Lew Mander: Difference between revisions
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{{Short description|New Zealand-born Australian organic chemist (1939–2020)}} |
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{{Use dmy dates|date=March 2020}} |
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{{Infobox scientist |
{{Infobox scientist |
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| image = |
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| image_size = 150px| |
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| name = Lew Mander |
| name = Lew Mander |
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| birth_name = Lewis Norman Mander |
| birth_name = Lewis Norman Mander |
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| birth_date = {{Birth date |
| birth_date = {{Birth date|df=yes|1939|9|8}} |
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| birth_place = [[Auckland]], [[New Zealand]] |
| birth_place = [[Auckland]], [[New Zealand]] |
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| death_date = |
| death_date = {{Death date and age|df=yes|2020|02|08|1939|9|8}} |
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| death_place = |
| death_place = [[Canberra]], [[Australia]] |
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| residence = [[Canberra]], [[Australia]] |
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| doctoral_students = [[Jacqueline Whalley]] |
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| awards = Companion of the Order of Australia 2018 |
| awards = [[Companion of the Order of Australia|AC]] <small>(2018)</small> |
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| field = [[Organic |
| field = [[Organic chemistry]] |
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| work_institution = [[Australian National University]] |
| work_institution = [[Australian National University]] |
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}} |
}} |
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'''Lewis Norman Mander''', [[Australian Academy of Science|FAA]], [[Royal Society|FRS]] ( |
'''Lewis Norman Mander''', {{post-nominals|country=AUS|size=100%|AC}}, [[Australian Academy of Science|FAA]], [[Royal Society|FRS]] (8 September 1939 – 8 February 2020) was a [[New Zealand]]-born Australian [[organic chemist]]. He has widely explored the synthesis and chemistry of the [[gibberellin]] class of [[diterpenes]] over a 20-year period at the [[Australian National University]] (ANU).<ref>{{cite web |url=http://rsc.anu.edu.au/RSC/ChemResearch/Chemists/mander.html |title=Professor Lewis N. Mander |accessdate=2007-03-26 |url-status=dead |archiveurl=https://web.archive.org/web/20050616004927/http://rsc.anu.edu.au/RSC/ChemResearch/Chemists/mander.html |archivedate=16 June 2005}}</ref><ref>{{Cite web|url=http://www.eoas.info/biogs/P004075b.htm|title=Mander, Lewis Norman (Lew) - Biographical entry - Encyclopedia of Australian Science|first=The University of Melbourne eScholarship Research|last=Centre|website=www.eoas.info}}</ref> In particular, he studied the effect of these hormones on stem growth and on the reasons why plant undergo [[bolting (horticulture)|bolting]] during [[plant development]]. The July 2004 edition of the [[Australian Journal of Chemistry]] was dedicated to Mander on the occasion of his 65th birthday. He retired in 2002 but remained active at the ANU until 2014. In 2018 Mander was made a Companion in the General Division in the Order of Australia which "...is awarded for eminent achievement and merit of the highest degree in service to Australia or humanity at large".<ref>{{cite web |title=COMPANION OF THE ORDER OF AUSTRALIA |url=https://www.pmc.gov.au/government/its-honour/companion-order-australia |publisher=Australian Government |accessdate=21 January 2019}}</ref> |
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In an interview he gave after winning his award, Mander said that his goal was to improve the efficiency of extracting food from plants with the possibility of reducing food shortages in the future.<ref name="auto">{{cite news |last1=Shirley |first1=Adam |title=ANU Professor Lewis Mander awarded a Companion of the Order (AC) in the 2018 Australia Day Honours |url=https://www.abc.net.au/radio/canberra/programs/breakfast/anu-professor-lewis-mander-awarded-ac/9364182 |accessdate=21 January 2019 |work=ABC Canberra Breakfast Show |publisher=Australian Broadcasting Commission |date=26 January 2018}}</ref> |
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==Education== |
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[[File:University of Auckland Science Centre entrance and sign.JPG|thumb|University of Auckland Science Centre entrance]] |
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Mander then moved with Ireland to [[Caltech]] in 1965 (after his PhD had been conferred) for an additional two years. Mander then returned to [[Australia]] in 1966 to join the academic fraternity as a Lecturer in Organic Chemistry at the [[University of Adelaide]]. Mander was [[promoted]] to [[Senior Lecturer]] in [[Organic Chemistry]] in 1970 where he remained until 1975 when he relocated to the [[Australian National University]] Research School of Chemistry as a Senior Fellow where he has risen through the ranks to become one of [[Australia|Australia's]] leading Organic Chemistry professors. In 2004 the [[Australian Journal of Chemistry]] published a special issue for the occasion of Mander's 65th Birthday.<ref>[http://publish.csiro.au/nid/20/pid/3966.htm [[Australian Journal of Chemistry]] Special Issue]</ref> |
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⚫ | He then moved to [[Australia]] in 1962 to undertake a [[Doctor of Philosophy|PhD]] degree at the [[University of Sydney]] before committing to an initial [[Postdoctoral researcher|postdoctoral fellowship]] at the [[University of Michigan]]. Mander then moved to [[Caltech]] in 1965 (after his PhD had been conferred) for an additional two years. |
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==Career== |
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Mander returned to [[Australia]] in 1966 to become a lecturer in organic chemistry at the [[University of Adelaide]]. He was promoted to [[Senior Lecturer]] in [[organic chemistry]] in 1970, where he remained until 1975. During this time Mander visited the [[University of Cambridge]] to research "...pathways to the pigments of life".<ref>{{cite journal |last1=Battersby |first1=Alan |title=Lewis N. Mander |journal=Australian Journal of Chemistry |date=July 2004 |volume=57 |issue=7 |pages=611–617 |doi=10.1071/ch04134|doi-access=free }}</ref> In 1977, he served as a [[Fulbright Program|Fulbright Senior Scholar]] at the [[California Institute of Technology]]. He was a distinguished Alumnus Professor at the [[University of Auckland]] in 1992 and an Eminent Scientist of [[RIKEN]] at [[Wakō, Saitama|Wako]], in [[Saitama Prefecture]], Japan from 1995 to 1996. |
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In Australia, he relocated to the [[Australian National University]] Research School of Chemistry as a Senior Fellow. He retired in 2002 but retained the title of Professor Emeritus at the [[Australian National University]]. |
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Notable students of Mander's include [[Jacqueline Whalley]], professor at [[Auckland University of Technology]].<ref>{{Cite thesis |url=http://hdl.handle.net/1885/139967 |date=1995 |last=Whalley |first=Jacqueline Louise |title=Synthetic studies towards the total synthesis of sordaricin |degree=PhD |publisher=Australian National University|hdl=1885/139967 }}</ref> |
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==Death== |
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Mander died at home in [[Canberra, Australia]] on 8 February 2020, at age 80.<ref>{{Cite web|url=https://tributes.canberratimes.com.au/obituaries/canberratimes-au/obituary.aspx?n=lewis-mander&pid=195407598&fhid=15591|title=Lewis MANDER Death Notice - Belconnen, Australian Capital Territory | The Canberra Times}}</ref> |
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==Research interests== |
==Research interests== |
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[[File:Gibberellic acid.svg|thumb|right|Gibberellic acid]] In the early days, Mander was involved in extracting chemicals in plants that might help fight against cancer.<ref name="auto"/> Eventually, he turned his research skills to “...the gibberellin family of plant bioregulators".<ref>{{cite journal |last1=Mander |first1=Lewis N. |title=Twenty years of gibberellin research |journal=Natural Product Reports |date=28 November 2002 |volume=20 |issue=1 |pages=49–69 |url=https://pubs.rsc.org/en/content/articlehtml/2003/np/b007744p?page=search |doi=10.1039/b007744p|pmid=12636083 }}</ref> He further developed his interest in this chemical group to include an understanding of their role in [[plant development]]. Professor Sir [[Alan R. Battersby]] said that Mander's “...synthesis of [[gibberellic acid]] was a brilliant landmark achievement. This molecule is of daunting complexity and he developed two flexible routes to it, both depending on many ingenious and novel synthetic procedures".<ref>{{cite journal |last1=Battersby |first1=Alan |title=Lewis N. Mander |journal=Australian Journal of Chemistry |date=2004 |volume=57 |issue=7 |pages=611–617 |doi=10.1071/ch04134|doi-access=free }}</ref> |
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Other interests include: |
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*Synthesis and preparation of semi-synthetic derivatives of [[gibberellins]]. |
*Synthesis and preparation of semi-synthetic derivatives of [[gibberellins]]. |
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*Molecular basis of [[Plant hormone|plant growth regulation]] with gibberellins. |
*Molecular basis of [[Plant hormone|plant growth regulation]] with gibberellins. |
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*Synthesis of [[Terpenoid|diterpenoid]] [[natural products]] with high [[Biological activity|bioactivity]]. |
*Synthesis of [[Terpenoid|diterpenoid]] [[natural products]] with high [[Biological activity|bioactivity]]. |
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*Dissolving metal-mediated reductive [[alkylation]] of |
*Dissolving metal-mediated reductive [[alkylation]] of benzenoid synthons. |
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*C-selective [[acylation]] of [[enol]]ates using [[methyl cyanoformate]] (Mander's reagent). |
*C-selective [[acylation]] of [[enol]]ates using [[methyl cyanoformate]] (Mander's reagent). |
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==Fellowships and |
==Fellowships and awards== |
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*Nuffield Commonwealth Fellow 1971–1972 (Cambridge)<ref>{{cite web|title=Mander, Lewis Norman (Lew) (1939–)|url=http://www.eoas.info/biogs/P004075b.htm|website=Encyclopedia of Australian Science|accessdate=28 February 2018}}</ref> |
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*Nuttfield Commonwealth Fellow 1971–1972 (Cambridge) |
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*[[Fulbright Program|Fulbright Senior Scholar]] ([[California Institute of Technology]], 1977, and [[Harvard]] University, 1986) |
*[[Fulbright Program|Fulbright Senior Scholar]] ([[California Institute of Technology]], 1977, and [[Harvard]] University, 1986) |
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*H.G. Smith Memorial Medal 1981 ([[Royal Australian Chemical Institute|RACI]]) |
*H.G. Smith Memorial Medal 1981 ([[Royal Australian Chemical Institute|RACI]])<ref>{{cite web |title=Information on RACIs Past Award Recipients |url=https://www.raci.org.au/document/item/239 |publisher=RACI |accessdate=21 January 2019}}</ref> |
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*Member of the [[Australian Academy of Science]] 1983 |
*Member of the [[Australian Academy of Science]] 1983 |
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*Flintoff Medal and Prize ([[Royal Society of Chemistry|RSC]]) |
*Flintoff Medal and Prize ([[Royal Society of Chemistry|RSC]]) 1990<ref>{{cite web |title=Flintoff Medal Winners |url=http://www.rsc.org/ScienceAndTechnology/Awards/Archive/FlintoffMedal/Index.asp |publisher=Royal Society of Chemistry |accessdate=21 January 2019}}</ref> |
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* |
*Fellow of the [[Royal Society of London]] 1990 |
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*Made a Companion of the [[Order of Australia]] "for eminent service to science through pioneering contributions to organic chemistry in the field of plant growth hormones, to higher education as an academic, researcher and author, and to national and international scientific societies"<ref>{{Cite news|url=http://www.smh.com.au/national/australia-day-honours-2018-the-full-list-20180125-h0o20j.html|title=Australia Day Honours 2018: The full list|date=2018-01-26|work=The Sydney Morning Herald|access-date=2018-01-25|language=en-US}}</ref> |
*Hon. Fellow of the [[Royal Society of New Zealand]] 1991 (FRSNZ Hon)<ref>{{cite web |title=View our current Honorary Fellows |url=https://royalsociety.org.nz/who-we-are/our-people/our-fellows/view-our-honorary-fellows/ |publisher=Royal Society of New Zealand |accessdate=21 January 2019}}</ref> |
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*Made a Companion of the [[Order of Australia]] "for eminent service to science through pioneering contributions to organic chemistry in the field of plant growth hormones, to higher education as an academic, researcher and author, and to national and international scientific societies".<ref>{{Cite news|url=http://www.smh.com.au/national/australia-day-honours-2018-the-full-list-20180125-h0o20j.html|title=Australia Day Honours 2018: The full list|date=2018-01-26|work=The Sydney Morning Herald|access-date=2018-01-25|language=en-US}}</ref> |
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==Representative Publications== |
==Representative Publications== |
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*King G.R., Mander L.N., Monck N.J.T., Morris J.C. and Zhang H. A New and Efficient Strategy for the Total Synthesis of Polycyclic Diterpenoids: The Preparation of Gibberellins (±)-GA103 and (±)-GA73. J. Am. Chem. Soc. 1997, 119, |
*King G.R., Mander L.N., Monck N.J.T., Morris J.C. and Zhang H. A New and Efficient Strategy for the Total Synthesis of Polycyclic Diterpenoids: The Preparation of Gibberellins (±)-GA103 and (±)-GA73. J. Am. Chem. Soc. 1997, 119, 3828–3829. |
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*Frey, B., Wells, A. P., Rogers, D. R. and Mander, L. N. Synthesis of the Unusual Diterpenoid Tropones, Hainanolidol and Harringtonolide. J. Am. Chem. Soc. 1998, 120, 1914–1915. |
*Frey, B., Wells, A. P., Rogers, D. R. and Mander, L. N. Synthesis of the Unusual Diterpenoid Tropones, Hainanolidol and Harringtonolide. J. Am. Chem. Soc. 1998, 120, 1914–1915. |
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*Mander, L. N. Twenty years of gibberellin research. Natural Product Reports, 2003, 20, |
*Mander, L. N. Twenty years of gibberellin research. Natural Product Reports, 2003, 20, 49–69. |
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*Mander, L. N. and McLachlan, M. M. Total synthesis of the Galbulimima alkaloid GB 13. J. Am. Chem. Soc., 2003, 125, 2400–2401. |
*Mander, L. N. and McLachlan, M. M. Total synthesis of the Galbulimima alkaloid GB 13. J. Am. Chem. Soc., 2003, 125, 2400–2401. |
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*Mander, L. N. and Thomson, R. J. Total synthesis of Sordaricin. Org. Lett., 2003, 5, 1321–1324. |
*Mander, L. N. and Thomson, R. J. Total synthesis of Sordaricin. Org. Lett., 2003, 5, 1321–1324. |
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{{DEFAULTSORT:Mander, Lew}} |
{{DEFAULTSORT:Mander, Lew}} |
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[[Category:1939 births]] |
[[Category:1939 births]] |
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[[Category: |
[[Category:2020 deaths]] |
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[[Category:New Zealand chemists]] |
[[Category:New Zealand chemists]] |
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[[Category:Australian chemists]] |
[[Category:Australian chemists]] |
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[[Category:Organic chemists]] |
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[[Category:Harvard University people]] |
[[Category:Harvard University people]] |
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[[Category:New Zealand emigrants to Australia]] |
[[Category:New Zealand emigrants to Australia]] |
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[[Category:University of Adelaide |
[[Category:Academic staff of the University of Adelaide]] |
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[[Category:University of Auckland alumni]] |
[[Category:University of Auckland alumni]] |
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[[Category:University of Sydney alumni]] |
[[Category:University of Sydney alumni]] |
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[[Category:Fellows of the Australian Academy of Science]] |
[[Category:Fellows of the Australian Academy of Science]] |
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[[Category:Fellows of the Royal Society of New Zealand]] |
[[Category:Honorary Fellows of the Royal Society of New Zealand]] |
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[[Category:Fellows of the Royal Society]] |
[[Category:New Zealand Fellows of the Royal Society]] |
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[[Category:University of Michigan fellows]] |
[[Category:University of Michigan fellows]] |
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[[Category:Companions of the Order of Australia]] |
Latest revision as of 03:43, 25 March 2024
Lew Mander | |
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Born | Lewis Norman Mander 8 September 1939 |
Died | 8 February 2020 | (aged 80)
Awards | AC (2018) |
Scientific career | |
Fields | Organic chemistry |
Institutions | Australian National University |
Doctoral students | Jacqueline Whalley |
Lewis Norman Mander, AC, FAA, FRS (8 September 1939 – 8 February 2020) was a New Zealand-born Australian organic chemist. He has widely explored the synthesis and chemistry of the gibberellin class of diterpenes over a 20-year period at the Australian National University (ANU).[1][2] In particular, he studied the effect of these hormones on stem growth and on the reasons why plant undergo bolting during plant development. The July 2004 edition of the Australian Journal of Chemistry was dedicated to Mander on the occasion of his 65th birthday. He retired in 2002 but remained active at the ANU until 2014. In 2018 Mander was made a Companion in the General Division in the Order of Australia which "...is awarded for eminent achievement and merit of the highest degree in service to Australia or humanity at large".[3] In an interview he gave after winning his award, Mander said that his goal was to improve the efficiency of extracting food from plants with the possibility of reducing food shortages in the future.[4]
Bildung
[edit]Mander completed a BSc degree at the University of Auckland, New Zealand in 1960, followed by an MSc degree in 1961 from the same institution. He then moved to Australia in 1962 to undertake a PhD degree at the University of Sydney before committing to an initial postdoctoral fellowship at the University of Michigan. Mander then moved to Caltech in 1965 (after his PhD had been conferred) for an additional two years.
Career
[edit]Mander returned to Australia in 1966 to become a lecturer in organic chemistry at the University of Adelaide. He was promoted to Senior Lecturer in organic chemistry in 1970, where he remained until 1975. During this time Mander visited the University of Cambridge to research "...pathways to the pigments of life".[5] In 1977, he served as a Fulbright Senior Scholar at the California Institute of Technology. He was a distinguished Alumnus Professor at the University of Auckland in 1992 and an Eminent Scientist of RIKEN at Wako, in Saitama Prefecture, Japan from 1995 to 1996.
In Australia, he relocated to the Australian National University Research School of Chemistry as a Senior Fellow. He retired in 2002 but retained the title of Professor Emeritus at the Australian National University.
Notable students of Mander's include Jacqueline Whalley, professor at Auckland University of Technology.[6]
Death
[edit]Mander died at home in Canberra, Australia on 8 February 2020, at age 80.[7]
Research interests
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/a/ac/Gibberellic_acid.svg/220px-Gibberellic_acid.svg.png)
In the early days, Mander was involved in extracting chemicals in plants that might help fight against cancer.[4] Eventually, he turned his research skills to “...the gibberellin family of plant bioregulators".[8] He further developed his interest in this chemical group to include an understanding of their role in plant development. Professor Sir Alan R. Battersby said that Mander's “...synthesis of gibberellic acid was a brilliant landmark achievement. This molecule is of daunting complexity and he developed two flexible routes to it, both depending on many ingenious and novel synthetic procedures".[9]
Amongst his many scholarly activities, Mander contributed a chapter on 'Stereoselective Synthesis' to the classic text 'Stereochemistry of Organic Compounds' by Professors Ernest L. Eliel and Samuel H. Wilen.
Other interests include:
- Synthesis and preparation of semi-synthetic derivatives of gibberellins.
- Molecular basis of plant growth regulation with gibberellins.
- Synthesis of diterpenoid natural products with high bioactivity.
- Dissolving metal-mediated reductive alkylation of benzenoid synthons.
- C-selective acylation of enolates using methyl cyanoformate (Mander's reagent).
Fellowships and awards
[edit]- Nuffield Commonwealth Fellow 1971–1972 (Cambridge)[10]
- Fulbright Senior Scholar (California Institute of Technology, 1977, and Harvard University, 1986)
- H.G. Smith Memorial Medal 1981 (RACI)[11]
- Member of the Australian Academy of Science 1983
- Flintoff Medal and Prize (RSC) 1990[12]
- Fellow of the Royal Society of London 1990
- Hon. Fellow of the Royal Society of New Zealand 1991 (FRSNZ Hon)[13]
- Made a Companion of the Order of Australia "for eminent service to science through pioneering contributions to organic chemistry in the field of plant growth hormones, to higher education as an academic, researcher and author, and to national and international scientific societies".[14]
Representative Publications
[edit]- King G.R., Mander L.N., Monck N.J.T., Morris J.C. and Zhang H. A New and Efficient Strategy for the Total Synthesis of Polycyclic Diterpenoids: The Preparation of Gibberellins (±)-GA103 and (±)-GA73. J. Am. Chem. Soc. 1997, 119, 3828–3829.
- Frey, B., Wells, A. P., Rogers, D. R. and Mander, L. N. Synthesis of the Unusual Diterpenoid Tropones, Hainanolidol and Harringtonolide. J. Am. Chem. Soc. 1998, 120, 1914–1915.
- Mander, L. N. Twenty years of gibberellin research. Natural Product Reports, 2003, 20, 49–69.
- Mander, L. N. and McLachlan, M. M. Total synthesis of the Galbulimima alkaloid GB 13. J. Am. Chem. Soc., 2003, 125, 2400–2401.
- Mander, L. N. and Thomson, R. J. Total synthesis of Sordaricin. Org. Lett., 2003, 5, 1321–1324.
References
[edit]- ^ "Professor Lewis N. Mander". Archived from the original on 16 June 2005. Retrieved 26 March 2007.
- ^ Centre, The University of Melbourne eScholarship Research. "Mander, Lewis Norman (Lew) - Biographical entry - Encyclopedia of Australian Science". www.eoas.info.
- ^ "COMPANION OF THE ORDER OF AUSTRALIA". Australian Government. Retrieved 21 January 2019.
- ^ a b Shirley, Adam (26 January 2018). "ANU Professor Lewis Mander awarded a Companion of the Order (AC) in the 2018 Australia Day Honours". ABC Canberra Breakfast Show. Australian Broadcasting Commission. Retrieved 21 January 2019.
- ^ Battersby, Alan (July 2004). "Lewis N. Mander". Australian Journal of Chemistry. 57 (7): 611–617. doi:10.1071/ch04134.
- ^ Whalley, Jacqueline Louise (1995). Synthetic studies towards the total synthesis of sordaricin (PhD thesis). Australian National University. hdl:1885/139967.
- ^ "Lewis MANDER Death Notice - Belconnen, Australian Capital Territory | The Canberra Times".
- ^ Mander, Lewis N. (28 November 2002). "Twenty years of gibberellin research". Natural Product Reports. 20 (1): 49–69. doi:10.1039/b007744p. PMID 12636083.
- ^ Battersby, Alan (2004). "Lewis N. Mander". Australian Journal of Chemistry. 57 (7): 611–617. doi:10.1071/ch04134.
- ^ "Mander, Lewis Norman (Lew) (1939–)". Encyclopedia of Australian Science. Retrieved 28 February 2018.
- ^ "Information on RACIs Past Award Recipients". RACI. Retrieved 21 January 2019.
- ^ "Flintoff Medal Winners". Royal Society of Chemistry. Retrieved 21 January 2019.
- ^ "View our current Honorary Fellows". Royal Society of New Zealand. Retrieved 21 January 2019.
- ^ "Australia Day Honours 2018: The full list". The Sydney Morning Herald. 26 January 2018. Retrieved 25 January 2018.
- 1939 births
- 2020 deaths
- New Zealand chemists
- Australian chemists
- Organic chemists
- Harvard University people
- New Zealand emigrants to Australia
- Academic staff of the University of Adelaide
- University of Auckland alumni
- University of Sydney alumni
- Fellows of the Australian Academy of Science
- Honorary Fellows of the Royal Society of New Zealand
- New Zealand Fellows of the Royal Society
- University of Michigan fellows
- Companions of the Order of Australia