Sclareol: Difference between revisions
Appearance
Content deleted Content added
Citation bot (talk | contribs) Add: pages, issue, volume, journal, date, title, doi-access, authors 1-2. | Use this bot. Report bugs. | Suggested by Marbletan | #UCB_webform |
Herravondure (talk | contribs) mNo edit summary |
||
Line 47: | Line 47: | ||
'''Sclareol''' is a fragrant chemical compound found in ''[[Salvia sclarea]]'', from which it derives its name. It is classified as a bicyclic [[diterpene]] [[alcohol (chemistry)|alcohol]]. It is an amber colored solid with a sweet, balsamic scent.<ref>[http://www.thegoodscentscompany.com/data/rw1018631.html Good Scents Company]</ref> |
'''Sclareol''' is a fragrant chemical compound found in ''[[Salvia sclarea]]'', from which it derives its name. It is classified as a bicyclic [[diterpene]] [[alcohol (chemistry)|alcohol]]. It is an amber colored solid with a sweet, balsamic scent.<ref>[http://www.thegoodscentscompany.com/data/rw1018631.html Good Scents Company]</ref> |
||
In an experiment in which sclareol was dissolved in [[jojoba oil]] and applied to mice, sclareol was detected in the blood (transdermal absorption) 30 minutes after application.<ref>{{cite journal | doi = 10.3390/women2030028| doi-access = free| title = Transdermal Absorption of Sclareol, an Active Ingredient in Clary Sage Oil: A Complementary and Alternative Medicine for Menopausal Symptoms| date = 2022| last1 = Matsumoto| first1 = Yutaka| last2 = Horikawa| first2 = Kazumasa| journal = Women| volume = 2| issue = 3| pages = 304–312}}</ref> In this study, higher concentrations of sclareol were detected in liver homogenates than in blood. Although sclareol accumulation in the liver was suggested, it was concluded that no acute liver dysfunction was seen because AST and ALT were not elevated. Sclareol is also able to kill human leukemic cells and colon cancer cells ''[[in vitro]]'' by [[apoptosis]].<ref>{{cite journal | doi = 10.1016/S0145-2126(98)00134-9 |author1=Dimas, Kostas |author2=Kokkinopoulos, Dimitrios |author3=Demetzos, Costas |author4=Vaos, Basilios |author5=Marselos, Marios |author6=Malamas, Mixalis |author7=Tzavaras, Theodoros | title = The effect of sclareol on growth and cell cycle progression of human leukemic cell lines | journal = Leukemia Research | year = 1999 | volume = 23 | issue = 3 | pages = 217–234 | pmid = 10071073}}</ref><ref>{{cite journal | author = K. Dimas | last2 = Hatziantoniou | first2 = S | last3 = Tseleni | first3 = S | last4 = Khan | first4 = H | last5 = Georgopoulos | first5 = A | last6 = Alevizopoulos | first6 = K | last7 = Wyche | first7 = JH | last8 = Pantazis | first8 = P | last9 = Demetzos | first9 = C | title = Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice | journal = Apoptosis | volume = 12 | issue = 4 | year = 2007 | pmid = 17260186 | pages = 685–694 | doi = 10.1007/s10495-006-0026-8 | s2cid = 42171668 }}</ref> |
In an experiment in which sclareol was dissolved in [[jojoba oil]] and applied to [[Mouse|mice]], sclareol was detected in the blood (transdermal absorption) 30 minutes after application.<ref>{{cite journal | doi = 10.3390/women2030028| doi-access = free| title = Transdermal Absorption of Sclareol, an Active Ingredient in Clary Sage Oil: A Complementary and Alternative Medicine for Menopausal Symptoms| date = 2022| last1 = Matsumoto| first1 = Yutaka| last2 = Horikawa| first2 = Kazumasa| journal = Women| volume = 2| issue = 3| pages = 304–312}}</ref> In this study, higher concentrations of sclareol were detected in [[liver]] homogenates than in blood. Although sclareol accumulation in the liver was suggested, it was concluded that no acute liver dysfunction was seen because AST and ALT were not elevated. Sclareol is also able to kill human [[Leukemia|leukemic]] cells and colon cancer cells ''[[in vitro]]'' by [[apoptosis]].<ref>{{cite journal | doi = 10.1016/S0145-2126(98)00134-9 |author1=Dimas, Kostas |author2=Kokkinopoulos, Dimitrios |author3=Demetzos, Costas |author4=Vaos, Basilios |author5=Marselos, Marios |author6=Malamas, Mixalis |author7=Tzavaras, Theodoros | title = The effect of sclareol on growth and cell cycle progression of human leukemic cell lines | journal = Leukemia Research | year = 1999 | volume = 23 | issue = 3 | pages = 217–234 | pmid = 10071073}}</ref><ref>{{cite journal | author = K. Dimas | last2 = Hatziantoniou | first2 = S | last3 = Tseleni | first3 = S | last4 = Khan | first4 = H | last5 = Georgopoulos | first5 = A | last6 = Alevizopoulos | first6 = K | last7 = Wyche | first7 = JH | last8 = Pantazis | first8 = P | last9 = Demetzos | first9 = C | title = Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice | journal = Apoptosis | volume = 12 | issue = 4 | year = 2007 | pmid = 17260186 | pages = 685–694 | doi = 10.1007/s10495-006-0026-8 | s2cid = 42171668 }}</ref> |
||
==References== |
==References== |
Latest revision as of 22:25, 2 July 2024
Names | |
---|---|
IUPAC name
Labd-14-ene-8,13-diol
| |
Systematic IUPAC name
(1R,2R,4aS,8aS)-1-[(3R)-3-Hydroxy-3-methylpent-4-en-1-yl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol | |
Identifiers | |
3D model (JSmol)
|
|
ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.007.450 |
KEGG | |
PubChem CID
|
|
UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C20H36O2 | |
Molar mass | 308.506 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Sclareol is a fragrant chemical compound found in Salvia sclarea, from which it derives its name. It is classified as a bicyclic diterpene alcohol. It is an amber colored solid with a sweet, balsamic scent.[1]
In an experiment in which sclareol was dissolved in jojoba oil and applied to mice, sclareol was detected in the blood (transdermal absorption) 30 minutes after application.[2] In this study, higher concentrations of sclareol were detected in liver homogenates than in blood. Although sclareol accumulation in the liver was suggested, it was concluded that no acute liver dysfunction was seen because AST and ALT were not elevated. Sclareol is also able to kill human leukemic cells and colon cancer cells in vitro by apoptosis.[3][4]
References
[edit]- ^ Good Scents Company
- ^ Matsumoto, Yutaka; Horikawa, Kazumasa (2022). "Transdermal Absorption of Sclareol, an Active Ingredient in Clary Sage Oil: A Complementary and Alternative Medicine for Menopausal Symptoms". Women. 2 (3): 304–312. doi:10.3390/women2030028.
- ^ Dimas, Kostas; Kokkinopoulos, Dimitrios; Demetzos, Costas; Vaos, Basilios; Marselos, Marios; Malamas, Mixalis; Tzavaras, Theodoros (1999). "The effect of sclareol on growth and cell cycle progression of human leukemic cell lines". Leukemia Research. 23 (3): 217–234. doi:10.1016/S0145-2126(98)00134-9. PMID 10071073.
- ^ K. Dimas; Hatziantoniou, S; Tseleni, S; Khan, H; Georgopoulos, A; Alevizopoulos, K; Wyche, JH; Pantazis, P; Demetzos, C (2007). "Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice". Apoptosis. 12 (4): 685–694. doi:10.1007/s10495-006-0026-8. PMID 17260186. S2CID 42171668.