St. Alexius Hospital (Missouri)

For the institution of a similar name in Illinois, see St. Alexius Medical Center (Illinois).

For the institution of a similar name in North Dakota, see CHI St. Alexius Health Bismarck.

St. Alexius Hospital was an American hospital in St. Louis, Missouri, founded in 1869 by the Catholic order of the Alexian Brothers, a healing order of Catholic men. In 1870, it began operation as a two-bed facility. In 1874, a larger building was erected. In 1890, a four-story main building was completed with a fifth floor was added in 1897. In 1909, the hospital became affiliated with St. Louis University. Between 1928 and 1952, the hospital operated a training school for male nurses. It only offered its services to men only until 1962. In 1997, the hospital began management by the Sisters of Mercy. In 2000, became known as St. Alexius Hospital under a sponsorship of St. Anthony's Medical Center as it was previously known as Alexian Brothers’ Hospital or the Alexian Brothers’ Hospital and Insane Asylum.

This hospital which closed in 2023 claimed to be the oldest American hospital west of the Mississippi River. The hospital was located about four miles south of the Gateway Arch and near the riverfront in south St. Louis. The main St. Louis hospital was located at 3933 South Broadway. It also ran the Lutheran School of Nursing at 2639 Miami Street until it shut down in 2022. The hospital claimed that the novel and movie The Exorcist was partly inspired by a 12-week exorcism that took place at this location in 1949 but the wings of that part of the hospital torn down in 1976.

In 2004, the hospital was acquired by Argilla HealthCare, which became Envision Hospital Corporation after a merger. In 2008, Florida-based Success Healthcare bought the hospital. Various bankruptcies followed. Around 2020, the hospital was renamed South City Hospital. The hospital had a capacity of 178 beds.