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{{Short description|Chemical compound}}
{{unreferenced|date=May 2011}}
{{cs1 config|name-list-style=vanc}}
{{Drugbox
{{Drugbox
| IUPAC_name = (8S)-7-[(2S)-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
| IUPAC_name = (8''S'')-7-[(2''S'')-2-<nowiki/>{[(1''S'')-1-Carboxy-3-phenylpropyl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
| image = Spiraprilat.svg
| image = Spiraprilat.svg
| width = 222
| width = 222
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| elimination_half-life =
| elimination_half-life =
| excretion =
| excretion =

<!--Identifiers-->
<!--Identifiers-->
⚫
| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number =
| CAS_number = 83602-05-5
| CAS_supplemental =
| UNII_Ref = {{fdacite|correct|FDA}}
⚫
| UNII = QS56V5Y7EC
| ATCvet =
| ATCvet =
| ATC_prefix = <!-- 'none' if uncategorised -->
| ATC_prefix = <!-- 'none' if uncategorised -->
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| PubChemSubstance =
| PubChemSubstance =
| IUPHAR_ligand = 6576
| IUPHAR_ligand = 6576
| DrugBank =
| DrugBank =
| ChEBI = 141522
⚫
| UNII_Ref = {{fdacite|correct|FDA}}
⚫
| UNII = QS56V5Y7EC
| ChEMBL = 579
| ChEMBL = 579
| synonyms =
| synonyms =
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<!--Chemical data-->
<!--Chemical data-->
| chemical_formula =
| chemical_formula =
| C=20 | H=26 | Ag= | As= | Au= | B= | Bi= | Br= | Cl= | Co= | F= | Fe= | Gd= | I= | K= | Mn=
| C=20 | H=26 | N=2 | O=5 | S=2
| N=2 | Na=
| O=5 | P= | Pt=
| S=2 | Se= | Sr= | Tc=| charge =
| molecular_weight = 438.6 g/mol
| SMILES = C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2CC3(C[C@H]2C(=O)O)SCCS3
| SMILES = C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2CC3(C[C@H]2C(=O)O)SCCS3
| StdInChI =1S/C20H26N2O5S2/c1-13(21-15(18(24)25)8-7-14-5-3-2-4-6-14)17(23)22-12-20(28-9-10-29-20)11-16(22)19(26)27/h2-6,13,15-16,21H,7-12H2,1H3,(H,24,25)(H,26,27)/t13-,15-,16-/m0/s1
| StdInChI =1S/C20H26N2O5S2/c1-13(21-15(18(24)25)8-7-14-5-3-2-4-6-14)17(23)22-12-20(28-9-10-29-20)11-16(22)19(26)27/h2-6,13,15-16,21H,7-12H2,1H3,(H,24,25)(H,26,27)/t13-,15-,16-/m0/s1
| StdInChIKey = FMMDBLMCSDRUPA-BPUTZDHNSA-N
| StdInChIKey = FMMDBLMCSDRUPA-BPUTZDHNSA-N
| InChI = 1/C20H26N2O5S2/c1-13(21-15(18(24)25)8-7-14-5-3-2-4-6-14)17(23)22-12-20(28-9-10-29-20)11-16(22)19(26)27/h2-6,13,15-16,21H,7-12H2,1H3,(H,24,25)(H,26,27)/t13-,15-,16-/m0/s1
| InChIKey = FMMDBLMCSDRUPA-BPUTZDHNBY
| density =
| density =
| melting_point =
| melting_point =
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}}
}}


'''Spiraprilat''' is the [[active metabolite]] of [[spirapril]].<ref>{{cite journal | vauthors = Noble S, Sorkin EM | title = Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension | journal = Drugs | volume = 49 | issue = 5 | pages = 750–66 | date = May 1995 | pmid = 7601014 | doi = 10.2165/00003495-199549050-00008 | s2cid = 195691037 }}</ref>
'''Spiraprilat''' is the [[active metabolite]] of [[Spirapril]].

==References==
{{Reflist}}

==External links==
*{{Commonscatinline}}

{{Angiotensin receptor modulators}}


[[Category:ACE inhibitors]]
[[Category:ACE inhibitors]]
[[Category:Human drug metabolites]]
[[Category:1,3-Dithiolanes]]




Latest revision as of 09:31, 9 May 2024

Spiraprilat
Identifiers
  • (8S)-7-[(2S)-2-{[(1S)-1-Carboxy-3-phenylpropyl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H26N2O5S2
Molar mass438.56 g·mol−1
3D model (JSmol)
  • C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2CC3(C[C@H]2C(=O)O)SCCS3
  • InChI=1S/C20H26N2O5S2/c1-13(21-15(18(24)25)8-7-14-5-3-2-4-6-14)17(23)22-12-20(28-9-10-29-20)11-16(22)19(26)27/h2-6,13,15-16,21H,7-12H2,1H3,(H,24,25)(H,26,27)/t13-,15-,16-/m0/s1
  • Key:FMMDBLMCSDRUPA-BPUTZDHNSA-N

Spiraprilat is the active metabolite of spirapril.[1]

References

[edit]
  1. ^ Noble S, Sorkin EM (May 1995). "Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension". Drugs. 49 (5): 750–66. doi:10.2165/00003495-199549050-00008. PMID 7601014. S2CID 195691037.
[edit]


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