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{{Short description|Poisoning of heart electrophysiology or muscle}}
{{Short description|Poisoning of heart electrophysiology or muscle}}
'''Cardiotoxicity''' is the occurrence of heart electrophysiology dysfunction or [[Cardiomyopathy|muscle damage]]; that results in heart toxicity.<ref>{{Citation |last=Sishi |first=Balindiwe J. N. |title=Chapter 10 - Autophagy Upregulation Reduces Doxorubicin-Induced Cardiotoxicity |date=2015-01-01 |url=https://www.sciencedirect.com/science/article/pii/B9780128010334000102 |work=Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging |pages=157–173 |editor-last=Hayat |editor-first=M. A. |place=Amsterdam |publisher=Academic Press |language=en |doi=10.1016/b978-0-12-801033-4.00010-2 |isbn=978-0-12-801033-4 |access-date=2022-07-06}}</ref> The heart becomes weaker and is not as efficient in pumping and therefore circulating blood. Cardiotoxicity may be caused by [[chemotherapy]] (a usual example is the class of [[anthracyclines]])<ref>{{cite journal |pages=675–83 |doi=10.1161/CIRCULATIONAHA.109.902221 |title=Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice. Cardiotoxins are the second most toxic venom while neurotoxins are the first. |year=2010 |last1=Huang |first1=C. |last2=Zhang |first2=X. |last3=Ramil |first3=J. M. |last4=Rikka |first4=S. |last5=Kim |first5=L. |last6=Lee |first6=Y. |last7=Gude |first7=N. A. |last8=Thistlethwaite |first8=P. A. |last9=Sussman |first9=M. A. |journal=Circulation |volume=121 |issue=5 |pmid=20100968 |pmc=2834271 }}</ref><ref name=Volkova>{{cite journal | title = Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment| authors = Volkova M, Russell R| journal = Curr Cardiol Rev| year = 2011 | volume = 7| issue = 4| pages = 214–220| doi = 10.2174/157340311799960645 | pmid = 22758622| pmc = 3322439 }}</ref> treatment including radiotherapy;<ref>{{Cite journal |last=Suchorska |first=Wiktoria M. |date=2020-01-01 |title=Radiobiological models in prediction of radiation cardiotoxicity |journal=Reports of Practical Oncology & Radiotherapy |language=en |volume=25 |issue=1 |pages=46–49 |doi=10.1016/j.rpor.2019.12.001 |issn=1507-1367 |pmc=6931197 |pmid=31889920}}</ref> complications from [[anorexia nervosa]]; adverse effects of [[Toxic heavy metal|heavy metals]] intake;<ref>{{Cite journal |last=Nigra |first=Anne E |last2=Ruiz-Hernandez |first2=Adrian |last3=Redon |first3=Josep |last4=Navas-Acien |first4=Ana |last5=Tellez-Plaza |first5=Maria |year=2016 |title=Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review beyond Lead and Cadmium |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801549/ |journal=Current environmental health reports |volume=3 |issue=4 |pages=416–433 |doi=10.1007/s40572-016-0117-9 |issn=2196-5412 |pmc=5801549 |pmid=27783356}}</ref> the long-term abuse of or ingestion at high doses of certain strong [[stimulant]]s such as [[cocaine]];<ref>{{Cite journal |last=Pergolizzi |first=Joseph V |last2=Magnusson |first2=Peter |last3=LeQuang |first3=Jo Ann K |last4=Breve |first4=Frank |last5=Varrassi |first5=Giustino |title=Cocaine and Cardiotoxicity: A Literature Review |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136464/ |journal=Cureus |volume=13 |issue=4 |pages=e14594 |doi=10.7759/cureus.14594 |issn=2168-8184 |pmc=8136464 |pmid=34036012}}</ref> or an incorrectly administered drug such as [[bupivacaine]].<ref>{{cite journal | vauthors = de La Coussaye JE, Eledjam JJ, Brugada J, Sassine A | title = [Cardiotoxicity of local anesthetics] | journal = Cahiers d'Anesthésiologie | volume = 41 | issue = 6 | pages = 589–598 | date = 1993 | pmid = 8287299 }}</ref>
'''Cardiotoxicity''' is the occurrence of heart electrophysiology dysfunction or [[Cardiomyopathy|muscle damage]]; that results in heart toxicity.<ref>{{Citation |last=Sishi |first=Balindiwe J. N. |title=Chapter 10 - Autophagy Upregulation Reduces Doxorubicin-Induced Cardiotoxicity |date=2015-01-01 |url=https://www.sciencedirect.com/science/article/pii/B9780128010334000102 |work=Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging |pages=157–173 |editor-last=Hayat |editor-first=M. A. |place=Amsterdam |publisher=Academic Press |language=en |doi=10.1016/b978-0-12-801033-4.00010-2 |isbn=978-0-12-801033-4 |access-date=2022-07-06}}</ref> The heart becomes weaker and is not as efficient in pumping and therefore circulating blood. Cardiotoxicity may be caused by [[chemotherapy]] (a usual example is the class of [[anthracyclines]])<ref>{{cite journal |pages=675–83 |doi=10.1161/CIRCULATIONAHA.109.902221 |title=Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice. Cardiotoxins are the second most toxic venom while neurotoxins are the first. |year=2010 |last1=Huang |first1=C. |last2=Zhang |first2=X. |last3=Ramil |first3=J. M. |last4=Rikka |first4=S. |last5=Kim |first5=L. |last6=Lee |first6=Y. |last7=Gude |first7=N. A. |last8=Thistlethwaite |first8=P. A. |last9=Sussman |first9=M. A. |journal=Circulation |volume=121 |issue=5 |pmid=20100968 |pmc=2834271 }}</ref><ref name=Volkova>{{cite journal | title = Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment| authors = Volkova M, Russell R| journal = Curr Cardiol Rev| year = 2011 | volume = 7| issue = 4| pages = 214–220| doi = 10.2174/157340311799960645 | pmid = 22758622| pmc = 3322439 }}</ref> treatment including radiotherapy;<ref>{{Cite journal |last=Suchorska |first=Wiktoria M. |date=2020-01-01 |title=Radiobiological models in prediction of radiation cardiotoxicity |journal=Reports of Practical Oncology & Radiotherapy |language=en |volume=25 |issue=1 |pages=46–49 |doi=10.1016/j.rpor.2019.12.001 |issn=1507-1367 |pmc=6931197 |pmid=31889920}}</ref> complications from [[anorexia nervosa]]; adverse effects of [[Toxic heavy metal|heavy metals]] intake;<ref>{{Cite journal |last1=Nigra |first1=Anne E |last2=Ruiz-Hernandez |first2=Adrian |last3=Redon |first3=Josep |last4=Navas-Acien |first4=Ana |last5=Tellez-Plaza |first5=Maria |year=2016 |title=Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review beyond Lead and Cadmium |journal=Current Environmental Health Reports |volume=3 |issue=4 |pages=416–433 |doi=10.1007/s40572-016-0117-9 |issn=2196-5412 |pmc=5801549 |pmid=27783356}}</ref> the long-term abuse of or ingestion at high doses of certain strong [[stimulant]]s such as [[cocaine]];<ref>{{Cite journal |last1=Pergolizzi |first1=Joseph V |last2=Magnusson |first2=Peter |last3=LeQuang |first3=Jo Ann K |last4=Breve |first4=Frank |last5=Varrassi |first5=Giustino |title=Cocaine and Cardiotoxicity: A Literature Review |journal=Cureus |year=2021 |volume=13 |issue=4 |pages=e14594 |doi=10.7759/cureus.14594 |issn=2168-8184 |pmc=8136464 |pmid=34036012}}</ref> or an incorrectly administered drug such as [[bupivacaine]].<ref>{{cite journal | vauthors = de La Coussaye JE, Eledjam JJ, Brugada J, Sassine A | title = [Cardiotoxicity of local anesthetics] | journal = Cahiers d'Anesthésiologie | volume = 41 | issue = 6 | pages = 589–598 | date = 1993 | pmid = 8287299 }}</ref>


One of the ways to detect cardiotoxicity at early stages when there is a subconical dysfunction is by measuring changes in [[regional function of the heart]] using strains.{{cn|date=January 2021}}
One of the ways to detect cardiotoxicity at early stages when there is a subconical dysfunction is by measuring changes in [[regional function of the heart]] using strains.{{cn|date=January 2021}}

Revision as of 01:36, 4 December 2022

Cardiotoxicity is the occurrence of heart electrophysiology dysfunction or muscle damage; that results in heart toxicity.[1] The heart becomes weaker and is not as efficient in pumping and therefore circulating blood. Cardiotoxicity may be caused by chemotherapy (a usual example is the class of anthracyclines)[2][3] treatment including radiotherapy;[4] complications from anorexia nervosa; adverse effects of heavy metals intake;[5] the long-term abuse of or ingestion at high doses of certain strong stimulants such as cocaine;[6] or an incorrectly administered drug such as bupivacaine.[7]

One of the ways to detect cardiotoxicity at early stages when there is a subconical dysfunction is by measuring changes in regional function of the heart using strains.[citation needed]

See also

References

  1. ^ Sishi, Balindiwe J. N. (2015-01-01), Hayat, M. A. (ed.), "Chapter 10 - Autophagy Upregulation Reduces Doxorubicin-Induced Cardiotoxicity", Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Amsterdam: Academic Press, pp. 157–173, doi:10.1016/b978-0-12-801033-4.00010-2, ISBN 978-0-12-801033-4, retrieved 2022-07-06
  2. ^ Huang, C.; Zhang, X.; Ramil, J. M.; Rikka, S.; Kim, L.; Lee, Y.; Gude, N. A.; Thistlethwaite, P. A.; Sussman, M. A. (2010). "Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice. Cardiotoxins are the second most toxic venom while neurotoxins are the first". Circulation. 121 (5): 675–83. doi:10.1161/CIRCULATIONAHA.109.902221. PMC 2834271. PMID 20100968.
  3. ^ "Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment". Curr Cardiol Rev. 7 (4): 214–220. 2011. doi:10.2174/157340311799960645. PMC 3322439. PMID 22758622. {{cite journal}}: Unknown parameter |authors= ignored (help)
  4. ^ Suchorska, Wiktoria M. (2020-01-01). "Radiobiological models in prediction of radiation cardiotoxicity". Reports of Practical Oncology & Radiotherapy. 25 (1): 46–49. doi:10.1016/j.rpor.2019.12.001. ISSN 1507-1367. PMC 6931197. PMID 31889920.
  5. ^ Nigra, Anne E; Ruiz-Hernandez, Adrian; Redon, Josep; Navas-Acien, Ana; Tellez-Plaza, Maria (2016). "Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review beyond Lead and Cadmium". Current Environmental Health Reports. 3 (4): 416–433. doi:10.1007/s40572-016-0117-9. ISSN 2196-5412. PMC 5801549. PMID 27783356.
  6. ^ Pergolizzi, Joseph V; Magnusson, Peter; LeQuang, Jo Ann K; Breve, Frank; Varrassi, Giustino (2021). "Cocaine and Cardiotoxicity: A Literature Review". Cureus. 13 (4): e14594. doi:10.7759/cureus.14594. ISSN 2168-8184. PMC 8136464. PMID 34036012.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  7. ^ de La Coussaye JE, Eledjam JJ, Brugada J, Sassine A (1993). "[Cardiotoxicity of local anesthetics]". Cahiers d'Anesthésiologie. 41 (6): 589–598. PMID 8287299.


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