Periplocin: Difference between revisions
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| pmid=27973416 }}</ref><ref name=guo>{{cite journal| url=https://www.sciencedirect.com/science/article/abs/pii/S037887411300192X?via%3Dihub | author=Guo H, Mao H, Pan G, Zhang H, Fan G, Li W, Zhou K, Zhu Y, Yanagihara N, Gao X| title=Antagonism of Cortex Periplocae extract-induced catecholamines secretion by Panax notoginseng saponins in cultured bovine adrenal medullary cells by drug combinations.| journal=J Ethnopharmacol. 2013; 147(2):447-55| doi=10.1016/j.jep.2013.03.036|pmid=23524165}}</ref> |
| pmid=27973416 }}</ref><ref name=guo>{{cite journal| url=https://www.sciencedirect.com/science/article/abs/pii/S037887411300192X?via%3Dihub | author=Guo H, Mao H, Pan G, Zhang H, Fan G, Li W, Zhou K, Zhu Y, Yanagihara N, Gao X| title=Antagonism of Cortex Periplocae extract-induced catecholamines secretion by Panax notoginseng saponins in cultured bovine adrenal medullary cells by drug combinations.| journal=J Ethnopharmacol. 2013; 147(2):447-55| doi=10.1016/j.jep.2013.03.036|pmid=23524165}}</ref> |
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CPP's healing activities have long been recognized in [[traditional Chinese medicine]]<ref name=guo/> where it has been used to treat [[rheumatoid arthritis]].<ref name=liy/> Scientific |
CPP's healing activities have long been recognized in [[traditional Chinese medicine]]<ref name=guo/> where it has been used to treat [[rheumatoid arthritis]].<ref name=liy/> Scientific studies of CPP have identified over 100 components of which periplocin has been a major focus both for its toxicity as well as for its potential beneficial pharmaceutical effects.<ref name=liy/> Besides the cardiac glycosides with periplocin as its main constituent, the CPP contains different C21-steroidal glycosides such as periplocodides and [[pregnene]] derivatives, [[fatty acid]]s, [[volatile oil]]s, [[terpene]]s, and others.<ref name=liy/> |
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Higher doses of periplocin are toxic as a cardiac glycoside.<ref>{{cite journal |url=https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jssc.202001262| authors= |
Higher doses of periplocin are toxic as a cardiac glycoside.<ref>{{cite journal |url=https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jssc.202001262| authors= |
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Revision as of 13:58, 24 June 2023
Periplocin is a plant-derived glycoside whereby the sugar moiety is linked to a steroid. It can be extracted from cortex periplocae (CPP), the dry root of Periploca sepium.[1][2]
CPP's healing activities have long been recognized in traditional Chinese medicine[2] where it has been used to treat rheumatoid arthritis.[1] Scientific studies of CPP have identified over 100 components of which periplocin has been a major focus both for its toxicity as well as for its potential beneficial pharmaceutical effects.[1] Besides the cardiac glycosides with periplocin as its main constituent, the CPP contains different C21-steroidal glycosides such as periplocodides and pregnene derivatives, fatty acids, volatile oils, terpenes, and others.[1]
Higher doses of periplocin are toxic as a cardiac glycoside.[3]
Potential medical applications of periplocin are focused on these areas:[1]
- Anti-inflammatory effects. Periplocin and its derivatives have shown anti-inflammatory effects.
- Antitumor activity. A number of in vivo and in vitro studies suggest that periplocin inhibits tumor growth. Studies show both inhibition of growth as well as induction of apoptosis.
- Cardiotonic activity. Traditional use includes an application for heart failure. Structure and function of cardiac muscle were improved in rats.
Periplocin's metabolites, periplocymarin and periplogenin,[4] have also shown some pharmacological effects.
References
- ^ a b c d e "A Review on Phytochemistry and Pharmacology of Cortex Periplocae". Molecules. 2016 Dec 10;21(12):1702. doi:10.3390/molecules21121702. PMID 27973416.
{{cite journal}}: Cite uses deprecated parameter|authors=(help)CS1 maint: unflagged free DOI (link) - ^ a b Guo H, Mao H, Pan G, Zhang H, Fan G, Li W, Zhou K, Zhu Y, Yanagihara N, Gao X. "Antagonism of Cortex Periplocae extract-induced catecholamines secretion by Panax notoginseng saponins in cultured bovine adrenal medullary cells by drug combinations". J Ethnopharmacol. 2013; 147(2):447-55. doi:10.1016/j.jep.2013.03.036. PMID 23524165.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Metabolomics study on the periplocin-induced cardiotoxicity and the compatibility of periplocin and Panax notoginseng saponins in reducing cardiotoxicity in rats by GC-MS". Journal of Separation Science, 44(14), 2785-2797. doi:10.1002/jssc.202001262. PMID 33961332.
{{cite journal}}: Cite uses deprecated parameter|authors=(help) - ^ "Simultaneous determination of periplocin, periplocymarin, periplogenin, periplocoside M and periplocoside N of Cortex Periplocae in rat plasma and its application to a pharmacokinetic study". Biomedical Chromatography. doi:10.1002/bmc.5283. PMID 34816469.
{{cite journal}}: Cite uses deprecated parameter|authors=(help)