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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Orphan|date=February 2009}}
{{cs1 config|name-list-style=vanc}}
{{PBB|geneid=988}}
{{Infobox_gene}}
'''CDC5 cell division cycle 5-like (S. pombe)''', also known as '''CDC5L''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDC5L CDC5 cell division cycle 5-like (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=988| accessdate = }}</ref>
'''Cell division cycle 5-like protein''' is a [[protein]] that in humans is encoded by the ''CDC5L'' [[gene]].<ref name="pmid9598309">{{cite journal | vauthors = Groenen PM, Vanderlinden G, Devriendt K, Fryns JP, Van de Ven WJ | title = Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia | journal = Genomics | volume = 49 | issue = 2 | pages = 218–29 | date = Apr 1998 | pmid = 9598309 | doi = 10.1006/geno.1998.5254 }}</ref><ref name="pmid9038199">{{cite journal | vauthors = Bernstein HS, Coughlin SR | title = Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling | journal = The Journal of Biological Chemistry | volume = 272 | issue = 9 | pages = 5833–7 | date = Feb 1997 | pmid = 9038199 | doi = 10.1074/jbc.272.9.5833 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDC5L CDC5 cell division cycle 5-like (S. pombe)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=988}}</ref>


== Function ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->

{{PBB_Summary
The protein encoded by this gene shares a significant similarity with ''[[Schizosaccharomyces pombe]]'' cdc5 gene product, which is a [[cell cycle]] regulator important for [[G2 phase|G<sub>2</sub>]]/[[M phase|M]] transition. This protein has been demonstrated to act as a positive regulator of cell cycle G<sub>2</sub>/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.<ref name="entrez"/>
| section_title =

| summary_text = The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.<ref name="entrez">{{cite web | title = Entrez Gene: CDC5L CDC5 cell division cycle 5-like (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=988| accessdate = }}</ref>
== Interactions ==
}}

CDC5L has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[ASF/SF2]],<ref name = pmid11101529/>
* [[BZW1]],<ref name = pmid11101529/>
* [[CWC15]],<ref name = pmid11101529/>
* [[DNA-PKcs]],<ref name = pmid11101529/>
* [[DYNC1H1]],<ref name = pmid11101529/>
* [[GCN1L1]],<ref name = pmid11101529/>
* [[HSPA8]],<ref name = pmid11101529/>
* [[ILF2]],<ref name = pmid11101529/>
* [[PLRG1]],<ref name = pmid11101529/><ref name = pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | pages = 89 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 | author18 = Bukhman Yury V | author19 = Ethier Martin | author16 = Zhang Shudong | author17 = Ornatsky Olga | author14 = Heilbut Adrian | author15 = Moore Lynda | author34 = Morin Gregg B | author13 = Ho Yuen | author36 = Figeys Daniel | author30 = Muskat Brenda | author31 = Kinach Robert | author33 = Moran Michael F | author32 = Adams Sally-Lin | author29 = Gladwish Katharine | author28 = Colwill Karen | author23 = Lambert Jean-Philippe | author22 = Abu-Farha Mohamed | author21 = Vasilescu Julian | author20 = Sheng Yinglun | author27 = Hogue Kelly | author26 = Kuehl Bonnie | author25 = Stewart Ian I | author24 = Duewel Henry S | author35 = Topaloglou Thodoros | year=2007}}</ref><ref name = pmid14576297>{{cite journal | vauthors = Ajuh P, Lamond AI | title = Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1 | journal = Nucleic Acids Research | volume = 31 | issue = 21 | pages = 6104–16 | date = Nov 2003 | pmid = 14576297 | pmc = 275459 | doi = 10.1093/nar/gkg817}}</ref><ref name = pmid11544257>{{cite journal | vauthors = Ajuh P, Sleeman J, Chusainow J, Lamond AI | title = A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing | journal = The Journal of Biological Chemistry | volume = 276 | issue = 45 | pages = 42370–81 | date = Nov 2001 | pmid = 11544257 | doi = 10.1074/jbc.M105453200 | doi-access = free }}</ref>
* [[PPM1D]],<ref name = pmid11101529/>
* [[PPP1CA]],<ref name = pmid11101529/>
* [[PRPF19]],<ref name = pmid11101529/>
* [[RBMX]]<ref name = pmid11101529/> and
* [[RPL12]],<ref name = pmid11101529/>
* [[RPL13]],<ref name = pmid11101529/>
* [[RPS16]],<ref name = pmid11101529/>
* [[RPS25]],<ref name = pmid11101529/>
* [[SF3A1]],<ref name = pmid11101529/>
* [[SF3B1]],<ref name = pmid11101529/>
* [[SF3B2]],<ref name = pmid11101529/>
* [[SF3B4]],<ref name = pmid11101529/>
* [[SFPQ]],<ref name = pmid11101529/>
* [[SFRS2]],<ref name = pmid11101529/>
* [[SNRPA1]],<ref name = pmid11101529/>
* [[SNRPD3]],<ref name = pmid11101529/>
* [[SRRM1]],<ref name = pmid11101529>{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6569–81 | date = Dec 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}</ref>
* [[Small nuclear ribonucleoprotein D1]],<ref name = pmid11101529/>
* [[Small nuclear ribonucleoprotein D2]],<ref name = pmid11101529/>
* [[Small nuclear ribonucleoprotein polypeptide A]],<ref name = pmid11101529/>
* [[TOP2A]],<ref name = pmid11101529/> and
* [[TTF2]].<ref name = pmid12927788>{{cite journal | vauthors = Leonard D, Ajuh P, Lamond AI, Legerski RJ | title = hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing | journal = Biochemical and Biophysical Research Communications | volume = 308 | issue = 4 | pages = 793–801 | date = Sep 2003 | pmid = 12927788 | doi = 10.1016/s0006-291x(03)01486-4| citeseerx = 10.1.1.539.8359 }}</ref>
{{Div col end}}

==See also==
*[[G2/M checkpoint]]


==References==
==References==
{{reflist}}
{{Reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 }}
*{{cite journal | author=Heaney JP, Jacobson A |title=Simplified control of upper abdominal hemorrhage from the vena cava. |journal=Surgery |volume=78 |issue= 2 |pages= 138–41 |year= 1975 |pmid= 1154257 |doi= }}
*{{cite journal | author=Hirayama T, Shinozaki K |title=A cdc5+ homolog of a higher plant, Arabidopsis thaliana. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 23 |pages= 13371–6 |year= 1996 |pmid= 8917598 |doi=10.1073/pnas.93.23.13371 }}
*{{cite journal | author=Bernstein HS, Coughlin SR |title=Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 5833–7 |year= 1997 |pmid= 9038199 |doi=10.1074/jbc.272.9.5833 }}
*{{cite journal | author=Ishikawa K, Nagase T, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 5 |pages= 307–13 |year= 1998 |pmid= 9455477 |doi=10.1093/dnares/4.5.307 }}
*{{cite journal | author=Bernstein HS, Coughlin SR |title=A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry. |journal=J. Biol. Chem. |volume=273 |issue= 8 |pages= 4666–71 |year= 1998 |pmid= 9468527 |doi=10.1074/jbc.273.8.4666 }}
*{{cite journal | author=Groenen PM, Vanderlinden G, Devriendt K, ''et al.'' |title=Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia. |journal=Genomics |volume=49 |issue= 2 |pages= 218–29 |year= 1998 |pmid= 9598309 |doi= 10.1006/geno.1998.5254 }}
*{{cite journal | author=Ohi R, Feoktistova A, McCann S, ''et al.'' |title=Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes. |journal=Mol. Cell. Biol. |volume=18 |issue= 7 |pages= 4097–108 |year= 1998 |pmid= 9632794 |doi= }}
*{{cite journal | author=Neubauer G, King A, Rappsilber J, ''et al.'' |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
*{{cite journal | author=Burns CG, Ohi R, Krainer AR, Gould KL |title=Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 24 |pages= 13789–94 |year= 2000 |pmid= 10570151 |doi=10.1073/pnas.96.24.13789 }}
*{{cite journal | author=Boudrez A, Beullens M, Groenen P, ''et al.'' |title=NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25411–7 |year= 2000 |pmid= 10827081 |doi= 10.1074/jbc.M001676200 }}
*{{cite journal | author=Lei XH, Shen X, Xu XQ, Bernstein HS |title=Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein. |journal=J. Cell. Sci. |volume=113 Pt 24 |issue= |pages= 4523–31 |year= 2001 |pmid= 11082045 |doi= }}
*{{cite journal | author=Ajuh P, Kuster B, Panov K, ''et al.'' |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. |journal=Embo J. |volume=19 |issue= 23 |pages= 6569–81 |year= 2001 |pmid= 11101529 |doi= 10.1093/emboj/19.23.6569 }}
*{{cite journal | author=Harrington JJ, Sherf B, Rundlett S, ''et al.'' |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 }}
*{{cite journal | author=Ajuh P, Sleeman J, Chusainow J, Lamond AI |title=A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 42370–81 |year= 2001 |pmid= 11544257 |doi= 10.1074/jbc.M105453200 }}
*{{cite journal | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793–801 |year= 2003 |pmid= 12927788 |doi=10.1016/S0006-291X(03)01486-4 }}
*{{cite journal | author=Liu L, Gräub R, Hlaing M, ''et al.'' |title=Distinct domains of human CDC5 direct its nuclear import and association with the spliceosome. |journal=Cell Biochem. Biophys. |volume=39 |issue= 2 |pages= 119–32 |year= 2004 |pmid= 14515018 |doi=10.1385/CBB:39:2:119 }}
}}
{{refend}}


== Further reading ==
{{gene-6-stub}}
{{Refbegin| 2}}
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = Jun 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 | citeseerx = 10.1.1.500.923 }}
* {{cite journal | vauthors = Heaney JP, Jacobson A | title = Simplified control of upper abdominal hemorrhage from the vena cava | journal = Surgery | volume = 78 | issue = 2 | pages = 138–41 | date = Aug 1975 | pmid = 1154257 }}
* {{cite journal | vauthors = Hirayama T, Shinozaki K | title = A cdc5+ homolog of a higher plant, Arabidopsis thaliana | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 23 | pages = 13371–6 | date = Nov 1996 | pmid = 8917598 | pmc = 24100 | doi = 10.1073/pnas.93.23.13371 | doi-access = free }}
* {{cite journal | vauthors = Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 4 | issue = 5 | pages = 307–13 | date = Oct 1997 | pmid = 9455477 | doi = 10.1093/dnares/4.5.307 | doi-access = free }}
* {{cite journal | vauthors = Bernstein HS, Coughlin SR | title = A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry | journal = The Journal of Biological Chemistry | volume = 273 | issue = 8 | pages = 4666–71 | date = Feb 1998 | pmid = 9468527 | doi = 10.1074/jbc.273.8.4666 | doi-access = free }}
* {{cite journal |author6-link=Joseph S. Lipsick | vauthors = Ohi R, Feoktistova A, McCann S, Valentine V, Look AT, Lipsick JS, Gould KL | title = Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes | journal = Molecular and Cellular Biology | volume = 18 | issue = 7 | pages = 4097–108 | date = Jul 1998 | pmid = 9632794 | pmc = 108994 | doi = 10.1128/mcb.18.7.4097}}
* {{cite journal | vauthors = Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M | title = Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex | journal = Nature Genetics | volume = 20 | issue = 1 | pages = 46–50 | date = Sep 1998 | pmid = 9731529 | doi = 10.1038/1700 | s2cid = 585778 }}
* {{cite journal | vauthors = Burns CG, Ohi R, Krainer AR, Gould KL | title = Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 24 | pages = 13789–94 | date = Nov 1999 | pmid = 10570151 | pmc = 24143 | doi = 10.1073/pnas.96.24.13789 | doi-access = free | bibcode = 1999PNAS...9613789B }}
* {{cite journal | vauthors = Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M | title = NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry | journal = The Journal of Biological Chemistry | volume = 275 | issue = 33 | pages = 25411–7 | date = Aug 2000 | pmid = 10827081 | doi = 10.1074/jbc.M001676200 | doi-access = free }}
* {{cite journal | vauthors = Lei XH, Shen X, Xu XQ, Bernstein HS | title = Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein | journal = Journal of Cell Science | volume = 113 | issue = 24| pages = 4523–31 | date = Dec 2000 | pmid = 11082045 | series = 113 | doi = 10.1242/jcs.113.24.4523 }}
* {{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6569–81 | date = Dec 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}
* {{cite journal | vauthors = Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M | title = Creation of genome-wide protein expression libraries using random activation of gene expression | journal = Nature Biotechnology | volume = 19 | issue = 5 | pages = 440–5 | date = May 2001 | pmid = 11329013 | doi = 10.1038/88107 | s2cid = 25064683 }}
* {{cite journal | vauthors = Ajuh P, Sleeman J, Chusainow J, Lamond AI | title = A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing | journal = The Journal of Biological Chemistry | volume = 276 | issue = 45 | pages = 42370–81 | date = Nov 2001 | pmid = 11544257 | doi = 10.1074/jbc.M105453200 | doi-access = free }}
* {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | date = Apr 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
* {{cite journal | vauthors = Leonard D, Ajuh P, Lamond AI, Legerski RJ | title = hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing | journal = Biochemical and Biophysical Research Communications | volume = 308 | issue = 4 | pages = 793–801 | date = Sep 2003 | pmid = 12927788 | doi = 10.1016/S0006-291X(03)01486-4 | citeseerx = 10.1.1.539.8359 }}
* {{cite journal | vauthors = Liu L, Gräub R, Hlaing M, Epting CL, Turck CW, Xu XQ, Zhang L, Bernstein HS | title = Distinct domains of human CDC5 direct its nuclear import and association with the spliceosome | journal = [[Cell Biochemistry and Biophysics]] | volume = 39 | issue = 2 | pages = 119–32 | year = 2004 | pmid = 14515018 | doi = 10.1385/CBB:39:2:119 | s2cid = 22472390 }}
{{Refend}}


==External links==
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
* {{UCSC gene info|CDC5L}}
{{PBB_Controls
{{PDB Gallery|geneid=988}}
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

Revision as of 21:42, 25 March 2024

CDC5L
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDC5L, CDC5, CDC5-LIKE, CEF1, PCDC5RP, dJ319D22.1, cell division cycle 5 like
External IDsOMIM: 602868; MGI: 1918952; HomoloGene: 13291; GeneCards: CDC5L; OMA:CDC5L - orthologs
Orthologs
SpeciesHumanMouse
Entrez

988

71702

Ensembl

ENSG00000096401

ENSMUSG00000023932

UniProt

Q99459

Q6A068

RefSeq (mRNA)

NM_001253

NM_152810

RefSeq (protein)

NP_001244

NP_690023

Location (UCSC)Chr 6: 44.39 – 44.45 MbChr 17: 45.7 – 45.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.[5][6][7]

Function

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.[7]

Interactions

CDC5L has been shown to interact with:

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000096401 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023932 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Groenen PM, Vanderlinden G, Devriendt K, Fryns JP, Van de Ven WJ (Apr 1998). "Rearrangement of the human CDC5L gene by a t(6;19)(p21;q13.1) in a patient with multicystic renal dysplasia". Genomics. 49 (2): 218–29. doi:10.1006/geno.1998.5254. PMID 9598309.
  6. ^ Bernstein HS, Coughlin SR (Feb 1997). "Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling". The Journal of Biological Chemistry. 272 (9): 5833–7. doi:10.1074/jbc.272.9.5833. PMID 9038199.
  7. ^ a b "Entrez Gene: CDC5L CDC5 cell division cycle 5-like (S. pombe)".
  8. ^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
  9. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  10. ^ Ajuh P, Lamond AI (Nov 2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Research. 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC 275459. PMID 14576297.
  11. ^ Ajuh P, Sleeman J, Chusainow J, Lamond AI (Nov 2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". The Journal of Biological Chemistry. 276 (45): 42370–81. doi:10.1074/jbc.M105453200. PMID 11544257.
  12. ^ Leonard D, Ajuh P, Lamond AI, Legerski RJ (Sep 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/s0006-291x(03)01486-4. PMID 12927788.

Further reading

Retrieved from "https://en.wikipedia.org/w/index.php?title=CDC5L&oldid=1215561327"