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The '''thyrotropin receptor''' (or '''TSH receptor''') is a receptor (and associated protein) that responds to [[thyroid-stimulating hormone]] (also known as "thyrotropin") and stimulates the production of [[thyroxine]] (T4) and [[triiodothyronine]] (T3). The TSH receptor is a member of the [[G protein-coupled receptor]] superfamily of [[integral membrane protein]]s<ref name="pmid15231707">{{cite journal | vauthors = Farid NR, Szkudlinski MW | title = Minireview: structural and functional evolution of the thyrotropin receptor | journal = Endocrinology | volume = 145 | issue = 9 | pages = 4048–57 | date = Sep 2004 | pmid = 15231707 | doi = 10.1210/en.2004-0437 | doi-access = free }}</ref> and is coupled to the [[Gs alpha subunit|G<sub>s</sub>]] protein.<ref name="pmid20378719">{{cite journal | vauthors = Calebiro D, Nikolaev VO, Lohse MJ | title = Imaging of persistent cAMP signaling by internalized G protein-coupled receptors | journal = Journal of Molecular Endocrinology | volume = 45 | issue = 1 | pages = 1–8 | date = Jul 2010 | pmid = 20378719 | doi = 10.1677/JME-10-0014 | doi-access = free }}</ref> |
The '''thyrotropin receptor''' (or '''TSH receptor''') is a receptor (and associated protein) that responds to [[thyroid-stimulating hormone]] (also known as "thyrotropin") and stimulates the production of [[thyroxine]] (T4) and [[triiodothyronine]] (T3). The TSH receptor is a member of the [[G protein-coupled receptor]] superfamily of [[integral membrane protein]]s<ref name="pmid15231707">{{cite journal | vauthors = Farid NR, Szkudlinski MW | title = Minireview: structural and functional evolution of the thyrotropin receptor | journal = Endocrinology | volume = 145 | issue = 9 | pages = 4048–57 | date = Sep 2004 | pmid = 15231707 | doi = 10.1210/en.2004-0437 | doi-access = free }}</ref> and is coupled to the [[Gs alpha subunit|G<sub>s</sub>]] protein.<ref name="pmid20378719">{{cite journal | vauthors = Calebiro D, Nikolaev VO, Lohse MJ | title = Imaging of persistent cAMP signaling by internalized G protein-coupled receptors | journal = Journal of Molecular Endocrinology | volume = 45 | issue = 1 | pages = 1–8 | date = Jul 2010 | pmid = 20378719 | doi = 10.1677/JME-10-0014 | doi-access = free }}</ref> |
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It is primarily found on the surface of the [[thyroid epithelial cell]]s, but also found on adipose tissue and fibroblasts. The latter explains the reason of the myxedema finding during Graves disease. In addition, it has also been found to be expressed in the anterior pituitary gland, hypothalamus and kidneys. Its presence in the anterior pituitary gland may be involved in mediating the paracrine signaling feedback inhibition of thyrotropin along the hypothalamus-pituitary-thyroid axis.<ref>{{Cite journal|last=Williams|first=G. R.|date=2011-04-01|title=Extrathyroidal expression of TSH receptor|url=http://www.sciencedirect.com/science/article/pii/S0003426611000333|journal=Annales d'Endocrinologie|series=54es Journees internationales d'Endocrinologie clinique|language=en|volume=72|issue=2|pages=68–73|doi=10.1016/j.ando.2011.03.006|issn=0003-4266}}</ref> |
It is primarily found on the surface of the [[thyroid epithelial cell]]s, but also found on adipose tissue and fibroblasts. The latter explains the reason of the myxedema finding during Graves disease. In addition, it has also been found to be expressed in the anterior pituitary gland, hypothalamus and kidneys. Its presence in the anterior pituitary gland may be involved in mediating the paracrine signaling feedback inhibition of thyrotropin along the hypothalamus-pituitary-thyroid axis.<ref>{{Cite journal|last=Williams|first=G. R.|date=2011-04-01|title=Extrathyroidal expression of TSH receptor|url=http://www.sciencedirect.com/science/article/pii/S0003426611000333|journal=Annales d'Endocrinologie|series=54es Journees internationales d'Endocrinologie clinique|language=en|volume=72|issue=2|pages=68–73|doi=10.1016/j.ando.2011.03.006|pmid=21511243|issn=0003-4266}}</ref> |
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== Function == |
== Function == |
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* {{cite journal | vauthors = Führer D, Wonerow P, Willgerodt H, Paschke R | title = Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 82 | issue = 12 | pages = 4234–8 | date = Dec 1997 | pmid = 9398746 | doi = 10.1210/jc.82.12.4234 }} |
* {{cite journal | vauthors = Führer D, Wonerow P, Willgerodt H, Paschke R | title = Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 82 | issue = 12 | pages = 4234–8 | date = Dec 1997 | pmid = 9398746 | doi = 10.1210/jc.82.12.4234 }} |
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* {{cite journal | vauthors = Farid NR, Kascur V, Balazs C | title = The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations | journal = European Journal of Endocrinology| volume = 143 | issue = 1 | pages = 25–30 | date = Jul 2000 | pmid = 10870027 | doi = 10.1530/eje.0.1430025 | doi-access = free }} |
* {{cite journal | vauthors = Farid NR, Kascur V, Balazs C | title = The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations | journal = European Journal of Endocrinology| volume = 143 | issue = 1 | pages = 25–30 | date = Jul 2000 | pmid = 10870027 | doi = 10.1530/eje.0.1430025 | doi-access = free }} |
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* {{cite journal | vauthors = Szkudlinski MW, Fremont V, Ronin C, Weintraub BD | title = Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships | journal = Physiological Reviews | volume = 82 | issue = 2 | pages = 473–502 | date = Apr 2002 | pmid = 11917095 | doi = 10.1152/physrev.00031.2001 | url = https://semanticscholar.org/paper/14a5636e2788d63866670400d20a03ffb2bcb167 }} |
* {{cite journal | vauthors = Szkudlinski MW, Fremont V, Ronin C, Weintraub BD | title = Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships | journal = Physiological Reviews | volume = 82 | issue = 2 | pages = 473–502 | date = Apr 2002 | pmid = 11917095 | doi = 10.1152/physrev.00031.2001 | s2cid = 2919509 | url = https://semanticscholar.org/paper/14a5636e2788d63866670400d20a03ffb2bcb167 }} |
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* {{cite journal | vauthors = Tonacchera M, Vitti P, De Servi M, Agretti P, De Marco G, Chiovato L, Pinchera A | title = Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis | journal = [[Journal of Endocrinological Investigation]] | volume = 26 | issue = 2 Suppl | pages = 2–6 | year = 2004 | pmid = 12762632 }} |
* {{cite journal | vauthors = Tonacchera M, Vitti P, De Servi M, Agretti P, De Marco G, Chiovato L, Pinchera A | title = Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis | journal = [[Journal of Endocrinological Investigation]] | volume = 26 | issue = 2 Suppl | pages = 2–6 | year = 2004 | pmid = 12762632 }} |
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* {{cite journal | vauthors = Arturi F, Scarpelli D, Coco A, Sacco R, Bruno R, Filetti S, Russo D | title = Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions | journal = Thyroid | volume = 13 | issue = 4 | pages = 341–3 | date = Apr 2003 | pmid = 12804102 | doi = 10.1089/105072503321669811 }} |
* {{cite journal | vauthors = Arturi F, Scarpelli D, Coco A, Sacco R, Bruno R, Filetti S, Russo D | title = Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions | journal = Thyroid | volume = 13 | issue = 4 | pages = 341–3 | date = Apr 2003 | pmid = 12804102 | doi = 10.1089/105072503321669811 }} |
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| Line 25: | Line 25: | ||
* {{cite journal | vauthors = Graves PN, Tomer Y, Davies TF | title = Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain | journal = Biochemical and Biophysical Research Communications | volume = 187 | issue = 2 | pages = 1135–43 | date = Sep 1992 | pmid = 1530609 | doi = 10.1016/0006-291X(92)91315-H }} |
* {{cite journal | vauthors = Graves PN, Tomer Y, Davies TF | title = Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain | journal = Biochemical and Biophysical Research Communications | volume = 187 | issue = 2 | pages = 1135–43 | date = Sep 1992 | pmid = 1530609 | doi = 10.1016/0006-291X(92)91315-H }} |
||
* {{cite journal | vauthors = Loosfelt H, Pichon C, Jolivet A, Misrahi M, Caillou B, Jamous M, Vannier B, Milgrom E | title = Two-subunit structure of the human thyrotropin receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 9 | pages = 3765–9 | date = May 1992 | pmid = 1570295 | pmc = 525571 | doi = 10.1073/pnas.89.9.3765 }} |
* {{cite journal | vauthors = Loosfelt H, Pichon C, Jolivet A, Misrahi M, Caillou B, Jamous M, Vannier B, Milgrom E | title = Two-subunit structure of the human thyrotropin receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 9 | pages = 3765–9 | date = May 1992 | pmid = 1570295 | pmc = 525571 | doi = 10.1073/pnas.89.9.3765 }} |
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* {{cite journal | vauthors = Nagayama Y, Russo D, Wadsworth HL, Chazenbalk GD, Rapoport B | title = Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding | journal = The Journal of Biological Chemistry | volume = 266 | issue = 23 | pages = 14926–30 | date = Aug 1991 | pmid = 1651314 }} |
* {{cite journal | vauthors = Nagayama Y, Russo D, Wadsworth HL, Chazenbalk GD, Rapoport B | title = Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding | journal = The Journal of Biological Chemistry | volume = 266 | issue = 23 | pages = 14926–30 | date = Aug 1991 | doi = 10.1016/S0021-9258(18)98566-2 | pmid = 1651314 }} |
||
* {{cite journal | vauthors = Murakami M, Mori M | title = Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease | journal = Biochemical and Biophysical Research Communications | volume = 171 | issue = 1 | pages = 512–8 | date = Aug 1990 | pmid = 1697467 | doi = 10.1016/0006-291X(90)91423-P }} |
* {{cite journal | vauthors = Murakami M, Mori M | title = Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease | journal = Biochemical and Biophysical Research Communications | volume = 171 | issue = 1 | pages = 512–8 | date = Aug 1990 | pmid = 1697467 | doi = 10.1016/0006-291X(90)91423-P }} |
||
* {{cite journal | vauthors = Heldin NE, Gustavsson B, Westermark K, Westermark B | title = A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 73 | issue = 6 | pages = 1374–6 | date = Dec 1991 | pmid = 1955520 | doi = 10.1210/jcem-73-6-1374 }} |
* {{cite journal | vauthors = Heldin NE, Gustavsson B, Westermark K, Westermark B | title = A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 73 | issue = 6 | pages = 1374–6 | date = Dec 1991 | pmid = 1955520 | doi = 10.1210/jcem-73-6-1374 }} |
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Revision as of 05:02, 1 June 2021
The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin") and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins[5] and is coupled to the Gs protein.[6]
It is primarily found on the surface of the thyroid epithelial cells, but also found on adipose tissue and fibroblasts. The latter explains the reason of the myxedema finding during Graves disease. In addition, it has also been found to be expressed in the anterior pituitary gland, hypothalamus and kidneys. Its presence in the anterior pituitary gland may be involved in mediating the paracrine signaling feedback inhibition of thyrotropin along the hypothalamus-pituitary-thyroid axis.[7]
Function
Upon binding circulating TSH, a G-protein signal cascade activates adenylyl cyclase and intracellular levels of cAMP rise. cAMP activates all functional aspects of the thyroid cell, including iodine pumping; thyroglobulin synthesis, iodination, endocytosis, and proteolysis; thyroid peroxidase activity; and hormone release.
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000165409 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020963 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Farid NR, Szkudlinski MW (Sep 2004). "Minireview: structural and functional evolution of the thyrotropin receptor". Endocrinology. 145 (9): 4048–57. doi:10.1210/en.2004-0437. PMID 15231707.
- ^ Calebiro D, Nikolaev VO, Lohse MJ (Jul 2010). "Imaging of persistent cAMP signaling by internalized G protein-coupled receptors". Journal of Molecular Endocrinology. 45 (1): 1–8. doi:10.1677/JME-10-0014. PMID 20378719.
- ^ Williams, G. R. (2011-04-01). "Extrathyroidal expression of TSH receptor". Annales d'Endocrinologie. 54es Journees internationales d'Endocrinologie clinique. 72 (2): 68–73. doi:10.1016/j.ando.2011.03.006. ISSN 0003-4266. PMID 21511243.
Further reading
- Führer D, Wonerow P, Willgerodt H, Paschke R (Dec 1997). "Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism". The Journal of Clinical Endocrinology and Metabolism. 82 (12): 4234–8. doi:10.1210/jc.82.12.4234. PMID 9398746.
- Farid NR, Kascur V, Balazs C (Jul 2000). "The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations". European Journal of Endocrinology. 143 (1): 25–30. doi:10.1530/eje.0.1430025. PMID 10870027.
- Szkudlinski MW, Fremont V, Ronin C, Weintraub BD (Apr 2002). "Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships". Physiological Reviews. 82 (2): 473–502. doi:10.1152/physrev.00031.2001. PMID 11917095. S2CID 2919509.
- Tonacchera M, Vitti P, De Servi M, Agretti P, De Marco G, Chiovato L, Pinchera A (2004). "Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis". Journal of Endocrinological Investigation. 26 (2 Suppl): 2–6. PMID 12762632.
- Arturi F, Scarpelli D, Coco A, Sacco R, Bruno R, Filetti S, Russo D (Apr 2003). "Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions". Thyroid. 13 (4): 341–3. doi:10.1089/105072503321669811. PMID 12804102.
- Vaidya B, Campbell V, Tripp JH, Spyer G, Hattersley AT, Ellard S (Jun 2004). "Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation". Clinical Endocrinology. 60 (6): 711–8. doi:10.1111/j.1365-2265.2004.02040.x. PMID 15163335.
- Takeshita A, Nagayama Y, Fujiyama K, Yokoyama N, Namba H, Yamashita S, Izumi M, Nagataki S (Nov 1992). "Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript". Biochemical and Biophysical Research Communications. 188 (3): 1214–9. doi:10.1016/0006-291X(92)91360-3. PMID 1445355.
- Graves PN, Tomer Y, Davies TF (Sep 1992). "Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain". Biochemical and Biophysical Research Communications. 187 (2): 1135–43. doi:10.1016/0006-291X(92)91315-H. PMID 1530609.
- Loosfelt H, Pichon C, Jolivet A, Misrahi M, Caillou B, Jamous M, Vannier B, Milgrom E (May 1992). "Two-subunit structure of the human thyrotropin receptor". Proceedings of the National Academy of Sciences of the United States of America. 89 (9): 3765–9. doi:10.1073/pnas.89.9.3765. PMC 525571. PMID 1570295.
- Nagayama Y, Russo D, Wadsworth HL, Chazenbalk GD, Rapoport B (Aug 1991). "Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding". The Journal of Biological Chemistry. 266 (23): 14926–30. doi:10.1016/S0021-9258(18)98566-2. PMID 1651314.
- Murakami M, Mori M (Aug 1990). "Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease". Biochemical and Biophysical Research Communications. 171 (1): 512–8. doi:10.1016/0006-291X(90)91423-P. PMID 1697467.
- Heldin NE, Gustavsson B, Westermark K, Westermark B (Dec 1991). "A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism". The Journal of Clinical Endocrinology and Metabolism. 73 (6): 1374–6. doi:10.1210/jcem-73-6-1374. PMID 1955520.
- Libert F, Passage E, Lefort A, Vassart G, Mattei MG (1991). "Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization". Cytogenetics and Cell Genetics. 54 (1–2): 82–3. doi:10.1159/000132964. PMID 2249482.
- Frazier AL, Robbins LS, Stork PJ, Sprengel R, Segaloff DL, Cone RD (Aug 1990). "Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing". Molecular Endocrinology. 4 (8): 1264–76. doi:10.1210/mend-4-8-1264. PMID 2293030.
- Misrahi M, Loosfelt H, Atger M, Sar S, Guiochon-Mantel A, Milgrom E (Jan 1990). "Cloning, sequencing and expression of human TSH receptor". Biochemical and Biophysical Research Communications. 166 (1): 394–403. doi:10.1016/0006-291X(90)91958-U. PMID 2302212.
- Nagayama Y, Kaufman KD, Seto P, Rapoport B (Dec 1989). "Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor". Biochemical and Biophysical Research Communications. 165 (3): 1184–90. doi:10.1016/0006-291X(89)92727-7. PMID 2558651.
- Libert F, Lefort A, Gerard C, Parmentier M, Perret J, Ludgate M, Dumont JE, Vassart G (Dec 1989). "Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies". Biochemical and Biophysical Research Communications. 165 (3): 1250–5. doi:10.1016/0006-291X(89)92736-8. PMID 2610690.
- Cuddihy RM, Bryant WP, Bahn RS (Aug 1995). "Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor". Thyroid. 5 (4): 255–7. doi:10.1089/thy.1995.5.255. PMID 7488864.
- Bahn RS, Dutton CM, Heufelder AE, Sarkar G (Feb 1994). "A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy". The Journal of Clinical Endocrinology and Metabolism. 78 (2): 256–60. doi:10.1210/jc.78.2.256. PMID 7508946.
- Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S (Jan 1995). "Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene". The New England Journal of Medicine. 332 (3): 155–60. doi:10.1056/NEJM199501193320305. PMID 7528344.
External links
- "Glycoprotein Hormone Receptors: TSH". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Thyrotropin+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- SSFA-GPHR: Sequence Structure Function Analysis of Glycoprotein Hormone Receptors
- GRIS: Glycoprotein-hormone Receptor Information System
- Overview of all the structural information available in the PDB for UniProt: P16473 (Thyrotropin receptor) at the PDBe-KB.