Aristolochia clematitis: Difference between revisions

Aristolochia clematitis
Scientific classification
Kingdom:	Plantae
(unranked):	Angiosperms
(unranked):	Magnoliids
Order:	Piperales
Family:	Aristolochiaceae
Genus:	Aristolochia
Species:	A. clematitis
Binomial name
	Aristolochia clematitis; L.

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Revision as of 17:07, 14 July 2012

Aristolochia clematitis, (European) Birthwort, is a twining herbaceous plant in the Aristolochiaceae family, which is native to Europe. The leaves are heart shaped and the flowers are pale yellow and tubular in form. The plant seeks light by ascending the stems of surrounding plants.

Medicinal problems

It was formerly used as a medicinal plant (though poisonous) and is now occasionally found established outside of its native range as a relic of cultivation. A study that suggested that it is the cause for thousands of kidney failures in Romania, Bulgaria, Serbia and Croatia where the plant is unintentionally consumed through contaminated flour^[1] has been confirmed with urinary tract malignacies also being characterised^[2]. The link with the plants content of aristolochic acid was discovered after a clinic for obesity in Belgium used herbal products based on another plant of the same genus as a diuretic. After a few months, some of the patients experienced kidney carcinoma and kidney failure^[3].

References

^ Grollman, Arthur P. et al.(2007). http://www.pnas.org/content/104/29/12129/suppl/DC1 ‘Aristolochic Acid and the Etiology of Endemic (Balkan) Nephropathy’, Proceedings of the National Academy of Sciences, 104: 12129 –12134 <doi:10.1073/pnas.0701248104>
^ De Broe ME. Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy. Kidney Int. 2012 Mar;81(6):513-5. doi: 10.1038/ki.2011.428.
^ Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M, Richard C, Vandervelde D, Verbeelen D, Vanhaelen-Fastre R, et al. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet. 1993 Feb 13;341(8842):387-91.

Gallery

Habitus
Habitus

Flowers

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[1] Grollman, Arthur P. et al.(2007). http://www.pnas.org/content/104/29/12129/suppl/DC1 ‘Aristolochic Acid and the Etiology of Endemic (Balkan) Nephropathy’, Proceedings of the National Academy of Sciences, 104: 12129 –12134 <doi:10.1073/pnas.0701248104>

[2] De Broe ME. Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy. Kidney Int. 2012 Mar;81(6):513-5. doi: 10.1038/ki.2011.428.

[3] Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M, Richard C, Vandervelde D, Verbeelen D, Vanhaelen-Fastre R, et al. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet. 1993 Feb 13;341(8842):387-91.

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-{{Refimprove|date=June 2010}}
 '''''Aristolochia clematitis''''', '''(European) Birthwort''', is a twining [[herbaceous]] plant in the [[Aristolochiaceae]] family, which is native to Europe. The leaves are heart shaped and the flowers are pale yellow and tubular in form. The plant seeks light by ascending the stems of surrounding plants.
 ==Medicinal problems==
-It was formerly used as a medicinal plant (though [[poisonous]]) and is now occasionally found established outside of its native range as a relic of cultivation. A recent study suggests that it is the cause for thousands of kidney failures in Romania, Bulgaria, Serbia and Croatia where the plant is unintentionally consumed through flour.<ref>Grollman, Arthur P. et al.(2007). http://www.pnas.org/content/104/29/12129/suppl/DC1 ‘Aristolochic Acid and the Etiology of Endemic (Balkan) Nephropathy’, Proceedings of the National Academy of Sciences, 104: 12129 –12134 <doi:10.1073/pnas.0701248104></ref> This was discovered after a clinic for obesity in Belgium used aristolochic acid, a component of this plant, as a diuretic. After a few months, some of the patients experienced kidney carcinoma and kidney failure.{{Citation needed|date=April 2012}}
+It was formerly used as a medicinal plant (though [[poisonous]]) and is now occasionally found established outside of its native range as a relic of cultivation. A study that suggested that it is the cause for thousands of kidney failures in Romania, Bulgaria, Serbia and Croatia where the plant is unintentionally consumed through contaminated flour<ref>Grollman, Arthur P. et al.(2007). http://www.pnas.org/content/104/29/12129/suppl/DC1 ‘Aristolochic Acid and the Etiology of Endemic (Balkan) Nephropathy’, Proceedings of the National Academy of Sciences, 104: 12129 –12134 <doi:10.1073/pnas.0701248104></ref> has been confirmed with urinary tract malignacies also being characterised<ref>De Broe ME. Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid nephropathy. Kidney Int. 2012 Mar;81(6):513-5. doi: 10.1038/ki.2011.428.</ref>. The link with the plants content of [[aristolochic acid]] was discovered after a clinic for obesity in Belgium used herbal products based on another plant of the same genus as a diuretic. After a few months, some of the patients experienced kidney carcinoma and kidney failure<ref>Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M, Richard C, Vandervelde D, Verbeelen D, Vanhaelen-Fastre R, et al. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet. 1993 Feb 13;341(8842):387-91.</ref>.
 ==See also==