MMP8: Difference between revisions
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'''Neutrophil collagenase''', also known as '''matrix metalloproteinase-8''' (MMP-8) or PMNL collagenase (MNL-CL), is a [[collagen]] [[protease|cleaving]] [[enzyme]] which is present in the connective tissue of most mammals.<ref name="entrez">{{cite web | title = Entrez Gene: MMP8 matrix metallopeptidase 8 (neutrophil collagenase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4317| accessdate = }}</ref> In humans, the MMP-8 [[protein]] is encoded by the ''MMP8'' [[gene]].<ref name="pmid2164002">{{cite journal | author = Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL | title = Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases | journal = J. Biol. Chem. | volume = 265 | issue = 20 | pages = 11421–4 |date=July 1990 | pmid = 2164002 | doi = | url = http://www.jbc.org/cgi/reprint/265/20/11421 | issn = }}</ref><ref name="pmid1646048">{{cite journal | author = Devarajan P, Mookhtiar K, Van Wart H, Berliner N | title = Structure and expression of the cDNA encoding human neutrophil collagenase | journal = Blood | volume = 77 | issue = 12 | pages = 2731–8 |date=June 1991 | pmid = 1646048 | doi = | url = http://bloodjournal.hematologylibrary.org/cgi/reprint/77/12/2731 | issn = }}</ref> |
'''Neutrophil collagenase''', also known as '''matrix metalloproteinase-8''' (MMP-8) or PMNL collagenase (MNL-CL), is a [[collagen]] [[protease|cleaving]] [[enzyme]] which is present in the connective tissue of most mammals.<ref name="entrez">{{cite web | title = Entrez Gene: MMP8 matrix metallopeptidase 8 (neutrophil collagenase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4317| accessdate = }}</ref> In humans, the MMP-8 [[protein]] is encoded by the ''MMP8'' [[gene]].<ref name="pmid2164002">{{cite journal | author = Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL | title = Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases | journal = J. Biol. Chem. | volume = 265 | issue = 20 | pages = 11421–4 |date=July 1990 | pmid = 2164002 | doi = | url = http://www.jbc.org/cgi/reprint/265/20/11421 | issn = }}</ref><ref name="pmid1646048">{{cite journal | author = Devarajan P, Mookhtiar K, Van Wart H, Berliner N | title = Structure and expression of the cDNA encoding human neutrophil collagenase | journal = Blood | volume = 77 | issue = 12 | pages = 2731–8 |date=June 1991 | pmid = 1646048 | doi = | url = http://bloodjournal.hematologylibrary.org/cgi/reprint/77/12/2731 | issn = }}</ref> |
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Revision as of 06:29, 20 May 2016
Neutrophil collagenase, also known as matrix metalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in the connective tissue of most mammals.[5] In humans, the MMP-8 protein is encoded by the MMP8 gene.[6][7]
Function
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000118113 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005800 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: MMP8 matrix metallopeptidase 8 (neutrophil collagenase)".
- ^ Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL (July 1990). "Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases". J. Biol. Chem. 265 (20): 11421–4. PMID 2164002.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Devarajan P, Mookhtiar K, Van Wart H, Berliner N (June 1991). "Structure and expression of the cDNA encoding human neutrophil collagenase". Blood. 77 (12): 2731–8. PMID 1646048.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
Further reading
External links
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