Parathyroid hormone 2 receptor: Difference between revisions

PTH2R
Identifiers
Aliases	PTH2R, PTHR2, parathyroid hormone 2 receptor
External IDs	OMIM: 601469; MGI: 2180917; HomoloGene: 3701; GeneCards: PTH2R; OMA:PTH2R - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	208,854,503 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	65,428,403 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; testicle; ; human kidney; ; secondary oocyte; ; islet of Langerhans; ; Brodmann area 9; ; prefrontal cortex; ; right frontal lobe; ; Brodmann area 23; ; middle temporal gyrus;
	Top expressed in
	medial geniculate nucleus; ; spermatid; ; embryo; ; embryo; ; lumbar spinal ganglion; ; blastocyst; ; medial dorsal nucleus; ; medial ganglionic eminence; ; neural tube; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; G protein-coupled receptor activity; parathyroid hormone receptor activity; transmembrane signaling receptor activity; signal transducer activity; G protein-coupled peptide receptor activity; peptide hormone binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5746
	213527
	ENSG00000144407
	ENSMUSG00000025946
	P49190
	Q91V95
	NM_001309516; NM_005048
	NM_139270
	NP_001296445; NP_005039; NP_001358834; NP_001358835; NP_001358836
	NP_644676
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 01:15, 10 March 2024

Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene.^[5]

Function

The protein encoded by this gene is a member of the G protein-coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in the brain and pancreas.^[5]

The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144407 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025946 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PTH2R parathyroid hormone 2 receptor".
^ Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D (2017). "High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5". Biochemical Pharmacology. 127: 71–81. doi:10.1016/j.bcp.2016.12.013. PMC 5303546. PMID 28012961.

External links

"Parathyroid Hormone Receptors: PTH2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
Receptor,+Parathyroid+Hormone,+Type+2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144407 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025946 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PTH2R parathyroid hormone 2 receptor".

[6] Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D (2017). "High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5". Biochemical Pharmacology. 127: 71–81. doi:10.1016/j.bcp.2016.12.013. PMC 5303546. PMID 28012961.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=5746}}
+{{Infobox_gene}}
-'''Parathyroid hormone receptor 2''', also known as '''PTH2''', is a human [[protein]] encoded by the '''PTHR2''' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTHR2 parathyroid hormone receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5746| accessdate = }}</ref>
+'''Parathyroid hormone 2 receptor''' is a [[protein]] that in humans is encoded by the '''''PTH2R''''' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTH2R parathyroid hormone 2 receptor | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5746}}</ref>
+== Function ==
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas.<ref name="entrez">{{cite web | title = Entrez Gene: PTHR2 parathyroid hormone receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5746| accessdate = }}</ref>
-}}
+The protein encoded by this gene is a member of the [[G protein-coupled receptor]] family 2. This protein is a receptor for [[parathyroid hormone]] (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor ([[parathyroid hormone 1 receptor|PTH1R]]). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in the brain and pancreas.<ref name="entrez" />
+The molecular interaction of the PTH2 receptor with the [[peptide]] [[TIP39]] has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 in [[transmembrane helix]] 5 as a key residue for high affinity binding.<ref>{{cite journal  |vauthors=Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D |title=High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. |journal=Biochemical Pharmacology |volume= 127|pages= 71–81|year= 2017 |pmid= 28012961|pmc=5303546 |doi= 10.1016/j.bcp.2016.12.013
+ }}</ref>
 ==See also==
 * [[Parathyroid hormone receptor]]
@@ Line 16: / Line 17: @@
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  |vauthors=Usdin TB, Gruber C, Bonner TI |title=Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. |journal=J. Biol. Chem. |volume=270 |issue= 26 |pages= 15455–8 |year= 1995 |pmid= 7797535 |doi=10.1074/jbc.270.26.15455  |doi-access=free }}
-{{PBB_Further_reading
+*{{cite journal  |vauthors=Usdin TB, Modi W, Bonner TI |title=Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization. |journal=Genomics |volume=37 |issue= 1 |pages= 140–1 |year= 1997 |pmid= 8921382 |doi= 10.1006/geno.1996.0532 }}
-| citations =
-*{{cite journal  | author=Usdin TB, Gruber C, Bonner TI |title=Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. |journal=J. Biol. Chem. |volume=270 |issue= 26 |pages= 15455–8 |year= 1995 |pmid= 7797535 |doi=10.1074/jbc.270.26.15455  }}
+*{{cite journal  |vauthors=Clark JA, Bonner TI, Kim AS, Usdin TB |title=Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors. |journal=Mol. Endocrinol. |volume=12 |issue= 2 |pages= 193–206 |year= 1998 |pmid= 9482662 |doi=10.1210/mend.12.2.0063  |doi-access=free }}
-*{{cite journal  | author=Usdin TB, Modi W, Bonner TI |title=Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization. |journal=Genomics |volume=37 |issue= 1 |pages= 140–1 |year= 1997 |pmid= 8921382 |doi= 10.1006/geno.1996.0532 }}
+*{{cite journal  |vauthors=Hoare SR, Clark JA, Usdin TB |title=Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27274–83 |year= 2000 |pmid= 10854439 |doi= 10.1074/jbc.M003910200 |doi-access= free }}
-*{{cite journal  | author=Clark JA, Bonner TI, Kim AS, Usdin TB |title=Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors. |journal=Mol. Endocrinol. |volume=12 |issue= 2 |pages= 193–206 |year= 1998 |pmid= 9482662 |doi=10.1210/me.12.2.193  }}
+*{{cite journal   |vauthors=John MR, Arai M, Rubin DA, etal |title=Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. |journal=Endocrinology |volume=143 |issue= 3 |pages= 1047–57 |year= 2002 |pmid= 11861531 |doi=10.1210/endo.143.3.8698  |doi-access=free }}
-*{{cite journal  | author=Hoare SR, Clark JA, Usdin TB |title=Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27274–83 |year= 2000 |pmid= 10854439 |doi= 10.1074/jbc.M003910200 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=John MR, Arai M, Rubin DA, ''et al.'' |title=Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. |journal=Endocrinology |volume=143 |issue= 3 |pages= 1047–57 |year= 2002 |pmid= 11861531 |doi=10.1210/en.143.3.1047  }}
+*{{cite journal   |vauthors=Seeliger S, Hausberg M, Eue I, etal |title=The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism. |journal=Clin. Nephrol. |volume=59 |issue= 6 |pages= 429–35 |year= 2003 |pmid= 12834174 |doi=  10.5414/CNP59429}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Bisello A, Manen D, Pierroz DD, etal |title=Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization. |journal=Mol. Endocrinol. |volume=18 |issue= 6 |pages= 1486–98 |year= 2004 |pmid= 14988434 |doi= 10.1210/me.2003-0487 |doi-access= free }}
-*{{cite journal  | author=Seeliger S, Hausberg M, Eue I, ''et al.'' |title=The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism. |journal=Clin. Nephrol. |volume=59 |issue= 6 |pages= 429–35 |year= 2003 |pmid= 12834174 |doi=  }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}}
-*{{cite journal  | author=Bisello A, Manen D, Pierroz DD, ''et al.'' |title=Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization. |journal=Mol. Endocrinol. |volume=18 |issue= 6 |pages= 1486–98 |year= 2004 |pmid= 14988434 |doi= 10.1210/me.2003-0487 }}
+*{{cite journal  |vauthors=Mahon MJ, Shimada M |title=Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors. |journal=FEBS Lett. |volume=579 |issue= 3 |pages= 803–7 |year= 2005 |pmid= 15670850 |doi= 10.1016/j.febslet.2004.12.056 |s2cid=6471940 |doi-access=free }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  |vauthors=Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D |title=High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. |journal=Biochemical Pharmacology |volume= 127|pages= 71–81|year= 2017 |pmid= 28012961|pmc=5303546 |doi= 10.1016/j.bcp.2016.12.013
+ }}
-*{{cite journal  | author=Mahon MJ, Shimada M |title=Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors. |journal=FEBS Lett. |volume=579 |issue= 3 |pages= 803–7 |year= 2005 |pmid= 15670850 |doi= 10.1016/j.febslet.2004.12.056 }}
-}}
 {{refend}}
 ==External links==
-*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2970 | title = Parathyroid Hormone Receptors: PTH2 | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
+*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2970 | title = Parathyroid Hormone Receptors: PTH2 | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-09 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303192534/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2970 | url-status = dead }}
 * {{MeshName|Receptor,+Parathyroid+Hormone,+Type+2}}
 {{G protein-coupled receptors}}
-{{transmembranereceptor-stub}}
 {{NLM content}}
-[[Category:G protein coupled receptors]]
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+[[Category:G protein-coupled receptors]]
-{{PBB_Controls
+{{transmembranereceptor-stub}}
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