Heel (corporation): Difference between revisions
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==Effect of Traumeel== |
==Effect of Traumeel== |
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{{Advert|date=July 2023}} |
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Traumeel® is a multitarget, multicomponent medication that supports inflammation resolution and shortens the inflammation resolution interval. It alleviates the inflammation symptoms without blocking the process, helping to accelerate healing and provides sustained recovery from injury. Traumeel®'s mode of action is different from other medications, suggesting the prevention of typical side effects while showing the same effectiveness for symptom relief. As a result, it helps you regain your normal mobility and activity faster. |
Traumeel® is a multitarget, multicomponent medication that supports inflammation resolution and shortens the inflammation resolution interval. It alleviates the inflammation symptoms without blocking the process, helping to accelerate healing and provides sustained recovery from injury. Traumeel®'s mode of action is different from other medications, suggesting the prevention of typical side effects while showing the same effectiveness for symptom relief. As a result, it helps you regain your normal mobility and activity faster.{{Citation needed|date=July 2023}} |
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In particular, it has been shown that the mechanism of action of Traumeel differs from that of the widely used non-steroidal anti-inflammatory drug diclofenac (approx. diclofenac has a specific effect, it directly inhibits the Cox2 enzyme). Traumeel does not have a direct inhibitory effect on the Cox2 enzyme, and the downstream mediators PGI2, PGD2 and PGE2 perform their functions. Traumeel reduces mRNA levels in the leukotriene synthesis pathway by activating the Nrf2/KEAP2 pathway. Thus, it provides a more natural wound healing process.<ref>{{cite journal | vauthors = Laurent GS, Toma I, Seilheimer B, Cesnulevicius K, Schultz M, Tackett M, Zhou J, Ri M, Shtokalo D, Antonets D, Jepson T, McCaffrey TA | title = RNAseq analysis of treatment-dependent signaling changes during inflammation in a mouse cutaneous wound healing model | journal = BMC Genomics | volume = 22 | issue = 854 | date = November 2021 | pmid = 34823472 | pmc = 8614049 | doi = 10.1186/s12864-021-08083-2 }}</ref> |
In particular, it has been shown that the mechanism of action of Traumeel differs from that of the widely used non-steroidal anti-inflammatory drug diclofenac (approx. diclofenac has a specific effect, it directly inhibits the Cox2 enzyme).{{Citation needed|date=July 2023}} Traumeel does not have a direct inhibitory effect on the Cox2 enzyme, and the downstream mediators PGI2, PGD2 and PGE2 perform their functions. Traumeel reduces mRNA levels in the leukotriene synthesis pathway by activating the Nrf2/KEAP2 pathway. Thus, it provides a more natural wound healing process.<ref>{{cite journal | vauthors = Laurent GS, Toma I, Seilheimer B, Cesnulevicius K, Schultz M, Tackett M, Zhou J, Ri M, Shtokalo D, Antonets D, Jepson T, McCaffrey TA | title = RNAseq analysis of treatment-dependent signaling changes during inflammation in a mouse cutaneous wound healing model | journal = BMC Genomics | volume = 22 | issue = 854 | date = November 2021 | pmid = 34823472 | pmc = 8614049 | doi = 10.1186/s12864-021-08083-2 }}</ref> |
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==Criticism== |
==Criticism== |
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Revision as of 09:52, 22 July 2023
Heel is a developer, producer and distributor of homeopathic preparations. It was founded in 1936 by Hans-Heinrich Reckeweg. Heel has offices in 40 countries worldwide including the United States where it is located in Albuquerque, NM.
History
Dr. Reckeweg was a German physician, who received his medical degree in Berlin, who practiced homeopathy. In 1936, Biologische Heilmittel Heel GmbH was founded in Berlin to develop and market his preparations. In 1953 Reckweg moved the company to its present location in Baden-Baden. Between the companies founding year 1936 and 1979 (when Reckeweg relocated to Albuquerque) he developed over 1,000 different homeopathic preparations available through Heel GmbH. When Reckeweg relocated to Albuquerque he created Biological Homeopathic Industries (BHI) and began manufacturing combination remedies in tablet form. In 1997, the Albuquerque company was renamed Heel USA Inc. In 2014, Heel USA became independent from the German Heel organization and operates under the name MediNatura Inc, which now manufactures and distributes BHI products and is the only legal importer of Heel products in the USA.
FDA violations
In 1984 BHI received letters and warnings from the Food and Drug Administration that it was in violation of FDA regulations in regards to marketing of homeopathic remedies.[1] BHI was given multiple FDA citations and fines during the 1980s and early 1990s for violation of the Compliance Policy Guidelines labelling guidelines established by the FDA in 1988. These were corrected and have not recurred,[2][3] though in August 2013 the company again agreed to dial down its health claims tied to its over-the-counter remedies and pay a $1 million class settlement to resolve accusations that it exaggerated the products’ effectiveness to consumers.[4]
Effect of Traumeel
 | This article contains content that is written like an advertisement. (July 2023) |
Traumeel® is a multitarget, multicomponent medication that supports inflammation resolution and shortens the inflammation resolution interval. It alleviates the inflammation symptoms without blocking the process, helping to accelerate healing and provides sustained recovery from injury. Traumeel®'s mode of action is different from other medications, suggesting the prevention of typical side effects while showing the same effectiveness for symptom relief. As a result, it helps you regain your normal mobility and activity faster.[citation needed] In particular, it has been shown that the mechanism of action of Traumeel differs from that of the widely used non-steroidal anti-inflammatory drug diclofenac (approx. diclofenac has a specific effect, it directly inhibits the Cox2 enzyme).[citation needed] Traumeel does not have a direct inhibitory effect on the Cox2 enzyme, and the downstream mediators PGI2, PGD2 and PGE2 perform their functions. Traumeel reduces mRNA levels in the leukotriene synthesis pathway by activating the Nrf2/KEAP2 pathway. Thus, it provides a more natural wound healing process.[5]
Criticism
In 2012, Heel was criticized for funding a German blogger who smears scientists critical of homeopathy.[6][7]
References
- ^ Chastonay RJ. Request for limited inspection Re: Homeopathic Products. Memo, Oct 26, 1984
- ^ FDA Enforcement Report, March 25, 1992, p 6.
- ^ Health Fraud Actions, October 1993 - September 1994. Rockville, MD: FDA, 1994, p 3.
- ^ "Homeopathic Drugmaker Puts Up $1M To End False Ad Claims - Law360". www.law360.com. Retrieved 2021-02-19.
- ^ Laurent GS, Toma I, Seilheimer B, Cesnulevicius K, Schultz M, Tackett M, Zhou J, Ri M, Shtokalo D, Antonets D, Jepson T, McCaffrey TA (November 2021). "RNAseq analysis of treatment-dependent signaling changes during inflammation in a mouse cutaneous wound healing model". BMC Genomics. 22 (854). doi:10.1186/s12864-021-08083-2. PMC 8614049. PMID 34823472.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ "German Homeopathy Companies Pay Journalist who Smears UK Academic – The Quackometer Blog". Retrieved 2021-02-19.
- ^ Zeitung, Süddeutsche. "Schmutzige Methoden der sanften Medizin". Süddeutsche.de (in German). Retrieved 2021-02-19.
