TAS2R1: Difference between revisions

TAS2R1
Identifiers
Aliases	TAS2R1, T2R1, TRB7, taste 2 receptor member 1
External IDs	OMIM: 604796; MGI: 2681253; HomoloGene: 10480; GeneCards: TAS2R1; OMA:TAS2R1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	9,712,378 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	32,178,440 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; stromal cell of endometrium; ; epithelium of colon; ; placenta; ; caudate nucleus; ; putamen; ; nucleus accumbens; ; hippocampal formation; ; prefrontal cortex;
	Top expressed in
	proximal tubule; ; right kidney; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; taste receptor activity; bitter taste receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; response to stimulus; sensory perception of taste;
	Sources:Amigo / QuickGO
Orthologs
	50834
	57254
	ENSG00000169777
	ENSMUSG00000045267
	Q9NYW7
	Q9JKT2
	NM_019599; NM_001386348
	NM_020503
	NP_062545
	NP_065249
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 14:28, 20 May 2016

Taste receptor type 2 member 1 is a protein that in humans is encoded by the TAS2R1 gene.^[5]^[6]^[7]

Function

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169777 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045267 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ ^a ^b "Entrez Gene: TAS2R1 taste receptor, type 2, member 1".

Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Firestein S (2000). "The good taste of genomics". Nature. 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221.
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169777 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045267 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10761934-5] Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[pmid10766242-6] Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. doi:10.1038/35007072. PMID 10766242.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[entrez-7] "Entrez Gene: TAS2R1 taste receptor, type 2, member 1".

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+{{Infobox_gene}}
-{{PBB|geneid=50834}}
 '''Taste receptor type 2 member 1''' is a [[protein]] that in humans is encoded by the ''TAS2R1'' [[gene]].<ref name="pmid10761934">{{cite journal | author = Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS | title = A novel family of mammalian taste receptors | journal = Cell | volume = 100 | issue = 6 | pages = 693–702 | date = Apr 2000 | pmid = 10761934 | pmc =  | doi = 10.1016/S0092-8674(00)80705-9 }}</ref><ref name="pmid10766242">{{cite journal | author = Matsunami H, Montmayeur JP, Buck LB | title = A family of candidate taste receptors in human and mouse | journal = Nature | volume = 404 | issue = 6778 | pages = 601–4 | date = Apr 2000 | pmid = 10766242 | pmc =  | doi = 10.1038/35007072 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAS2R1 taste receptor, type 2, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50834| accessdate = }}</ref>

TAS2R1: Difference between revisions

Revision as of 14:28, 20 May 2016

Function

See also

References

Further reading