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'''Famprofazone''' ('''Gewodin''', '''Gewolen''') is a [[non-steroidal anti-inflammatory agent]] (NSAID) of the [[pyrazolone]] series which is available [[over-the-counter]] in some countries such as [[Taiwan]].<ref name="isbn3-88763-075-0">{{cite book | author = Swiss Pharmaceutical Society | title = Index Nominum 2000: International Drug Directory (Book with CD-ROM) | publisher = Medpharm Scientific Publishers | location = Boca Raton | year = 2000 | pages = 1932 | isbn = 3-88763-075-0 | oclc = | doi = | url = http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA426&dq=famprofazone&pg=PA426#v=onepage&q=famprofazone&f=false}}</ref><ref name="isbn0-7514-0499-3">{{cite book |author1=Hall, Judith A. |author2=Morton, Ian | title = Concise dictionary of pharmacological agents: properties and synonyms | publisher = Kluwer Academic | location = | year = 1999 | pages = 342 | isbn = 0-7514-0499-3 | oclc = | doi = | url = http://books.google.com/books?id=mqaOMOtk61IC&lpg=PA118&dq=famprofazone&pg=PA118#v=onepage&q=famprofazone&f=false}}</ref><ref name="pmid20663288">{{cite journal |vauthors=Chan KH, Hsu MC, Tseng CY, Chu WL | title = Famprofazone use can be misinterpreted as methamphetamine abuse | journal = Journal of Analytical Toxicology | volume = 34 | issue = 6 | pages = 347–53 | year = 2010 | pmid = 20663288 | doi = 10.1093/jat/34.6.347| url = http://openurl.ingenta.com/content/nlm?genre=article&issn=0146-4760&volume=34&issue=6&spage=347&aulast=Chan}}</ref> It has [[analgesic]], [[anti-inflammatory]], and [[antipyretic]] effects.<ref name="isbn3-88763-075-0"/><ref name="isbn0-7514-0499-3"/> Famprofazone has been known to produce [[methamphetamine]] as an [[activity (chemistry)|active]] [[metabolite]], with 15-20% of an oral dose being converted to it.<ref name="pmid1496827">{{cite journal |vauthors=Oh ES, Hong SK, Kang GI | title = Plasma and urinary concentrations of methamphetamine after oral administration of famprofazone to man | journal = Xenobiotica | volume = 22 | issue = 3 | pages = 377–84 |date=March 1992 | pmid = 1496827 | doi = 10.3109/00498259209046649 | url = http://informahealthcare.com/doi/abs/10.3109/00498259209046649}}</ref><ref name="pmid9491970">{{cite journal |vauthors=Shin HS, Park BB, Choi SN, Oh JJ, Hong CP, Ryu H | title = Identification of new urinary metabolites of famprofazone in humans | journal = Journal of Analytical Toxicology | volume = 22 | issue = 1 | pages = 55–60 | year = 1998 | pmid = 9491970 | doi = 10.1093/jat/22.1.55| url = http://openurl.ingenta.com/content/nlm?genre=article&issn=0146-4760&volume=22&issue=1&spage=55&aulast=Shin}}</ref> As a result, famprofazone has occasionally been implicated in causing false positives on [[drug test]]s for [[substituted amphetamine|amphetamine]]s.<ref name="pmid20663288"/> |
'''Famprofazone''' ('''Gewodin''', '''Gewolen''') is a [[non-steroidal anti-inflammatory agent]] (NSAID) of the [[pyrazolone]] series which is available [[over-the-counter]] in some countries such as [[Taiwan]].<ref name="isbn3-88763-075-0">{{cite book | author = Swiss Pharmaceutical Society | title = Index Nominum 2000: International Drug Directory (Book with CD-ROM) | publisher = Medpharm Scientific Publishers | location = Boca Raton | year = 2000 | pages = 1932 | isbn = 3-88763-075-0 | oclc = | doi = | url = http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA426&dq=famprofazone&pg=PA426#v=onepage&q=famprofazone&f=false}}</ref><ref name="isbn0-7514-0499-3">{{cite book |author1=Hall, Judith A. |author2=Morton, Ian | title = Concise dictionary of pharmacological agents: properties and synonyms | publisher = Kluwer Academic | location = | year = 1999 | pages = 342 | isbn = 0-7514-0499-3 | oclc = | doi = | url = http://books.google.com/books?id=mqaOMOtk61IC&lpg=PA118&dq=famprofazone&pg=PA118#v=onepage&q=famprofazone&f=false}}</ref><ref name="pmid20663288">{{cite journal |vauthors=Chan KH, Hsu MC, Tseng CY, Chu WL | title = Famprofazone use can be misinterpreted as methamphetamine abuse | journal = Journal of Analytical Toxicology | volume = 34 | issue = 6 | pages = 347–53 | year = 2010 | pmid = 20663288 | doi = 10.1093/jat/34.6.347| url = http://openurl.ingenta.com/content/nlm?genre=article&issn=0146-4760&volume=34&issue=6&spage=347&aulast=Chan}}</ref> It has [[analgesic]], [[anti-inflammatory]], and [[antipyretic]] effects.<ref name="isbn3-88763-075-0"/><ref name="isbn0-7514-0499-3"/> Famprofazone has been known to produce [[methamphetamine]] as an [[activity (chemistry)|active]] [[metabolite]], with 15-20% of an oral dose being converted to it.<ref name="pmid1496827">{{cite journal |vauthors=Oh ES, Hong SK, Kang GI | title = Plasma and urinary concentrations of methamphetamine after oral administration of famprofazone to man | journal = Xenobiotica | volume = 22 | issue = 3 | pages = 377–84 |date=March 1992 | pmid = 1496827 | doi = 10.3109/00498259209046649 | url = http://informahealthcare.com/doi/abs/10.3109/00498259209046649}}</ref><ref name="pmid9491970">{{cite journal |vauthors=Shin HS, Park BB, Choi SN, Oh JJ, Hong CP, Ryu H | title = Identification of new urinary metabolites of famprofazone in humans | journal = Journal of Analytical Toxicology | volume = 22 | issue = 1 | pages = 55–60 | year = 1998 | pmid = 9491970 | doi = 10.1093/jat/22.1.55| url = http://openurl.ingenta.com/content/nlm?genre=article&issn=0146-4760&volume=22&issue=1&spage=55&aulast=Shin}}</ref> As a result, famprofazone has occasionally been implicated in causing false positives on [[drug test]]s for [[substituted amphetamine|amphetamine]]s.<ref name="pmid20663288"/> |
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==See also== |
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* [[Difenamizole]] |
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* [[Morazone]] |
* [[Morazone]] |
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==References== |
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{{Reflist}} |
{{Reflist|2}} |
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{{Anti-inflammatory products}} |
{{Anti-inflammatory products}} |
Revision as of 07:36, 2 June 2016
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Clinical data | |
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Routes of administration | Oral |
ATC code |
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Identifiers | |
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CAS Number | |
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ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.041.153 |
Chemical and physical data | |
Formula | C24H31N3O |
Molar mass | 377.52 g/mol g·mol−1 |
3D model (JSmol) | |
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Famprofazone (Gewodin, Gewolen) is a non-steroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan.[1][2][3] It has analgesic, anti-inflammatory, and antipyretic effects.[1][2] Famprofazone has been known to produce methamphetamine as an active metabolite, with 15-20% of an oral dose being converted to it.[4][5] As a result, famprofazone has occasionally been implicated in causing false positives on drug tests for amphetamines.[3]
See also
References
- ^ a b Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932. ISBN 3-88763-075-0.
- ^ a b Hall, Judith A.; Morton, Ian (1999). Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. p. 342. ISBN 0-7514-0499-3.
- ^ a b Chan KH, Hsu MC, Tseng CY, Chu WL (2010). "Famprofazone use can be misinterpreted as methamphetamine abuse". Journal of Analytical Toxicology. 34 (6): 347–53. doi:10.1093/jat/34.6.347. PMID 20663288.
- ^ Oh ES, Hong SK, Kang GI (March 1992). "Plasma and urinary concentrations of methamphetamine after oral administration of famprofazone to man". Xenobiotica. 22 (3): 377–84. doi:10.3109/00498259209046649. PMID 1496827.
- ^ Shin HS, Park BB, Choi SN, Oh JJ, Hong CP, Ryu H (1998). "Identification of new urinary metabolites of famprofazone in humans". Journal of Analytical Toxicology. 22 (1): 55–60. doi:10.1093/jat/22.1.55. PMID 9491970.