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==Career and research==
==Career and research==
Following her PhD, Zeggini was a [[postdoctoral researcher]] at the [[Wellcome Trust Centre for Human Genetics]] at the [[University of Oxford]] where she later became a [[Wellcome Trust]] Research Career Development Fellow. She has been a group leader at the Sanger since 2008.<ref name=orcid/> According to [[Scopus]]<ref name=scopus>{{Scopus|id=6602598642}}</ref> her most cited work has been published in ''[[Science (journal)|Science]]''<ref>{{cite doi| 10.1126/science.1141634}}</ref><ref>{{cite doi|10.1126/science.1142364}}</ref> and ''[[Nature Genetics]]''.<ref name="ZegginiScott2008">{{cite journal|last1=Zeggini|first1=Eleftheria|last2=Scott|first2=Laura J|last3=Saxena|first3=Richa|last4=Voight|first4=Benjamin F|last5=Marchini|first5=Jonathan L|last6=Hu|first6=Tianle|last7=de Bakker|first7=Paul IW|last8=Abecasis|first8=Gonçalo R|last9=Almgren|first9=Peter|last10=Andersen|first10=Gitte|last11=Ardlie|first11=Kristin|last12=Boström|first12=Kristina Bengtsson|last13=Bergman|first13=Richard N|last14=Bonnycastle|first14=Lori L|last15=Borch-Johnsen|first15=Knut|last16=Burtt|first16=Noël P|last17=Chen|first17=Hong|last18=Chines|first18=Peter S|last19=Daly|first19=Mark J|last20=Deodhar|first20=Parimal|last21=Ding|first21=Chia-Jen|last22=Doney|first22=Alex S F|last23=Duren|first23=William L|last24=Elliott|first24=Katherine S|last25=Erdos|first25=Michael R|last26=Frayling|first26=Timothy M|last27=Freathy|first27=Rachel M|last28=Gianniny|first28=Lauren|last29=Grallert|first29=Harald|last30=Grarup|first30=Niels|last31=Groves|first31=Christopher J|last32=Guiducci|first32=Candace|last33=Hansen|first33=Torben|last34=Herder|first34=Christian|last35=Hitman|first35=Graham A|last36=Hughes|first36=Thomas E|last37=Isomaa|first37=Bo|last38=Jackson|first38=Anne U|last39=Jørgensen|first39=Torben|last40=Kong|first40=Augustine|last41=Kubalanza|first41=Kari|last42=Kuruvilla|first42=Finny G|last43=Kuusisto|first43=Johanna|last44=Langenberg|first44=Claudia|last45=Lango|first45=Hana|last46=Lauritzen|first46=Torsten|last47=Li|first47=Yun|last48=Lindgren|first48=Cecilia M|last49=Lyssenko|first49=Valeriya|last50=Marvelle|first50=Amanda F|last51=Meisinger|first51=Christa|last52=Midthjell|first52=Kristian|last53=Mohlke|first53=Karen L|last54=Morken|first54=Mario A|last55=Morris|first55=Andrew D|last56=Narisu|first56=Narisu|last57=Nilsson|first57=Peter|last58=Owen|first58=Katharine R|last59=Palmer|first59=Colin NA|last60=Payne|first60=Felicity|last61=Perry|first61=John R B|last62=Pettersen|first62=Elin|last63=Platou|first63=Carl|last64=Prokopenko|first64=Inga|last65=Qi|first65=Lu|last66=Qin|first66=Li|last67=Rayner|first67=Nigel W|last68=Rees|first68=Matthew|last69=Roix|first69=Jeffrey J|last70=Sandbæk|first70=Anelli|last71=Shields|first71=Beverley|last72=Sjögren|first72=Marketa|last73=Steinthorsdottir|first73=Valgerdur|last74=Stringham|first74=Heather M|last75=Swift|first75=Amy J|last76=Thorleifsson|first76=Gudmar|last77=Thorsteinsdottir|first77=Unnur|last78=Timpson|first78=Nicholas J|last79=Tuomi|first79=Tiinamaija|last80=Tuomilehto|first80=Jaakko|last81=Walker|first81=Mark|last82=Watanabe|first82=Richard M|last83=Weedon|first83=Michael N|last84=Willer|first84=Cristen J|last85=Illig|first85=Thomas|last86=Hveem|first86=Kristian|last87=Hu|first87=Frank B|last88=Laakso|first88=Markku|last89=Stefansson|first89=Kari|last90=Pedersen|first90=Oluf|last91=Wareham|first91=Nicholas J|last92=Barroso|first92=Inês|last93=Hattersley|first93=Andrew T|last94=Collins|first94=Francis S|last95=Groop|first95=Leif|last96=McCarthy|first96=Mark I|last97=Boehnke|first97=Michael|last98=Altshuler|first98=David|title=Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes|journal=Nature Genetics|volume=40|issue=5|year=2008|pages=638–645|issn=1061-4036|doi=10.1038/ng.120|pmid=18372903|pmc=2672416|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672416/}}</ref><ref name="WillerSpeliotes2008">{{cite journal|last1=Willer|first1=Cristen J|last2=Speliotes|first2=Elizabeth K|last3=Loos|first3=Ruth J F|last4=Li|first4=Shengxu|last5=Lindgren|first5=Cecilia M|last6=Heid|first6=Iris M|last7=Berndt|first7=Sonja I|last8=Elliott|first8=Amanda L|last9=Jackson|first9=Anne U|last10=Lamina|first10=Claudia|last11=Lettre|first11=Guillaume|last12=Lim|first12=Noha|last13=Lyon|first13=Helen N|last14=McCarroll|first14=Steven A|last15=Papadakis|first15=Konstantinos|last16=Qi|first16=Lu|last17=Randall|first17=Joshua C|last18=Roccasecca|first18=Rosa Maria|last19=Sanna|first19=Serena|last20=Scheet|first20=Paul|last21=Weedon|first21=Michael N|last22=Wheeler|first22=Eleanor|last23=Zhao|first23=Jing Hua|last24=Jacobs|first24=Leonie C|last25=Prokopenko|first25=Inga|last26=Soranzo|first26=Nicole|last27=Tanaka|first27=Toshiko|last28=Timpson|first28=Nicholas J|last29=Almgren|first29=Peter|last30=Bennett|first30=Amanda|last31=Bergman|first31=Richard N|last32=Bingham|first32=Sheila A|last33=Bonnycastle|first33=Lori L|last34=Brown|first34=Morris|last35=Burtt|first35=Noël P|last36=Chines|first36=Peter|last37=Coin|first37=Lachlan|last38=Collins|first38=Francis S|last39=Connell|first39=John M|last40=Cooper|first40=Cyrus|last41=Smith|first41=George Davey|last42=Dennison|first42=Elaine M|last43=Deodhar|first43=Parimal|last44=Elliott|first44=Paul|last45=Erdos|first45=Michael R|last46=Estrada|first46=Karol|last47=Evans|first47=David M|last48=Gianniny|first48=Lauren|last49=Gieger|first49=Christian|last50=Gillson|first50=Christopher J|last51=Guiducci|first51=Candace|last52=Hackett|first52=Rachel|last53=Hadley|first53=David|last54=Hall|first54=Alistair S|last55=Havulinna|first55=Aki S|last56=Hebebrand|first56=Johannes|last57=Hofman|first57=Albert|last58=Isomaa|first58=Bo|last59=Jacobs|first59=Kevin B|last60=Johnson|first60=Toby|last61=Jousilahti|first61=Pekka|last62=Jovanovic|first62=Zorica|last63=Khaw|first63=Kay-Tee|last64=Kraft|first64=Peter|last65=Kuokkanen|first65=Mikko|last66=Kuusisto|first66=Johanna|last67=Laitinen|first67=Jaana|last68=Lakatta|first68=Edward G|last69=Luan|first69=Jian'an|last70=Luben|first70=Robert N|last71=Mangino|first71=Massimo|last72=McArdle|first72=Wendy L|last73=Meitinger|first73=Thomas|last74=Mulas|first74=Antonella|last75=Munroe|first75=Patricia B|last76=Narisu|first76=Narisu|last77=Ness|first77=Andrew R|last78=Northstone|first78=Kate|last79=O'Rahilly|first79=Stephen|last80=Purmann|first80=Carolin|last81=Rees|first81=Matthew G|last82=Ridderstråle|first82=Martin|last83=Ring|first83=Susan M|last84=Rivadeneira|first84=Fernando|last85=Ruokonen|first85=Aimo|last86=Sandhu|first86=Manjinder S|last87=Saramies|first87=Jouko|last88=Scott|first88=Laura J|last89=Scuteri|first89=Angelo|last90=Silander|first90=Kaisa|last91=Sims|first91=Matthew A|last92=Song|first92=Kijoung|last93=Stephens|first93=Jonathan|last94=Stevens|first94=Suzanne|last95=Stringham|first95=Heather M|last96=Tung|first96=Y C Loraine|last97=Valle|first97=Timo T|last98=Van Duijn|first98=Cornelia M|last99=Vimaleswaran|first99=Karani S|last100=Vollenweider|first100=Peter|last101=Waeber|first101=Gerard|last102=Wallace|first102=Chris|last103=Watanabe|first103=Richard M|last104=Waterworth|first104=Dawn M|last105=Watkins|first105=Nicholas|last106=Witteman|first106=Jacqueline C M|last107=Zeggini|first107=Eleftheria|last108=Zhai|first108=Guangju|last109=Zillikens|first109=M Carola|last110=Altshuler|first110=David|last111=Caulfield|first111=Mark J|last112=Chanock|first112=Stephen J|last113=Farooqi|first113=I Sadaf|last114=Ferrucci|first114=Luigi|last115=Guralnik|first115=Jack M|last116=Hattersley|first116=Andrew T|last117=Hu|first117=Frank B|last118=Jarvelin|first118=Marjo-Riitta|last119=Laakso|first119=Markku|last120=Mooser|first120=Vincent|last121=Ong|first121=Ken K|last122=Ouwehand|first122=Willem H|last123=Salomaa|first123=Veikko|last124=Samani|first124=Nilesh J|last125=Spector|first125=Timothy D|last126=Tuomi|first126=Tiinamaija|last127=Tuomilehto|first127=Jaakko|last128=Uda|first128=Manuela|last129=Uitterlinden|first129=André G|last130=Wareham|first130=Nicholas J|last131=Deloukas|first131=Panagiotis|last132=Frayling|first132=Timothy M|last133=Groop|first133=Leif C|last134=Hayes|first134=Richard B|last135=Hunter|first135=David J|last136=Mohlke|first136=Karen L|last137=Peltonen|first137=Leena|last138=Schlessinger|first138=David|last139=Strachan|first139=David P|last140=Wichmann|first140=H-Erich|last141=McCarthy|first141=Mark I|last142=Boehnke|first142=Michael|last143=Barroso|first143=Inês|last144=Abecasis|first144=Gonçalo R|last145=Hirschhorn|first145=Joel N|title=Six new loci associated with body mass index highlight a neuronal influence on body weight regulation|journal=Nature Genetics|volume=41|issue=1|year=2008|pmid=19079261|pages=25–34|issn=1061-4036|doi=10.1038/ng.287|pmc=2695662|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695662/}}</ref>
Following her PhD, Zeggini was a [[postdoctoral researcher]] at the [[Wellcome Trust Centre for Human Genetics]] at the [[University of Oxford]] where she later became a [[Wellcome Trust]] Research Career Development Fellow. She has been a group leader at the Sanger since 2008.<ref name=orcid/> According to [[Scopus]]<ref name=scopus>{{Scopus|id=6602598642}}</ref> her most cited work has been published in ''[[Science (journal)|Science]]''<ref>{{Cite journal | doi = 10.1126/science.1141634| title = A Common Variant in the FTO Gene is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity| journal = Science| volume = 316| issue = 5826| pages = 889–94| year = 2007| last1 = Frayling | first1 = T. M.| last2 = Timpson | first2 = N. J.| last3 = Weedon | first3 = M. N.| last4 = Zeggini | first4 = E.| last5 = Freathy | first5 = R. M.| last6 = Lindgren | first6 = C. M.| last7 = Perry | first7 = J. R. B.| last8 = Elliott | first8 = K. S.| last9 = Lango | first9 = H.| last10 = Rayner | first10 = N. W.| last11 = Shields | first11 = B.| last12 = Harries | first12 = L. W.| last13 = Barrett | first13 = J. C.| last14 = Ellard | first14 = S.| last15 = Groves | first15 = C. J.| last16 = Knight | first16 = B.| last17 = Patch | first17 = A. -M. | last18 = Ness | first18 = A. R.| last19 = Ebrahim | first19 = S.| last20 = Lawlor | first20 = D. A.| last21 = Ring | first21 = S. M.| last22 = Ben-Shlomo | first22 = Y.| last23 = Jarvelin | first23 = M. -R. | last24 = Sovio | first24 = U.| last25 = Bennett | first25 = A. J.| last26 = Melzer | first26 = D.| last27 = Ferrucci | first27 = L.| last28 = Loos | first28 = R. J. F.| last29 = Barroso | first29 = I.| last30 = Wareham | first30 = N. J.| display-authors = 29 | pmid=17434869 | pmc=2646098}}</ref><ref>{{Cite journal | last1 = Zeggini | first1 = E. | last2 = Weedon | first2 = M. N. | last3 = Lindgren | first3 = C. M. | last4 = Frayling | first4 = T. M. | last5 = Elliott | first5 = K. S. | last6 = Lango | first6 = H. | last7 = Timpson | first7 = N. J. | last8 = Perry | first8 = J. R. B. | last9 = Rayner | first9 = N. W. | last10 = Freathy | first10 = R. M. | last11 = Barrett | first11 = J. C. | last12 = Shields | first12 = B. | last13 = Morris | first13 = A. P. | last14 = Ellard | first14 = S. | last15 = Groves | first15 = C. J. | last16 = Harries | first16 = L. W. | last17 = Marchini | first17 = J. L. | last18 = Owen | first18 = K. R. | last19 = Knight | first19 = B. | last20 = Cardon | first20 = L. R. | last21 = Walker | first21 = M. | last22 = Hitman | first22 = G. A. | last23 = Morris | first23 = A. D. | last24 = Doney | first24 = A. S. F.| author25 = Wellcome Trust Case Control Consortium (WTCCC) | last26 = Burton | first26 = P. R. | last27 = McCarthy | first27 = D. G. | last28 = Hattersley | first28 = N. | last29 = Deloukas | first29 = P. | last30 = Duncanson | first30 = A. | last31 = Kwiatkowski | first31 = D. P. | title = Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes | journal = Science | volume = 316 | issue = 5829 | pages = 1336–1341 | year = 2007 | pmid = 17463249 | doi = 10.1126/science.1142364 }}</ref> and ''[[Nature Genetics]]''.<ref name="ZegginiScott2008">{{cite journal|last1=Zeggini|first1=Eleftheria|last2=Scott|first2=Laura J|last3=Saxena|first3=Richa|last4=Voight|first4=Benjamin F|last5=Marchini|first5=Jonathan L|last6=Hu|first6=Tianle|last7=de Bakker|first7=Paul IW|last8=Abecasis|first8=Gonçalo R|last9=Almgren|first9=Peter|last10=Andersen|first10=Gitte|last11=Ardlie|first11=Kristin|last12=Boström|first12=Kristina Bengtsson|last13=Bergman|first13=Richard N|last14=Bonnycastle|first14=Lori L|last15=Borch-Johnsen|first15=Knut|last16=Burtt|first16=Noël P|last17=Chen|first17=Hong|last18=Chines|first18=Peter S|last19=Daly|first19=Mark J|last20=Deodhar|first20=Parimal|last21=Ding|first21=Chia-Jen|last22=Doney|first22=Alex S F|last23=Duren|first23=William L|last24=Elliott|first24=Katherine S|last25=Erdos|first25=Michael R|last26=Frayling|first26=Timothy M|last27=Freathy|first27=Rachel M|last28=Gianniny|first28=Lauren|last29=Grallert|first29=Harald|last30=Grarup|first30=Niels|last31=Groves|first31=Christopher J|last32=Guiducci|first32=Candace|last33=Hansen|first33=Torben|last34=Herder|first34=Christian|last35=Hitman|first35=Graham A|last36=Hughes|first36=Thomas E|last37=Isomaa|first37=Bo|last38=Jackson|first38=Anne U|last39=Jørgensen|first39=Torben|last40=Kong|first40=Augustine|last41=Kubalanza|first41=Kari|last42=Kuruvilla|first42=Finny G|last43=Kuusisto|first43=Johanna|last44=Langenberg|first44=Claudia|last45=Lango|first45=Hana|last46=Lauritzen|first46=Torsten|last47=Li|first47=Yun|last48=Lindgren|first48=Cecilia M|last49=Lyssenko|first49=Valeriya|last50=Marvelle|first50=Amanda F|last51=Meisinger|first51=Christa|last52=Midthjell|first52=Kristian|last53=Mohlke|first53=Karen L|last54=Morken|first54=Mario A|last55=Morris|first55=Andrew D|last56=Narisu|first56=Narisu|last57=Nilsson|first57=Peter|last58=Owen|first58=Katharine R|last59=Palmer|first59=Colin NA|last60=Payne|first60=Felicity|last61=Perry|first61=John R B|last62=Pettersen|first62=Elin|last63=Platou|first63=Carl|last64=Prokopenko|first64=Inga|last65=Qi|first65=Lu|last66=Qin|first66=Li|last67=Rayner|first67=Nigel W|last68=Rees|first68=Matthew|last69=Roix|first69=Jeffrey J|last70=Sandbæk|first70=Anelli|last71=Shields|first71=Beverley|last72=Sjögren|first72=Marketa|last73=Steinthorsdottir|first73=Valgerdur|last74=Stringham|first74=Heather M|last75=Swift|first75=Amy J|last76=Thorleifsson|first76=Gudmar|last77=Thorsteinsdottir|first77=Unnur|last78=Timpson|first78=Nicholas J|last79=Tuomi|first79=Tiinamaija|last80=Tuomilehto|first80=Jaakko|last81=Walker|first81=Mark|last82=Watanabe|first82=Richard M|last83=Weedon|first83=Michael N|last84=Willer|first84=Cristen J|last85=Illig|first85=Thomas|last86=Hveem|first86=Kristian|last87=Hu|first87=Frank B|last88=Laakso|first88=Markku|last89=Stefansson|first89=Kari|last90=Pedersen|first90=Oluf|last91=Wareham|first91=Nicholas J|last92=Barroso|first92=Inês|last93=Hattersley|first93=Andrew T|last94=Collins|first94=Francis S|last95=Groop|first95=Leif|last96=McCarthy|first96=Mark I|last97=Boehnke|first97=Michael|last98=Altshuler|first98=David|title=Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes|journal=Nature Genetics|volume=40|issue=5|year=2008|pages=638–645|issn=1061-4036|doi=10.1038/ng.120|pmid=18372903|pmc=2672416|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672416/}}</ref><ref name="WillerSpeliotes2008">{{cite journal|last1=Willer|first1=Cristen J|last2=Speliotes|first2=Elizabeth K|last3=Loos|first3=Ruth J F|last4=Li|first4=Shengxu|last5=Lindgren|first5=Cecilia M|last6=Heid|first6=Iris M|last7=Berndt|first7=Sonja I|last8=Elliott|first8=Amanda L|last9=Jackson|first9=Anne U|last10=Lamina|first10=Claudia|last11=Lettre|first11=Guillaume|last12=Lim|first12=Noha|last13=Lyon|first13=Helen N|last14=McCarroll|first14=Steven A|last15=Papadakis|first15=Konstantinos|last16=Qi|first16=Lu|last17=Randall|first17=Joshua C|last18=Roccasecca|first18=Rosa Maria|last19=Sanna|first19=Serena|last20=Scheet|first20=Paul|last21=Weedon|first21=Michael N|last22=Wheeler|first22=Eleanor|last23=Zhao|first23=Jing Hua|last24=Jacobs|first24=Leonie C|last25=Prokopenko|first25=Inga|last26=Soranzo|first26=Nicole|last27=Tanaka|first27=Toshiko|last28=Timpson|first28=Nicholas J|last29=Almgren|first29=Peter|last30=Bennett|first30=Amanda|last31=Bergman|first31=Richard N|last32=Bingham|first32=Sheila A|last33=Bonnycastle|first33=Lori L|last34=Brown|first34=Morris|last35=Burtt|first35=Noël P|last36=Chines|first36=Peter|last37=Coin|first37=Lachlan|last38=Collins|first38=Francis S|last39=Connell|first39=John M|last40=Cooper|first40=Cyrus|last41=Smith|first41=George Davey|last42=Dennison|first42=Elaine M|last43=Deodhar|first43=Parimal|last44=Elliott|first44=Paul|last45=Erdos|first45=Michael R|last46=Estrada|first46=Karol|last47=Evans|first47=David M|last48=Gianniny|first48=Lauren|last49=Gieger|first49=Christian|last50=Gillson|first50=Christopher J|last51=Guiducci|first51=Candace|last52=Hackett|first52=Rachel|last53=Hadley|first53=David|last54=Hall|first54=Alistair S|last55=Havulinna|first55=Aki S|last56=Hebebrand|first56=Johannes|last57=Hofman|first57=Albert|last58=Isomaa|first58=Bo|last59=Jacobs|first59=Kevin B|last60=Johnson|first60=Toby|last61=Jousilahti|first61=Pekka|last62=Jovanovic|first62=Zorica|last63=Khaw|first63=Kay-Tee|last64=Kraft|first64=Peter|last65=Kuokkanen|first65=Mikko|last66=Kuusisto|first66=Johanna|last67=Laitinen|first67=Jaana|last68=Lakatta|first68=Edward G|last69=Luan|first69=Jian'an|last70=Luben|first70=Robert N|last71=Mangino|first71=Massimo|last72=McArdle|first72=Wendy L|last73=Meitinger|first73=Thomas|last74=Mulas|first74=Antonella|last75=Munroe|first75=Patricia B|last76=Narisu|first76=Narisu|last77=Ness|first77=Andrew R|last78=Northstone|first78=Kate|last79=O'Rahilly|first79=Stephen|last80=Purmann|first80=Carolin|last81=Rees|first81=Matthew G|last82=Ridderstråle|first82=Martin|last83=Ring|first83=Susan M|last84=Rivadeneira|first84=Fernando|last85=Ruokonen|first85=Aimo|last86=Sandhu|first86=Manjinder S|last87=Saramies|first87=Jouko|last88=Scott|first88=Laura J|last89=Scuteri|first89=Angelo|last90=Silander|first90=Kaisa|last91=Sims|first91=Matthew A|last92=Song|first92=Kijoung|last93=Stephens|first93=Jonathan|last94=Stevens|first94=Suzanne|last95=Stringham|first95=Heather M|last96=Tung|first96=Y C Loraine|last97=Valle|first97=Timo T|last98=Van Duijn|first98=Cornelia M|last99=Vimaleswaran|first99=Karani S|last100=Vollenweider|first100=Peter|last101=Waeber|first101=Gerard|last102=Wallace|first102=Chris|last103=Watanabe|first103=Richard M|last104=Waterworth|first104=Dawn M|last105=Watkins|first105=Nicholas|last106=Witteman|first106=Jacqueline C M|last107=Zeggini|first107=Eleftheria|last108=Zhai|first108=Guangju|last109=Zillikens|first109=M Carola|last110=Altshuler|first110=David|last111=Caulfield|first111=Mark J|last112=Chanock|first112=Stephen J|last113=Farooqi|first113=I Sadaf|last114=Ferrucci|first114=Luigi|last115=Guralnik|first115=Jack M|last116=Hattersley|first116=Andrew T|last117=Hu|first117=Frank B|last118=Jarvelin|first118=Marjo-Riitta|last119=Laakso|first119=Markku|last120=Mooser|first120=Vincent|last121=Ong|first121=Ken K|last122=Ouwehand|first122=Willem H|last123=Salomaa|first123=Veikko|last124=Samani|first124=Nilesh J|last125=Spector|first125=Timothy 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{{As of|2015}} her work investigates the [[genetics]] of complex [[phenotypic trait]]s in humans using [[genetic association]] studies to identify [[Locus (genetics)|novel disease loci]].<ref name="Zeggini2011">{{cite journal|last1=Zeggini|first1=Eleftheria|title=Next-generation association studies for complex traits|journal=Nature Genetics|volume=43|issue=4|year=2011|pages=287–288|issn=1061-4036|doi=10.1038/ng0411-287|pmc=3435533|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435533/}}</ref><ref name="CrawfordBabron2012">{{cite journal|last1=Crawford|first1=Dana C.|last2=Babron|first2=Marie-Claude|last3=de Tayrac|first3=Marie|last4=Rutledge|first4=Douglas N.|last5=Zeggini|first5=Eleftheria|last6=Génin|first6=Emmanuelle|title=Rare and Low Frequency Variant Stratification in the UK Population: Description and Impact on Association Tests|journal=PLoS ONE|volume=7|issue=10|year=2012|pages=e46519|issn=1932-6203|doi=10.1371/journal.pone.0046519|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465327/|pmc=3465327}} {{open access}}</ref>
{{As of|2015}} her work investigates the [[genetics]] of complex [[phenotypic trait]]s in humans using [[genetic association]] studies to identify [[Locus (genetics)|novel disease loci]].<ref name="Zeggini2011">{{cite journal|last1=Zeggini|first1=Eleftheria|title=Next-generation association studies for complex traits|journal=Nature Genetics|volume=43|issue=4|year=2011|pages=287–288|issn=1061-4036|doi=10.1038/ng0411-287|pmc=3435533|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435533/}}</ref><ref name="CrawfordBabron2012">{{cite journal|last1=Crawford|first1=Dana C.|last2=Babron|first2=Marie-Claude|last3=de Tayrac|first3=Marie|last4=Rutledge|first4=Douglas N.|last5=Zeggini|first5=Eleftheria|last6=Génin|first6=Emmanuelle|title=Rare and Low Frequency Variant Stratification in the UK Population: Description and Impact on Association Tests|journal=PLoS ONE|volume=7|issue=10|year=2012|pages=e46519|issn=1932-6203|doi=10.1371/journal.pone.0046519|url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465327/|pmc=3465327}} {{open access}}</ref>

Revision as of 07:27, 2 December 2015

Ele Zeggini
Born
Ελευθερία Ζεγγίνη[4]
Alma mater
Scientific career
Institutions
ThesisGenetic dissection of the major histocompatibility complex in juvenile oligoarthritis (2002)
Doctoral students
  • Sophie Hackinger[2]
  • Fernando Aguilera[3]
Websitewww.sanger.ac.uk/people/directory/zeggini-eleftheria

Eleftheria Zeggini is research group leader at the Wellcome Trust Sanger Institute and an Honorary Professor in the Department of Health Sciences at the University of Leicester in the UK.[5][6][7][8][9]

Bildung

Zeggini was educated at the University of Manchester Institute of Science and Technology (UMIST) where she was awarded a Bachelor of Science degree in Biochemistry in 1999. She continued her studies on the immunogenetics of the major histocompatibility complex in childhood arthritis at the Arthritis Research Campaign (ARC) Epidemiology Unit at the University of Manchester, and was awarded a PhD in 2002.[10][11]

Career and research

Following her PhD, Zeggini was a postdoctoral researcher at the Wellcome Trust Centre for Human Genetics at the University of Oxford where she later became a Wellcome Trust Research Career Development Fellow. She has been a group leader at the Sanger since 2008.[5] According to Scopus[8] her most cited work has been published in Science[12][13] and Nature Genetics.[14][15]

As of 2015 her work investigates the genetics of complex phenotypic traits in humans using genetic association studies to identify novel disease loci.[16][17]

References

  1. ^ "Wellcome Trust Centre for Human Genetics - Eleftheria Zeggini". Oxford: University of Oxford. Archived from the original on 2009-11-18.
  2. ^ "Sophie Hackinger, PhD Student". HInxton: Wellcome Trust Sanger Institute. Archived from the original on 2015-11-23.
  3. ^ "Fernando Riveros Mckay Aguilera, PhD Student". Hinxton: Wellcome Trust Sanger Institute. Archived from the original on 2015-11-23.
  4. ^ "Ελευθερία Ζεγγίνη: Η γενετίστρια που έκανε διάσημα τα Ανώγεια". tanea.gr. Archived from the original on 2014-07-28.
  5. ^ a b Eleftheria Zeggini's ORCID 0000-0003-4238-659X
  6. ^ "People in the Department of Health Sciences". University of Leicester. Archived from the original on 2015-11-01.
  7. ^ Eleftheria Zeggini on X
  8. ^ a b Eleftheria Zeggini's publications indexed by the Scopus bibliographic database. (subscription required)
  9. ^ "Professor Eleftheria Zeggini, Group Leader". Hinxton: Wellcome Trust Sanger Institute. Archived from the original on 2015-11-11.
  10. ^ Zeggini, Eleftheria (2002). Genetic dissection of the major histocompatibility complex in juvenile oligoarthritis (PhD thesis). University of Manchester. Archived from the original on 2015-11-24.
  11. ^ Zeggini, E. (2002). "Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis". Rheumatology. 41 (4): 462–465. doi:10.1093/rheumatology/41.4.462. ISSN 1460-2172. PMID 11961180.
  12. ^ Frayling, T. M.; Timpson, N. J.; Weedon, M. N.; Zeggini, E.; Freathy, R. M.; Lindgren, C. M.; Perry, J. R. B.; Elliott, K. S.; Lango, H.; Rayner, N. W.; Shields, B.; Harries, L. W.; Barrett, J. C.; Ellard, S.; Groves, C. J.; Knight, B.; Patch, A. -M.; Ness, A. R.; Ebrahim, S.; Lawlor, D. A.; Ring, S. M.; Ben-Shlomo, Y.; Jarvelin, M. -R.; Sovio, U.; Bennett, A. J.; Melzer, D.; Ferrucci, L.; Loos, R. J. F.; Barroso, I.; et al. (2007). "A Common Variant in the FTO Gene is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity". Science. 316 (5826): 889–94. doi:10.1126/science.1141634. PMC 2646098. PMID 17434869.
  13. ^ Zeggini, E.; Weedon, M. N.; Lindgren, C. M.; Frayling, T. M.; Elliott, K. S.; Lango, H.; Timpson, N. J.; Perry, J. R. B.; Rayner, N. W.; Freathy, R. M.; Barrett, J. C.; Shields, B.; Morris, A. P.; Ellard, S.; Groves, C. J.; Harries, L. W.; Marchini, J. L.; Owen, K. R.; Knight, B.; Cardon, L. R.; Walker, M.; Hitman, G. A.; Morris, A. D.; Doney, A. S. F.; Wellcome Trust Case Control Consortium (WTCCC); Burton, P. R.; McCarthy, D. G.; Hattersley, N.; Deloukas, P.; Duncanson, A.; Kwiatkowski, D. P. (2007). "Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes". Science. 316 (5829): 1336–1341. doi:10.1126/science.1142364. PMID 17463249.
  14. ^ Zeggini, Eleftheria; Scott, Laura J; Saxena, Richa; Voight, Benjamin F; Marchini, Jonathan L; Hu, Tianle; de Bakker, Paul IW; Abecasis, Gonçalo R; Almgren, Peter; Andersen, Gitte; Ardlie, Kristin; Boström, Kristina Bengtsson; Bergman, Richard N; Bonnycastle, Lori L; Borch-Johnsen, Knut; Burtt, Noël P; Chen, Hong; Chines, Peter S; Daly, Mark J; Deodhar, Parimal; Ding, Chia-Jen; Doney, Alex S F; Duren, William L; Elliott, Katherine S; Erdos, Michael R; Frayling, Timothy M; Freathy, Rachel M; Gianniny, Lauren; Grallert, Harald; Grarup, Niels; Groves, Christopher J; Guiducci, Candace; Hansen, Torben; Herder, Christian; Hitman, Graham A; Hughes, Thomas E; Isomaa, Bo; Jackson, Anne U; Jørgensen, Torben; Kong, Augustine; Kubalanza, Kari; Kuruvilla, Finny G; Kuusisto, Johanna; Langenberg, Claudia; Lango, Hana; Lauritzen, Torsten; Li, Yun; Lindgren, Cecilia M; Lyssenko, Valeriya; Marvelle, Amanda F; Meisinger, Christa; Midthjell, Kristian; Mohlke, Karen L; Morken, Mario A; Morris, Andrew D; Narisu, Narisu; Nilsson, Peter; Owen, Katharine R; Palmer, Colin NA; Payne, Felicity; Perry, John R B; Pettersen, Elin; Platou, Carl; Prokopenko, Inga; Qi, Lu; Qin, Li; Rayner, Nigel W; Rees, Matthew; Roix, Jeffrey J; Sandbæk, Anelli; Shields, Beverley; Sjögren, Marketa; Steinthorsdottir, Valgerdur; Stringham, Heather M; Swift, Amy J; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Timpson, Nicholas J; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Walker, Mark; Watanabe, Richard M; Weedon, Michael N; Willer, Cristen J; Illig, Thomas; Hveem, Kristian; Hu, Frank B; Laakso, Markku; Stefansson, Kari; Pedersen, Oluf; Wareham, Nicholas J; Barroso, Inês; Hattersley, Andrew T; Collins, Francis S; Groop, Leif; McCarthy, Mark I; Boehnke, Michael; Altshuler, David (2008). "Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes". Nature Genetics. 40 (5): 638–645. doi:10.1038/ng.120. ISSN 1061-4036. PMC 2672416. PMID 18372903.
  15. ^ Willer, Cristen J; Speliotes, Elizabeth K; Loos, Ruth J F; Li, Shengxu; Lindgren, Cecilia M; Heid, Iris M; Berndt, Sonja I; Elliott, Amanda L; Jackson, Anne U; Lamina, Claudia; Lettre, Guillaume; Lim, Noha; Lyon, Helen N; McCarroll, Steven A; Papadakis, Konstantinos; Qi, Lu; Randall, Joshua C; Roccasecca, Rosa Maria; Sanna, Serena; Scheet, Paul; Weedon, Michael N; Wheeler, Eleanor; Zhao, Jing Hua; Jacobs, Leonie C; Prokopenko, Inga; Soranzo, Nicole; Tanaka, Toshiko; Timpson, Nicholas J; Almgren, Peter; Bennett, Amanda; Bergman, Richard N; Bingham, Sheila A; Bonnycastle, Lori L; Brown, Morris; Burtt, Noël P; Chines, Peter; Coin, Lachlan; Collins, Francis S; Connell, John M; Cooper, Cyrus; Smith, George Davey; Dennison, Elaine M; Deodhar, Parimal; Elliott, Paul; Erdos, Michael R; Estrada, Karol; Evans, David M; Gianniny, Lauren; Gieger, Christian; Gillson, Christopher J; Guiducci, Candace; Hackett, Rachel; Hadley, David; Hall, Alistair S; Havulinna, Aki S; Hebebrand, Johannes; Hofman, Albert; Isomaa, Bo; Jacobs, Kevin B; Johnson, Toby; Jousilahti, Pekka; Jovanovic, Zorica; Khaw, Kay-Tee; Kraft, Peter; Kuokkanen, Mikko; Kuusisto, Johanna; Laitinen, Jaana; Lakatta, Edward G; Luan, Jian'an; Luben, Robert N; Mangino, Massimo; McArdle, Wendy L; Meitinger, Thomas; Mulas, Antonella; Munroe, Patricia B; Narisu, Narisu; Ness, Andrew R; Northstone, Kate; O'Rahilly, Stephen; Purmann, Carolin; Rees, Matthew G; Ridderstråle, Martin; Ring, Susan M; Rivadeneira, Fernando; Ruokonen, Aimo; Sandhu, Manjinder S; Saramies, Jouko; Scott, Laura J; Scuteri, Angelo; Silander, Kaisa; Sims, Matthew A; Song, Kijoung; Stephens, Jonathan; Stevens, Suzanne; Stringham, Heather M; Tung, Y C Loraine; Valle, Timo T; Van Duijn, Cornelia M; Vimaleswaran, Karani S; Vollenweider, Peter; Waeber, Gerard; Wallace, Chris; Watanabe, Richard M; Waterworth, Dawn M; Watkins, Nicholas; Witteman, Jacqueline C M; Zeggini, Eleftheria; Zhai, Guangju; Zillikens, M Carola; Altshuler, David; Caulfield, Mark J; Chanock, Stephen J; Farooqi, I Sadaf; Ferrucci, Luigi; Guralnik, Jack M; Hattersley, Andrew T; Hu, Frank B; Jarvelin, Marjo-Riitta; Laakso, Markku; Mooser, Vincent; Ong, Ken K; Ouwehand, Willem H; Salomaa, Veikko; Samani, Nilesh J; Spector, Timothy D; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Uda, Manuela; Uitterlinden, André G; Wareham, Nicholas J; Deloukas, Panagiotis; Frayling, Timothy M; Groop, Leif C; Hayes, Richard B; Hunter, David J; Mohlke, Karen L; Peltonen, Leena; Schlessinger, David; Strachan, David P; Wichmann, H-Erich; McCarthy, Mark I; Boehnke, Michael; Barroso, Inês; Abecasis, Gonçalo R; Hirschhorn, Joel N (2008). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nature Genetics. 41 (1): 25–34. doi:10.1038/ng.287. ISSN 1061-4036. PMC 2695662. PMID 19079261.
  16. ^ Zeggini, Eleftheria (2011). "Next-generation association studies for complex traits". Nature Genetics. 43 (4): 287–288. doi:10.1038/ng0411-287. ISSN 1061-4036. PMC 3435533.
  17. ^ Crawford, Dana C.; Babron, Marie-Claude; de Tayrac, Marie; Rutledge, Douglas N.; Zeggini, Eleftheria; Génin, Emmanuelle (2012). "Rare and Low Frequency Variant Stratification in the UK Population: Description and Impact on Association Tests". PLoS ONE. 7 (10): e46519. doi:10.1371/journal.pone.0046519. ISSN 1932-6203. PMC 3465327.{{cite journal}}: CS1 maint: unflagged free DOI (link) Open access icon
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