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'''Elephantiasis''' is the enlargement and hardening of limbs or body parts due to tissue swelling.<ref name=":0">{{Cite web|url=https://www.merriam-webster.com/dictionary/elephantiasis|title=Definition of ELEPHANTIASIS|website=www.merriam-webster.com|language=en|access-date=2018-06-28}}</ref><ref name=":1">{{Citation|title=elephantiasis|url=https://medical-dictionary.thefreedictionary.com/elephantiasis|work=The Free Dictionary|access-date=2018-06-28}}</ref> It is characterised by [[edema]], hypertrophy, and fibrosis of skin and subcutaneous tissues, due to obstruction of lymphatic vessels.<ref name=":1" /> It may affect the genitalia.<ref name=":1" /> The term elephantiasis is often used in reference to (symptoms caused by) parasitic worm infections,<ref name=":0" /><ref name=":1" /> but may refer to a variety of diseases where parts of a person's body swell to massive proportions.<ref name=":1" />
'''Elephantiasis''', often incorrectly called '''elephantitis''', is the enlargement and hardening of limbs or body parts due to tissue swelling.<ref name=":0">{{Cite web|url=https://www.merriam-webster.com/dictionary/elephantiasis|title=Definition of ELEPHANTIASIS|website=www.merriam-webster.com|language=en|access-date=2018-06-28}}</ref><ref name=":1">{{Citation|title=elephantiasis|url=https://medical-dictionary.thefreedictionary.com/elephantiasis|work=The Free Dictionary|access-date=2018-06-28}}</ref> It is characterised by [[edema]], hypertrophy, and fibrosis of skin and subcutaneous tissues, due to obstruction of lymphatic vessels.<ref name=":1" /> It may affect the genitalia.<ref name=":1" /> The term elephantiasis is often used in reference to (symptoms caused by) parasitic worm infections,<ref name=":0" /><ref name=":1" /> but may refer to a variety of diseases that swell parts of the subject's body to exceptionally massive proportions.<ref name=":1" />
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Some conditions that present with elephantiasis include:
Some conditions that present with elephantiasis include:
* [[Elephantiasis nostras]], due to longstanding chronic lymphangitis{{Citation needed|date=June 2018}}
* [[Elephantiasis nostras]], due to longstanding chronic lymphangitis{{Citation needed|date=June 2018}}
* [[Elephantiasis tropica]] (known as lymphatic filariasis), caused by a number of parasitic worms, particularly ''[[Wuchereria bancrofti]]''. More than 120 million people, mostly in Africa and Southeast Asia, are affected.<ref>{{cite web|last1=Carlson|first1=Emily|title=Taking the 'Bite' Out of Vector-Borne Diseases - Inside Life Science Series - National Institute of General Medical Sciences|url=https://publications.nigms.nih.gov/insidelifescience/vector-borne-diseases.html |publisher=publications.nigms.nih.gov|access-date=29 November 2016|date=27 March 2013}}</ref>
* [[Elephantiasis tropica]] (known as lymphatic filariasis), caused by a number of parasitic worms, particularly ''[[Wuchereria bancrofti]]''. More than 120 million people, mostly in Africa and Southeast Asia, are affected.<ref>{{cite web|last1=Carlson|first1=Emily|title=Taking the 'Bite' Out of Vector-Borne Diseases - Inside Life Science Series - National Institute of General Medical Sciences|url=https://publications.nigms.nih.gov/insidelifescience/vector-borne-diseases.html|publisher=publications.nigms.nih.gov|access-date=29 November 2016|date=27 March 2013|archive-date=28 July 2018|archive-url=https://web.archive.org/web/20180728010133/https://publications.nigms.nih.gov/insidelifescience/vector-borne-diseases.html|url-status=dead}}</ref>
* [[Nonfilarial elephantiasis]] (or podoconiosis), an immune disease affecting the lymph vessels{{Citation needed|date=June 2018}}
* [[Nonfilarial elephantiasis]] (or podoconiosis), an immune disease affecting the lymph vessels{{Citation needed|date=June 2018}}
* [[Leishmaniasis]]<ref name=":1" />
* [[Leishmaniasis]]<ref name=":1" />
* Elephantiasis, Grade 3 [[lymphedema]] which may occur in people with [[breast cancer]]<ref>{{cite web|title=Lymphedema|url=https://www.cancer.gov/about-cancer/treatment/side-effects/lymphedema/lymphedema-pdq |publisher=National Cancer Institute|access-date=29 November 2016|date=29 May 2015}}</ref>
* Elephantiasis, Grade 3 [[lymphedema]] which may occur in people with [[breast cancer]]<ref>{{cite web|title=Lymphedema|url=https://www.cancer.gov/about-cancer/treatment/side-effects/lymphedema/lymphedema-pdq |publisher=National Cancer Institute|access-date=29 November 2016|date=29 May 2015}}</ref>
* Genital elephantiasis, end result of [[lymphogranuloma venereum]]{{Citation needed|date=June 2018}}
* Genital elephantiasis, result of [[lymphogranuloma venereum]]{{Citation needed|date=June 2018}}
* [[Proteus syndrome]], a genetic disorder best known as the condition possibly suffered by [[Joseph Merrick]], the so-called "Elephant Man."{{Citation needed|date=June 2018}}
* [[Proteus syndrome]], a genetic disorder best known as the condition possibly experienced by [[Joseph Merrick]], the so-called "Elephant Man"{{Citation needed|date=June 2018}}


Other causes may include:
Other causes may include:
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* Hereditary birth defects<ref name=":1" />
* Hereditary birth defects<ref name=":1" />
* [[Pretibial myxedema]]
* [[Pretibial myxedema]]

Other diseases, such as the rare [[Klippel–Trénaunay syndrome]], can initially be misdiagnosed as elephantiasis.


==References==
==References==
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== External links ==
== External links ==
* {{cite EB9 |wstitle = Elephantiasis |volume= VIII | page=126 |short=1 }}
* {{cite web |title=Lymphatic filariasis |url=https://www.who.int/news-room/fact-sheets/detail/lymphatic-filariasis |website=World Health Organization |access-date=1 June 2018}}

{{set index article}}
{{Medical resources
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* {{cite web |title=Lymphatic filariasis |url=https://www.who.int/news-room/fact-sheets/detail/lymphatic-filariasis |website=World Health Organization |access-date=1 June 2018}}
{{set index}}


[[Category:Symptoms and signs: Skin and subcutaneous tissue]]
[[Category:Symptoms and signs: Skin and subcutaneous tissue]]

Revision as of 07:54, 21 July 2024

Elephantiasis
Elephantiasis of the legs due to filariasis.
SpecialtyInfectious disease, general surgery
SymptomsSwelling of the skin

Elephantiasis, often incorrectly called elephantitis, is the enlargement and hardening of limbs or body parts due to tissue swelling.[1][2] It is characterised by edema, hypertrophy, and fibrosis of skin and subcutaneous tissues, due to obstruction of lymphatic vessels.[2] It may affect the genitalia.[2] The term elephantiasis is often used in reference to (symptoms caused by) parasitic worm infections,[1][2] but may refer to a variety of diseases that swell parts of the subject's body to exceptionally massive proportions.[2]

Cause

Some conditions that present with elephantiasis include:

Other causes may include:

Other diseases, such as the rare Klippel–Trénaunay syndrome, can initially be misdiagnosed as elephantiasis.

References

  1. ^ a b "Definition of ELEPHANTIASIS". www.merriam-webster.com. Retrieved 2018-06-28.
  2. ^ a b c d e f g h i "elephantiasis", The Free Dictionary, retrieved 2018-06-28
  3. ^ Carlson, Emily (27 March 2013). "Taking the 'Bite' Out of Vector-Borne Diseases - Inside Life Science Series - National Institute of General Medical Sciences". publications.nigms.nih.gov. Archived from the original on 28 July 2018. Retrieved 29 November 2016.
  4. ^ "Lymphedema". National Cancer Institute. 29 May 2015. Retrieved 29 November 2016.