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{{PBB|geneid=56975}}
{{protein

|Name=family with sequence similarity 20, member C
|caption=
|image=
|width=
|HGNCid=22140
|Symbol=FAM20C
|AltSymbols=RNS; DMP4
|EntrezGene=56975
|OMIM=611061
|RefSeq=NM_020223
|UniProt= Q8IXL6
|PDB=
|ECnumber=
|Chromosome=7
|Arm=p
|Band=22.3
|LocusSupplementaryData=
}}
'''Family with sequence similarity 20, member C''' also known as '''FAM20C''' or '''DMP4''' is a [[protein]] which in humans is encoded by the ''FAM20C'' [[gene]].<ref name="pmid15676076">{{cite journal | author = Nalbant D, Youn H, Nalbant SI, Sharma S, Cobos E, Beale EG, Du Y, Williams SC | title = FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells | journal = BMC Genomics | volume = 6 | issue = 1 | pages = 11 | year = 2005 | pmid = 15676076 | pmc = 548683 | doi = 10.1186/1471-2164-6-11 | url = | issn = }}</ref><ref name="pmid17369251">{{cite journal | author = Hao J, Narayanan K, Muni T, Ramachandran A, George A | title = Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation | journal = J. Biol. Chem. | volume = 282 | issue = 21 | pages = 15357–65 | year = 2007 | month = May | pmid = 17369251 | doi = 10.1074/jbc.M701547200 | url = | issn = }}</ref><ref name="pmid17924334">{{cite journal | author = Simpson MA, Hsu R, Keir LS, Hao J, Sivapalan G, Ernst LM, Zackai EH, Al-Gazali LI, Hulskamp G, Kingston HM, Prescott TE, Ion A, Patton MA, Murday V, George A, Crosby AH | title = Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development | journal = Am. J. Hum. Genet. | volume = 81 | issue = 5 | pages = 906–12 | year = 2007 | month = November | pmid = 17924334 | pmc = 2265657 | doi = 10.1086/522240 | url = | issn = }}</ref>
'''Family with sequence similarity 20, member C''' also known as '''FAM20C''' or '''DMP4''' is a [[protein]] which in humans is encoded by the ''FAM20C'' [[gene]].<ref name="pmid15676076">{{cite journal | author = Nalbant D, Youn H, Nalbant SI, Sharma S, Cobos E, Beale EG, Du Y, Williams SC | title = FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells | journal = BMC Genomics | volume = 6 | issue = 1 | pages = 11 | year = 2005 | pmid = 15676076 | pmc = 548683 | doi = 10.1186/1471-2164-6-11 | url = | issn = }}</ref><ref name="pmid17369251">{{cite journal | author = Hao J, Narayanan K, Muni T, Ramachandran A, George A | title = Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation | journal = J. Biol. Chem. | volume = 282 | issue = 21 | pages = 15357–65 | year = 2007 | month = May | pmid = 17369251 | doi = 10.1074/jbc.M701547200 | url = | issn = }}</ref><ref name="pmid17924334">{{cite journal | author = Simpson MA, Hsu R, Keir LS, Hao J, Sivapalan G, Ernst LM, Zackai EH, Al-Gazali LI, Hulskamp G, Kingston HM, Prescott TE, Ion A, Patton MA, Murday V, George A, Crosby AH | title = Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development | journal = Am. J. Hum. Genet. | volume = 81 | issue = 5 | pages = 906–12 | year = 2007 | month = November | pmid = 17924334 | pmc = 2265657 | doi = 10.1086/522240 | url = | issn = }}</ref>


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{{Reflist}}
{{Reflist}}


==Further reading==
{{refbegin | 2}}
*{{cite journal |author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal |author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal |author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal |author=Hao J, Narayanan K, Muni T, ''et al.'' |title=Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation. |journal=J. Biol. Chem. |volume=282 |issue= 21 |pages= 15357-65 |year= 2007 |pmid= 17369251 |doi= 10.1074/jbc.M701547200 }}
*{{cite journal |author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal |author=Simpson MA, Scheuerle A, Hurst J, ''et al.'' |title=Mutations in FAM20C also identified in non-lethal osteosclerotic bone dysplasia. |journal=Clin. Genet. |volume=75 |issue= 3 |pages= 271-6 |year= 2009 |pmid= 19250384 |doi= 10.1111/j.1399-0004.2008.01118.x }}
{{refend}}


{{gene-7-stub}}
{{gene-7-stub}}

Revision as of 21:20, 20 March 2010

Template:PBB

Family with sequence similarity 20, member C also known as FAM20C or DMP4 is a protein which in humans is encoded by the FAM20C gene.[1][2][3]

Function

Dmp4 causes differentiation of mesenchymal stem cells into functional odontoblast cells and is likely to function as a regulator of dentin mineralization.[2]

Clinical significance

Mutations in the FAM20C gene are associated with Raine syndrome.[3]

References

  1. ^ Nalbant D, Youn H, Nalbant SI, Sharma S, Cobos E, Beale EG, Du Y, Williams SC (2005). "FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells". BMC Genomics. 6 (1): 11. doi:10.1186/1471-2164-6-11. PMC 548683. PMID 15676076.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  2. ^ a b Hao J, Narayanan K, Muni T, Ramachandran A, George A (2007). "Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation". J. Biol. Chem. 282 (21): 15357–65. doi:10.1074/jbc.M701547200. PMID 17369251. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  3. ^ a b Simpson MA, Hsu R, Keir LS, Hao J, Sivapalan G, Ernst LM, Zackai EH, Al-Gazali LI, Hulskamp G, Kingston HM, Prescott TE, Ion A, Patton MA, Murday V, George A, Crosby AH (2007). "Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development". Am. J. Hum. Genet. 81 (5): 906–12. doi:10.1086/522240. PMC 2265657. PMID 17924334. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

Further reading

  • Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Hao J, Narayanan K, Muni T; et al. (2007). "Dentin matrix protein 4, a novel secretory calcium-binding protein that modulates odontoblast differentiation". J. Biol. Chem. 282 (21): 15357–65. doi:10.1074/jbc.M701547200. PMID 17369251. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Simpson MA, Scheuerle A, Hurst J; et al. (2009). "Mutations in FAM20C also identified in non-lethal osteosclerotic bone dysplasia". Clin. Genet. 75 (3): 271–6. doi:10.1111/j.1399-0004.2008.01118.x. PMID 19250384. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
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