Warthin–Finkeldey cell: Difference between revisions
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A '''Warthin–Finkeldey cell''' is a type of giant multinucleate cell found in hyperplastic [[lymph node]]s early in the course of [[measles]] and also in [[HIV]]-infected individuals,<ref name="Burke1994">{{cite journal | author = Burke AP, Anderson D, Mannan P, Ribas JL, Liang YH, Smialek J, Virmani R. | title=Systemic lymphadenopathic histology in human immunodeficiency virus-1-seropositive drug addicts without apparent acquired immunodeficiency syndrome | journal=Hum Pathol. | year=1994 | volume=25 | issue=3 | pages = 248–56 | pmid=8150456}}</ref> as well as in [[Kimura disease]],<ref name="">{{cite journal | author = Abuel-Haija M, Hurford MT | year = 2007 | title = Kimura Disease | journal = Archives of Pathology & Laboratory Medicine | volume = 131 | issue=4 | pages=650–651 | pmid=17425383 | doi=10.1043/1543-2165(2007)131[650:KD]2.0.CO;2}} |
A '''Warthin–Finkeldey cell''' is a type of giant multinucleate cell found in hyperplastic [[lymph node]]s early in the course of [[measles]] and also in [[HIV]]-infected individuals,<ref name="Burke1994">{{cite journal | author = Burke AP, Anderson D, Mannan P, Ribas JL, Liang YH, Smialek J, Virmani R. | title=Systemic lymphadenopathic histology in human immunodeficiency virus-1-seropositive drug addicts without apparent acquired immunodeficiency syndrome | journal=Hum Pathol. | year=1994 | volume=25 | issue=3 | pages = 248–56 | pmid=8150456}}</ref> as well as in [[Kimura disease]],<ref name="">{{cite journal | author = Abuel-Haija M, Hurford MT | year = 2007 | title = Kimura Disease | journal = Archives of Pathology & Laboratory Medicine | volume = 131 | issue=4 | pages=650–651 | pmid=17425383 | doi=10.1043/1543-2165(2007)131[650:KD]2.0.CO;2}} |
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</ref> and more rarely in a number of neoplastic (e.g. [[lymphoma]]) and non-neoplastic lymph node disorders.<ref name="Kjedsberg">{{cite journal | author = Kjeldsberg CR, Kim H. | title = Polykaryocytes resembling Warthin-Finkeldey giant cells in reactive and neoplastic lymphoid disorders. | journal = Hum Pathol. | year = 1981 | volume = 12 | issue=3 | pages = 267–72 | pmid = 7228021 | url = http://www.sciencedirect.com/science/article/pii/S0046817781801281}}</ref> Their origin is uncertain, but they have previously been shown to stain with markers similar to those of [[follicular dendritic cell]]s, including CD21.<ref name="Orenstein">{{cite journal | author = Orenstein JM | journal = Ultrastructural Pathology | year = 1988 | volume = 22 | pages = 293–303 | title = The Warthin-Finkeldey-Type Giant Cell in HIV Infection, What Is It? | url = http://informahealthcare.com/doi/pdf/10.3109/01913129809103350 | doi=10.3109/01913129809103350}}</ref> Under the light microscope, these cells consist of a large, grape-like cluster of nuclei. |
</ref> and more rarely in a number of neoplastic (e.g. [[lymphoma]]) and non-neoplastic lymph node disorders.<ref name="Kjedsberg">{{cite journal | author = Kjeldsberg CR, Kim H. | title = Polykaryocytes resembling Warthin-Finkeldey giant cells in reactive and neoplastic lymphoid disorders. | journal = Hum Pathol. | year = 1981 | volume = 12 | issue=3 | pages = 267–72 | pmid = 7228021 | url = http://www.sciencedirect.com/science/article/pii/S0046817781801281 | doi=10.1016/S0046-8177(81)80128-1}}</ref> Their origin is uncertain, but they have previously been shown to stain with markers similar to those of [[follicular dendritic cell]]s, including CD21.<ref name="Orenstein">{{cite journal | author = Orenstein JM | journal = Ultrastructural Pathology | year = 1988 | volume = 22 | pages = 293–303 | title = The Warthin-Finkeldey-Type Giant Cell in HIV Infection, What Is It? | url = http://informahealthcare.com/doi/pdf/10.3109/01913129809103350 | doi=10.3109/01913129809103350}}</ref> Under the light microscope, these cells consist of a large, grape-like cluster of nuclei. |
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==References== |
==References== |
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Revision as of 20:48, 6 February 2014
A Warthin–Finkeldey cell is a type of giant multinucleate cell found in hyperplastic lymph nodes early in the course of measles and also in HIV-infected individuals,[1] as well as in Kimura disease,[2] and more rarely in a number of neoplastic (e.g. lymphoma) and non-neoplastic lymph node disorders.[3] Their origin is uncertain, but they have previously been shown to stain with markers similar to those of follicular dendritic cells, including CD21.[4] Under the light microscope, these cells consist of a large, grape-like cluster of nuclei.
References
- ^ Burke AP, Anderson D, Mannan P, Ribas JL, Liang YH, Smialek J, Virmani R. (1994). "Systemic lymphadenopathic histology in human immunodeficiency virus-1-seropositive drug addicts without apparent acquired immunodeficiency syndrome". Hum Pathol. 25 (3): 248–56. PMID 8150456.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Abuel-Haija M, Hurford MT (2007). "Kimura Disease". Archives of Pathology & Laboratory Medicine. 131 (4): 650–651. doi:10.1043/1543-2165(2007)131[650:KD]2.0.CO;2. PMID 17425383.
- ^ Kjeldsberg CR, Kim H. (1981). "Polykaryocytes resembling Warthin-Finkeldey giant cells in reactive and neoplastic lymphoid disorders". Hum Pathol. 12 (3): 267–72. doi:10.1016/S0046-8177(81)80128-1. PMID 7228021.
- ^ Orenstein JM (1988). "The Warthin-Finkeldey-Type Giant Cell in HIV Infection, What Is It?". Ultrastructural Pathology. 22: 293–303. doi:10.3109/01913129809103350.
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