Sebaceoma: Difference between revisions
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{{Infobox medical condition (new) |
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| ⚫ | '''Sebaceoma''' |
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| synonym = Sebaceous epithelioma |
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| image = Sebaceoma.jpg |
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Sebaceoma. From the skin near the armpit. 80 year old man. |
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| specialty = [[Dermatology]] |
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| ⚫ | '''Sebaceoma''', also known as a '''sebaceous epithelioma''', is a cutaneous condition that appears as a yellow or orange [[papule]].<ref name="Andrews">{{cite book |author1=James, William D. |author2=Berger, Timothy G. |title=Andrews' Diseases of the Skin: Clinical Dermatology |publisher=Saunders Elsevier |year=2006 |isbn=0-7216-2921-0 |display-authors=etal}}</ref>{{rp|662}} |
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== Signs and symptoms == |
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Sebaceoma is a smooth-bordered, plump, well-circumscribed benign tumor that may expand into the subcutis, middle dermis, and deep dermis. Lesions range in size from tiny lesions to 20 mm. Clinically, the tumor appears as a single flesh-colored or [[Erythema|erythematous]] [[Nodule (medicine)|nodule]] or plaque in the head and neck region. It is seldom seen in other body locations. It can also occasionally become crusted or erosive.<ref name="Sebaceous Neoplasms">{{cite journal | last=Flux | first=Katharina | title=Sebaceous Neoplasms | journal=Surgical Pathology Clinics | publisher=Elsevier BV | volume=10 | issue=2 | year=2017 | issn=1875-9181 | doi=10.1016/j.path.2017.01.009 | pages=367–382| pmid=28477886 }}</ref> |
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== Causes == |
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Sebaceoma is associated with [[Muir-Torre syndrome]].<ref name="n110">{{cite journal | last1=Roberts | first1=Maegan E. | last2=Riegert-Johnson | first2=Douglas L. | last3=Thomas | first3=Brittany C. | last4=Thomas | first4=Colleen S. | last5=Heckman | first5=Michael G | last6=Krishna | first6=Murli | last7=DiCaudo | first7=David J. | last8=Bridges | first8=Alina G | last9=Hunt | first9=Katherine S. | last10=Rumilla | first10=Kandelaria M. | last11=Cappel | first11=Mark A | title=Screening for Muir-Torre Syndrome Using Mismatch Repair Protein Immunohistochemistry of Sebaceous Neoplasms | journal=Journal of Genetic Counseling | publisher=Wiley | volume=22 | issue=3 | date=2012-12-06 | issn=1059-7700 | doi=10.1007/s10897-012-9552-4 | pages=393–405| pmid=23212176 }}</ref> |
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== Diagnosis == |
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Strict histologic criteria, extensive tissue sample, and wide excision [[biopsy]] should all be fulfilled before a diagnosis of sebaceoma is made.<ref name="eyelid">{{cite journal | last1=Mittal | first1=Ruchi | last2=Tripathy | first2=Devjyoti | title=Sebaceoma of the eyelid: a rare entity | journal=Canadian Journal of Ophthalmology | publisher=Elsevier BV | volume=49 | issue=3 | year=2014 | issn=0008-4182 | doi=10.1016/j.jcjo.2014.03.014 | pages=e78–e80| pmid=24862791 }}</ref> |
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Sebaceomas are tumors of the skin according to histopathology, however they usually raise the epidermis. The individual lobules, which are made up of mature sebaceous cells and basaloid cells, are divided by dense [[eosinophilic]] [[connective tissue]]. There is stromal-tumor clefting, no peripheral palisading, and no organized lobular architecture. There may be visible little nucleoli, but there is no nuclear pleomorphism. There are either very few or no mitoses. Duct development is frequent, and sebaceous debris-filled cysts with an eosinophilic cuticle are occasionally observed. In the basaloid section, there is no tumor necrosis.<ref name="s379">{{cite journal | last1=Sidhu | first1=Harleen K. | last2=Patel | first2=Rita V. | last3=Goldenberg | first3=Gary | title=Dermatology Clinics | journal=Dermatologic Clinics | publisher=Elsevier BV | volume=30 | issue=4 | year=2012 | issn=0733-8635 | doi=10.1016/j.det.2012.06.009 | pages=623–641| pmid=23021050 }}</ref> |
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== See also == |
== See also == |
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* [[Sebaceous carcinoma]] |
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* [[Sebaceous adenoma]] |
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* [[Skin lesion]] |
* [[Skin lesion]] |
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{{reflist}} |
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== Further reading == |
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{{Dermatology-stub}} |
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* {{cite journal | last1=Bourlond | first1=F. | last2=Velter | first2=C. | last3=Cribier | first3=B. | title=Clinicopathological study of 47 cases of sebaceoma | journal=Annales de Dermatologie et de Vénéréologie | publisher=Elsevier BV | volume=143 | issue=12 | year=2016 | issn=0151-9638 | doi=10.1016/j.annder.2016.06.013 | pages=814–824 | pmid=27836252 | ref=none}} |
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* {{cite journal | last1=Yonekawa | first1=Yoshihiro | last2=Jakobiec | first2=Frederick A. | last3=Zakka | first3=Fouad R. | last4=Fay | first4=Aaron | title=Sebaceoma of the Eyelid | journal=Ophthalmology | publisher=Elsevier BV | volume=119 | issue=12 | year=2012 | issn=0161-6420 | doi=10.1016/j.ophtha.2012.07.054 | pages=2645–2645.e4 | pmid=23207023 | ref=none}} |
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== External links == |
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* [https://dermnetnz.org/topics/sebaceoma-pathology DermNet] |
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* [https://www.pathologyoutlines.com/topic/skintumornonmelanocyticsebaceoma.html Pathology Outlines] |
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{{Medical resources |
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| ICD11 = {{ICD11|XH0QL4}} |
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| ICD10 = {{ICD10|D23.9}} |
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| SNOMED CT = 403933005 |
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{{Tumors of skin appendages}} |
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Latest revision as of 02:24, 12 June 2024
| Sebaceoma | |
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| Other names | Sebaceous epithelioma |
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| Sebaceoma. From the skin near the armpit. 80 year old man. | |
| Specialty | Dermatology |
Sebaceoma, also known as a sebaceous epithelioma, is a cutaneous condition that appears as a yellow or orange papule.[1]: 662
Signs and symptoms
[edit]Sebaceoma is a smooth-bordered, plump, well-circumscribed benign tumor that may expand into the subcutis, middle dermis, and deep dermis. Lesions range in size from tiny lesions to 20 mm. Clinically, the tumor appears as a single flesh-colored or erythematous nodule or plaque in the head and neck region. It is seldom seen in other body locations. It can also occasionally become crusted or erosive.[2]
Causes
[edit]Sebaceoma is associated with Muir-Torre syndrome.[3]
Diagnosis
[edit]Strict histologic criteria, extensive tissue sample, and wide excision biopsy should all be fulfilled before a diagnosis of sebaceoma is made.[4]
Sebaceomas are tumors of the skin according to histopathology, however they usually raise the epidermis. The individual lobules, which are made up of mature sebaceous cells and basaloid cells, are divided by dense eosinophilic connective tissue. There is stromal-tumor clefting, no peripheral palisading, and no organized lobular architecture. There may be visible little nucleoli, but there is no nuclear pleomorphism. There are either very few or no mitoses. Duct development is frequent, and sebaceous debris-filled cysts with an eosinophilic cuticle are occasionally observed. In the basaloid section, there is no tumor necrosis.[5]
See also
[edit]References
[edit]- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ Flux, Katharina (2017). "Sebaceous Neoplasms". Surgical Pathology Clinics. 10 (2). Elsevier BV: 367–382. doi:10.1016/j.path.2017.01.009. ISSN 1875-9181. PMID 28477886.
- ^ Roberts, Maegan E.; Riegert-Johnson, Douglas L.; Thomas, Brittany C.; Thomas, Colleen S.; Heckman, Michael G; Krishna, Murli; DiCaudo, David J.; Bridges, Alina G; Hunt, Katherine S.; Rumilla, Kandelaria M.; Cappel, Mark A (2012-12-06). "Screening for Muir-Torre Syndrome Using Mismatch Repair Protein Immunohistochemistry of Sebaceous Neoplasms". Journal of Genetic Counseling. 22 (3). Wiley: 393–405. doi:10.1007/s10897-012-9552-4. ISSN 1059-7700. PMID 23212176.
- ^ Mittal, Ruchi; Tripathy, Devjyoti (2014). "Sebaceoma of the eyelid: a rare entity". Canadian Journal of Ophthalmology. 49 (3). Elsevier BV: e78–e80. doi:10.1016/j.jcjo.2014.03.014. ISSN 0008-4182. PMID 24862791.
- ^ Sidhu, Harleen K.; Patel, Rita V.; Goldenberg, Gary (2012). "Dermatology Clinics". Dermatologic Clinics. 30 (4). Elsevier BV: 623–641. doi:10.1016/j.det.2012.06.009. ISSN 0733-8635. PMID 23021050.
Further reading
[edit]- Bourlond, F.; Velter, C.; Cribier, B. (2016). "Clinicopathological study of 47 cases of sebaceoma". Annales de Dermatologie et de Vénéréologie. 143 (12). Elsevier BV: 814–824. doi:10.1016/j.annder.2016.06.013. ISSN 0151-9638. PMID 27836252.
- Yonekawa, Yoshihiro; Jakobiec, Frederick A.; Zakka, Fouad R.; Fay, Aaron (2012). "Sebaceoma of the Eyelid". Ophthalmology. 119 (12). Elsevier BV: 2645–2645.e4. doi:10.1016/j.ophtha.2012.07.054. ISSN 0161-6420. PMID 23207023.