Kebuzone: Difference between revisions
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'''Kebuzone''' (or '''ketophenylbutazone''') is a [[non-steroidal anti-inflammatory drug]] |
'''Kebuzone''' (or '''ketophenylbutazone''') is a [[non-steroidal anti-inflammatory drug]]. |
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==Synthesis== |
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The key intermediate is obtainable by [[Michael addition]] of the anion from [[diethyl malonate]] to [[methyl vinyl ketone]] followed by ketalization with [[ethylene glycol]]. Condensation with [[hydrazobenzene]] leads to pyrazolodione; hydrolysis of the ketone affords [[ketazone]]. |
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[[File:Kebuzone synthesis.svg|thumb|center|700px|Kebuzone synthesis: {{US patent|2910481}}]] |
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{{Anti-inflammatory and antirheumatic products}} |
{{Anti-inflammatory and antirheumatic products}} |
Revision as of 12:32, 10 January 2015
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.011.560 |
Chemical and physical data | |
Formula | C19H18N2O3 |
Molar mass | 322.35782 g/mol g·mol−1 |
3D model (JSmol) | |
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Kebuzone (or ketophenylbutazone) is a non-steroidal anti-inflammatory drug.