development-personalised-cancer-medicine|title=PBCP study takes breast cancer research to the next level in the development of personalised cancer medicine {{!}} Cambridge University Hospitals|website=www.cuh.nhs.uk|access-date=2019-08-29}}</ref>
Professor Caldas leads the Personalised Breast Cancer Programme in Cambridge, where woman diagnosed with breast cancer have a sample of their tumour and blood sent for [[DNA sequencing|DNA]] and [[RNA sequencing]]. The sequencing results help determine the best course of treatment for patients and can reveal if their tumour is developing resistance to treatment.<ref>{{Cite news|url=https://www.bbc.com/news/health-44455354|title=DNA 'barcode' can transform cancer care|last=Walsh|first=Fergus|date=2018-06-27|access-date=2019-08-29}}</ref><ref>{{Cite web|url=https://www.cambridge-news.co.uk/news/health/breast-cancer-dna-barcode-addenbookes-14942750|title=Breast cancer DNA 'barcoding' programme set to expand|last=Pilgrim|first=Tom|date=2018-07-23|website=cambridgenews|access-date=2019-08-29}}</ref><ref>{{Cite web|url=https://www.cuh.nhs.uk/news/breast-unit/pbcp-study-takes-breast-cancer-research-next-level-development-personalised-cancer-medicine|title=PBCP study takes breast cancer research to the next level in the development of personalised cancer medicine {{!}} Cambridge University Hospitals|website=www.cuh.nhs.uk|access-date=2019-08-29}}</ref>


== Awards and honours ==
== Awards and honours ==


* [[Academy of Medical Sciences (United Kingdom)|Academy of Medical Sciences]] Fellow, 2004<ref>{{Cite web|url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-Carlos-Caldas-0006182|title=Professor Carlos Caldas {{!}} The Academy of Medical Sciences|website=acmedsci.ac.uk|access-date=2019-08-29}}</ref>
* [[Academy of Medical Sciences (United Kingdom)|Academy of Medical Sciences]] Fellow, 2004<ref>{{Cite web|url=https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-Carlos-Caldas-0006182|title=Professor Carlos Caldas {{!}} The Academy of Medical Sciences|website=acmedsci.ac.uk|access-date=2019-08-29}}</ref>
* European Academy of Cancer Sciences Fellow, 2010<ref>{{Cite web|url=https://www.europeancanceracademy.eu/content/directory.php|title=Fellows{{!}} European Academy of Cancer Sciences|website=www.europeancanceracademy.eu|access-date=2019-08-29}}</ref>
* European Academy of Cancer Sciences Fellow, 2010<ref>{{Cite web|url=https://www.europeancanceracademy.eu/content/directory.php|title=Fellows{{!}} European Academy of Cancer Sciences|website=www.europeancanceracademy.eu|access-date=2019-08-29|archive-date=2019-07-04|archive-url=https://web.archive.org/web/20190704091011/https://www.europeancanceracademy.eu/content/directory.php|url-status=dead}}</ref>
* [[European Molecular Biology Organization|EMBO]] member, 2015<ref>{{Cite web|url=https://people.embo.org/profile/carlos-caldas|title=Find people in the EMBO Communities|website=people.embo.org|access-date=2019-08-29}}</ref><ref>{{Cite web|url=https://www.cruk.cam.ac.uk/2015/05/20/three-cruk-ci-group-leaders-elected-to-embo-membership|title=Three Group Leaders elected to EMBO Membership|date=2015-05-20|website=Cancer Research UK Cambridge Institute|language=en-GB|access-date=2019-08-29}}</ref>
* [[European Molecular Biology Organization|EMBO]] member, 2015<ref>{{Cite web|url=https://people.embo.org/profile/carlos-caldas|title=Find people in the EMBO Communities|website=people.embo.org|access-date=2019-08-29}}</ref><ref>{{Cite web|url=https://www.cruk.cam.ac.uk/2015/05/20/three-cruk-ci-group-leaders-elected-to-embo-membership|title=Three Group Leaders elected to EMBO Membership|date=2015-05-20|website=Cancer Research UK Cambridge Institute|access-date=2019-08-29}}</ref>
* [[European Society for Medical Oncology]] Hamilton Fairley Award, 2016<ref>{{Cite web|url=https://www.esmo.org/Press-Office/ESMO-Recognises-Carlos-Caldas-with-Hamilton-Fairley-Award|title=Press Release: ESMO Recognises Carlos Caldas with Hamilton Fairley Award {{!}} ESMO|website=www.esmo.org|access-date=2019-08-29}}</ref>
* [[European Society for Medical Oncology]] Hamilton Fairley Award, 2016<ref>{{Cite web|url=https://www.esmo.org/Press-Office/ESMO-Recognises-Carlos-Caldas-with-Hamilton-Fairley-Award|title=Press Release: ESMO Recognises Carlos Caldas with Hamilton Fairley Award {{!}} ESMO|website=www.esmo.org|access-date=2019-08-29}}</ref>
* [[European Society of Human Genetics]] ESHG Award Laureate, 2021<ref>{{Cite web|url=https://2021.eshg.org/eshg-award/|title=ESHG Award {{!}} ESHG|website=www.eshg.org|access-date=2021-03-25}}</ref>


== References ==
== References ==


{{Reflist}}
<references />


{{Authority control}}


{{DEFAULTSORT:Caldas, Carlos}}
{{DEFAULTSORT:Caldas, Carlos}}
[[Category:Living people]]
[[Category:Living people]]
[[Category:British oncologists]]
[[Category:British oncologists]]
[[Category:Fellows of the Academy of Medical Sciences]]
[[Category:Fellows of the Academy of Medical Sciences (United Kingdom)]]
[[Category:Members of the European Molecular Biology Organization]]
[[Category:Members of the European Molecular Biology Organization]]
[[Category:Fellows of Robinson College, Cambridge]]
[[Category:1960 births]]
[[Category:1960 births]]
[[Category:NIHR Senior Investigators]]

Latest revision as of 07:12, 26 January 2024

Carlos Caldas
FMedSci
Born
Carlos Manuel Simão da Silva Caldas

27 June 1960
Alma materUniversity of Lisbon Medical School
AwardsFellow of the Academy of Medical Sciences
Scientific career
InstitutionsUniversity of Cambridge Addenbrooke's Hospital
Robinson College, Cambridge
Websitehttps://www.oncology.cam.ac.uk/directory/c-caldas

Professor Carlos Caldas FMedSci is a clinician scientist and Professor of Cancer Medicine at the University of Cambridge. He is the Chair of Cancer Medicine at the University of Cambridge, an Honorary Consultant Medical Oncologist at Addenbrooke's Hospital and Director of the Cambridge Breast Cancer Research Unit.[1][2] He is a fellow of Robinson College, Cambridge[3] and an Emeritus Senior Investigator at the National Institute for Health Research (NIHR).[4]

Education

[edit]

Professor Carlos Caldas graduated from the University of Lisbon Medical School before training in Internal Medicine in University of Texas Southwestern, Dallas and Medical Oncology at Johns Hopkins Hospital, Baltimore. He then moved to the Institute of Cancer Research, London to complete a research fellowship.[1]

Research and career

[edit]

Caldas' research focuses on the functional genomics of breast cancer.[5][6] Caldas led the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) study, analysing the genome and transcriptome of tumours from nearly 2,000 women and comparing this with long-term clinical information including survival, age and diagnosis. The METABRIC study concluded that breast cancer was at least ten different subtypes, characterised by distinct genomic drivers.[7][8] In 2019, the team published research showing the subtype a women's breast cancer is initially placed in could predict the likelihood of the tumour returning or metastasising over the next 20 years.[9][10][11]

Professor Caldas leads the Personalised Breast Cancer Programme in Cambridge, where woman diagnosed with breast cancer have a sample of their tumour and blood sent for DNA and RNA sequencing. The sequencing results help determine the best course of treatment for patients and can reveal if their tumour is developing resistance to treatment.[12][13][14]

Awards and honours

[edit]

References

[edit]
  1. ^ a b "Prof C Caldas | Cambridge University Hospitals". www.cuh.nhs.uk. Retrieved 2019-08-29.
  2. ^ [email protected]. "Professor Carlos Caldas — Department of Oncology". www.oncology.cam.ac.uk. Retrieved 2019-08-29.{{cite web}}: CS1 maint: numeric names: authors list (link)
  3. ^ Caldas's Robinson College webpage
  4. ^ "NIHR Senior Investigators 2020". NIHR. Retrieved 2022-02-09.
  5. ^ "Carlos Caldas - Google Scholar Citations". scholar.google.co.uk. Retrieved 2019-08-29.
  6. ^ "Caldas Group". Cancer Research UK Cambridge Institute. Retrieved 2019-08-29.
  7. ^ Aparicio, Samuel; Caldas, Carlos; Tavaré, Simon; Brenton, James D.; Børresen-Dale, Anne-Lise; Purushotham, Arnie; Ellis, Ian; Murphy, Leigh; Markowetz, Florian (June 2012). "The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups". Nature. 486 (7403): 346–352. Bibcode:2012Natur.486..346.. doi:10.1038/nature10983. ISSN 1476-4687. PMC 3440846. PMID 22522925.
  8. ^ Gallagher, James (2012-04-18). "Breast cancer map 'a key moment'". Retrieved 2019-08-29.
  9. ^ Curtis, Christina; Caldas, Carlos; Aparicio, Samuel; Rueda, Cristina; Pharoah, Paul D.; Ellis, Ian O.; Purushotham, Arnie; Murphy, Leigh; Green, Andrew R. (March 2019). "Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups". Nature. 567 (7748): 399–404. Bibcode:2019Natur.567..399R. doi:10.1038/s41586-019-1007-8. ISSN 1476-4687. PMC 6647838. PMID 30867590.
  10. ^ Gallagher, James (2019-03-14). "Cancer's 'internal wiring' predicts relapse risk". Retrieved 2019-08-29.
  11. ^ "Breast cancer test could predict chances of disease's return 20 years later, study shows". The Independent. 2019-03-13. Retrieved 2019-08-29.
  12. ^ Walsh, Fergus (2018-06-27). "DNA 'barcode' can transform cancer care". Retrieved 2019-08-29.
  13. ^ Pilgrim, Tom (2018-07-23). "Breast cancer DNA 'barcoding' programme set to expand". cambridgenews. Retrieved 2019-08-29.
  14. ^ "PBCP study takes breast cancer research to the next level in the development of personalised cancer medicine | Cambridge University Hospitals". www.cuh.nhs.uk. Retrieved 2019-08-29.
  15. ^ "Professor Carlos Caldas | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 2019-08-29.
  16. ^ "Fellows| European Academy of Cancer Sciences". www.europeancanceracademy.eu. Archived from the original on 2019-07-04. Retrieved 2019-08-29.
  17. ^ "Find people in the EMBO Communities". people.embo.org. Retrieved 2019-08-29.
  18. ^ "Three Group Leaders elected to EMBO Membership". Cancer Research UK Cambridge Institute. 2015-05-20. Retrieved 2019-08-29.
  19. ^ "Press Release: ESMO Recognises Carlos Caldas with Hamilton Fairley Award | ESMO". www.esmo.org. Retrieved 2019-08-29.
  20. ^ "ESHG Award | ESHG". www.eshg.org. Retrieved 2021-03-25.
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